公开(公告)号：US20130119277A1

公开(公告)日：2013-05-16

申请号：US13737279

申请日：2013-01-09

Applicant: Molecular Devices, LLC

Inventor： Josef J. Atzler ,  Bernhard Schinwald

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: Systems and methods for measuring a target in a sample, the target being capable of generating an emitted light in response to an excitation light. In an example system, an excitation light source generates the excitation light along an excitation optical path. An attenuation filter arrangement selectively adds an attenuation filter to the excitation optical path. The attenuation filter attenuates the excitation light by a corresponding attenuation factor. The excitation light exits the attenuation filter arrangement along the excitation optical path to illuminate the sample. A light energy detector receives the emitted light generated in response to the excitation light, and outputs a measured signal level corresponding to an emitted light level. If the light energy detector indicates an overflow, signal measurement is repeated with attenuation filters of increasing attenuation factors until the measured signal level does not overflow.

Abstract translation: 用于测量样本中的目标的系统和方法，所述目标能够响应于激发光产生发射的光。 在示例性系统中，激发光源沿着激发光路产生激发光。 衰减滤波器装置选择性地将衰减滤波器添加到激励光路。 衰减滤波器通过相应的衰减因子衰减激发光。 激发光沿着激发光路离开衰减滤光器装置以照亮样品。 光能检测器接收响应于激发光产生的发射光，并且输出与发射的光级相对应的测量信号电平。 如果光能检测器指示溢出，则使用增加衰减因子的衰减滤波器重复信号测量，直到测量信号电平不会溢出。

公开(公告)号：US20120304729A1

公开(公告)日：2012-12-06

申请号：US13516088

申请日：2010-12-14

Applicant: Brian Dwayne O'Dell ,  Marcus LaGrone ,  Martin Leuschen

Inventor： Brian Dwayne O'Dell ,  Marcus LaGrone ,  Martin Leuschen

IPC: G01N7/00 ,  G01N37/00

CPC classification number: G01N21/783 ,  G01N21/77 ,  G01N33/0057 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/024

Abstract: The invention provides for a multiple analyte detector that is capable of detecting and identifying explosive, chemical or biological substances having multiple analytes with a single system having multiple reporters. The reporters include fluorescent polymers, conducting polymers, metal oxide elements electrochemical cells, etc. The reporters may be combinations of other reporters that are optimized for broadband detection.

Abstract translation: 本发明提供了一种多分析物检测器，其能够利用具有多个记录器的单个系统来检测和识别具有多个分析物的爆炸性，化学或生物物质。 记者包括荧光聚合物，导电聚合物，金属氧化物元件电化学电池等。记者可以是针对宽带检测而优化的其它记者的组合。

公开(公告)号：US20120260719A1

公开(公告)日：2012-10-18

申请号：US13501779

申请日：2010-10-07

Applicant: Wolfgang Schade

Inventor： Wolfgang Schade

IPC: G01N21/17 ,  H05K13/00

CPC classification number: G01N21/1702 ,  G01N2021/1704 ,  G01N2201/024 ,  Y10T29/41

Abstract: A photo-acoustic gas sensor and methods for producing same, the gas sensor having a resonance body and a device for detecting a vibration of the resonance body, including a device for optically detecting the location of at least one partial surface of the resonance body, wherein the resonance body and the device for detecting a vibration are disposed on exactly one substrate, the resonance body is formed by at least one first recess of the substrate, and the substrate is a semiconductor material.

Abstract translation: 一种光声气体传感器及其制造方法，所述气体传感器具有共振体和用于检测所述共振体的振动的装置，所述装置包括用于光学地检测所述共振体的至少一个部分表面的位置的装置， 其中所述共振体和用于检测振动的装置设置在恰好一个基板上，所述谐振体由所述基板的至少一个第一凹部形成，并且所述基板是半导体材料。

公开(公告)号：US08119066B2

公开(公告)日：2012-02-21

申请号：US11351181

申请日：2006-02-08

Applicant: Daniel M. Stock ,  Josef J. Atzler

Inventor： Daniel M. Stock ,  Josef J. Atzler

IPC: G01N21/00

CPC classification number: G01N21/645 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The cartridge has one or more light sources and/or optical systems and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 盒具有一个或多个光源和/或光学系统以及其它特定于某种类型的应用，如荧光，吸光度或发光的组件。 用于特定应用的光源，光学系统和其他部件容纳在单个盒中。 该系统具有用于多模仪器的不同应用的多个盒。 盒可以以“插入”格式可移除地与设备接合，使得一个盒可以从设备移除，并且另一个盒可以容易地安装。

公开(公告)号：US07869679B2

公开(公告)日：2011-01-11

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US20100110439A1

公开(公告)日：2010-05-06

申请号：US12449649

申请日：2008-02-25

Applicant: Roman Gruler ,  Konrad Faulstich

Inventor： Roman Gruler ,  Konrad Faulstich

IPC: G01N21/01 ,  G01N1/10 ,  G01N21/55 ,  G01T1/10

CPC classification number: G01N21/645 ,  G01N21/255 ,  G01N21/8483 ,  G01N2201/0228 ,  G01N2201/024

Abstract: The invention provides for an optical measuring instrument and measuring device. The optical measuring instrument for investigating a specimen contained in a sample comprises at least one source for providing at least one electromagnetic beam intended to irradiate the sample and to interact with the specimen within the sample, at least one sensor for detecting an output of the interaction between the specimen and the electromagnetic beam, an integrally formed mechanical bench for the optical and electronic components, a sample holder for holding the sample, wherein the at least one source, the at least one sensor, and the mechanical bench are integrated in one monolithic optoelectronic module and the sample holder can be connected to this module.

Abstract translation: 本发明提供一种光学测量仪器和测量装置。 用于调查包含在样品中的样本的光学测量仪器包括至少一个源，用于提供用于照射样品的至少一个电磁束并与样品内的样品相互作用，用于检测相互作用的输出的至少一个传感器 在样品和电磁束之间，用于光学和电子部件的整体形成的机械台，用于保持样品的样品保持器，其中所述至少一个源，所述至少一个传感器和所述机械台被集成在一个单片 光电模块和样品架可以连接到该模块。

公开(公告)号：US20090218517A1

公开(公告)日：2009-09-03

申请号：US12391293

申请日：2009-02-24

Applicant: William Bedingham ,  Peter D. Ludowise ,  Barry W. Robole

Inventor： William Bedingham ,  Peter D. Ludowise ,  Barry W. Robole

IPC: G01N21/64

CPC classification number: G01N35/00069 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/024

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules. Each of the removable optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector.

Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可拆卸光学模块。 每个可移动光学模块被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。

公开(公告)号：US20090158865A1

公开(公告)日：2009-06-25

申请号：US12298273

申请日：2007-04-23

Applicant: Jacques Dallongeville ,  Philippe Dubois

Inventor： Jacques Dallongeville ,  Philippe Dubois

IPC: G01N21/88 ,  B65G47/24

CPC classification number: G01N21/90 ,  G01N2021/8411 ,  G01N2033/0081 ,  G01N2201/024

Abstract: A control module including means for controlling an article, means for regulating at least one parameter of the article control means, and means for driving the article towards the control means. More specifically, the module is movable and includes a releasable means of connection with a fixed frame. Preferably the drive means includes a carousel having at least one cell for housing the article, for example a glass bottle.

Abstract translation: 一种控制模块，包括用于控制物品的装置，用于调节物品控制装置的至少一个参数的装置，以及用于朝向控制装置驱动物品的装置。 更具体地，该模块是可移动的并且包括与固定框架连接的可释放装置。 优选地，驱动装置包括具有用于容纳物品的至少一个单元的转盘，例如玻璃瓶。

公开(公告)号：US07507575B2

公开(公告)日：2009-03-24

申请号：US11174754

申请日：2005-07-05

Applicant: William Bedingham ,  Peter D. Ludowise ,  Barry W. Robole

Inventor： William Bedingham ,  Peter D. Ludowise ,  Barry W. Robole

IPC: C12M1/34 ,  C12M1/00 ,  C12Q1/68

CPC classification number: G01N35/00069 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/024

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules. Each of the removable optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector.

Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可拆卸光学模块。 每个可移动光学模块被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。

公开(公告)号：US20080144028A1

公开(公告)日：2008-06-19

申请号：US11885068

申请日：2006-03-03

Applicant: Roman Gruler

Inventor： Roman Gruler

IPC: G01J3/30

CPC classification number: G01N21/6486 ,  B33Y80/00 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024

Abstract: Disclosed is a fluorescence meter for analyzing a sample, comprising a main beam path and at least one optical module. The fluorescence meter is embodied so as to provide at least one electromagnetic beam for exciting the sample and receive at least one electromagnetic beam emitted by the sample, at least some sections of at least two of the electromagnetic beams being located on one plane while extending along the main beam path.

Abstract translation: 公开了一种用于分析样品的荧光计，包括主光束路径和至少一个光学模块。 荧光计的实施是为了提供至少一个电磁波束，用于激发样品并接收由样品发射的至少一个电磁波束，至少两个电磁波束的至少一些部分位于一个平面上，同时沿着 主梁路径。