公开(公告)号：US12173034B2

公开(公告)日：2024-12-24

申请号：US16766596

申请日：2018-11-22

Applicant: OSAKA UNIVERSITY

Inventor： Yukako Fujinaga ,  Sho Amatsu ,  Masahiro Kinooka

IPC: C07K14/33 ,  C12N15/85

Abstract: The present invention provides a miniaturized hemagglutinin complex protein having function inhibitory activity against E-cadherin, wherein (a) all or a part of at least HA1 subcomponent, and/or a part of HA3 subcomponent are/is deleted, (b) regions in HA2 and HA3 subcomponents that contribute to binding with E-cadherin are present, and (c) the HA3 subcomponent is derived from Clostridium botulinum type A or type B, and an E-cadherin function inhibitor containing the hemagglutinin complex protein.

公开(公告)号：US12172949B2

公开(公告)日：2024-12-24

申请号：US17428097

申请日：2019-09-17

Applicant: OSAKA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Tomoo Mizugaki ,  Kiyotomi Kaneda ,  Yasuteru Kajikawa ,  Yuuichirou Hirai

IPC: C07C29/149 ,  B01J21/06 ,  B01J23/42 ,  B01J23/652 ,  B01J37/02

Abstract: The present invention provides a method for selectively producing an alcohol by efficiently hydrogenating a lactone. The present invention is a method for producing an alcohol, the method including hydrogenating a substrate lactone represented by Formula (1), in the presence of a catalyst described below, to produce an alcohol that is represented by Formula (2).
In the formulae, R represents a divalent hydrocarbon group which may have a hydroxyl group.
The catalyst comprises: metal species including M1 and M2; and a support supporting the metal species, and wherein M1 is rhodium, platinum, ruthenium, iridium, or palladium; M2 is tin, vanadium, molybdenum, tungsten, or rhenium; and the support is hydroxyapatite, fluorapatite, hydrotalcite, or ZrO2.

公开(公告)号：US12163028B2

公开(公告)日：2024-12-10

申请号：US17050172

申请日：2019-04-26

Applicant: BRIDGESTONE CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hiroyuki Fudemoto ,  Atsushi Fukushima ,  Masahiro Homma ,  Yuji Ohkubo ,  Kazuya Yamamura

IPC: C08L9/06 ,  B60C1/00 ,  B60C15/04

Abstract: A resin-rubber composite includes: a resin member that has a treated surface, to which a surface treatment by means of a plasma treatment has been applied; and a rubber member that is disposed in contact with the treated surface of the resin member and includes a rubber, a filler having a silanol group, and a silane coupling agent, with a filler content of from 30 phr to 100 phr with respect to 100 phr of the rubber, and a silane coupling agent content of from 2 parts by mass to 15 parts by mass with respect to 100 parts by mass of the filler.

公开(公告)号：US12151947B2

公开(公告)日：2024-11-26

申请号：US17310482

申请日：2020-02-07

Applicant: National University Corporation Tokai National Higher Education and Research System ,  OSAKA UNIVERSITY ,  NICHIA CORPORATION

Inventor： Tsukasa Torimoto ,  Tatsuya Kameyama ,  Susumu Kuwabata ,  Taro Uematsu ,  Daisuke Oyamatsu

IPC: C01G15/00 ,  B82Y20/00 ,  B82Y40/00 ,  C09K11/58 ,  C09K11/62 ,  H01L33/50

Abstract: Provided is a method for producing a semiconductor nanoparticle including preparing a mixture containing a Ag salt, a salt containing at least one of In and Ga, and an organic solvent; raising the temperature of the mixture to a raised temperature in a range of from 120° C. to 300° C.; and adding a supply source of S to the mixture at the raised temperature in such a manner that a ratio of a number of S atoms to a number of Ag atoms in the mixture increases at a rate of not more than 10/min.

公开(公告)号：US20240374930A1

公开(公告)日：2024-11-14

申请号：US18578283

申请日：2022-06-24

Applicant: OSAKA UNIVERSITY ,  MIZUHO RESEARCH & TECHNOLOGIES, LTD.

Inventor： Teiji NISHIO ,  Yuya Nemoto ,  Hidemasa MAEKAWA

IPC: A61N5/10

Abstract: A support apparatus includes an irradiation device for emitting a particle beam, a detection device for detecting a particle beam irradiation region, and a control unit for acquiring the irradiation region. The control unit specifies an attention region within the irradiation region in a treatment plan for a patient, and specifies the irradiation position for pre-irradiation within the attention region. The control unit instructs the irradiation device to carry out pre-irradiation with irradiation energy in the treatment plan at the irradiation position, and acquires the irradiation region detected by the detection device. The control unit further adjusts irradiation conditions in the treatment plan according to the irradiation region in the pre-irradiation and instructs the irradiation device to carry out post-irradiation under the adjusted irradiation conditions.

公开(公告)号：US20240360222A1

公开(公告)日：2024-10-31

申请号：US18662493

申请日：2024-05-13

Applicant: OSAKA UNIVERSITY

Inventor： Naoki HOSEN ,  Haruo SUGIYAMA ,  Atsushi KUMANOGOH ,  Junichi TAKAGI

IPC: C07K16/28 ,  A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K16/30 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09

CPC classification number: C07K16/2839 ,  A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K16/30 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/03 ,  C07K2319/33

Abstract: Provided is an active ingredient of a pharmaceutical composition for treating myeloma. Specifically, provided is an antibody whose epitope is present in the region of the amino acid residue positions 20 to 109 of human integrin β7.

公开(公告)号：US20240344134A1

公开(公告)日：2024-10-17

申请号：US18292652

申请日：2022-07-26

Applicant: OSAKA UNIVERSITY

Inventor： Hayato HIKITA ,  Yuta MYOJIN ,  Tetsuo TAKEHARA

IPC: C12Q1/6886 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  G01N33/57438 ,  C12Q2600/158

Abstract: The method of the present invention for evaluating the risk of developing liver cancer in a subject includes (1) a step of measuring a GDF15 level of a subject and (2) a step of relating the GDF15 level to the risk of developing liver cancer. When the GDF15 level measured in step (1) is not less than a cutoff value set in advance, the GDF15 level becomes an indicator that the subject has a high risk of developing liver cancer, and when the GDF15 level is less than the cutoff value, it becomes an indicator that the risk of developing liver cancer is low. The present invention also provides a kit for measuring GDF15 levels in a subject for use in the method of the present invention, and a diagnostic agent for evaluating the risk of developing liver cancer in a subject, which contains an anti-GDF15-specific antibody.

公开(公告)号：US12104154B2

公开(公告)日：2024-10-01

申请号：US17666341

申请日：2022-02-07

Applicant: Osaka University

Inventor： Satoshi Obika ,  Reiko Waki ,  Takao Inoue ,  Tokuyuki Yoshida ,  Kunihiko Morihiro ,  Yuya Kasahara ,  Atsushi Mikami

IPC: C12N15/113 ,  A61K31/7115 ,  A61K31/712

CPC classification number: C12N15/113 ,  A61K31/7115 ,  A61K31/712

Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2′,4′-bridged nucleic acids, 2′,4′-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2′,4′-non-bridged nucleic acid residue(s) is/are modified.

公开(公告)号：US20240315124A1

公开(公告)日：2024-09-19

申请号：US18564850

申请日：2022-06-06

Applicant: OSAKA UNIVERSITY ,  DAIHACHI CHEMICAL INDUSTRY CO., LTD. ,  National University Corporation Kyoto Institute of Technology ,  Public University Corporation Nagoya City University

Inventor： Toshikazu Hirao ,  Toru Amaya ,  Kahori Kiriyama ,  Keiho Tsuchiya ,  Yuhi Inada ,  Takeshi Yamao ,  Ryo Okazaki

IPC: H10K85/10 ,  C08G61/12 ,  H10K30/50

CPC classification number: H10K85/113 ,  C08G61/126 ,  H10K30/50 ,  C08G2261/11 ,  C08G2261/147 ,  C08G2261/228 ,  C08G2261/324 ,  C08G2261/43

Abstract: The present invention provides an electrically conductive polymer having excellent electrical conductivity. A polythiophene compound comprising a structural unit of following general formula (A) (wherein L is alkylene or the like; each of M1 and M2 is independently an alkyl group, a hydrogen atom, an alkali metal, an alkaline earth metal or an ammonium group; R1A is a hydrogen atom, an alkyl group, an alkoxy group, an acyl group or a group represented by formula (15); and each of L1, M1c and M2c are respectively the same as L, M1 and M2) and having a high absorbance ratio calculated by calculation formula (A2000/A407) from absorbance (A2000) at the wavelength of 2,000 nm and absorbance (A407) at the wavelength of 407 nm achieves excellent electrical conductivity. Further, an electrical conductive polymer of the present invention is useful as a material for solar cells.

公开(公告)号：US12094710B2

公开(公告)日：2024-09-17

申请号：US17219320

申请日：2021-03-31

Applicant: TOKYO ELECTRON LIMITED ,  OSAKA UNIVERSITY

Inventor： Nobuaki Takahashi ,  Hitoshi Miura ,  Koji Neishi ,  Ryuji Katayama ,  Yusuke Mori ,  Masayuki Imanishi

IPC: C23C14/00 ,  C23C14/06 ,  C23C14/34 ,  H01J37/34 ,  H01L21/02

CPC classification number: H01L21/02631 ,  C23C14/0641 ,  C23C14/34 ,  H01J37/3426 ,  H01L21/02458 ,  H01L21/0254 ,  H01J2237/332 ,  H01L21/02389 ,  H01L21/0242 ,  H01L21/02513 ,  H01L21/02576 ,  H01L21/02579

Abstract: The method of forming a nitride semiconductor film includes intermittently sputtering a target of gallium nitride inside a vacuum chamber containing nitrogen and argon, and depositing sputtered particles of the gallium nitride that are scattered from the target inside the vacuum chamber, on a substrate having a temperature of 560 degrees C. or higher and 650 degrees C. or lower. A ratio of a flow rate of the nitrogen to a sum of the flow rate of the nitrogen and a flow rate of the argon supplied to the vacuum chamber is 6% or higher and 18% or lower.