公开(公告)号：US20190195779A1

公开(公告)日：2019-06-27

申请号：US16322254

申请日：2017-08-03

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Salim BOUTAMI ,  Mathieu DUPOY ,  Boris TAUREL

IPC: G01N21/01 ,  G01N21/3504

CPC classification number: G01N21/01 ,  G01N21/031 ,  G01N21/3504 ,  G01N2021/0378 ,  G01N2201/08

Abstract: An optical device for a biological or chemical sensor includes: an absorption cavity configured to receive a biological or chemical medium; an injection waveguide to inject an analysis light beam into the absorption cavity; and an extraction waveguide to extract a measurement light beam, corresponding to the analysis light beam after transit through the absorption cavity. The absorption cavity has a shape of a right cylinder with an elliptical base. One end of the injection waveguide is placed at a first focus of the ellipse and one and of the extraction waveguide is placed at a second focus of the ellipse. A core of the injection waveguide and a core of the extraction waveguide each have a tip-shaped end, with a constant height in a plane parallel to the generatrix of the right cylinder and a tip-shaped cross section in planes parallel to the base of the right cylinder.

公开(公告)号：US20190183346A1

公开(公告)日：2019-06-20

申请号：US16284514

申请日：2019-02-25

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  G16H40/67 ,  G01N33/15 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01J3/02 ,  A61C19/04 ,  G01J3/14 ,  G01N33/49 ,  G01N33/44

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  A61C1/0046 ,  A61C19/04 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A smart phone or tablet includes laser diodes, at least some of which may be pulsed and generate near-infrared light and include Bragg reflectors to direct light to tissue/skin. An array of laser diodes generates near-infrared light and has an assembly in front of the array that forms the light into a plurality of spots on the tissue/skin. A receiver includes detectors that receive light reflected from the tissue/skin. An infrared camera receives light reflected from the tissue/skin and generates data based on the received light. The smart phone or tablet is configured to generate a two-dimensional or three-dimensional image using at least part of the data from the infrared camera.

公开(公告)号：US20180364154A1

公开(公告)日：2018-12-20

申请号：US15625899

申请日：2017-06-16

Applicant: CANON USA INC. ,  THE GENERAL HOSPITAL CORPORATION

Inventor： Tzu-Yu Wu ,  Mitsuhiro Ikuta ,  Dongkyun Kang ,  Guillermo J. Tearney

IPC: G01N21/31 ,  G02B23/24 ,  G02B23/26

CPC classification number: G01N21/31 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00186 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  G01J3/0218 ,  G01J3/06 ,  G01J3/2823 ,  G01N2201/0633 ,  G01N2201/08 ,  G02B3/0087 ,  G02B6/00 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/106 ,  G02B26/108

Abstract: An apparatus for spectrally encoded endoscopy (SEE) comprising an illumination element, a detection light guiding element, a rotary element, and a two-dimensional sensor. The illumination element is configured to direct an illumination light beam towards a sample. The detection light guiding element is configured to collect a reflected light beam from the sample. At least one of the illumination element and the detection light guiding element is configured to spectrally dispersed the illumination light beam or the reflected light beam, respectively. The rotary element is configured to rotate or oscillate the reflected light beam. The reflected light beam is guided from the rotary element to the two-dimensional sensor.

公开(公告)号：US20180364152A1

公开(公告)日：2018-12-20

申请号：US16001966

申请日：2018-06-07

Applicant: CI SYSTEMS (ISRAEL) LTD.

Inventor： Yoram Naor

IPC: G01N21/01 ,  G01N21/59

CPC classification number: G01N21/01 ,  G01N21/05 ,  G01N21/59 ,  G01N2021/0106 ,  G01N2201/068 ,  G01N2201/08 ,  G01N2201/128

Abstract: A flow cell analyzes a fluid sample. A flow cell body contains a reference material and includes at least one hollow chamber to contain the fluid sample. Opposing surfaces of the flow cell body each have at least one transparent portion thereof. An optical path for light traversing through the flow cell body is defined in part by the transparent portions. A switching mechanism adjusts the amount of the reference material in the optical path to effect switching of the flow cell between a reference measurement state and a fluid sample measurement state. The reference measurement state corresponds to a first light intensity measurement and the fluid sample measurement state corresponds to a second light intensity measurement.

公开(公告)号：US20180326422A1

公开(公告)日：2018-11-15

申请号：US15774953

申请日：2016-10-25

Applicant: Beijing Wantai Biological Pharmacy Enterprise Co. Ltd. ,  BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY ,  Xiamen University

Inventor： Xianbo Qiu ,  Xiangzhong Ye ,  Shengxiang Ge ,  Shiyin Zhang ,  Pengfei Gao ,  Shangzhi Ji ,  Yongliang Yang ,  Zixin Qiu ,  Ningshao Xia

IPC: B01L7/00 ,  G01N21/64

CPC classification number: B01L7/52 ,  B01L2300/1805 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/6471 ,  G01N2201/08

Abstract: The present invention relates to a detection mechanism for polymerase chain reaction and a polymerase chain reaction device, wherein the detection mechanism comprises at least one excitation module group, each of the excitation module groups comprising two excitation modules for providing excitation light with two wavelengths; an excitation optical fiber, connected to the excitation modules, the excitation optical fiber transmitting the excitation light to at least one reaction tube, each of the reaction tubes receiving excitation light with two wavelengths; a receiving optical fiber, for collecting and transmitting a fluorescent signal from the reaction tube; at least one receiving module group, connected to the receiving optical fiber, each of the receiving module groups comprising two receiving modules, to respectively receive the fluorescent signal of two wavelengths from the same said reaction tube, and convert the fluorescent signal into an electrical signal for output; the detection mechanism is configured to detect the reaction tube in a time division manner, and multiplex the receiving module group to obtain an output result.

公开(公告)号：US20180266994A1

公开(公告)日：2018-09-20

申请号：US15915804

申请日：2018-03-08

Applicant: INFOMED SA

Inventor： Ivano ZALUNARDO

IPC: G01N29/02 ,  G01N21/59 ,  G01N29/22 ,  A61M1/36

CPC classification number: G01N29/02 ,  A61M1/3626 ,  A61M5/365 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2205/3375 ,  G01N21/51 ,  G01N21/59 ,  G01N29/032 ,  G01N29/221 ,  G01N29/222 ,  G01N29/223 ,  G01N29/2462 ,  G01N2201/08 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/02433 ,  G01N2291/044 ,  G01N2291/048 ,  G01N2291/101 ,  G01N2291/102

Abstract: Disclosed is an assembly for detecting the presence of a gas in a liquid contained or circulating in a conduit including an element for supporting the conduit and a sensor allowing the transmission and reception of acoustic or light waves. The sensor is arranged on the support of the conduit facing the one and the same side of the conduit and the support element includes a waveguide capable of routing the wave transmitted by the transmitter of the sensor to the receiver of the sensor.

公开(公告)号：US20180195938A1

公开(公告)日：2018-07-12

申请号：US15737414

申请日：2016-06-16

Applicant: TASCOM CO., LTD.

Inventor： Sung Dong LEE

IPC: G01N1/40 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76

CPC classification number: G01N1/4077 ,  B04B5/0407 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/76 ,  G01N33/491 ,  G01N2001/4083 ,  G01N2021/0325 ,  G01N2021/0378 ,  G01N2035/00504 ,  G01N2201/0423 ,  G01N2201/08 ,  G01N2201/0846

Abstract: A biological material measuring instrument is described. The biological material measuring instrument includes a rotating body and a main body. The rotating body includes one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react. The main body includes a pair of light-emitting parts and light-receiving parts to optically measure the analyte in the sample. The rotating body further includes a light-emitting optical waveguide for guiding the light of the light-emitting parts to the cuvette and a light-receiving optical waveguide for guiding.

公开(公告)号：US09995722B2

公开(公告)日：2018-06-12

申请号：US15855201

申请日：2017-12-27

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  G01N33/15 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/44 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18 ,  G01M3/38

CPC classification number: G01N33/15 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/0088 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3513 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  H01S3/302

Abstract: A measurement system includes a light source having semiconductor sources configured to generate an input optical beam, a multiplexer configured form an intermediate optical beam from the input optical beam, fibers including a fused silica fiber configured to receive the intermediate optical beam and to form an output optical beam. The output optical beam comprises wavelengths between 700 and 2500 nanometers with a bandwidth of at least 10 nanometers. A measurement apparatus is configured to deliver the output beam to a sample to generate a spectroscopy output beam. A receiver is configured to receive and process the spectroscopy output beam to generate an output signal, wherein the receiver processing includes chemometrics or multivariate analysis methods to permit identification of materials within the sample, the light source and the receiver are remote from the sample, and the sample includes plastics or food industry goods.

公开(公告)号：US20180140198A1

公开(公告)日：2018-05-24

申请号：US15860065

申请日：2018-01-02

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. ISLAM

IPC: A61B5/00 ,  G01J3/453 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/10 ,  G01J3/28 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01N21/88 ,  G01M3/38 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device includes a measurement device having light emitting diodes (LEDs) measuring a physiological parameter. The measurement device modulates the LEDs to generate an optical beam having a near-infrared wavelength between 700-2500 nanometers. Lenses receive and deliver the optical beam to tissue, which reflects the optical beam to a receiver having spatially separated detectors coupled to analog-to-digital converters configured to generate receiver outputs. The receiver captures light while the LEDs are off, and reflected light from the tissue while the LEDs are on, to generate first and second signals, respectively. Signal-to-noise ratio is improved by differencing the first and second signals and by differencing the receiver outputs. The measurement device further improves signal-to-noise ratio of the reflected optical beam by increasing light intensity of the LEDs relative to an initial light intensity. The measurement device generates an output signal representing a non-invasive measurement on blood contained within the tissue.

公开(公告)号：US09904181B2

公开(公告)日：2018-02-27

申请号：US14901993

申请日：2014-06-13

Applicant: ASML Netherlands B.V.

Inventor： Richard Quintanilha

IPC: G03B27/54 ,  G03F7/20 ,  G01N21/956

CPC classification number: G03F7/70625 ,  G01N21/95623 ,  G01N2201/061 ,  G01N2201/08 ,  G01N2201/12 ,  G03F7/70633

Abstract: The present invention determines property of a target (30) on a substrate (W), such as a grating on a wafer. An inspection apparatus has an illumination source (702, 710) with two or more illumination beams (716, 716′, 716″, 716′″) in the pupil plane of a high numerical aperture objective lens (L3). The substrate and target are illuminated via the objective lens from different angles of incidence with respect to the plane of the substrate. In the case of four illumination beams, a quad wedge optical device (QW) is used to separately redirect diffraction orders of radiation scattered from the substrate and separates diffraction orders from the two or more illumination beams. For example four 0th diffraction orders are separated for four incident directions. After capture in multimode fibers (MF), spectrometers (S1-S4) are used to measure the intensity of the separately redirected 0th diffraction orders as a function of wavelength. This may then be used in determining a property of a target.