公开(公告)号：US12146891B2

公开(公告)日：2024-11-19

申请号：US16515501

申请日：2019-07-18

Applicant: Labrador Diagnostics LLC

Inventor： James R. Wasson ,  John Kent Frankovich ,  Elizabeth A. Holmes ,  Timothy Smith ,  Michael Chen ,  Daniel Young

IPC: B01L3/00 ,  B01L3/02 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  B01L9/00

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US12054791B2

公开(公告)日：2024-08-06

申请号：US17171951

申请日：2021-02-09

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Chandan Shee ,  Clarissa Lui

IPC: C12Q1/689 ,  C12Q1/04 ,  G01N33/53 ,  G01N33/569

CPC classification number: C12Q1/689 ,  C12Q1/04 ,  G01N33/53 ,  G01N33/56911 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2469/10 ,  G01N2469/20

Abstract: Systems and methods for determining pathogens and antimicrobial resistance of pathogens in a sample are provided.

公开(公告)号：US11545241B1

公开(公告)日：2023-01-03

申请号：US14480405

申请日：2014-09-08

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Daniel Young

IPC: G06Q50/22 ,  G16H10/40 ,  G06Q10/06

Abstract: Systems, methods, and devices are provided for clinical laboratory testing using less than 1 mL of sample collected from a subject. Some embodiments collect between 1 mL and about 10 uL of sample from a subject. A method is also provided for analyte testing, wherein a mobile computing device may be used for laboratory test requests and for handling of the analyte testing process.

公开(公告)号：US11385252B2

公开(公告)日：2022-07-12

申请号：US16541404

申请日：2019-08-15

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Timothy Smith ,  Alexander Loo ,  Daniel Young

IPC: G01N35/10 ,  G01N21/00 ,  G01N33/50 ,  G01N35/00

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

公开(公告)号：US11320355B2

公开(公告)日：2022-05-03

申请号：US16259511

申请日：2019-01-28

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Elizabeth A. Holmes

IPC: G01N15/04 ,  G01N15/05 ,  G01N33/49 ,  G01N15/00

Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.

公开(公告)号：US11249799B2

公开(公告)日：2022-02-15

申请号：US14181486

申请日：2014-02-14

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young

IPC: G06F15/16 ,  G06F9/48 ,  G01N35/00 ,  H04L67/10 ,  H04L67/12

Abstract: Provided herein are medical testing devices, systems, and methods that integrate multiplex, multi-technology, multi-configuration, multisample, or multi-threading capabilities. These capabilities are achieved using one or more of a level operations and communications architecture, a protocol execution engine, and a machine vision and processing system, method, or device in order to make testing of biologic or other samples more efficient in terms of cost, time, energy, or by prioritizing at least one other objective.

公开(公告)号：US11195624B2

公开(公告)日：2021-12-07

申请号：US15952983

申请日：2018-04-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

IPC: G16H50/50 ,  G16H50/70 ,  G16H50/20 ,  G16H50/80 ,  G16Z99/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

公开(公告)号：US20210333127A1

公开(公告)日：2021-10-28

申请号：US17228391

申请日：2021-04-12

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Timothy Smith ,  Scott Ridel ,  John Kent Frankovich ,  Michael Siegel

IPC: G01D5/14 ,  B04B9/14 ,  B04B5/04 ,  B04B13/00 ,  B04B9/10 ,  B04B7/08 ,  B04B15/02 ,  G01P3/488 ,  G01D5/347

Abstract: In one nonlimiting example, an automated system is provided for separating one or more components in a biological fluid, wherein the system comprises: (a) a centrifuge comprising one or more bucket configured to receive a container to effect said separating of one or more components in a fluid sample; and (b) the container, wherein the container includes one or more shaped feature that is complementary to a shaped feature of the bucket.

公开(公告)号：US11137391B2

公开(公告)日：2021-10-05

申请号：US15952966

申请日：2018-04-13

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20210186393A1

公开(公告)日：2021-06-24

申请号：US17111831

申请日：2020-12-04

Applicant: Labrador Diagnostics LLC

Inventor： Patricia McHale ,  Michael Chen ,  Pey-Jiun Ko ,  Tammy Burd ,  Adrit Lath ,  Elizabeth A. Holmes ,  Joy Roy

IPC: A61B5/15 ,  G01N1/10 ,  A61B10/00 ,  A61B5/154 ,  A61B5/151 ,  A61B5/155 ,  B01L3/00 ,  G01N1/14

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.