公开(公告)号：US10580633B2

公开(公告)日：2020-03-03

申请号：US15985188

申请日：2018-05-21

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/00 ,  H01J49/42

Abstract: The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.

公开(公告)号：US10555694B2

公开(公告)日：2020-02-11

申请号：US16539562

申请日：2019-08-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  H01J49/34 ,  H01J49/16 ,  H01J49/04 ,  A61M25/00 ,  A61M11/00 ,  A61B10/00 ,  G01N33/483 ,  A61B5/145 ,  A61B5/15 ,  G01N1/02 ,  A61B5/157

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10395913B2

公开(公告)日：2019-08-27

申请号：US15104405

申请日：2014-12-22

Applicant: Purdue Research Foundation ,  INDIAN INSTITUTE OF TECHNOLOGY MADRAS

Inventor： Robert Graham Cooks ,  Depanjan Sarkar ,  Thalappil Pradeep ,  Rahul Narayanan

IPC: H01J49/16 ,  H01J49/04 ,  H05K1/18 ,  H01J49/00

Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.

公开(公告)号：US20190237315A1

公开(公告)日：2019-08-01

申请号：US16280319

申请日：2019-02-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  Soumabha Bag ,  Yafeng Li

IPC: H01J49/04

CPC classification number: H01J49/0436 ,  H01J49/0013

Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.

公开(公告)号：US20190189415A1

公开(公告)日：2019-06-20

申请号：US16260924

申请日：2019-01-29

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Guangtao Li ,  Guangming Huang ,  Jason Duncan ,  Xin Li ,  Ewa Sokol ,  Xin Yan

IPC: H01J49/04 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/045 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/0445 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US20190035614A1

公开(公告)日：2019-01-31

申请号：US16047267

申请日：2018-07-27

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/00

Abstract: The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.

公开(公告)号：US20190019662A1

公开(公告)日：2019-01-17

申请号：US16020524

申请日：2018-06-27

Applicant: Purdue Research Foundation ,  AMGEN INC.

Inventor： Robert Graham Cooks ,  Tawnya Flick

IPC: H01J49/04 ,  G01N27/447

Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).

公开(公告)号：US20180356426A1

公开(公告)日：2018-12-13

申请号：US16002749

申请日：2018-06-07

Applicant: Purdue Research Foundation ,  AMGEN

Inventor： Stephen T. Ayrton ,  Robert Graham Cooks ,  Tawnya Flick ,  Da Ren

IPC: G01N33/68 ,  H01J49/00 ,  H01J49/10

CPC classification number: G01N33/6848 ,  H01J49/0031 ,  H01J49/10

Abstract: The invention generally relates to methods for determining whether a peptide includes aspartate or isoaspartate. In certain aspects, methods of the invention involve binding an aspartate/isoaspartate residue in a peptide with a label to produce a labeled peptide. The labeled peptide is then ionized. The ionizing process causes the label to undergo rearrangement in a gas phase at a higher rate if the label is bound to the aspartate residue as compared to if the label is bound to the isoaspartate residue. The methods of the invention then involve performing a mass spectrometry analysis to detect the rearrangement of the label, thereby determining whether the peptide includes aspartate or isoaspartate.

公开(公告)号：US20180286651A1

公开(公告)日：2018-10-04

申请号：US15988698

申请日：2018-05-24

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

IPC: H01J49/04 ,  H01J49/42 ,  H01J49/40 ,  H01J49/26 ,  H01J49/10 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/0404 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/4215

Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

公开(公告)号：US20180061620A1

公开(公告)日：2018-03-01

申请号：US15697560

申请日：2017-09-07

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Michael Stanley Wleklinski ,  Soumabha Bag ,  Yafeng Li

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/0436 ,  H01J49/0013

Abstract: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.