公开(公告)号：US20060238764A1

公开(公告)日：2006-10-26

申请号：US11302993

申请日：2005-12-13

Applicant: Dean Hafeman ,  Calvin Chow

Inventor： Dean Hafeman ,  Calvin Chow

IPC: G01N21/00 ,  G01J3/427

CPC classification number: G01J3/08 ,  G01J3/1804 ,  G01N21/253 ,  G01N21/31 ,  G01N21/314 ,  G01N21/6452

Abstract: Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical pathlength of liquid samples containing the solvent. This relationship is used to establish the optical pathlength for samples containing an unknown concentration of analyte but having similar solvent composition. Further disclosed are methods and devices for determining the concentration of analyte in such samples where both the optical pathlength and the concentration of analyte are unknown. The methods and devices rely on separately determining, at different wavelengths of light, light absorption by the solvent and light absorption by the analyte. Light absorption by the analyte, together with the optical pathlength so determined, is used to calculate the concentration of the analyte. Devices for carrying out the methods particularly advantageously include vertical-beam photometers containing samples disposed within the wells of multi-assay plates, wherein the photometer is able to monitor light absorption of each sample at multiple wavelengths, including in the visible or UV-visible region of the spectrum, as well as in the near-infrared region of the electromagnetic spectrum. Novel photometer devices are described which automatically determine the concentration of analytes in such multi-assay plates directly without employing a standard curve.

公开(公告)号：US20060141466A1

公开(公告)日：2006-06-29

申请号：US10539771

申请日：2003-12-19

Applicant: Eric Pinet ,  Gaetan Duplain

Inventor： Eric Pinet ,  Gaetan Duplain

IPC: C12Q1/68 ,  C12M1/34 ,  G01J3/42 ,  G01J3/427

CPC classification number: G01N21/23

Abstract: A method and sensor for detecting a chemical substance in an analyte. An anisotropic material is subjected to the analyte. Light is passed through the anisotropic material and collected. A change of an optical anisotropy of the collected light is detected, the change being indicative of the chemical substance in the analyte.

Abstract translation: 一种用于检测分析物中的化学物质的方法和传感器。 对各向异性材料进行分析。 光通过各向异性材料并收集。 检测到所收集的光的光学各向异性的变化，该变化表示分析物中的化学物质。

公开(公告)号：US07050164B2

公开(公告)日：2006-05-23

申请号：US09943395

申请日：2001-08-30

Applicant: Kouhei Kabuki ,  Yoshisada Ebata ,  Tadashi Suzuki ,  Atsushi Hiyama

Inventor： Kouhei Kabuki ,  Yoshisada Ebata ,  Tadashi Suzuki ,  Atsushi Hiyama

IPC: G01J3/427

CPC classification number: G01J3/28

Abstract: In order to improve spectral measurement accuracy during high-speed wavelength shifting, the appropriate sensitivity of the detection system is maintained by, prior to measurement of a sample, measuring the voltage value, then storing this value into a table, and maintaining the voltage value to be applied to the photodetector, and during measurement of the sample, reading out the maintained voltage value and applying it to the photodetector.

公开(公告)号：US06969857B2

公开(公告)日：2005-11-29

申请号：US10753614

申请日：2004-01-08

Applicant: Thomas E. Owen

Inventor： Thomas E. Owen

IPC: G01J3/427 ,  G01N20060101 ,  G01N21/05 ,  G01N21/31 ,  G01N21/35 ,  G01N21/61 ,  G01N33/00

CPC classification number: G01N21/3518 ,  G01J3/0232 ,  G01J3/427 ,  G01N21/05 ,  G01N21/314 ,  G01N21/3504 ,  G01N21/61 ,  G01N33/004 ,  G01N33/0054 ,  G01N2021/3125 ,  G01N2021/3137 ,  G01N2201/0675 ,  G01N2201/1211 ,  G01N2201/1218 ,  Y02A50/244 ,  Y02A50/246

Abstract: A gas sensor, whose chamber uses filters and choppers in either a semicircular geometry or annular geometry, and incorporates separate infrared radiation filters and optical choppers. This configuration facilitates the use of a single infrared radiation source and a single detector for infrared measurements at two wavelengths, such that measurement errors may be compensated.

Abstract translation: 气体传感器，其室使用半圆形几何形状或环形几何形状的过滤器和斩波器，并且包含单独的红外辐射滤波器和光学切割器。 这种配置有助于在两个波长处使用单个红外辐射源和单个检测器用于红外测量，从而可以补偿测量误差。

公开(公告)号：US20050164160A1

公开(公告)日：2005-07-28

申请号：US10380192

申请日：2001-08-22

Applicant: Rolf Gunter ,  Leif Brand ,  Christian Eggeling ,  Karsten Gall ,  Claus Seidel

Inventor： Rolf Gunter ,  Leif Brand ,  Christian Eggeling ,  Karsten Gall ,  Claus Seidel

IPC: G01N21/64 ,  C12Q1/00 ,  C12M1/34 ,  G01J3/42 ,  G01J3/427

CPC classification number: G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441

Abstract: A device for the measurement of chemical and/or biological samples, in particular by means of luminescence spectroscopy, comprises an irradiation unit (12), a sample receiver (10), at least one optical unit (30) and a detector unit (40). Electromagnetic radiation of various wavelength ranges and/or polarizations are led from the sample (10) from the irradiation unit (12). The color marker in the sample (10), which contains at least one color marker, is stimulated into producing luminescence and gives off light. The emitted light is led by means of an optical unit to a detector unit. The light emitted by the color markers is detected by detectors (42, 44, 46, 48) in the detector unit. According to the invention, the measurement results may be improved on the irradiation unit (12) generating a pulsed irradiation. The irradiation unit is thus preferably controlled by a control unit (18) in such a way that the irradiation pulses impinge on the sample (10) in a temporal sequence.

Abstract translation: 用于测量化学和/或生物样品，特别是通过发光光谱测量的装置包括照射单元（12），样品接收器（10），至少一个光学单元（30）和检测器单元（40 ）。 从样品（10）从照射单元（12）引出各种波长范围和/或偏振的电磁辐射。 包含至少一种颜色标记的样品（10）中的颜色标记被刺激产生发光并发光。 发射的光通过光学单元被引导到检测器单元。 由彩色标记发出的光由检测器单元中的检测器（42,44,46,48）检测。 根据本发明，可以在产生脉冲照射的照射单元（12）上改善测量结果。 照射单元因此优选地由控制单元（18）控制，使得照射脉冲以时间顺序照射在样品（10）上。

公开(公告)号：US20050133693A1

公开(公告)日：2005-06-23

申请号：US10739831

申请日：2003-12-18

Applicant: Julie Fouquet ,  Rene Helbing

Inventor： Julie Fouquet ,  Rene Helbing

IPC: G01J3/10 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/427 ,  H01J40/14 ,  G01J3/50

CPC classification number: G01J3/427 ,  G01J3/10 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/501 ,  G01J3/51 ,  G01J2003/1213

Abstract: An object to be imaged or detected is illuminated by a single broadband light source or multiple light sources emitting light at different wavelengths. The light is detected by a detector, which includes a light-detecting sensor covered by a hybrid filter. The hybrid filter includes a multi-band narrowband filter mounted over a patterned filter layer. The light strikes the narrowband filter, which passes light at or near the multiple wavelengths of interest while blocking light at all other wavelengths. The patterned filter layer alternately passes the light at one particular wavelength while blocking light at the other wavelengths of interest. This allows the sensor to determine either simultaneously or alternately the intensity of the light at the wavelengths of interest. Filters may also be mounted over the light sources to narrow the spectra of the light sources.

Abstract translation: 要成像或检测的物体被单个宽带光源或发射不同波长的光的多个光源照射。 光被检测器检测，检测器包括由混合滤波器覆盖的光检测传感器。 混合滤波器包括安装在图案化滤波器层上的多频带窄带滤波器。 光照射窄带滤光片，该滤光片在所有其他波长处阻挡光线，使其处于感兴趣的多个波长处或附近的光线。 图案化的滤光层在一个特定波长处交替地传递光，同时阻挡在感兴趣的其它波长处的光。 这允许传感器同时或交替地确定感兴趣波长处的光的强度。 滤光片也可安装在光源上，以缩小光源的光谱。

公开(公告)号：US20050130325A1

公开(公告)日：2005-06-16

申请号：US11006624

申请日：2004-12-08

Applicant: Yoshitada Oshida ,  Hiroshi Kishida

Inventor： Yoshitada Oshida ,  Hiroshi Kishida

IPC: G01N15/14 ,  G01N21/03 ,  G01N21/64 ,  G01N33/53 ,  G01N37/00 ,  C12M1/34 ,  G01J3/42 ,  G01J3/427 ,  G01N33/544 ,  G01N33/546

CPC classification number: G01N21/6428 ,  G01N15/147 ,  G01N21/645

Abstract: A method and a device for accurately detecting with fluorescence some arranged beads through utilization of fluorescent beads in a flow path because each diameter the beads is small in respect to an inner diameter of the flow path and the beads are not arranged in a linear manner. A fine elongated excitation light is radiated in a direction perpendicular to the flow path to the samples having a plurality of units with fluorescent members being applied to some relative large beads, this is relatively scanned in a direction toward the flow path so as to perform a well-separable and accurate detection of the beads without being influenced by the adjoining beads.

Abstract translation: 一种用于通过利用荧光珠在流动路径中精确地检测荧光的方法和装置，因为珠粒相对于流动路径的内径是小的，并且珠粒不以线性方式排列。 细长的激发光在垂直于具有多个单元的样品的流动方向的方向上辐射，其中荧光部件被施加到一些相对较大的珠，这在朝向流动路径的方向上被相对扫描，以便执行 良好的可分离和准确的珠粒检测，而不受相邻珠子的影响。

公开(公告)号：US20050012926A1

公开(公告)日：2005-01-20

申请号：US10875640

申请日：2004-06-24

Applicant: Paul Trpkovski

Inventor： Paul Trpkovski

IPC: G01N21/25 ,  G01N21/35 ,  G01N21/68 ,  G01N21/958 ,  G01J3/427

CPC classification number: G01N21/68 ,  G01N21/251 ,  G01N21/3504 ,  G01N21/958

Abstract: An apparatus and method for measuring the color and gas fill concentration of insulating glass units is disclosed. One apparatus includes a color measuring device and gas fill concentration measuring device coupled to a production line for manufacturing insulating glass units. One method of the invention involves measuring the color and gas fill concentration of insulating glass units after they have been filled with gas and sealed.

Abstract translation: 公开了一种用于测量中空玻璃单元的颜色和气体填充浓度的装置和方法。 一种装置包括耦合到用于制造绝缘玻璃单元的生产线的颜色测量装置和气体填充浓度测量装置。 本发明的一种方法包括测量中空玻璃单元在填充气体并密封后的颜色和气体填充浓度。

公开(公告)号：US5585636A

公开(公告)日：1996-12-17

申请号：US353504

申请日：1994-12-09

Applicant: Erich Dollansky

Inventor： Erich Dollansky

IPC: G01J3/427 ,  G01N21/31 ,  H01S3/00 ,  G01N21/61

CPC classification number: G01N21/31

Abstract: Apparatus and methods for monitoring characteristic absorption of a substance in a mixture include applying radiation pulses with a wavelength characteristic of the substance to be measured and a wavelength uncharacteristic of the substance to a measuring path and to a reference path without the substance mixture. The difference of signals generated between the measuring path and the reference path are conditioned to provide a measurement value.

Abstract translation: 用于监测混合物中物质的特征吸收的装置和方法包括将具有待测物质的波长特性的辐射脉冲和物质的波长非特性施加到测量路径和没有物质混合物的参考路径。 在测量路径和参考路径之间产生的信号的差异被调节以提供测量值。

公开(公告)号：US5550630A

公开(公告)日：1996-08-27

申请号：US34919

申请日：1993-03-19

Applicant: Joseph Chrastil

Inventor： Joseph Chrastil

IPC: G01N21/31 ,  G01J3/00 ,  G01J3/42 ,  G01J3/427

CPC classification number: G01N21/31

Abstract: A method for analyzing the structures of chemical organic compounds, polymers, polynucleotides and peptides is disclosed. The method uses the integrated intensity of spectral light absorption in wide or narrow regions of the ultraviolet and/or visible spectrum and relates these parameters additively to the structural characteristics of the analyzed chemical compound. For the analysis of polymers, nucleotides and/or peptides the integrated intensities of spectral absorption are used sequentially in narrow regions of the ultraviolet light which enables the determination of the molecular weight and the complete amino acid composition of the analyzed compound. All these procedures are interconnected in an automatic spectrophotometric structural analyzer.

Abstract translation: 公开了分析化学有机化合物，聚合物，多核苷酸和肽的结构的方法。 该方法使用在紫外线和/或可见光谱的宽或窄区域中的光谱吸收的积分强度，并将这些参数与分析的化合物的结构特征相加。 对于聚合物，核苷酸和/或肽的分析，在紫外光的窄区域中依次使用光谱吸收的积分强度，其能够测定分析化合物的分子量和完整的氨基酸组成。 所有这些程序在自动分光光度结构分析仪中相互连接。