公开(公告)号：US09821314B2

公开(公告)日：2017-11-21

申请号：US14429407

申请日：2013-09-18

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Li Jiang ,  Matthew Mancuso

IPC: C12Q1/68 ,  C12P19/34 ,  B01L7/00 ,  G01N35/00 ,  B01L3/00

CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L3/502715 ,  B01L7/5255 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1861 ,  C12Q1/686 ,  G01N2035/00158 ,  C12Q2565/629

Abstract: Disclosed are methods and apparatus for solar-thermal microfluidic polymerase chain reaction. A device comprises a microfluidic chip including at least one PCR region, an energy absorption layer disposed adjacent to the microfluidic chip, a solar energy concentrator adapted to produce a plurality of temperature profiles on the microfluidic chip adapted to facilitate PCR, and a photomask disposed between the solar energy concentrator and the microfluidic chip.

公开(公告)号：US20150038361A1

公开(公告)日：2015-02-05

申请号：US14377962

申请日：2013-02-14

Applicant: Cornell University

Inventor： David Erickson ,  Matthew Mancuso ,  Ethel Cesarman ,  Li Jiang

IPC: C12Q1/70 ,  G01N33/569 ,  G01N33/553 ,  C12Q1/68 ,  G01N33/543

CPC classification number: C12Q1/705 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/689 ,  C12Q1/703 ,  C12Q2565/628 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5088 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56994 ,  G01N33/587 ,  C12Q2537/143

Abstract: Methods and systems for colorimetric detection of a target. Nucleic acid is obtained from a sample potentially containing two pathogens of interest, and is contacted with a plurality of nanoparticles. A first portion of the plurality of nanoparticles are functionalized with oligonucleotides complementary to a first region of the first target and oligonucleotides complementary to a second region of the first target, and a second portion of the plurality of nanoparticles are functionalized with oligonucleotides complementary to a first region of the second target and oligonucleotides complementary to a second region of the second target. The presence of the target nucleic acid causes a detectable colorimetric change, thereby diagnosing the presence of the pathogen.

Abstract translation: 目标的比色检测方法和系统。 从潜在含有两种感兴趣病原体的样品获得核酸，并与多个纳米颗粒接触。 多个纳米颗粒的第一部分用与第一靶标的第一区域互补的寡核苷酸和与第一靶标的第二区域互补的寡核苷酸功能化，并且多个纳米颗粒的第二部分用与第一靶标互补的寡核苷酸功能化 区域和与第二靶标的第二区域互补的寡核苷酸。 靶核酸的存在导致可检测的比色变化，从而诊断病原体的存在。

公开(公告)号：US20160080548A1

公开(公告)日：2016-03-17

申请号：US14804386

申请日：2015-07-21

Applicant: Cornell University

Inventor： David Erickson ,  Seoho Lee ,  Dakota O'Dell ,  Saurabh Mehta ,  Vlad-Victor Oncescu ,  Matthew Mancuso

IPC: H04M1/725 ,  H04N5/225 ,  G01N21/80 ,  G01N33/487 ,  G01N21/78 ,  G06K9/46 ,  G06T7/40

CPC classification number: H04M1/72527 ,  G01N21/78 ,  G01N21/80 ,  G01N21/8483 ,  G01N33/48785 ,  G01N2021/7759 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/127 ,  H04N5/2251

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

Abstract translation: 使用智能手机获得测试条上的分析物的收集点的选定定量标记的方法涉及对由于智能手机的测试条照明而在其上发生目标样品的比色反应的测试条进行成像。 智能手机包括智能手机应用程序和智能手机附件，可提供独立于所使用智能手机平台的外部环境独立/内部无光环境的成像环境。 然后可以将结果定量呈现或变成更为消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后使用，并传达到从业者可以提供额外审查的位置。 此外，社交媒体整合可以允许将设备结果广播给特定的受众，将健康生活与他人进行比较，以竞争健康的游戏，创建映射和其他应用程序。

公开(公告)号：US09787815B2

公开(公告)日：2017-10-10

申请号：US14804386

申请日：2015-07-21

Applicant: Cornell University

Inventor： David Erickson ,  Seoho Lee ,  Dakota O'Dell ,  Saurabh Mehta ,  Vlad-Victor Oncescu ,  Matthew Mancuso

IPC: H04M1/725 ,  G01N33/487 ,  G01N21/77 ,  G01N21/78 ,  G01N21/80 ,  G01N21/84 ,  H04N5/225

CPC classification number: H04M1/72527 ,  G01N21/78 ,  G01N21/80 ,  G01N21/8483 ,  G01N33/48785 ,  G01N2021/7759 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/127 ,  H04N5/2251

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

公开(公告)号：US09445749B2

公开(公告)日：2016-09-20

申请号：US14762214

申请日：2014-01-21

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Dakota O'Dell ,  Vlad-Victor Oncescu ,  Matthew Mancuso ,  Seoho Lee

IPC: A61B5/103 ,  G01N33/52 ,  G01N21/78 ,  G01N21/80 ,  A61B5/00 ,  G01N33/558 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G06T7/40 ,  A61B5/15 ,  A61B5/157

CPC classification number: A61B5/1032 ,  A61B5/0022 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6898 ,  G01N21/78 ,  G01N21/80 ,  G01N33/52 ,  G01N33/558 ,  G06F19/00 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024 ,  G16H40/67

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

Abstract translation: 使用智能手机获得测试条上的分析物的收集点的选定定量标记的方法涉及对由于智能手机的测试条照明而在其上发生目标样品的比色反应的测试条进行成像。 智能手机包括智能手机应用程序和智能手机附件，可提供独立于所使用智能手机平台的外部环境独立/内部无光环境的成像环境。 然后可以将结果定量呈现或变成更为消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后使用，并传达到从业者可以提供额外审查的位置。 此外，社交媒体整合可以允许将设备结果广播给特定的受众，将健康生活与他人进行比较，以竞争健康的游戏，创建映射和其他应用程序。

公开(公告)号：US20150238967A1

公开(公告)日：2015-08-27

申请号：US14429407

申请日：2013-09-18

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Li Jiang ,  Matthew Mancuso

IPC: B01L7/00 ,  C12Q1/68 ,  B01L3/00

CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L3/502715 ,  B01L7/5255 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1861 ,  C12Q1/686 ,  G01N2035/00158 ,  C12Q2565/629

Abstract: Disclosed are methods and apparatus for solar-thermal microfluidic polymerase chain reaction. A device comprises a microfluidic chip including at least one PCR region, an energy absorption layer disposed adjacent to the microfluidic chip, a solar energy concentrator adapted to produce a plurality of temperature profiles on the microfluidic chip adapted to facilitate PCR, and a photomask disposed between the solar energy concentrator and the microfluidic chip.

Abstract translation: 公开了用于太阳热微流体聚合酶链反应的方法和装置。 一种装置包括微流体芯片，其包括至少一个PCR区域，与该微流体芯片相邻设置的能量吸收层，适于在适于促进PCR的微流体芯片上产生多个温度分布的太阳能集中器，以及设置在 太阳能集中器和微流控芯片。

公开(公告)号：US09686395B2

公开(公告)日：2017-06-20

申请号：US14427049

申请日：2013-09-06

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Matthew Mancuso ,  Seoho Lee

IPC: H04M1/725 ,  G01N21/31 ,  G01N21/17 ,  G01N21/78 ,  G06Q50/22 ,  G01N33/48 ,  G01N33/487 ,  G06F19/00 ,  G01N15/00 ,  B01L3/00 ,  G01N35/00

CPC classification number: H04M1/72527 ,  B01L3/502715 ,  G01N21/31 ,  G01N21/78 ,  G01N33/48792 ,  G01N2015/0038 ,  G01N2035/00881 ,  G01N2201/062 ,  G01N2201/12 ,  G06F19/00 ,  G06F19/3418 ,  G06Q50/22 ,  G16H10/40 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26

Abstract: A system, methods, and apparatus for biomolecular measurements, monitoring, and tracking uses a smartphone-based system. A biological sample, including, but not limited to blood, saliva, biopsy, or sweat, is collected on a modular diagnostic test platform, which is then inserted into a smartphone accessory. Optical, electrical, mechanical, or other means are used to transduce a biomolecular binding event, including antibody, aptamer, enzymatic, base-pair matching, or other biological recognition reaction and communicate the results with the smartphone. Some specific examples of targets include 25-hydroxyvitamin D, folic acid, DNA, or proteins from infectious agents, and zinc. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later comparison, and communicated to a central hub location where medical professionals can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with friends, to compete in health based games, create mappings, and other applications.

公开(公告)号：US20150359458A1

公开(公告)日：2015-12-17

申请号：US14762214

申请日：2014-01-21

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Dakota O'Dell ,  Vlad-Victor Oncescu ,  Matthew Mancuso ,  Seoho Lee

IPC: A61B5/103 ,  G06T7/40 ,  G01N21/78

CPC classification number: A61B5/1032 ,  A61B5/0022 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6898 ,  G01N21/78 ,  G01N21/80 ,  G01N33/52 ,  G01N33/558 ,  G06F19/00 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024 ,  G16H40/67

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

Abstract translation: 使用智能手机获得测试条上的分析物的收集点的选定定量标记的方法涉及对由于智能手机的测试条照明而在其上发生目标样品的比色反应的测试条进行成像。 智能手机包括智能手机应用程序和智能手机附件，可提供独立于所使用智能手机平台的外部环境独立/内部无光环境的成像环境。 然后可以将结果定量呈现或变成更为消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后使用，并传达到从业者可以提供额外审查的位置。 此外，社交媒体整合可以允许将设备结果广播给特定的受众，将健康生活与他人进行比较，以竞争健康的游戏，创建映射和其他应用程序。

公开(公告)号：US20150244852A1

公开(公告)日：2015-08-27

申请号：US14427049

申请日：2013-09-06

Applicant: CORNELL UNIVERSITY

Inventor： David Erickson ,  Matthew Mancuso ,  Seoho Lee

IPC: H04M1/725 ,  G01N21/78 ,  G01N21/31

CPC classification number: H04M1/72527 ,  B01L3/502715 ,  G01N21/31 ,  G01N21/78 ,  G01N33/48792 ,  G01N2015/0038 ,  G01N2035/00881 ,  G01N2201/062 ,  G01N2201/12 ,  G06F19/00 ,  G06F19/3418 ,  G06Q50/22 ,  G16H10/40 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26

Abstract: A system, methods, and apparatus for biomolecular measurements, monitoring, and tracking uses a smartphone-based system. A biological sample, including, but not limited to blood, saliva, biopsy, or sweat, is collected on a modular diagnostic test platform, which is then inserted into a smartphone accessory. Optical, electrical, mechanical, or other means are used to transduce a biomolecular binding event, including antibody, aptamer, enzymatic, base-pair matching, or other biological recognition reaction and communicate the results with the smartphone. Some specific examples of targets include 25-hydroxyvitamin D, folic acid, DNA, or proteins from infectious agents, and zinc. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later comparison, and communicated to a central hub location where medical professionals can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with friends, to compete in health based games, create mappings, and other applications.

Abstract translation: 用于生物分子测量，监测和跟踪的系统，方法和装置使用基于智能手机的系统。 将生物样品（包括但不限于血液，唾液，活组织检查或汗液）收集在模块化诊断测试平台上，然后将其插入智能手机附件。 光学，电学，机械或其他手段用于转导生物分子结合事件，包括抗体，适体，酶，碱基对匹配或其他生物识别反应，并将结果与​​智能手机通信。 目标的一些具体实例包括25-羟基维生素D，叶酸，DNA或来自感染剂的蛋白质和锌。 然后可以将结果定量呈现或变成对消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后比较，并传达给医疗专业人员可以提供的中心枢纽位置 额外的评论。 此外，社交媒体整合可以允许将设备结果广播到特定的观众，将健康生活与朋友进行比较，竞争健康游戏，创建映射和其他应用程序。