公开(公告)号：US07505128B2

公开(公告)日：2009-03-17

申请号：US11400948

申请日：2006-04-10

Applicant: Anis Zribi ,  Stacey Joy Kennerly ,  Glenn Scott Claydon ,  Long Que ,  Ayan Banerjee ,  Shankar Chandrasekaran ,  Shivappa Ningappa Goravar ,  David Cecil Hays

Inventor： Anis Zribi ,  Stacey Joy Kennerly ,  Glenn Scott Claydon ,  Long Que ,  Ayan Banerjee ,  Shankar Chandrasekaran ,  Shivappa Ningappa Goravar ,  David Cecil Hays

IPC: G01J3/44

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/26 ,  G01J3/44 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/0221

Abstract: An integrated spectrometer instrument, including an optical source formed on a chip, the optical source configured to generate an incident optical beam upon a sample to be measured. Collection optics formed on the chip are configured to receive a scattered optical beam from the sample, and filtering optics formed on the chip are configured to remove elastically scattered light from the scattered optical beam at a wavelength corresponding to the optical source. A tunable filter formed on the chip is configured to pass selected wavelengths of the scattered optical beam, and a photo detector device formed on the chip is configured to generate an output signal corresponding to the intensity of photons passed through the tunable filter.

Abstract translation: 一种集成光谱仪器，包括形成在芯片上的光源，所述光源被配置为在待测样品上产生入射光束。 形成在芯片上的采集光学元件被配置为接收来自样品的散射光束，并且形成在芯片上的滤光光学元件被配置为以对应于光源的波长去除来自散射光束的弹性散射光。 形成在芯片上的可调滤波器被配置为通过散射光束的选定波长，并且形成在芯片上的光检测器装置被配置为产生对应于通过可调谐滤波器的光子的强度的输出信号。

公开(公告)号：US20080239306A1

公开(公告)日：2008-10-02

申请号：US11693277

申请日：2007-03-29

Applicant: William Scott Sutherland ,  Anis Zribi ,  Long Que ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar Chandrasekaran ,  David Cecil Hays ,  Victor Samper ,  Dirk Lange ,  Marko Baller ,  Min-Yi Shih ,  Sandip Maity

Inventor： William Scott Sutherland ,  Anis Zribi ,  Long Que ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar Chandrasekaran ,  David Cecil Hays ,  Victor Samper ,  Dirk Lange ,  Marko Baller ,  Min-Yi Shih ,  Sandip Maity

IPC: G01J3/44 ,  G01N21/55 ,  G02B26/08

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G02B26/02 ,  G02B26/0808 ,  G02B26/0816

Abstract: A system and method for managing optical power for controlling thermal alteration of a sample undergoing spectroscopic analysis is provided. The system includes a moveable laser beam generator for irradiating the sample and a beam shaping device for moving and shaping the laser beam to prevent thermal overload or build up in the sample. The moveable laser beam generator includes at least one beam shaping device selected from the group consisting of at least one optical lens, at least one optical diffractor, at least one optical path difference modulator, at least one moveable mirror, at least one Micro-Electro-Mechanical Systems (MEMS) integrated circuit (IC), and/or a liquid droplet. The system also includes an at least two degree of freedom (2 DOF) moveable substrate platform and a controller for controlling the laser beam generator and the substrate platform, and for analyzing light reflected from the sample.

Abstract translation: 提供了一种用于管理用于控制进行光谱分析的样品的热变化的光功率的系统和方法。 该系统包括用于照射样品的可移动激光束发生器和用于移动和成形激光束的光束整形装置，以防止样品中的热过载或积聚。 可移动激光束发生器包括至少一个光束成形装置，其选自由至少一个光学透镜，至少一个光学衍射器，至少一个光程差调制器，至少一个可动反射镜，至少一个微电极 机电系统（MEMS）集成电路（IC）和/或液滴。 该系统还包括至少两个自由度（2自由度）可移动基板平台和用于控制激光束发生器和基板平台的控制器，并用于分析从样品反射的光。

公开(公告)号：US20080018890A1

公开(公告)日：2008-01-24

申请号：US11459449

申请日：2006-07-24

Applicant: Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

Inventor： Sandip Maity ,  Ayan Banerjee ,  Anis Zribi ,  Stacey Kennerly ,  Long Que ,  Glenn Claydon ,  Shankar Chandrasekaran ,  Shivappa Goravar

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J1/44 ,  G01J3/02 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0286 ,  G01J3/0297 ,  G01J3/1895 ,  G01J3/4338 ,  G02B26/04 ,  H01L31/107

Abstract: A method of Raman detection for a portable, integrated spectrometer instrument includes directing Raman scattered photons by a sample to an avalanche photodiode (APD), the APD configured to generate an output signal responsive to the intensity of the Raman scattered photons incident thereon. The output signal of the APD is amplified and passed through a discriminator so as to reject at least one or more of amplifier noise and dark noise. A number of discrete output pulses within a set operational range of the discriminator is counted so as to determine a number of photons detected by the APD.

Abstract translation: 用于便携式，集成光谱仪器的拉曼检测方法包括将样品的拉曼散射光子引导到雪崩光电二极管（APD），APD被配置为响应入射在其上的拉曼散射光子的强度产生输出信号。 APD的输出信号被放大并通过鉴频器，以便抑制至少一个或多个放大器噪声和暗噪声。 对鉴别器的设定操作范围内的多个离散输出脉冲进行计数，以便确定APD检测到的光子数量。

公开(公告)号：US20070200549A1

公开(公告)日：2007-08-30

申请号：US11356332

申请日：2006-02-16

Applicant: Ertugrul Berkcan ,  Shankar Chandrasekaran

Inventor： Ertugrul Berkcan ,  Shankar Chandrasekaran

IPC: G01R15/18

CPC classification number: G01R15/148

Abstract: A micro-electromechanical system (MEMS) current and magnetic field sensor for sensing a magnetic field produced by a conductor includes a magneto-MEMS component for sensing the magnetic field and an interference-MEMS component for sensing an interference, wherein the magneto-MEMS component and the interference MEMS component are used to provide an indication of the current in the conductor.

Abstract translation: 用于感测由导体产生的磁场的微机电系统（MEMS）电流和磁场传感器包括用于感测磁场的磁MEMS组件和用于感测干扰的干涉MEMS组件，其中磁MEMS组件 并且使用干涉MEMS分量来提供导体中的电流的指示。

公开(公告)号：US07221144B2

公开(公告)日：2007-05-22

申请号：US11289910

申请日：2005-11-30

Applicant: Ertugrul Berkcan ,  Shankar Chandrasekaran ,  Christopher James Kapusta ,  Laura Jean Meyer ,  Glenn Scott Claydon ,  Debbie Gahaton Jones ,  Anis Zribi

Inventor： Ertugrul Berkcan ,  Shankar Chandrasekaran ,  Christopher James Kapusta ,  Laura Jean Meyer ,  Glenn Scott Claydon ,  Debbie Gahaton Jones ,  Anis Zribi

IPC: G01R31/00

CPC classification number: G01R15/207 ,  G01R15/148 ,  G01R33/0283 ,  G01R33/0286 ,  G01R35/005 ,  Y10T29/49002

Abstract: A micro-electromechanical system (MEMS) based current & magnetic field sensor includes a MEMS-based magnetic field sensing component a structural component comprising a silicon substrate and a compliant layer comprising a material selected from the group consisting of silicon dioxide and silicon nitride, a magnetic-to-mechanical converter coupled to the structural component to provide a mechanical indication of the magnetic field, and a strain responsive component coupled to the structural component to sense the mechanical indication and to provide an indication of the current in the current carrying conductor in response thereto.

Abstract translation: 基于微机电系统（MEMS）的电流和磁场传感器包括基于MEMS的磁场感测部件，包括硅衬底的结构部件和包括选自二氧化硅和氮化硅的材料的柔性层， 耦合到所述结构部件以提供所述磁场的机械指示的磁 - 机械转换器，以及耦合到所述结构部件以感测所述机械指示并且提供所述载流导体中的电流的指示的应变响应部件 回应。

公开(公告)号：US08229537B2

公开(公告)日：2012-07-24

申请号：US12725865

申请日：2010-03-17

Applicant: Shankar Chandrasekaran ,  Juha Virtanen ,  Shivappa Goravar

Inventor： Shankar Chandrasekaran ,  Juha Virtanen ,  Shivappa Goravar

IPC: A61B5/04 ,  A61B5/0478 ,  A61B5/11

CPC classification number: A61B5/0408 ,  A61B5/0428 ,  A61B5/685 ,  A61B5/721 ,  A61B2562/0219 ,  A61B2562/028 ,  A61B2562/125

Abstract: An electrode system for the measurement of biopotential signals includes a substrate. A microelectrode is coupled to the substrate. An accelerometer is coupled to the substrate. A biopotential amplifier is electrically coupled to the microelectrode and acceleration measurement circuit is electrically coupled to the accelerometer. A method of measuring a biopotential from a patient includes sensing a biopotential with a microelectrode. The biopotential is amplified with an amplifier in electrical communication with the microelectrode. A movement of the electrode is sensed with an accelerometer integrated with the electrode substrate. The sensed biopotential and the sensed movement are provided to an electronic controller. Portions of the sensed biopotential that correspond to sensed movement are identified as artifact contaminated portions.

Abstract translation: 用于测量生物电位信号的电极系统包括基底。 微电极耦合到衬底。 加速度传感器耦合到基板。 生物电位放大器电耦合到微电极，加速度测量电路电耦合到加速度计。 从患者测量生物潜力的方法包括用微电极感测生物电位。 生物电位用与微电极电连通的放大器放大。 用与电极基板一体化的加速度计感测电极的移动。 感测到的生物电势和感测的运动被提供给电子控制器。 对应于感测到的移动的感测生物电位的部分被识别为伪影污染部分。

公开(公告)号：US08083069B2

公开(公告)日：2011-12-27

申请号：US12533180

申请日：2009-07-31

Applicant: Sunil Srinivasa Murthy ,  Aaron Joseph Dulgar-Tulloch ,  James William Bray ,  Shankar Chandrasekaran ,  Arvind Kumar Tiwari

Inventor： Sunil Srinivasa Murthy ,  Aaron Joseph Dulgar-Tulloch ,  James William Bray ,  Shankar Chandrasekaran ,  Arvind Kumar Tiwari

IPC: B03C1/00 ,  B07C5/02

CPC classification number: B03C1/288 ,  B03C1/0332 ,  B03C1/0335 ,  B03C2201/18 ,  B03C2201/26

Abstract: The present application discloses a process for the high throughput separation of at least one distinct biological material from a sample using magnetic tags and a magnetic separation set up capable of processing at least about 106 units/second. A magnetic field gradient is used to deflect target material bearing a magnet tag from one laminar flow stream to another so that the magnetically tagged target material exits a separation chamber via a different outlet than the rest of the sample. The process is applicable to isolating several distinct biological materials by directing each via magnetic deflection to its own unique outlet. The application also discloses a system for performing the process and a kit that includes the system and the magnetic tags.

Abstract translation: 本申请公开了一种使用磁性标签和至少能够处理至少约106单位/秒的磁分离装置从至少一种不同的生物材料与样品分离高通量的方法。 使用磁场梯度将具有磁性标签的目标材料从一个层流流转移到另一层，使得磁标记的靶材料通过与样品其余部分不同的出口离开分离室。 该方法适用于通过将每个通过磁偏转指向其自己的独特出口来分离几种不同的生物材料。 本申请还公开了一种用于执行该过程的系统和包括该系统和磁性标签的套件。

公开(公告)号：US20110244588A1

公开(公告)日：2011-10-06

申请号：US12751457

申请日：2010-03-31

Applicant: Sandip Maity ,  Sameer Dinkar Vartak ,  Veena Besige Narayan Rao ,  Masako Yamada ,  Shankar Chandrasekaran ,  Abhijit Vishwas Patil ,  Ayan Banerjee ,  Umakant Damodar Rapol

Inventor： Sandip Maity ,  Sameer Dinkar Vartak ,  Veena Besige Narayan Rao ,  Masako Yamada ,  Shankar Chandrasekaran ,  Abhijit Vishwas Patil ,  Ayan Banerjee ,  Umakant Damodar Rapol

IPC: G01N21/55 ,  G01B11/02

CPC classification number: G01N21/45

Abstract: An optical sensing device is provided. The device comprises a cavity defined by at least an anomalous reflective element having an anomalous reflection surface, and a non-absorptive element having a non-absorptive reflection surface disposed in a direction away from the anomalous reflection surface.

Abstract translation: 提供光学传感装置。 该装置包括由至少具有异常反射表面的异常反射元件限定的空腔和具有沿远离异常反射表面的方向设置的非吸收性反射表面的非吸收元件。

公开(公告)号：US07796269B2

公开(公告)日：2010-09-14

申请号：US11502187

申请日：2006-08-10

Applicant: Anis Zribi ,  Glenn S. Claydon ,  Long Que ,  Stacey Kennerly ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  David C. Hays ,  Ayan Banerjee

Inventor： Anis Zribi ,  Glenn S. Claydon ,  Long Que ,  Stacey Kennerly ,  Shankar Chandrasekaran ,  Shivappa Goravar ,  David C. Hays ,  Ayan Banerjee

IPC: G01J3/45

CPC classification number: G01J3/26 ,  G01J3/06 ,  G02B26/001

Abstract: According to one embodiment, a micro-electrical mechanical system apparatus includes (i) a comb drive actuator having at least one irregularly shaped finger and (ii) a movable Fabry-Perot filter cavity mirror coupled to the comb drive actuator. According to some embodiments, a relationship between a voltage applied to the comb drive actuator and an amount of displacement associated with the movable mirror is substantially linear.

Abstract translation: 根据一个实施例，微电机械系统装置包括（i）具有至少一个不规则形状的指状物的梳状驱动致动器和（ii）耦合到梳状驱动致动器的可移动的法布里 - 珀罗滤光镜反射镜。 根据一些实施例，施加到梳状驱动致动器的电压与与可移动镜相关联的位移量之间的关系基本上是线性的。

公开(公告)号：US07692785B2

公开(公告)日：2010-04-06

申请号：US11693277

申请日：2007-03-29

Applicant: Willam Scott Sutherland ,  Anis Zribi ,  Long Que ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar Chandrasekaran ,  David Cecil Hays ,  Victor Samper ,  Dirk Lange ,  Marko Baller ,  Min-Yi Shih ,  Sandip Maity

Inventor： Willam Scott Sutherland ,  Anis Zribi ,  Long Que ,  Glenn Scott Claydon ,  Stacey Joy Kennerly ,  Ayan Banerjee ,  Shivappa Ningappa Goravar ,  Shankar Chandrasekaran ,  David Cecil Hays ,  Victor Samper ,  Dirk Lange ,  Marko Baller ,  Min-Yi Shih ,  Sandip Maity

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G02B26/02 ,  G02B26/0808 ,  G02B26/0816

Abstract: A system and method for managing optical power for controlling thermal alteration of a sample undergoing spectroscopic analysis is provided. The system includes a moveable laser beam generator for irradiating the sample and a beam shaping device for moving and shaping the laser beam to prevent thermal overload or build up in the sample. The moveable laser beam generator includes at least one beam shaping device selected from the group consisting of at least one optical lens, at least one optical diffractor, at least one optical path difference modulator, at least one moveable mirror, at least one Micro-Electro-Mechanical Systems (MEMS) integrated circuit (IC), and/or a liquid droplet. The system also includes an at least two degree of freedom (2 DOF) moveable substrate platform and a controller for controlling the laser beam generator and the substrate platform, and for analyzing light reflected from the sample.

Abstract translation: 提供了一种用于管理用于控制进行光谱分析的样品的热变化的光功率的系统和方法。 该系统包括用于照射样品的可移动激光束发生器和用于移动和成形激光束的光束整形装置，以防止样品中的热过载或积聚。 可移动激光束发生器包括至少一个光束成形装置，其选自由至少一个光学透镜，至少一个光学衍射器，至少一个光程差调制器，至少一个可动反射镜，至少一个微电极 机电系统（MEMS）集成电路（IC）和/或液滴。 该系统还包括至少两个自由度（2自由度）可移动基板平台和用于控制激光束发生器和基板平台的控制器，并用于分析从样品反射的光。