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公开(公告)号：US11931341B2
公开(公告)日：2024-03-19
申请号：US17040368
申请日：2019-03-22
Applicant: University of Iowa Research Foundation
Inventor： Rasna Sabharwal , Robert Weiss
IPC: A61K31/4178 , A61K9/00 , A61K45/06
CPC classification number: A61K31/4178 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K45/06
Abstract: The present invention relates to a new use of compounds that are angiotensin II (Ang II) agonists, more particularly agonists of the Ang II type 2 receptor (the AT2 receptor), and especially agonists that bind selectively to the AT2 receptor, for the prevention or treatment of muscular dystrophy or complications associated with muscular dystrophy.
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公开(公告)号：US20240084163A1
公开(公告)日：2024-03-14
申请号：US18507969
申请日：2023-11-13
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Elise Lin Cheng , C. Allan Guymon , Marlan R. Hansen , Braden Leigh
IPC: C09D133/10 , A61L27/16 , A61L27/34 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10 , C08K5/11 , C09D5/16 , C09D133/26 , C09D151/08
CPC classification number: C09D133/10 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/048 , A61L31/10 , C08K5/11 , C09D5/1675 , C09D133/26 , C09D151/085 , A61L2300/404 , A61L2420/08
Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.
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公开(公告)号：US20240082238A1
公开(公告)日：2024-03-14
申请号：US17890757
申请日：2022-08-18
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Aliasger K. Salem , Kareem Ebeid , Youssef Wahib Naguib Ibrahim , Sanjib Saha , Emad I. Wafa , Suhaila Alhaj-Suliman
IPC: A61K31/495 , A61K9/16 , A61K31/337 , A61P15/00 , A61P35/00
CPC classification number: A61K31/495 , A61K9/1647 , A61K31/337 , A61P15/00 , A61P35/00
Abstract: The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer).
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24.发明授权公开(公告)号：US11911416B2
公开(公告)日：2024-02-27
申请号：US16529186
申请日：2019-08-01
Applicant: University of Iowa Research Foundation
Inventor： Bernd Fritzsch , Karen Elliott Thompson , Marlan Hansen
CPC classification number: A61K35/36 , A61K35/12 , A61N1/0541 , C12N5/0603
Abstract: Described herein is a method for treating or restoring loss of hearing and balance in a subject in need thereof. In certain aspects, the disclosed method is comprised of transplanting a humanized otocyst to a target delivery site in the subject. According to certain aspects, the otocyst is obtained from a humanized non-human mammal embryo. In certain exemplary aspects, the non-human mammal is a pig. In certain embodiments, prior to transplantation, the otocyst is cultured in a species-specific tissue culture buffer.
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公开(公告)号：US11903612B2
公开(公告)日：2024-02-20
申请号：US15034004
申请日：2014-11-04
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Ibrahim T. Ozbolat , Howard Chen , Yin Yu , Yahui Zhang
IPC: B29C64/209 , B29C64/227 , A61B17/34 , B33Y80/00 , B33Y10/00 , B33Y30/00 , C12M3/00 , C12M1/26 , B41J3/407 , B41J3/54 , C09D11/38 , C09D11/30 , B29C64/40 , B29C64/118 , C09D11/04 , C09D11/102 , B33Y50/02 , B29K105/00
CPC classification number: A61B17/3468 , B29C64/118 , B29C64/209 , B29C64/227 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y80/00 , B41J3/407 , B41J3/543 , C09D11/04 , C09D11/102 , C09D11/30 , C09D11/38 , C12M21/08 , C12M33/00 , B29K2105/0061 , B33Y50/02
Abstract: A bioprinter and methods of using the bioprinter. The bioprinter permits selective three-dimensional movement of multiple nozzle assemblies during operation of the bioprinter. The bioprinter can be used to produce scaffold-free tissue constructs having a plurality of cellular elements interspersed among a semi-permeable vascular network. The bioprinter can also be used to print a tissue construct directly onto a tissue defect of a subject. The bioprinter can be provided as part of a bioprinting system that includes a scanner for imaging the tissue defect.
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Patent Agency Ranking
公开(公告)号：US20240002882A1
公开(公告)日：2024-01-04
申请号：US18313661
申请日：2023-05-08
Inventor： Ziying Yan , John F. Engelhardt , Jianming Qiu
IPC: C12N15/86 , C07K14/015
CPC classification number: C12N15/86 , C07K14/015 , C12N2750/14143 , C12N2800/22 , C12N2810/6027
Abstract: A method of preparing a chimeric virus comprising bocavirus capsid protein (VP) and a recombinant adeno-associated (AAV) viral genome, and isolated mutant bocavirus genomes, are provided.
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公开(公告)号：US20230277483A1
公开(公告)日：2023-09-07
申请号：US18110094
申请日：2023-02-15
Applicant: University of Iowa Research Foundation
Inventor： Liu Hong , Jeff Banas , Ling Yang , Min Zhu , Yi Shu
Abstract: A composition comprising an amount of one or more agents comprising a hydroxy(C1-10)(COOH) or salt thereof, wherein C1-10 can be substituted or form a ring, a dicarboxylic acid, a purine nucleoside or analog thereof, a pyrimidine nucleoside or an analog thereof, or an amino acid or analog thereof, effective to inhibit inflammation, and methods of using the composition, are provided.
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公开(公告)号：US11730799B2
公开(公告)日：2023-08-22
申请号：US17304953
申请日：2021-06-29
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRS
Inventor： David M. Lubaroff , Delbert L. Harris
CPC classification number: A61K39/001193 , A61K39/001194 , A61K39/001195 , A61P35/00 , C12N7/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/884 , C12N2710/10341 , C12N2770/36123 , C12N2770/36143
Abstract: A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.
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公开(公告)号：US20230250431A1
公开(公告)日：2023-08-10
申请号：US17674683
申请日：2022-02-17
Applicant: University of Iowa Research Foundation
Inventor： Steven M. Varga , Kevin L. Legge
IPC: C12N15/113 , A61K31/713 , A61K31/7105 , A61K9/00
CPC classification number: C12N15/1136 , A61K31/713 , A61K31/7105 , A61K9/0048 , C12N15/113 , C12N2310/321 , C12N2320/31 , C12N2310/14 , C12N2320/30
Abstract: Disclosed are compositions and methods for vaccinating susceptible individuals against infection by respiratory syncytial virus (RSV). The disclosed compositions include vaccine compositions comprising an effective amount of respiratory syncytial virus (RSV) F protein in a pre-fusion stabilized form and/or M protein incorporated into biodegradable polyanhydride polymer particles for inducing an immune response against RSV. The vaccine compositions also may include a suitable adjuvant.
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公开(公告)号：US11680079B2
公开(公告)日：2023-06-20
申请号：US16847585
申请日：2020-04-13
Applicant: University of Iowa Research Foundation , The United States Government As Represented By The Department Of Veterans Affairs
Inventor： Paloma H. Giangrande , Francis Miller , Kevin Urak
IPC: C12N15/11 , C07H21/02 , C12N15/115 , A61P29/02 , A61K9/00
CPC classification number: C07H21/02 , A61K9/007 , A61K9/0019 , A61P29/02 , C12N15/115 , C12N2310/16 , C12N2310/321
Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
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