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    Method and system for efficient collection and storage of experimental data
    21.
    发明申请
    Method and system for efficient collection and storage of experimental data 有权
    有效收集和储存实验数据的方法和系统

    公开(公告)号：US20040139103A1

    公开(公告)日：2004-07-15

    申请号：US10649323

    申请日：2003-08-27

    Applicant: Cellomics, Inc.

    Inventor： Keith S. Boyce ,  Brian K. McKenna ,  Phillip W. Glick ,  R. Terry Dunlay

    IPC: G06F017/00

    CPC classification number: G06K9/00127 ,  G01N15/1475 ,  G01N2015/1477 ,  G01N2015/1497 ,  G01N2035/00158 ,  Y10S707/99943 ,  Y10S707/99945

    Abstract: Methods and system for efficient collection and storage of experimental data. These methods and system allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing managing and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells. The methods and system can also be used to provide new bioinformatic techniques to manipulate experimental data including multiple digital photographic images.

    Abstract translation: 有效收集和储存实验数据的方法和系统。 这些方法和系统允许高吞吐量，功能丰富的数据收集系统（例如高通量小区数据收集系统）的实验数据被有效地收集，存储，管理和显示。 可以使用方法和系统，例如用于存储管理和显示从包括多个孔的微孔板和其中将实验化合物应用于细胞群的各种生物芯片的微孔板收集的细胞图像数据和细胞特征数据。 这些方法和系统提供了一个灵活和可扩展的实验数据库，包括多个位置的多个数据库，包括易于管理的直通数据库，并允许细胞数据进行分析，操作和归档。 方法和系统可以改善已经应用于细胞群体的新药物的鉴定，选择，验证和筛选。 方法和系统也可用于提供新的生物信息学技术来操纵包括多个数字摄影图像的实验数据。

    Slide holder assembly for comet assay
    24.
    发明授权
    Slide holder assembly for comet assay 有权
    用于彗星测定的滑轨架组件

    公开(公告)号：US09128046B2

    公开(公告)日：2015-09-08

    申请号：US13658263

    申请日：2012-10-23

    Applicant: Cellomics, Inc.

    Inventor： Brent A. Samson ,  Chandrasekaran Vasudevan ,  Keith R. Heffley ,  Joseph M. Zock ,  Dirk John Vandenberg, III

    IPC: G01N27/447 ,  B01L3/00 ,  B01L9/00 ,  G01N27/453

    CPC classification number: G01N27/44756 ,  B01L3/50 ,  B01L3/5085 ,  B01L3/50853 ,  B01L9/00 ,  G01N27/453

    Abstract: A slide holder assembly and method for use in high content screening of a comet assay. The slide holder assembly has an inside surface and is configured to receive a slide holding a plurality of biological cells on a top surface thereof. When the slide is secured within the slide holder assembly, the inside surface of the slide holder assembly and the top surface of the slide combine to form a cavity having an open top end. The cavity is watertight and configured to hold a liquid therein. A method of performing a comet assay using a slide disposed within a slide holder assembly. The method includes performing encapsulation, lysis, electrophoresis, staining, and imaging of cells on the slide while the slide remains secured within the slide holder assembly.

    Abstract translation: 用于彗星测定的高含量筛选的载片架组件和方法。 滑动支架组件具有内表面，并且构造成容纳在其顶表面上容纳多个生物细胞的载片。 当滑块固定在滑块保持器组件内时，滑块保持器组件的内表面和滑块的顶表面组合形成具有开放顶端的空腔。 空腔是水密的并且构造成在其中保持液体。 使用设置在载玻片保持器组件内的滑块进行彗星测定的方法。 该方法包括在载玻片保持固定在载玻片保持器组件内时，在载玻片上进行细胞的包封，裂解，电泳，染色和成像。

    PREDICTING TOXICITY OF A COMPOUND OVER A RANGE OF CONCENTRATIONS
    25.
    发明申请
    PREDICTING TOXICITY OF A COMPOUND OVER A RANGE OF CONCENTRATIONS 有权
    化合物对浓度范围的预测毒性

    公开(公告)号：US20140329717A1

    公开(公告)日：2014-11-06

    申请号：US14334453

    申请日：2014-07-17

    Applicant: CELLOMICS, INC.

    Inventor： Suk Jin Hong ,  Richik Niloy Ghosh

    IPC: G01N33/50 ,  G06T7/00

    CPC classification number: G01N33/5014 ,  G01N33/5067 ,  G01N2500/10 ,  G06F19/704 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30024

    Abstract: A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.

    Abstract translation: 预测化合物细胞毒性的方法包括：置于多个容器内的成像细胞，以获得成像的细胞靶标，每个容器用不同浓度的化合物处理，使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量值，以确定化合物的毒性。

    CELL-BASED METHOD TO DETECT SKIN SENSITIZERS
    26.
    发明申请
    CELL-BASED METHOD TO DETECT SKIN SENSITIZERS 审中-公开
    基于细胞的检测皮肤敏感剂的方法

    公开(公告)号：US20140194321A1

    公开(公告)日：2014-07-10

    申请号：US13734751

    申请日：2013-01-04

    Applicant: CELLOMICS, INC.

    Inventor： Monica Jo Tomaszewski

    IPC: C12Q1/02

    CPC classification number: G01N33/5047 ,  G01N33/5029 ,  G16B99/00

    Abstract: A method of predicting whether a compound is a skin sensitizer using an in vitro approach. The method includes a step of imaging immune effector cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of a compound. The method further includes a step of quantitatively measuring the imaged cellular targets over a range of concentrations of the compound to detect changes in multiple cellular targets of the immune effector cells associated with skin sensitivity. The method further includes a step of analyzing measurements obtained from the measured imaged cellular targets over the range of concentrations of the compound to determine whether the compound is a skin sensitizer.

    Abstract translation: 使用体外方法预测化合物是否为皮肤敏化剂的方法。 该方法包括对位于多个容器内的免疫效应细胞进行成像以获得成像细胞靶的步骤，每个容器用不同浓度的化合物处理。 该方法还包括在化合物的浓度范围内定量测量成像的细胞靶标以检测与皮肤敏感性相关的免疫效应细胞的多个细胞靶的变化的步骤。 该方法还包括在化合物浓度范围内分析从测量的成像细胞靶标获得的测量值以确定化合物是皮肤敏化剂的步骤。

    OPTICAL QUICKMOUNT
    27.
    发明申请
    OPTICAL QUICKMOUNT 有权

    公开(公告)号：US20140192404A1

    公开(公告)日：2014-07-10

    申请号：US13734748

    申请日：2013-01-04

    Applicant: CELLOMICS, INC.

    Inventor： Dirk John Vandenberg, III ,  Keith R. Heffley

    IPC: G02B7/00 ,  G02B21/00 ,  G02B26/00

    CPC classification number: G02B7/003 ,  G02B21/00 ,  G02B26/008 ,  Y10T29/49817 ,  Y10T29/49826

    Abstract: A filter wheel assembly includes a filter wheel and an optical assembly. The filter wheel includes a plurality of viewing openings. The optical assembly includes an optical element secured within an aperture of a housing. The optical assembly is securable to the filter wheel at a viewing opening by a magnetic force. An optical apparatus includes an optical assembly receiver and first and second optical assemblies. The first optical assembly is securable to the optical assembly receiver and the second optical assembly is securable to the first optical assembly by a magnetic force to align the optical assembly receiver and the optical assemblies. Methods of aligning apertures of optical assemblies with viewing openings of a filter wheel or an optical assembly receiver and securing the optical assemblies to the filter wheel or the optical assembly receiver using a magnetic force.

    Abstract translation: 滤光轮组件包括滤光轮和光学组件。 滤光轮包括多个观察孔。 光学组件包括固定在壳体的孔内的光学元件。 光学组件通过磁力固定在观察开口处的滤光轮上。 光学装置包括光学组件接收器和第一和第二光学组件。 第一光学组件可固定到光学组件接收器，并且第二光学组件通过磁力固定到第一光学组件，以对准光学组件接收器和光学组件。 将光学组件的孔径与滤光轮或光学组件接收器的观察孔对准的方法，并使用磁力将光学组件固定到滤光轮或光学组件接收器。

    Method for determining a best initial focal position estimate
    30.
    发明申请
    Method for determining a best initial focal position estimate 有权
    用于确定最佳初始焦点位置估计的方法

    公开(公告)号：US20020172964A1

    公开(公告)日：2002-11-21

    申请号：US10061525

    申请日：2002-02-01

    Applicant: Cellomics, Inc.

    Inventor： Kim Ippolito ,  Oleg Lapets ,  Michael Sipe ,  Randall Shopoff

    IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC classification number: G02B21/244 ,  G02B7/28

    Abstract: The invention provides a method for a method for determining a best initial focal position estimate for a current sample location on a substrate comprising multiple sample locations, comprising determining the best initial focal position estimate by using a result from one or more techniques selected from the group consisting of linear regression analysis of focal positions determined for at least two other sample locations on the substrate and quadratic regression analysis of focal positions determined for at least three other sample locations on the substrate.

    Abstract translation: 本发明提供了一种用于确定包括多个样本位置的衬底上的当前样本位置的最佳初始焦点位置估计的方法的方法，包括通过使用选自组中的一种或多种技术的结果来确定最佳初始焦点位置估计 包括对基底上的至少两个其他样本位置确定的焦点位置的线性回归分析和对基底上的至少三个其他样本位置确定的焦点位置的二次回归分析。

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