公开(公告)号：US11275013B1

公开(公告)日：2022-03-15

申请号：US16040131

申请日：2018-07-19

Applicant: Labrador Diagnostics LLC

Inventor： Peiqian Zhao

IPC: G01N15/08 ,  G01N15/02 ,  G01N15/14

Abstract: Methods and devices are provided for use with a biological sample, wherein in one example, the device comprising a sample holder and an excitation source for providing excitation energy into the light conduit towards the sample holder. In one embodiment, the device comprises an imaging cytometer. Optionally, the device comprises a flow cytometer. Optionally, a light conduit comprises an optical fiber. Optionally, the optical fiber has an outer cross-sectional shape different from an inner optical core cross-sectional shape.

公开(公告)号：US20220072554A1

公开(公告)日：2022-03-10

申请号：US17402816

申请日：2021-08-16

Applicant: Labrador Diagnostics LLC

Inventor： Gary Frenzel ,  Samartha Anekal ,  Daniel Young

IPC: B01L3/00

Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.

公开(公告)号：US20210370297A1

公开(公告)日：2021-12-02

申请号：US17318870

申请日：2021-05-12

Applicant: Labrador Diagnostics LLC

Inventor： Deborah Sloan ,  Channing Robertson

IPC: B01L3/00 ,  A61J1/05 ,  G01N1/40 ,  A61B5/15 ,  G01N33/49

Abstract: Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.

公开(公告)号：US11158429B2

公开(公告)日：2021-10-26

申请号：US15952957

申请日：2018-04-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

IPC: G16H50/50 ,  G16H50/70 ,  G16H50/80 ,  G16H50/20 ,  G06F19/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

公开(公告)号：US11143647B2

公开(公告)日：2021-10-12

申请号：US15160491

申请日：2016-05-20

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US11139084B2

公开(公告)日：2021-10-05

申请号：US15246401

申请日：2016-08-24

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

IPC: G16H50/50 ,  G16H50/80 ,  G16H50/70 ,  G16H50/20 ,  G06F19/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

公开(公告)号：US20210156848A1

公开(公告)日：2021-05-27

申请号：US17165249

申请日：2021-02-02

Applicant: LABRADOR DIAGNOSTICS LLC

Inventor： Tammy BURD ,  Ian GIBBONS ,  Elizabeth A. HOLMES ,  Gary FRENZEL ,  Anthony Joseph NUGENT

IPC: G01N33/53 ,  G16H10/40 ,  A61B5/15 ,  A61B5/151 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N33/543 ,  G01N33/574 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  B01L7/00 ,  B01L9/00 ,  G01N1/38 ,  G01N33/569 ,  G01N33/68 ,  G01N33/94

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20210148908A1

公开(公告)日：2021-05-20

申请号：US17082979

申请日：2020-10-28

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Karan Mohan ,  James R. Wasson

IPC: G01N33/569 ,  B01L3/00 ,  G01N15/10 ,  G02B21/00 ,  G02B21/12 ,  G01N21/05 ,  G02B21/08 ,  G01N33/50 ,  G01N1/30 ,  G01N33/53 ,  G01N33/58 ,  G01N21/64 ,  G02B7/09 ,  G01N21/03 ,  G01N21/17 ,  G02B21/24 ,  G01N33/487 ,  G01N33/49 ,  G01N21/27 ,  G02B21/16 ,  G02B21/36

Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

公开(公告)号：US20210031148A1

公开(公告)日：2021-02-04

申请号：US16931127

申请日：2020-07-16

Applicant: Labrador Diagnostics LLC

Inventor： Samartha Anekal ,  Deborah Sloan

IPC: B01D69/12 ,  A61M1/34 ,  B01D69/06 ,  B01D71/68 ,  B01D65/02 ,  B01D67/00

Abstract: In one embodiment described herein, a bodily fluid separation material is provided comprising a formed component capture region and a bodily fluid pass-through region. The pass-through region has structures with a reduced liquid leaching quality relative to than the capture region, wherein during separation material use, bodily fluid enters the capture region prior to entering the pass-through region. Optionally, a bodily fluid pass-through region has a reduced amount of liquid leaching material relative to than the capture region.

公开(公告)号：US10908093B2

公开(公告)日：2021-02-02

申请号：US14867271

申请日：2015-09-28

Applicant: Labrador Diagnostics LLC

Inventor： Ian Gibbons ,  Chengwang Wang ,  Shaunak Roy ,  Elizabeth A. Holmes

IPC: G01N21/76 ,  G01N33/53 ,  B01L3/00 ,  A61B5/151 ,  A61B5/157 ,  A61B5/145 ,  A61B5/00 ,  G16H40/63 ,  A61B5/15 ,  G01N33/50 ,  A61B5/155 ,  G01N33/543 ,  A61B5/1495

Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.