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    Systems and Methods for High-Throughput Turbidity Measurements
    14.
    发明申请
    Systems and Methods for High-Throughput Turbidity Measurements 审中-公开
    高通量浊度测量系统和方法

    公开(公告)号：US20100110220A1

    公开(公告)日：2010-05-06

    申请号：US12615093

    申请日：2009-11-09

    Applicant: Mary Anne Leugers ,  Tzu-Chi Kuo ,  Jodi Milhaupt Mecca ,  Carol Elaine Mohler

    Inventor： Mary Anne Leugers ,  Tzu-Chi Kuo ,  Jodi Milhaupt Mecca ,  Carol Elaine Mohler

    IPC: G06K9/00 ,  G01N21/59 ,  H04N5/222

    CPC classification number: G01N21/59 ,  G01N21/534 ,  G01N2021/5957 ,  G01N2201/0461 ,  G01N2201/1211

    Abstract: A turbidity measurement system includes a sample assembly that contains a plurality of samples, a light source that illuminates the sample assembly, and a light detection system that includes a two-dimensional light-sensitive array. The light-sensitive array is simultaneously exposed to light transmitted through each of the samples in the sample assembly. The exposure is analyzed to determine a mean transmitted light intensity for each sample and to calculate a turbidity value for each sample based on its mean transmitted light intensity. Multiple exposures may be taken during a measurement period so as to obtain time-resolved turbidity measurements of the samples. The temperature of the samples may be varied during the measurement period so as to measure turbidity as a function of temperature.

    Abstract translation: 浊度测量系统包括包含多个样品的样品组件，照亮样品组件的光源和包括二维光敏阵列的光检测系统。 光敏阵列同时暴露于透过样品组件中每个样品的光。 分析曝光以确定每个样品的平均透射光强度，并且基于其平均透射光强度来计算每个样品的浊度值。 在测量期间可以进行多次曝光，以获得样品的时间分辨浊度测量值。 样品的温度可以在测量期间变化，以便测量作为温度的函数的浊度。

    Method for automatic chemical analyzing
    15.
    发明授权
    Method for automatic chemical analyzing 失效
    自动化学分析方法

    公开(公告)号：US5116765A

    公开(公告)日：1992-05-26

    申请号：US510883

    申请日：1990-04-18

    Applicant: Haruhisa Watanabe ,  Satoshi Tanaka ,  Shinya Matsuyama

    Inventor： Haruhisa Watanabe ,  Satoshi Tanaka ,  Shinya Matsuyama

    IPC: G01N21/82 ,  G01N33/53 ,  G01N35/00 ,  G01N35/02

    CPC classification number: G01N33/5304 ,  G01N21/82 ,  G01N35/00 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N35/028

    Abstract: A method for detecting and measuring the image of an agglutination particle pattern produced in a test liquid in which the existence of hemolysis in a test liquid is judged at the same time as an analysis is conducted of particle patterns produced in the test liquid in response to an immunological agglutination reaction. By this method, it is possible to increase the precision of the analysis of the particle pattern by feeding back the result of the judgement of the existence of hemolysis in the test liquid. A reaction apparatus suitable for use in the method according to the invention is also disclosed. In this apparatus, a plurality of wells for containing the test liquid are formed, and a plurality of marks are formed in positions where the marks can be read through the test liquid by an optical system for detecting the particle patterns produced in the test liquid. Therefore, hemolysis existing in the test liquid can be objectively judged.

    Abstract translation: 用于检测和测量在测试液体中产生的凝集颗粒图案的图像，其中在与测试液体同时判断在测试液体中溶血的存在的同时进行响应于测试液体中产生的颗粒图案 免疫凝集反应。 通过该方法，可以通过反馈检测液中溶血存在的判断结果来提高粒子图案的分析精度。 还公开了适用于根据本发明的方法的反应装置。 在该装置中，形成容纳测试液体的多个孔，并且通过用于检测在测试液中产生的颗粒图案的光学系统通过测试液体读取标记的位置形成多个标记。 因此，可以客观地判断存在于测试液中的溶血。

    Solid-state optical assay imaging apparatus
    16.
    发明授权
    Solid-state optical assay imaging apparatus 失效
    固态光学测定成像装置

    公开(公告)号：US4737464A

    公开(公告)日：1988-04-12

    申请号：US780485

    申请日：1985-09-26

    Applicant: Harden M. McConnell ,  Jonathan Briggs ,  John W. Parce

    Inventor： Harden M. McConnell ,  Jonathan Briggs ,  John W. Parce

    IPC: G01N21/25 ,  G01N21/27 ,  G01N21/00

    CPC classification number: G01N21/253 ,  G01N21/272 ,  G01N21/6428 ,  G01N2201/0461 ,  Y10S436/805 ,  Y10S436/807 ,  Y10T436/11

    Abstract: An apparatus for determining a characteristic of a signal modulating component related to an analyte of interest at an assay site by measuring light modulated by the component. A light source uniformly illuminates the assay site and a reference site. The light is directed from the sites onto a group of memory cells on the surface of a random access memory. The memory cells will decay from a logical 1 to a logical 0 due to the light over a period of time which is a function of the intensity of the light and the reference voltage of the memory cells marking the difference between a 1 and a 0. The digital state of each of the memory cells in the group is measured a predetermined exposure time. The measured states of a group of memory cells corresponding to the assay site are compared to the memory cell states for a reference group. The measured states are then analyzed to determine a characteristic of the analyte.

    Abstract translation: 一种用于通过测量由该组分调制的光来确定在测定部位与感兴趣分析物相关的信号调节成分的特征的装置。 光源均匀地照射了测定部位和参考部位。 光从站点引导到随机存取存储器表面上的一组存储器单元上。 存储器单元将由于在一段时间内的光而从逻辑1衰减到逻辑0，该时间段是光的强度和记录单元的参考电压的函数，标记1和0之间的差。 在预定的曝光时间内测量组中的每个存储单元的数字状态。 将对应于测定位点的一组存储器单元的测量状态与参考组的存储器单元状态进行比较。 然后分析测量的状态以确定分析物的特征。

    METHODS AND RELATED ASPECTS FOR MOLECULAR TRACKING AND ANALYSIS
    17.
    发明公开
    METHODS AND RELATED ASPECTS FOR MOLECULAR TRACKING AND ANALYSIS 审中-公开

    公开(公告)号：US20230288331A1

    公开(公告)日：2023-09-14

    申请号：US18180228

    申请日：2023-03-08

    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

    Inventor： Shaopeng WANG ,  Yunlei ZHAO ,  Guangzhong MA

    IPC: G01N21/51 ,  B82Y15/00

    CPC classification number: G01N21/51 ,  B82Y15/00 ,  G01N2201/0461 ,  G01N2201/0484 ,  G01N2201/067

    Abstract: Provided herein are methods of determining molecular binding kinetics on particles, such as magnetic nanoparticles. In some embodiments, the methods include introducing an incident light from a light source toward a sample container that comprises a particle-bound biomolecule-ligand composition comprising a plurality of particle-bound biomolecules and a plurality of ligands that binds, or is capable of binding, to biomolecules of the plurality of particle-bound biomolecules, detecting light scattered from particle-bound biomolecule-ligand complexes in the particle-bound biomolecule-ligand composition over a duration to produce a set of imaging data using the detector, and determining size or volume changes of one or more of the particle-bound biomolecule-ligand complexes during at least a portion of the duration from the set of imaging data to thereby determine the molecular binding kinetics on the particles. Related systems and computer readable media are also provided.

    DETECTING METHOD, MICROARRAY ANALYZING METHOD, AND FLUORESCENCE READING DEVICE
    20.
    发明申请
    DETECTING METHOD, MICROARRAY ANALYZING METHOD, AND FLUORESCENCE READING DEVICE 有权
    检测方法，微波分析方法和荧光读取装置

    公开(公告)号：US20150276604A1

    公开(公告)日：2015-10-01

    申请号：US14433972

    申请日：2013-10-04

    Applicant: TORAY INDUSTRIES, INC.

    Inventor： Kunihisa Nagino ,  Syunpei Yoshikawa

    IPC: G01N21/64

    CPC classification number: G01N21/6486 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6441 ,  G01N2201/0461 ,  G06F17/10

    Abstract: A detecting method includes irradiating a substrate having a concave and convex shape, with laser light collected by a lens; and detecting a height difference of the concave and convex shape by acquiring light intensity of reflected light and/or scattered light from the substrate as image data, and a light irradiation surface of the substrate is arranged at a position closer to the lens than a focal position of the lens is, reflected light and/or scattered light from the light irradiation surface is received as detected light, and a height difference of the substrate is detected based on a change in intensity of the received light.

    Abstract translation: 检测方法包括用透镜收集的激光照射具有凹凸形状的基板; 并且通过从基板获取反射光和/或散射光的光强度作为图像数据来检测凹凸形状的高度差，并且将基板的光照射表面布置在比焦点更靠近透镜的位置 作为透镜的位置，作为检测光接收来自光照射面的反射光和/或散射光，并且基于接收光的强度的变化来检测基板的高度差。

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