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11.发明申请公开(公告)号：US20150328313A1
公开(公告)日：2015-11-19
申请号：US14650208
申请日：2013-12-18
Inventor： Robert H. Chow , Mark S. Humayun , Harry B. Gray , Robert H. Grubbs , Dennis Dougherty , Mark Thompson , Oliver Shafaat , Erin Lamb
CPC classification number: A61K41/00 , A61B3/113 , A61K41/0023 , A61N5/062 , A61N2005/0648 , C12N13/00
Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
Abstract translation: 方法和组合物调节电可兴奋细胞的活性。 在暴露于光能下，增加或减少细胞的电活动的光伏化合物。 这些补充和/或替代视觉基于视觉系统的某些单元内的光能转换为电能。 用于规避视觉系统中一个或多个缺陷，损坏或病变细胞的“补丁”或桥梁。 另外，在几个实施例中，具有正常视力的受试者可以受益于本文公开的方法，组合物，系统和/或装置，因为可以提高正常视力。 曝光引起能量（例如，光能的接收，电能的转换和电能的传递）从光伏化合物到细胞，从而改变细胞的跨膜电位和/或开放一个或 更多的离子通道，从而调节电可激发细胞的活性。
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公开(公告)号：US12295831B2
公开(公告)日：2025-05-13
申请号：US18508702
申请日：2023-11-14
Inventor： Yu-Chong Tai , Mark S. Humayun
IPC: A61F2/16
Abstract: An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
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公开(公告)号：US20240049701A1
公开(公告)日：2024-02-15
申请号：US18483917
申请日：2023-10-10
Inventor： Britney O. Pennington , Jeffrey K. Bailey , Mohamed A. Faynus , Cassidy Arnold , Lincoln V. Johnson , Dennis O. Clegg , Mark S. Humayun , David R. Hinton , Danhong Zhu , Debbie Mitra
CPC classification number: A01N1/021 , C12N5/0621 , C08G61/025
Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
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公开(公告)号：US11825839B2
公开(公告)日：2023-11-28
申请号：US16557897
申请日：2019-08-30
Inventor： Britney O. Pennington , Jeffrey K. Bailey , Mohamed A. Faynus , Cassidy Arnold , Lincoln V. Johnson , Dennis O. Clegg , Mark S. Humayun , David R. Hinton , Danhong Zhu , Debbie Mitra
CPC classification number: A01N1/021 , C12N5/0621 , C08G61/025
Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
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公开(公告)号：US11730358B2
公开(公告)日：2023-08-22
申请号：US16786377
申请日：2020-02-10
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Mark S. Humayun
CPC classification number: A61B3/101 , A61B5/6821 , A61B5/6867 , A61B10/0045 , G01F22/00 , G01G19/00 , G01N1/10 , G01N30/02 , G01N33/4875 , A61B2010/0067 , G01N2030/027
Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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Patent Agency Ranking
公开(公告)号：US11523939B2
公开(公告)日：2022-12-13
申请号：US16418899
申请日：2019-05-21
Inventor： Yu-Chong Tai , Aubrey M. Shapero , Nicholas E. Scianmarello , Mark S. Humayun
Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US11478272B2
公开(公告)日：2022-10-25
申请号：US16280956
申请日：2019-02-20
Applicant: University of Southern California
Inventor： Mark S. Humayun
Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.
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18.发明授权公开(公告)号：US11376344B2
公开(公告)日：2022-07-05
申请号：US16693646
申请日：2019-11-25
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor： John J. Whalen, III , Niki Bayat , Yi Zhang , Paulo Falabella , Mark E. Thompson , Mark S. Humayun
Abstract: The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.
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19.发明授权公开(公告)号：US11154226B2
公开(公告)日：2021-10-26
申请号：US15179744
申请日：2016-06-10
Inventor： Yu-Chong Tai , Hyuck Choo , Ramiro Magalhaes Ribeiro , Mark S. Humayun
IPC: A61B5/00 , A61B5/145 , A61B5/1459 , G02B6/10 , G02B6/122 , G01J3/44 , G01N21/65 , G02B6/34 , G01N21/64 , G02B6/12
Abstract: A medical sensor is described. In an example, the medical sensor includes a nanoscale tapered waveguide attached to a substrate. The nanoscale tapered waveguide includes a nanoscale channel that receives fluid and an excitation light and that outputs a response light. The excitation light propagates through the fluid. A receiving channel of the nanoscale channel is configured as a waveguide that receives and guides the excitation to a linearly tapered channel of the nanoscale channel. The linearly tapered channel has three dimensional linear tapering that focuses the excitation light guided from the receiving channel into an optical response channel of the nanoscale channel. In turn, the optical response channel is configured as a waveguide that outputs a response light in response to the excitation light focused from the linearly tapered channel. The response light corresponds to a response of an analyte of the fluid present in the optical response channel.
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公开(公告)号：US20190307928A1
公开(公告)日：2019-10-10
申请号：US16377979
申请日：2019-04-08
Inventor： Mark S. Humayun , Carlos Eduardo da Silveira Franciozi , Tzu-Chieh Chou , Yu-Chong Tai , Damien C. Rodger , C. Thomas Vangsness, JR.
Abstract: A polymeric substrate for treating a chondral or osteochondral defect includes a polymeric sheet having a predetermined shape and size for placement over a chondral or osteochondral defect. The polymeric sheet defines suture openings therein that allow fixation of the polymeric scaffold. Characteristically, the polymeric sheet includes biocompatible polymer. A method for treating a subject having a chondral or osteochondral defect is also provided.
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