公开(公告)号：US20150359458A1

公开(公告)日：2015-12-17

申请号：US14762214

申请日：2014-01-21

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Dakota O'Dell ,  Vlad-Victor Oncescu ,  Matthew Mancuso ,  Seoho Lee

IPC: A61B5/103 ,  G06T7/40 ,  G01N21/78

CPC classification number: A61B5/1032 ,  A61B5/0022 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6898 ,  G01N21/78 ,  G01N21/80 ,  G01N33/52 ,  G01N33/558 ,  G06F19/00 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024 ,  G16H40/67

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

Abstract translation: 使用智能手机获得测试条上的分析物的收集点的选定定量标记的方法涉及对由于智能手机的测试条照明而在其上发生目标样品的比色反应的测试条进行成像。 智能手机包括智能手机应用程序和智能手机附件，可提供独立于所使用智能手机平台的外部环境独立/内部无光环境的成像环境。 然后可以将结果定量呈现或变成更为消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后使用，并传达到从业者可以提供额外审查的位置。 此外，社交媒体整合可以允许将设备结果广播给特定的受众，将健康生活与他人进行比较，以竞争健康的游戏，创建映射和其他应用程序。

公开(公告)号：US20150244852A1

公开(公告)日：2015-08-27

申请号：US14427049

申请日：2013-09-06

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Matthew Mancuso ,  Seoho Lee

IPC: H04M1/725 ,  G01N21/78 ,  G01N21/31

CPC classification number: H04M1/72527 ,  B01L3/502715 ,  G01N21/31 ,  G01N21/78 ,  G01N33/48792 ,  G01N2015/0038 ,  G01N2035/00881 ,  G01N2201/062 ,  G01N2201/12 ,  G06F19/00 ,  G06F19/3418 ,  G06Q50/22 ,  G16H10/40 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26

Abstract: A system, methods, and apparatus for biomolecular measurements, monitoring, and tracking uses a smartphone-based system. A biological sample, including, but not limited to blood, saliva, biopsy, or sweat, is collected on a modular diagnostic test platform, which is then inserted into a smartphone accessory. Optical, electrical, mechanical, or other means are used to transduce a biomolecular binding event, including antibody, aptamer, enzymatic, base-pair matching, or other biological recognition reaction and communicate the results with the smartphone. Some specific examples of targets include 25-hydroxyvitamin D, folic acid, DNA, or proteins from infectious agents, and zinc. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later comparison, and communicated to a central hub location where medical professionals can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with friends, to compete in health based games, create mappings, and other applications.

Abstract translation: 用于生物分子测量，监测和跟踪的系统，方法和装置使用基于智能手机的系统。 将生物样品（包括但不限于血液，唾液，活组织检查或汗液）收集在模块化诊断测试平台上，然后将其插入智能手机附件。 光学，电学，机械或其他手段用于转导生物分子结合事件，包括抗体，适体，酶，碱基对匹配或其他生物识别反应，并将结果与​​智能手机通信。 目标的一些具体实例包括25-羟基维生素D，叶酸，DNA或来自感染剂的蛋白质和锌。 然后可以将结果定量呈现或变成对消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后比较，并传达给医疗专业人员可以提供的中心枢纽位置 额外的评论。 此外，社交媒体整合可以允许将设备结果广播到特定的观众，将健康生活与朋友进行比较，竞争健康游戏，创建映射和其他应用程序。

公开(公告)号：US20180196041A1

公开(公告)日：2018-07-12

申请号：US15875686

申请日：2018-01-19

Applicant: CORNELL UNIVERSITY

Inventor： Saurabh Mehta ,  David Erickson ,  Seoho Lee

IPC: G01N33/543 ,  B01L3/00 ,  C12Q1/18

CPC classification number: G01N33/54366 ,  B01L3/5023 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/0887 ,  C12Q1/18 ,  G01N33/558 ,  G01N2333/4737 ,  G01N2333/5753 ,  G01N2800/26

Abstract: A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. The second microfluidic channel has a longer pathway than the first microfluidic channel. A first test strip and a second test strip are each connected to both the first microfluidic channel and the second microfluidic channel, while a third test strip is connected only to the first microfluidic channel. Each test strip includes a conjugate section, a detection section, and a collection section.

公开(公告)号：US20170058249A1

公开(公告)日：2017-03-02

申请号：US15351715

申请日：2016-11-15

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Perry M. Schein

IPC: C12M1/00 ,  C12P7/06 ,  C12P7/16 ,  G02B6/293 ,  G02B6/26

CPC classification number: C12M31/10 ,  C12M21/02 ,  C12N1/12 ,  C12N1/20 ,  C12P7/04 ,  C12P7/065 ,  G02B6/262 ,  G02B6/29331 ,  Y02E50/17

Abstract: An optofluidic photoreactor including an optical waveguide having an input, characterized by an evanescent optical field confined along an outer surface of the optical waveguide produced by radiation propagating in the optical waveguide, means for inputting light to the input of the optical waveguide, and a photoactive material disposed substantially only within the evanescent field. A method for optically activating a photoactive material in an optofluidic photoreactor to convert carbon dioxide and water into other molecules that may be useful as a fuel or a chemical feedstock.

Abstract translation: 一种光流体光反应器，包括具有输入的光波导，其特征在于沿着在光波导中传播的辐射产生的沿着光波导的外表面限制的消逝光场，用于将光输入到光波导的输入的装置，以及光活性 材料基本上仅设置在消逝场内。 一种在光流体光反应器中光学活化光活性材料以将二氧化碳和水转化成可用作燃料或化学原料的其它分子的方法。

公开(公告)号：US20160002580A1

公开(公告)日：2016-01-07

申请号：US14770246

申请日：2014-03-07

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Largus Angenent ,  Devin Doud ,  Erica Jung ,  Michael Kalontarov

IPC: C12M1/00

CPC classification number: C12M21/02 ,  C12M29/00 ,  C12M29/04 ,  C12M29/16 ,  C12M31/02 ,  C12M31/04 ,  C12M31/08

Abstract: A photobioreactor includes an input light delivery component and a plurality of photobioreactor media disposed in a stacked relationship, each of which is coupled to the input light delivery component, wherein each photobioreactor medium is adapted to be inoculated with a photosynthetic, biofuel-producing culture, further wherein each photobioreactor medium includes at least one hollow fiber membrane (HFM) disposed thereon in a region that is adapted to be inoculated with the photosynthetic, biofuel-producing culture, that can transport at least one of a gas and a photobioreactor product producible by the photosynthetic, biofuel-producing culture, wherein each photobioreactor medium is characterized by an input light-scattering mechanism. A method for making a biofuel including providing a stacked photobioreactor assembly including a plurality of unit photobioreactor mediums each of which is inoculated with a photosynthetic, biofuel-producing culture, characterized by a light scattering mechanism and including at least one hollow fiber membrane (HFM) disposed in-situ on the photobioreactor medium; providing a nutrient gas to the biofuel-producing culture via the at least one HFM; and illuminating each unit photobioreactor medium with a selected spectrum of input light via the light scattering mechanism in each unit photobioreactor medium.

Abstract translation: 光生物反应器包括输入光输送组件和以堆叠关系布置的多个光生物反应器介质，每个光生物反应器介质都耦合到输入光输送组件，其中每个光生物反应器介质适于用光合，生物燃料生产培养物接种， 进一步其中每个光生物反应器介质包括至少一个中空纤维膜（HFM），所述中空纤维膜（HFM）设置在适于接受光合生物燃料生产培养物的区域中，所述培养物可以运输至少一种气体和光生物反应器产物 光合，生物燃料生产培养物，其中每个光生物反应器介质的特征在于输入光散射机理。 一种制造生物燃料的方法，包括提供堆叠的光生物反应器组件，其包括多个单位光生物反应器介质，每个单位光生物反应器介质接种有光合作用的生物燃料生产培养物，其特征在于光散射机理并且包括至少一个中空纤维膜（HFM） 放置在光生物反应器介质上; 通过所述至少一种HFM向生物燃料产生培养物提供营养气体; 并且通过每个单位光生物反应器介质中的光散射机构照射具有所选择的输入光谱的每个单位光生物反应器介质。

公开(公告)号：US20150038361A1

公开(公告)日：2015-02-05

申请号：US14377962

申请日：2013-02-14

Applicant: Cornell University

Inventor： David Erickson ,  Matthew Mancuso ,  Ethel Cesarman ,  Li Jiang

IPC: C12Q1/70 ,  G01N33/569 ,  G01N33/553 ,  C12Q1/68 ,  G01N33/543

CPC classification number: C12Q1/705 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/689 ,  C12Q1/703 ,  C12Q2565/628 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5088 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56994 ,  G01N33/587 ,  C12Q2537/143

Abstract: Methods and systems for colorimetric detection of a target. Nucleic acid is obtained from a sample potentially containing two pathogens of interest, and is contacted with a plurality of nanoparticles. A first portion of the plurality of nanoparticles are functionalized with oligonucleotides complementary to a first region of the first target and oligonucleotides complementary to a second region of the first target, and a second portion of the plurality of nanoparticles are functionalized with oligonucleotides complementary to a first region of the second target and oligonucleotides complementary to a second region of the second target. The presence of the target nucleic acid causes a detectable colorimetric change, thereby diagnosing the presence of the pathogen.

Abstract translation: 目标的比色检测方法和系统。 从潜在含有两种感兴趣病原体的样品获得核酸，并与多个纳米颗粒接触。 多个纳米颗粒的第一部分用与第一靶标的第一区域互补的寡核苷酸和与第一靶标的第二区域互补的寡核苷酸功能化，并且多个纳米颗粒的第二部分用与第一靶标互补的寡核苷酸功能化 区域和与第二靶标的第二区域互补的寡核苷酸。 靶核酸的存在导致可检测的比色变化，从而诊断病原体的存在。