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    Method for compensating for the aging of a reagent during fluorescence measurements carried out on particles, and biological analysis device implementing the method
    12.
    发明授权
    Method for compensating for the aging of a reagent during fluorescence measurements carried out on particles, and biological analysis device implementing the method 有权
    用于补偿在颗粒进行的荧光测量期间试剂的老化的方法，以及实施该方法的生物分析装置

    公开(公告)号：US09448175B2

    公开(公告)日：2016-09-20

    申请号：US14423030

    申请日：2013-08-19

    Applicant: HORIBA ABX SAS

    Inventor： Alexandra Urankar ,  Philippe Nerin ,  Moustapha Hariche ,  Gilles Cauet

    IPC: G01N21/64 ,  G01N21/27 ,  G01N15/14 ,  G01N33/49 ,  G01N35/00 ,  G01N15/10

    CPC classification number: G01N21/6486 ,  G01N15/147 ,  G01N21/274 ,  G01N21/6428 ,  G01N33/49 ,  G01N35/00663 ,  G01N2015/1006 ,  G01N2035/00673 ,  G01N2201/121

    Abstract: The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

    Abstract translation: 本发明涉及一种用于补偿存储在包含至少一种荧光化合物的水相中的试剂的分解的方法，并且能够鉴定颗粒，包括以下步骤：（i）测量荧光水平FLUOm（t） 用所述试剂标记的颗粒; （ii）在接近所述荧光水平FLUOm（t）测量时间的时间t测量所述试剂溶液的至少一个波长处的吸光度，以便确定至少一个当前光密度DO（t） 的试剂; 以及（iii）使用所述至少一个当前光密度DO（t）和至少一个未被分解的试剂的初始光密度DO（0）来计算荧光水平测量的校正。 本发明还涉及实现该方法的生物分析装置。

    OPTIMIZED SPECTRAL MATCHING AND DISPLAY
    13.
    发明申请
    OPTIMIZED SPECTRAL MATCHING AND DISPLAY 审中-公开
    优化光谱匹配和显示

    公开(公告)号：US20160259792A1

    公开(公告)日：2016-09-08

    申请号：US15060260

    申请日：2016-03-03

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Karl NEDWED ,  Ty ABSHEAR

    IPC: G06F17/30 ,  G06K9/52 ,  G06T11/20 ,  G06K9/62

    CPC classification number: G06F17/3053 ,  G01N21/35 ,  G01N21/552 ,  G01N2201/121 ,  G01N2201/127 ,  G01N2201/129 ,  G06F17/30554 ,  G06K9/4661 ,  G06K9/52 ,  G06K9/6215 ,  G06K9/6218 ,  G06K2209/05 ,  G06T11/203

    Abstract: Systems, methods, and apparatuses are provided for identifying an optimal spectral match and potentially display the compared spectra. A sample spectrum of a sample substance can be compared to reference spectra to identify matches, thereby determining possibilities for what the sample substance is. Correction parameter(s) may be used for the sample spectrum and/or the reference spectrum. Initial value(s) for the correction parameter(s) can be applied to the sample spectrum and/or a reference spectrum, and a similarity score can be determined. The value(s) for the correction parameter(s) can be updated and iteratively improved to provide an optimal similarity score that satisfies a convergence criterion. Data about the reference substances having optimal similarity scores that are above a threshold can be output to a user, e.g., the reference spectra can overlay the sample spectrum. A user can then make a final determination of which reference substance corresponds to the sample substance.

    Abstract translation: 提供系统，方法和装置用于识别最佳光谱匹配并潜在地显示所比较的光谱。 可以将样品物质的样品光谱与参考光谱进行比较以鉴定匹配，从而确定样品物质的可能性。 校正参数可用于样品光谱和/或参考光谱。 校正参数的初始值可以应用于采样频谱和/或参考频谱，并且可以确定相似性分数。 校正参数的值可以被更新和迭代地改进，以提供满足收敛准则的最佳相似度得分。 关于具有高于阈值的最佳相似性评分的参考物质的数据可以输出给用户，例如参考光谱可以覆盖样本光谱。 然后用户可以对哪个参考物质对应于样品物质进行最终确定。

    METHOD OF GENERATING A COMPENSATION MATRIX DURING A SUBSTRATE INSPECTION
    14.
    发明申请
    METHOD OF GENERATING A COMPENSATION MATRIX DURING A SUBSTRATE INSPECTION 审中-公开
    在基板检查期间产生补偿矩阵的方法

    公开(公告)号：US20160223468A1

    公开(公告)日：2016-08-04

    申请号：US15021341

    申请日：2014-09-11

    Applicant: KOH YOUNG TECHNOLOGY INC

    Inventor： Seungwon JUNG ,  Jongjin CHOI ,  Heewook YOU

    IPC: G01N21/88 ,  G01N21/956

    CPC classification number: G01N21/8851 ,  G01N21/956 ,  G01N21/95607 ,  G01N21/95684 ,  G01N2021/8896 ,  G01N2021/95638 ,  G01N2201/121 ,  G06T5/006 ,  G06T2207/20076 ,  G06T2207/30141

    Abstract: The present invention relates to a method for generating a compensation matrix during a substrate inspection. The method comprises the steps of: selecting information of N1 (N1≧2) feature objects which are randomly predetermined within a field of view (FOV) on a substrate; generating a first compensation matrix on the basis of information of the feature objects which are extracted on the substrate; comparing an offset value of each of all the feature objects with a predetermined reference value by applying all the feature objects within the FOV to the compensation matrix to count the number of the feature objects of which the offset value of the each of all the feature objects is less than the predetermined reference value; and repeatedly performing the above steps N2 times (N2≧1), and generating a second compensation matrix using information of the feature objects which have the offset value which is less than the predetermined reference value, in case the number of the counted feature objects is the maximum.

    Abstract translation: 本发明涉及在衬底检查期间产生补偿矩阵的方法。 该方法包括以下步骤：在衬底上选择在视场（FOV）内随机地预定的N1（N1≥2）个特征对象的信息; 基于在所述基板上提取的特征对象的信息生成第一补偿矩阵; 通过将FOV内的所有特征对象应用于补偿矩阵来对所有特征对象中的每一个的偏移值与预定的参考值进行比较，以对所有特征对象中的每一个的偏移值进行计数的特征对象的数量 小于预定的参考值; 并重复执行上述步骤N2次（N2≥1），并且使用具有小于预定参考值的偏移值的特征对象的信息生成第二补偿矩阵，在计数特征对象的数量为 最大值。

    Image processing apparatus and image processing method
    15.
    发明授权
    Image processing apparatus and image processing method 有权
    图像处理装置和图像处理方法

    公开(公告)号：US09294656B2

    公开(公告)日：2016-03-22

    申请号：US14522814

    申请日：2014-10-24

    Applicant: Sony Corporation

    Inventor： Yuichiro Ikenaga ,  Toru Shiono ,  Tetsuro Hoshino

    IPC: G06K9/00 ,  H04N1/60 ,  G01N21/64 ,  G01J3/44 ,  G01J3/46 ,  G02B21/36

    CPC classification number: H04N1/603 ,  G01J3/4406 ,  G01J3/46 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/121 ,  G02B21/365 ,  G06K9/00127

    Abstract: An image processing apparatus includes: an interface unit configured to input an image signal from an imaging apparatus that exposes a specimen dyed with a fluorescent dye to excitation light and images fluorescence by a color imaging element; and a color correction circuit configured to retain information on a percentage of each of a component of a second color and a component of a third color with respect to a component of a first color corresponding to the excitation light in the image signal, which is determined in advance based on color filter spectral characteristics of the color imaging element, and reduce each of an amount corresponding to the percentage of the component of the second color and an amount corresponding to the percentage of the component of the third color from the input image signal.

    Abstract translation: 一种图像处理装置，包括：接口单元，被配置为从成像装置输入图像信号，所述成像装置将用荧光染料染色的样本曝光到激发光，并通过彩色成像元件对荧光图像进行成像; 以及颜色校正电路，被配置为相对于所确定的图像信号中与激发光对应的第一颜色的分量，保持关于第二颜色和第三颜色的分量的分量中的每一个的百分比的信息 基于彩色成像元件的滤色器光谱特性预先提取，并且减少对应于第二颜色的分量的百分比的量和对应于来自输入图像信号的第三颜色的分量的百分比的量 。

    DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY
    16.
    发明申请
    DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY 审中-公开
    使用拉曼光谱法测定悬浮液中的固体含量

    公开(公告)号：US20150369743A1

    公开(公告)日：2015-12-24

    申请号：US14840116

    申请日：2015-08-31

    Applicant: MannKind Corporation

    Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

    IPC: G01N21/65 ,  G01G9/00 ,  G01N15/06

    CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

    Abstract translation: 提供了使用拉曼光谱测定悬浮液中固体重量百分比的方法和装置。 这些方法可用于从悬浮液中获得拉曼光谱数据，并确定例如在容器中进行的方法中固体的重量百分比，而不需要除去样品进行分析。 固体的重量百分比可以在相对较短的时间（通常为10分钟或更短）内以期望的精度确定。 获得的拉曼光谱数据可以通过化学计量学软件使用例如偏最小二乘法算法和数据预处理来提供重量百分比固体的预测值。 在一些实施方案中，本发明用于测定水溶液中二酮哌嗪微粒的重量百分比。

    Method for Compensating for the Aging of a Reagent During Fluorescence Measurements Carried out on Particles, and Biological Analysis Device Implementing the Method
    17.
    发明申请
    Method for Compensating for the Aging of a Reagent During Fluorescence Measurements Carried out on Particles, and Biological Analysis Device Implementing the Method 有权
    用于补偿在颗粒进行的荧光测量期间试剂的老化的方法和实施该方法的生物分析装置

    公开(公告)号：US20150241352A1

    公开(公告)日：2015-08-27

    申请号：US14423030

    申请日：2013-08-19

    Applicant: HORIBA ABX SAS

    Inventor： Alexandra Urankar ,  Philippe Nerin ,  Moustapha Hariche ,  Gilles Cauet

    IPC: G01N21/64 ,  G01N33/49

    CPC classification number: G01N21/6486 ,  G01N15/147 ,  G01N21/274 ,  G01N21/6428 ,  G01N33/49 ,  G01N35/00663 ,  G01N2015/1006 ,  G01N2035/00673 ,  G01N2201/121

    Abstract: The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

    Abstract translation: 本发明涉及一种用于补偿存储在包含至少一种荧光化合物的水相中的试剂的分解的方法，并且能够鉴定颗粒，包括以下步骤：（i）测量荧光水平FLUOm（t） 用所述试剂标记的颗粒; （ii）在接近所述荧光水平FLUOm（t）测量时间的时间t测量所述试剂溶液的至少一个波长处的吸光度，以便确定至少一个当前光密度DO（t） 的试剂; 以及（iii）使用所述至少一个当前光密度DO（t）和至少一个未被分解的试剂的初始光密度DO（0）来计算荧光水平测量的校正。 本发明还涉及实现该方法的生物分析装置。

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