公开(公告)号：US09890177B2

公开(公告)日：2018-02-13

申请号：US14920156

申请日：2015-10-22

Applicant: ANGUS Chemical Company

Inventor： Daniel M. Trauth ,  George D. Green ,  Raymond J. Swedo ,  Richard L. James ,  Ian A. Tomlinson

IPC: C07D498/10 ,  A01N43/76 ,  A01N43/90 ,  C07C201/08 ,  C07C201/12 ,  C07C205/02 ,  C07C205/06 ,  C07C205/18 ,  C07C215/08 ,  C07C215/42 ,  C07C239/10 ,  C07D263/04 ,  C07D263/52 ,  C07D498/04 ,  C08G18/32 ,  C07C205/04 ,  C07C205/05 ,  C07C205/15 ,  C07C205/16 ,  C07C215/20 ,  C07C215/28

CPC classification number: C07D498/10 ,  A01N43/76 ,  A01N43/90 ,  C07C201/08 ,  C07C201/12 ,  C07C205/02 ,  C07C205/04 ,  C07C205/05 ,  C07C205/06 ,  C07C205/15 ,  C07C205/16 ,  C07C205/18 ,  C07C215/08 ,  C07C215/20 ,  C07C215/28 ,  C07C215/42 ,  C07C239/10 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07D263/04 ,  C07D263/52 ,  C07D498/04 ,  C08G18/3271 ,  Y02P20/582

Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

公开(公告)号：US09758468B2

公开(公告)日：2017-09-12

申请号：US15293507

申请日：2016-10-14

Applicant: Nippon Soda Co., Ltd.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C209/74 ,  C07C17/12 ,  C07C17/00 ,  C07C201/14 ,  C07C209/32 ,  C07C205/12 ,  C07C211/52 ,  C07C17/06 ,  C07C201/08

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

公开(公告)号：US09751839B2

公开(公告)日：2017-09-05

申请号：US15160100

申请日：2016-05-20

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： John Demattei ,  Adam R. Looker ,  Bobbianna Neubert-Langille ,  Martin Trudeau ,  Stefanie Roeper ,  Michael P. Ryan ,  Dahrika Milfred Yap Guerette ,  Brian R. Krueger ,  Peter D. J. Grootenhuis ,  Fredrick F. Van Goor ,  Martyn C. Botfield ,  Gregor Zlokarnik

IPC: C07D215/56 ,  C07C229/66 ,  C07D215/233 ,  C07C69/96 ,  G01N33/50 ,  G01N33/68 ,  C07C68/02 ,  C07C201/08 ,  C07C213/02

CPC classification number: C07C205/43 ,  C07C68/02 ,  C07C69/96 ,  C07C201/08 ,  C07C213/02 ,  C07C229/66 ,  C07D215/233 ,  C07D215/56 ,  G01N33/5041 ,  G01N33/6872 ,  Y02P20/55

Abstract: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

公开(公告)号：US09464029B2

公开(公告)日：2016-10-11

申请号：US14768391

申请日：2014-04-25

Applicant: BASF SE

Inventor： Ralf Boehling ,  Michael Hayer ,  Alwin Rehfinger ,  Michael Schelper ,  Johann-Peter Melder ,  Martin Ernst ,  Joaquim Henrique Teles

IPC: C07C205/00 ,  C07C201/08 ,  B01J19/00

CPC classification number: C07C201/08 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/00795 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2219/00842 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  Y02P20/582 ,  C07C205/02

Abstract: The invention relates to a process for preparing nitroalkanes by reaction of at least one alkane with at least one nitrating agent in the gas phase, wherein the nitration is carried out in a microstructured reaction zone having parallel channels having hydraulic diameters of less than 2.5 mm and a total specific internal surface area of more than 1600 m2/m3 and the alkane and the nitrating agent are conveyed under a pressure of from 1 bar to 20 bar through the reaction zone and reacted at a temperature of from 150° C. to 650° C. and the reaction products are cooled downstream of the reaction zone and discharged and the at least one nitrating agent is introduced over from two to ten introduction points along the reaction zone.

Abstract translation: 本发明涉及通过在气相中至少一种烷烃与至少一种硝化剂反应来制备硝基烷烃的方法，其中硝化在具有水力直径小于2.5mm的平行通道的微结构反应区中进行，以及 超过1600m 2 / m 3的总比表面积和烷烃和硝化剂在1巴-20巴的压力下通过反应区输送，并在150℃至650℃的温度下反应 并且反应产物在反应区的下游冷却并排出，并且将至少一种硝化剂沿着反应区引入二至十个引入点。

公开(公告)号：US09371287B2

公开(公告)日：2016-06-21

申请号：US14286708

申请日：2014-05-23

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： John DeMattei ,  Adam R. Looker ,  Bobbianna Neubert-Langille ,  Martin Trudeau ,  Stefanie Roeper ,  Michael P. Ryan ,  Dahrika Milfred Yap Guerette ,  Brian R. Krueger ,  Peter D. J. Grootenhuis ,  Fredrick F. Van Goor ,  Martyn C. Botfield ,  Gregor Zlokarnik

IPC: C07D215/56 ,  G01N33/50 ,  G01N33/68 ,  C07C229/66 ,  C07D215/233 ,  C07C69/96 ,  C07C68/02 ,  C07C201/08 ,  C07C213/02

CPC classification number: C07C205/43 ,  C07C68/02 ,  C07C69/96 ,  C07C201/08 ,  C07C213/02 ,  C07C229/66 ,  C07D215/233 ,  C07D215/56 ,  G01N33/5041 ,  G01N33/6872 ,  Y02P20/55

Abstract: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

公开(公告)号：US09284257B2

公开(公告)日：2016-03-15

申请号：US14653687

申请日：2013-12-10

Applicant: BASF SE ,  SHANGHAI BASF POLYURETHANE COMPANY LIMITED

Inventor： Yuanshen Dai ,  Da Peng Li ,  Pei Shi Jia ,  Zhan Cai ,  Samuel Neto

IPC: C07C205/00 ,  C07C201/08

CPC classification number: C07C201/08 ,  B01D17/0217 ,  C07C201/16 ,  C07C205/06

Abstract: Proposed is a separation method in a toluene to dinitrotoluene process, wherein said method with a first process step comprising feeding a toluene comprising first stream (1) and a nitric acid comprising second stream (2) into a first reactor (R1), reacting of the toluene comprising first stream (1) and the nitric acid comprising second stream (2) within the first reactor (R1) to a first reaction mixture (3), said first reaction mixture (3) comprising a first liquid/liquid mixed phase of an acid phase and an organic phase comprising mononitrotoluene, feeding the first reaction mixture (3) into a first separation device (S1), separating the first reaction mixture (3) within the first separation device (S1) into a first forward stream (4) having a flow direction to a second process step and a first backward stream (5) having a flow direction back to the first reactor (R1), said method having a second process step comprising feeding the first forward stream (4) into a second reactor (R2), feeding a nitric acid comprising third stream (6) and a sulfuric acid comprising fourth stream (7) into the second reactor (R2), reacting of the first forward stream (4), the nitric acid comprising third stream (6) and the sulfuric acid comprising fourth stream (7) within the second reactor (R2) to a second reaction mixture (8), said second reaction mixture (8) comprising a second liquid/liquid mixed acid phase and an organic phase comprising mononitrotoluene and dinitrotoluene, feeding the second reaction mixture (8) into a second separation device (S2), separating the second reaction mixture (8) within the second separation device (S2) into a second forward stream (9) having a flow direction to a process output and a second backward stream (10) having a flow direction back to the first reactor (R1), wherein fine separating of at least one of the streams (4, 5, 9, 10) after the first separation step (S1) and/or the second separation step (S2) in a coalescer is carried out.

公开(公告)号：US09079822B2

公开(公告)日：2015-07-14

申请号：US13203360

申请日：2010-02-26

Applicant: Wolfgang Mackenroth ,  Johannes Buettner ,  Eckhard Stroefer ,  Wolfgang Voigt ,  Frank Bok

Inventor： Wolfgang Mackenroth ,  Johannes Buettner ,  Eckhard Stroefer ,  Wolfgang Voigt ,  Frank Bok

IPC: C07C209/00 ,  C07C201/08

CPC classification number: C07C201/08 ,  C07C205/06

Abstract: A process for the preparation of mononitroaromatics and dinitroaromatics, in which a hydrate melt of at least one metal nitrate M(NO3)3 is used as a nitrating medium, it being possible for M to be the metals Fe, Cr, Y, La, Ce, Al, Bi and In, and the metal nitrate having a water content of from 4 to 9 mol of water per M(NO3)3, leads to simplifications of the process and improved yields.

Abstract translation: 一种制备单硝基芳族化合物和二硝基溴化物的方法，其中使用至少一种金属硝酸盐M（NO 3）3的水合物熔融物作为硝化介质，M可以是金属Fe，Cr，Y，La， Ce，Al，Bi和In，每M（NO 3）3含水量为4〜9mol的金属硝酸盐导致工艺的简化和提高的产率。

公开(公告)号：US06933257B2

公开(公告)日：2005-08-23

申请号：US10680334

申请日：2003-10-07

Applicant: Mark Andrew Harmer ,  Qun Sun

Inventor： Mark Andrew Harmer ,  Qun Sun

IPC: C08J5/20 ,  B01J21/08 ,  B01J31/08 ,  B01J31/10 ,  B01J31/16 ,  B01J31/24 ,  B01J31/40 ,  B01J35/10 ,  C07B61/00 ,  C07C2/02 ,  C07C2/08 ,  C07C2/66 ,  C07C5/22 ,  C07C5/25 ,  C07C11/02 ,  C07C15/46 ,  C07C41/30 ,  C07C45/46 ,  C07C49/784 ,  C07C67/04 ,  C07C69/145 ,  C07C201/08 ,  C07C205/06 ,  C08G65/02 ,  C08G65/20 ,  B01J20/34 ,  B01J20/26

CPC classification number: B01J21/08 ,  B01J31/10 ,  B01J31/165 ,  B01J31/2419 ,  B01J31/4007 ,  B01J35/10 ,  B01J35/1019 ,  B01J35/1023 ,  B01J35/1038 ,  B01J35/1042 ,  B01J35/1047 ,  B01J35/1057 ,  B01J35/1061 ,  B01J35/1066 ,  B01J35/1071 ,  B01J35/109 ,  B01J2231/10 ,  B01J2231/323 ,  B01J2231/4205 ,  B01J2231/52 ,  B01J2231/54 ,  B01J2531/38 ,  B01J2531/821 ,  B01J2531/825 ,  B01J2531/842 ,  B01J2531/847 ,  C07C2/02 ,  C07C2/66 ,  C07C5/2266 ,  C07C5/2273 ,  C07C5/2562 ,  C07C41/30 ,  C07C45/46 ,  C07C67/04 ,  C07C201/08 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2521/12 ,  C07C2523/10 ,  C07C2523/14 ,  C07C2523/26 ,  C07C2523/28 ,  C07C2523/745 ,  C07C2531/08 ,  C07C2531/10 ,  C07C2531/20 ,  C07C2531/26 ,  C07C2531/34 ,  Y02P20/584 ,  C07C11/02 ,  C07C49/784 ,  C07C69/013 ,  C07C69/14 ,  C07C205/06 ,  C07C43/263

Abstract: Porous microcomposites have been prepared from perfluorinated ion-exchange polymer and metal oxides such as silica using the sol-gel process. Such microcomposites possess high surface area and exhibit extremely high catalytic activity.

公开(公告)号：US06855842B1

公开(公告)日：2005-02-15

申请号：US10110441

申请日：2000-10-23

Applicant: Thierry Schlama ,  Armand Mettling ,  Philippe Karrer

Inventor： Thierry Schlama ,  Armand Mettling ,  Philippe Karrer

IPC: C07B61/00 ,  C07C67/31 ,  C07C69/712 ,  C07C69/734 ,  C07C201/08 ,  C07C205/37 ,  C07C205/44 ,  C07C319/14 ,  C07C319/20 ,  C07C323/52 ,  C07D307/79 ,  C07D333/54 ,  C07C69/76

CPC classification number: C07D307/79 ,  C07C67/31 ,  C07C201/12 ,  C07C205/37 ,  C07D333/54 ,  C07C69/712

Abstract: The invention concerns novel nitroaromatic compounds of general formula (I′) wherein: R, R′1, R2, Z and n are as defined in claim 1. The invention also concerns a method for preparing nitroaromatic compounds nitrated in position 4. The invention further concerns the use of said compounds for preparing heterocyclic benzofuran or benzothiophene derivatives nitrated in position 5. The invention concerns particularly the preparation of 2-alkyl-5-nitrobezofuran.

Abstract translation: 本发明涉及通式（I'）的新型硝基芳族化合物，其中：R 1，R 1，R 2，Z和n如权利要求1中所定义。本发明还涉及在位置4中硝化的硝基芳族化合物的制备方法。 还涉及所述化合物用于制备在5位硝化的杂环苯并呋喃或苯并噻吩衍生物的用途。本发明特别涉及2-烷基-5-硝基吩呋呋喃的制备。

公开(公告)号：US5952531A

公开(公告)日：1999-09-14

申请号：US960924

申请日：1997-10-30

Applicant: Ian Jeffrey Grassham Priestley ,  James Peter Muxworthy ,  John Heathcote Atherton ,  Martin Lennon ,  Stephen Martin Brown

Inventor： Ian Jeffrey Grassham Priestley ,  James Peter Muxworthy ,  John Heathcote Atherton ,  Martin Lennon ,  Stephen Martin Brown

IPC: C07B43/02 ,  C07C201/08 ,  C07C205/38 ,  C07C205/59 ,  C07C231/12 ,  C07C235/44 ,  C07C303/40 ,  C07C311/51 ,  C07C43/00 ,  C07C29/00 ,  C07C205/00

CPC classification number: C07C303/40 ,  C07B43/02 ,  C07C201/08

Abstract: A process for the nitration of an aromatic or heteroaromatic compound with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids, characterised in that nitration is performed in a solvent comprising at least 50% v/v of a C.sub.1 -C.sub.6 alkyl ester of a C.sub.1 -C.sub.4 carboxylic acid. The process is of particular use for the nitration of diphenyl ethers to give compounds which are useful as herbicides or as intermediates in the synthesis of herbicides.

Abstract translation: 一种用包含硝酸或硝酸和硫酸的混合物的硝化剂硝化芳族或杂芳族化合物的方法，其特征在于，在包含至少50％v / v的C 1 -C 6烷基的溶剂中进行硝化 酯的C 1 -C 4羧酸。 该方法特别用于二苯醚的硝化，得到可用作除草剂的化合物或作为除草剂合成中的中间体。