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11.发明申请公开(公告)号：US20180180814A1
公开(公告)日：2018-06-28
申请号：US15886431
申请日：2018-02-01
Applicant: NORTHWESTERN UNIVERSITY , AMERICAN BIOOPTICS LLC
Inventor： Vadim Backman , Jeremy D. Rogers , Nikhil N. Mutyal , Bradley Gould , Andrew J. Radosevich
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
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12.发明申请公开(公告)号：US20180129863A1
公开(公告)日：2018-05-10
申请号：US15794101
申请日：2017-10-26
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Vadim Backman , Hariharan Subramanian , John E. Chandler , Craig White , Jeremy D. Rogers , Lusik Cherkezyan
IPC: G06K9/00 , H04N5/235 , H04N5/232 , G02B21/36 , G02B21/16 , G01J3/12 , G02B21/06 , G01N21/47 , G01J3/44 , G01J3/28
CPC classification number: G06K9/00127 , G01J3/1256 , G01J3/2823 , G01J3/44 , G01N21/47 , G01N2021/4709 , G02B21/06 , G02B21/16 , G02B21/365 , H04N5/23212 , H04N5/2354
Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.
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公开(公告)号：US09783855B2
公开(公告)日：2017-10-10
申请号：US14747596
申请日：2015-06-23
Inventor： Vadim Backman , Hariharan Subramanian , Dhwanil Damania , Hemant Roy , Dhananjay Kunte , Mart Angelo De la Cruz
IPC: C12Q1/68 , G01N1/28 , G01N21/41 , G01N33/574 , G01N21/64
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , G01N21/41 , G01N21/64 , G01N21/6486 , G01N33/57407 , G01N33/57411 , G01N33/57419 , G01N33/57484
Abstract: The present invention relates to detection of cancer, or assessment of risk of development thereof. In particular, the present invention provides compositions and methods detection of field carcinogenesis by identification of ultrastructural and molecular markers in a subject.
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公开(公告)号：US09619903B2
公开(公告)日：2017-04-11
申请号：US14698641
申请日：2015-04-28
Applicant: Northwestern University
Inventor： Ji Yi , Wenzhong Liu , Vadim Backman , Hao F. Zhang
CPC classification number: A61B3/102 , A61B1/04 , A61B3/1233 , A61B5/0066 , A61B5/0073 , A61B5/0205 , A61B5/0261 , A61B5/14507 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14542 , A61B5/14551 , G01B9/02091 , G06F17/10 , G06F17/13 , G06T7/0012 , G06T7/0014 , G06T11/003 , G06T2207/10028 , G06T2207/10101
Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
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15.发明授权Methods and apparatus for laser scanning structured illumination microscopy and tomography 有权激光扫描结构光学显微镜和断层扫描的方法和装置公开(公告)号：US09360660B2
公开(公告)日：2016-06-07
申请号：US13902288
申请日：2013-05-24
Applicant: Northwestern University
Inventor： Ji Yi , Vadim Backman , Qing Wei , Hao F. Zhang
CPC classification number: G02B21/0032 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/64 , G01N21/6458 , G01N2021/1787 , G01N2021/456 , G01N2201/067 , G01N2201/0691
Abstract: Certain examples provide a structured illumination microscopy system. The example system includes a laser source to generate excitation illumination directed toward a target. The example system includes a modulator to modulate the excitation illumination temporally in a controllable spatial pattern to be constructed on the target object to provide sub-diffractional resolution in a lateral direction with respect to the target. The example system includes two synchronized laser scanning mirror units in confocal arrangement, the laser scanning units to be synchronized and controlled by a computing device, a first of the scanning mirror units to receive the modulated excitation illumination and project the modulated excitation illumination on the target object and a second of the scanning mirror units to receive emission fluorescence from the target and project the emission fluorescence. The example system includes a detector to collect emission fluorescence from the target via the second of the scanning mirror units.
Abstract translation: 某些实例提供了结构化的照明显微镜系统。 该示例系统包括产生朝向目标的激发照明的激光源。 该示例系统包括一个调制器，用于以可控的空间图案临时调制激励照明，以在目标物体上构造，以在相对于目标的横向方向上提供子衍射分辨率。 示例系统包括共焦排列的两个同步的激光扫描镜单元，由计算装置同步和控制的激光扫描单元，用于接收经调制的激发照明并将调制的激发照明投影到目标上的第一扫描镜单元 物体和第二个扫描镜单元，以从目标接收发射荧光并投射发射荧光。 该示例系统包括用于经由第二扫描反射镜单元从目标物体收集发射荧光的检测器。
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Patent Agency Ranking
16.发明申请METHODS AND APPARATUS FOR LASER SCANNING STRUCTURED ILLUMINATION MICROSCOPY AND TOMOGRAPHY 有权激光扫描结构照明显微镜和TOMOGRAPHY的方法和装置公开(公告)号：US20130314717A1
公开(公告)日：2013-11-28
申请号：US13902288
申请日：2013-05-24
Applicant: Northwestern University
Inventor： Ji Yi , Vadim Backman , Qing Wei , Hao F. Zhang
CPC classification number: G02B21/0032 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/64 , G01N21/6458 , G01N2021/1787 , G01N2021/456 , G01N2201/067 , G01N2201/0691
Abstract: Certain examples provide a structured illumination microscopy system. The example system includes a laser source to generate excitation illumination directed toward a target. The example system includes a modulator to modulate the excitation illumination temporally in a controllable spatial pattern to be constructed on the target object to provide sub-diffractional resolution in a lateral direction with respect to the target. The example system includes two synchronized laser scanning mirror units in confocal arrangement, the laser scanning units to be synchronized and controlled by a computing device, a first of the scanning mirror units to receive the modulated excitation illumination and project the modulated excitation illumination on the target object and a second of the scanning mirror units to receive emission fluorescence from the target and project the emission fluorescence. The example system includes a detector to collect emission fluorescence from the target via the second of the scanning mirror units.
Abstract translation: 某些实例提供了结构化的照明显微镜系统。 该示例系统包括产生朝向目标的激发照明的激光源。 该示例系统包括一个调制器，用于以可控的空间图案临时调制激励照明，以在目标物体上构造，以在相对于目标的横向方向上提供子衍射分辨率。 示例系统包括共焦排列的两个同步的激光扫描镜单元，由计算装置同步和控制的激光扫描单元，用于接收经调制的激发照明并将调制的激发照明投影到目标上的第一扫描镜单元 物体和第二个扫描镜单元，以从目标接收发射荧光并投射发射荧光。 该示例系统包括用于经由第二扫描反射镜单元从目标物体收集发射荧光的检测器。
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公开(公告)号：US12252522B2
公开(公告)日：2025-03-18
申请号：US18151166
申请日：2023-01-06
Applicant: Northwestern University
Inventor： Hemant K. Roy , Vadim Backman
IPC: A61K38/18 , A61K31/282 , A61K38/00 , A61K38/19 , A61P3/10 , A61P9/00 , A61P35/00 , C07K14/47 , C07K14/475 , C07K14/52
Abstract: Disclosed are compositions comprising myokines and their methods of preparation and use. The disclosed myokine compositions and methods may comprise myokines having a molecular weight of greater than about 10 kDa such as myostatin and metrnl. The disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders. In particular, the disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders, such as cancer, and metabolic diseases and disorders, such as diabetes, non-alcoholic fatty liver disease, and heart disease.
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公开(公告)号：US10921212B2
公开(公告)日：2021-02-16
申请号：US16011034
申请日：2018-06-18
Applicant: NORTHWESTERN UNIVERSITY , AMERICAN BIOOPTICS, LLC
Inventor： Vadim Backman , Bradley Gould , Nikhil Mutyal , Frank Garrett, Jr. , The Quyen Nguyen , Michael Garrett
Abstract: An automated calibration system that includes a probe guide and a target assembly. The probe guide receives an optical probe, and the target assembly includes one or more calibration targets. The target assembly is slideable relative to the probe guide so that a first calibration target is aligned under the optical probe in a first position of the target assembly and a second calibration target is aligned under the optical probe in a second position of the target assembly.
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公开(公告)号：US09962075B2
公开(公告)日：2018-05-08
申请号：US15465285
申请日：2017-03-21
Applicant: Northwestern University
Inventor： Ji Yi , Wenzhong Liu , Vadim Backman , Hao F. Zhang , Kieren J. Patel
IPC: G06K9/00 , A61B3/10 , G06T7/00 , G01B9/02 , A61B5/1455 , A61B3/12 , A61B5/145 , A61B5/0205 , A61B1/04 , G06F17/13 , A61B5/00 , A61B5/026
CPC classification number: A61B3/102 , A61B1/04 , A61B3/1233 , A61B5/0066 , A61B5/0073 , A61B5/0205 , A61B5/0261 , A61B5/14507 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14542 , A61B5/14551 , G01B9/02091 , G06F17/10 , G06F17/13 , G06T7/0012 , G06T7/0014 , G06T11/003 , G06T2207/10028 , G06T2207/10101
Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
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20.发明授权公开(公告)号：US09885834B2
公开(公告)日：2018-02-06
申请号：US13963560
申请日：2013-08-09
Applicant: NORTHWESTERN UNIVERSITY , AMERICAN BIOOPTICS LLC
Inventor： Vadim Backman , Jeremy D. Rogers , Nikhil N. Mutyal , Bradley Gould , Andrew J. Radosevich
CPC classification number: G02B6/262 , A61B5/0066 , A61B5/0084 , G01N21/474 , G02B6/3807
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
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