公开(公告)号：US11320355B2

公开(公告)日：2022-05-03

申请号：US16259511

申请日：2019-01-28

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Elizabeth A. Holmes

IPC: G01N15/04 ,  G01N15/05 ,  G01N33/49 ,  G01N15/00

Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.

公开(公告)号：US20220137075A1

公开(公告)日：2022-05-05

申请号：US17470596

申请日：2021-09-09

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Paul Patel ,  Ian Gibbons ,  Elizabeth A. Holmes

IPC: G01N33/86 ,  C12Q1/56 ,  G01N21/84 ,  G01N33/49 ,  G01N33/58

Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 μL) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.

公开(公告)号：US20210140866A1

公开(公告)日：2021-05-13

申请号：US17028063

申请日：2020-09-22

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Elizabeth A. Holmes

IPC: G01N15/04 ,  G01N15/05 ,  G01N33/49

Abstract: Devices and methods are described for measuring formed blood component sedimentation rate. Some of the methods may use (1) centrifugal techniques for separating red blood cells from plasma and (2) video and/or still imaging capability. Both may be used alone or in combination to accelerate formed blood component sedimentation and to measure its rate. In one example, the method may advantageously enable rapid measurement of sedimentation rate using small blood sample volumes. Automated image analysis can be used to determine both sedimentation rate and hematocrit. Automated techniques may be used to compensate for effects of hematocrit on uncorrected sedimentation rate data.