公开(公告)号：US20170261423A1

公开(公告)日：2017-09-14

申请号：US15509682

申请日：2015-09-08

Applicant: Heraeus Quarzglas GmbH & Co. KG

Inventor： Stefan WEIDLICH ,  Clemens SCHMITT ,  Jörg WERNER ,  Markus SCHMIDT ,  Jens KOBELKE

IPC: G01N21/05 ,  G01N21/33 ,  G01N21/35

CPC classification number: G01N21/05 ,  G01N21/0303 ,  G01N21/33 ,  G01N21/35 ,  G01N2021/0378 ,  G01N2201/08

Abstract: A measuring cell includes a cavity for receiving a test sample to be used in a particle detection apparatus. The measuring cell is configured as an optical waveguide for guiding a light beam. The waveguide has a core which has a refractive index nK, extends along a longitudinal axis of the waveguide, has a cross-sectional area AK of less than 80 μm2 in a cross section perpendicular to the longitudinal axis, and which is surrounded by a cladding having a smaller refractive index than nK. The cavity forms a channel. The channel extends along the longitudinal axis, is formed inside of or in contact with the core, and has at least one open end with an opening area AH of less than 0.2 μm2.

公开(公告)号：US09759643B2

公开(公告)日：2017-09-12

申请号：US15001321

申请日：2016-01-20

Applicant: International Business Machines Corporation

Inventor： Phaedon Avouris ,  Michael Engel ,  Claudius Feger ,  Ronaldo Giro ,  Rodrigo Ferreira ,  Mathias Steiner

IPC: G01N11/04 ,  G01N21/71 ,  G06F17/50 ,  G01N33/24 ,  H01L29/16 ,  H01L29/49 ,  G01N11/00

CPC classification number: G01N11/04 ,  G01N21/71 ,  G01N33/24 ,  G01N2011/008 ,  G01N2201/08 ,  G06F17/5009 ,  G06F17/5072 ,  G06F2217/16 ,  H01L29/1606 ,  H01L29/4966

Abstract: An Integrated Circuit (IC) chip with a lab-on-a-chip, a method of manufacturing the lab-on-a-chip and a method of using the lab-on-a-chip for fluid flow analysis in physical systems through combination with computer modeling. The lab-on-a-chip includes cavities in a channel layer and a capping layer, preferably transparent, covering the cavities. Gates control two dimensional (2D) lattice structures acting as heaters, light sources and/or sensors in the cavities, or fluid channels. The gates and two dimensional (2D) lattice structures may be at the cavity bottoms or on the capping layer. Wiring connects the gates and the 2D lattice structures externally.

公开(公告)号：US20170245796A1

公开(公告)日：2017-08-31

申请号：US15508265

申请日：2015-09-03

Applicant: BAR ILAN UNlVERSITY

Inventor： Zeev ZALEVSKY ,  Yevgeny BEIDERMAN

IPC: A61B5/00 ,  A61B5/0205 ,  G02F1/01 ,  A61B5/145 ,  A61B5/026 ,  G01N21/47 ,  A61B5/1455

CPC classification number: A61B5/6804 ,  A61B5/0015 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/026 ,  A61B5/08 ,  A61B5/14546 ,  A61B5/14551 ,  A61B2560/0214 ,  G01B9/02049 ,  G01N21/47 ,  G01N21/658 ,  G01N2201/06113 ,  G01N2201/08 ,  G02B6/001 ,  G02F1/0128 ,  G02F1/295

Abstract: An optical sensing system is presented for monitoring one or more parameters or conditions of an object. The optical sensing system comprises: an elongated light guide configured for placing in proximity of the object, the light guide defining a cavity for light propagation therethrough along at least one light propagation path, and having a light input port and at least one light output port; and a detector system for receiving light propagating from the at least one light output port, the detector system being configured and operable for monitoring a signal modulated by light interaction with the object and being indicative of the at least one parameter/condition of the object.

公开(公告)号：US09746467B2

公开(公告)日：2017-08-29

申请号：US14354253

申请日：2012-10-25

Applicant: Thibaut Mercey

Inventor： Thibaut Mercey

IPC: G01J3/44 ,  G01N21/55 ,  C12M3/00 ,  G01N33/53 ,  G01N33/554 ,  C40B30/04 ,  C40B60/12 ,  G01N33/543 ,  G01N21/552 ,  G01N21/25

CPC classification number: G01N33/54373 ,  G01N21/253 ,  G01N21/553 ,  G01N2201/02 ,  G01N2201/08 ,  G01N2469/00

Abstract: A microstructured chip (3; 33; 43; 53; 63) for surface plasmon resonance (SPR) analysis, taking the form of a solid formed by: a base (5; 77); an upper surface (4; 44), at least part of which is covered with a metal layer (2; 22; 42; 52; 62); and at least one side surface (55; 66). The chip is characterized in that the aforementioned upper surface is provided with micrometric zones intended to receive species to be analyzed and selected from among n protrusions and m cavities, and in that when n+m≧2 the zones are separated from one another by planar surfaces, with n varying between 1 and j, m varying between 0 and i, and j and i being integers.

公开(公告)号：US20170219492A1

公开(公告)日：2017-08-03

申请号：US15489655

申请日：2017-04-17

Applicant: Pacific Biosciences of California, Inc.

Inventor： Paul LUNDQUIST ,  Stephen TURNER

IPC: G01N21/64 ,  G01N21/77 ,  G02B6/02

CPC classification number: C12Q1/6874 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7746 ,  G01N2021/7789 ,  G01N2201/08 ,  G02B6/0229 ,  G02B2006/12147

Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include integrated illumination elements and optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.

公开(公告)号：US09717419B2

公开(公告)日：2017-08-01

申请号：US15391514

申请日：2016-12-27

Applicant: FUJIFILM Corporation

Inventor： Kaku Irisawa

IPC: G02B6/38 ,  A61B5/00 ,  A61B8/00 ,  G01N21/17

CPC classification number: A61B5/0095 ,  A61B5/0035 ,  A61B5/0084 ,  A61B5/6848 ,  A61B5/7425 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/4444 ,  A61B8/4483 ,  A61B8/461 ,  A61B8/56 ,  A61B2562/0223 ,  A61B2562/228 ,  G01N21/1702 ,  G01N2201/08 ,  G02B6/00 ,  G02B6/02 ,  G02B6/3887 ,  G02B6/42

Abstract: A plug that is engaged with a receptacle for light emission of a light source unit that emits a light beam having a flat-shaped cross section and an optical fiber having a burr defect in a part of an outer peripheral portion of an incidence end surface on which the light beam is incident are included. The plug is attached to an incidence end portion of the optical fiber in an arrangement in which the burr defect is located in a short axis direction of a cross section on the incidence end surface of the light beam incident on the incidence end surface in a state in which the plug is engaged with the receptacle.

公开(公告)号：US20170184607A1

公开(公告)日：2017-06-29

申请号：US15461455

申请日：2017-03-16

Applicant: SRI INTERNATIONAL

Inventor： Nathan Collins ,  Peter B. Madrid

IPC: G01N33/68 ,  C08G69/36 ,  G01N21/64 ,  G01N33/543

CPC classification number: G01N33/6848 ,  B01J2219/0045 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00675 ,  B01J2219/00702 ,  C07B2200/11 ,  C08G69/36 ,  C40B40/14 ,  C40B50/14 ,  C40B60/12 ,  G01N21/6456 ,  G01N33/54313 ,  G01N2201/08 ,  G01N2201/105 ,  G01N2201/12 ,  G01N2560/00

Abstract: Devices, systems and methods for affinity reagent and catalyst discovery employing a library on a bead HTS platform, each bead comprising affixed non-natural polymers of a distinct bioactive monomer with sequence pre-defined branching and folding in tertiary structures, and fiber-optic array scanning technology.

公开(公告)号：US20170184492A1

公开(公告)日：2017-06-29

申请号：US14979465

申请日：2015-12-27

Applicant: COMDEK INDUSTRIAL CORPORATION

Inventor： Hsiang-Ann Hong ,  Chang-Yu Tsai ,  Chien-Pang Kuo ,  Yi-Sung Kuo

IPC: G01N21/25 ,  G01N21/31 ,  A61B5/08 ,  G01N33/00

CPC classification number: G01N21/255 ,  A61B5/0075 ,  A61B5/082 ,  A61B5/0836 ,  G01N21/05 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/85 ,  G01N33/004 ,  G01N2021/8578 ,  G01N2201/08

Abstract: According to one embodiment, the gas analyzer system comprises a gas adaptor, a light guide tube and a measure case. The gas adaptor is used for guiding a gas to be detected, wherein the gas is flowed in the gas adaptor along a flow direction. The light guide tube embedded in the gas adaptor, wherein the light guide tube has a light source end and a sensor end, the light guide tube has at least one aperture for the gas entering the light guide tube, and a normal vector of a cross surface defined by the aperture has an angle with respect to the gas inhale direction, wherein the angle is not 180 degrees. The measuring case for accommodating the gas adaptor comprises a light source corresponding to the light source end and a sensor corresponding to the sensor end of the light guide tube.

公开(公告)号：US09687157B2

公开(公告)日：2017-06-27

申请号：US14494080

申请日：2014-09-23

Applicant: Duke University

Inventor： Adam Wax ,  John W. Pyhtila

IPC: G01B9/02 ,  G01J3/45 ,  A61B5/00 ,  G01N21/31 ,  G01N21/47 ,  A61B1/00

CPC classification number: A61B5/0084 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/0075 ,  G01B9/02043 ,  G01B9/02044 ,  G01B9/02084 ,  G01B9/02087 ,  G01B9/0209 ,  G01B9/02091 ,  G01J3/45 ,  G01N21/31 ,  G01N21/4795 ,  G01N2021/4704 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/08

Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

公开(公告)号：US20170160196A1

公开(公告)日：2017-06-08

申请号：US15388602

申请日：2016-12-22

Applicant: Universal Bio Research Co., Ltd.

Inventor： Hideji Tajima ,  Takaki Sugimoto ,  Yu Matsukubo ,  Shuuichi Kobayashi ,  Tetsuya Ueda

IPC: G01N21/64 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N21/645 ,  B01L3/50825 ,  B01L2300/0654 ,  C12Q1/686 ,  G01N21/6428 ,  G01N21/78 ,  G01N35/00722 ,  G01N35/0098 ,  G01N35/10 ,  G01N35/1002 ,  G01N35/1083 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2035/103 ,  G01N2201/08

Abstract: The invention relates to a method and apparatus for measuring the optical state on the inside of a reaction vessel. The apparatus includes: linking portions that optically connect with the interior of the reaction vessel that is linkable with reaction vessels, a connecting end arranging body having an arranging surface that arranges and supports along a predetermined path, connecting ends to which is provided back ends of the light guide portions, the front ends thereof being provided to the linking portions, the connecting ends being provided to the linking portions; a measurement device having measuring ends that are successively optically connectable with the connecting ends, and in which light based on the optical state is receivable by optical connections between the connecting ends and the measuring ends; and a light guide switching mechanism that successively optically connects the connecting ends and the measuring ends.