-
公开(公告)号：US20160105968A1
公开(公告)日：2016-04-14
申请号：US14974242
申请日：2015-12-18
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Han-Chieh Chang
CPC classification number: H05K1/189 , A61N1/0543 , A61N1/36046 , H05K3/064 , H05K2201/0154 , H05K2201/052 , H05K2201/1003 , H05K2201/10151
Abstract: A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The bypass wing is folded in a line through the aperture and over a central portion of the ribbon cable, resulting in a ribbon cable with a narrow, stacked region. The narrow region can fit through small incisions in membranes, such as through an incision in a sclera of an eyeball. The ribbon cable can have an integrally-formed electrode array for attaching to a retina of an eyeball and other electronics for sending signals to the electrode array.
Abstract translation: 描述了一种生物兼容的微型制造的带状电缆，其中至少一组导体横向分开成通过带状电缆形成孔的旁路翼。 旁路翼片通过孔口并且在带状电缆的中心部分上折叠成一条线，导致带状电缆具有窄的堆叠区域。 狭窄的区域可以穿过膜中的小切口，例如通过眼球巩膜中的切口。 带状电缆可以具有整体形成的电极阵列，用于附接到眼球的视网膜和用于向电极阵列发送信号的其他电子装置。
-
公开(公告)号：US20150290466A1
公开(公告)日：2015-10-15
申请号：US14749487
申请日：2015-06-24
Inventor： Yu-Chong Tai , Yu Zhao , Mark S. Humayun , James D. Weiland
CPC classification number: A61F9/007 , A61F2/14 , A61F2250/0001 , A61N1/0529 , A61N1/0543 , A61N1/0551 , A61N1/36046 , A61N1/3605 , A61N1/3787 , C23F1/00 , H01F27/2804 , H01F2027/2809
Abstract: A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.
Abstract translation: 公开了一种三线圈电磁感应电力传输系统，用于视网膜假体和其他植入物。 第三缓冲线圈设置在外部发射线圈和埋在体内的接收器线圈之间，以提高效率和对准失准的鲁棒性。 可以使用微机械加工技术来制造一个或多个线圈，以在生物相容绝缘体的带中布置导体，将绝缘导体迹线的长度彼此纵向折叠，然后将它们螺旋化成环。 轨迹通过在折叠线上移动来改变环中的轴向位置。 迹线上的一个或多个U形部分可以被折叠，使得相邻的迹线可以彼此相对地突出，从而延长可以卷绕成线圈的所得到的带状物。
-
公开(公告)号：US08715345B2
公开(公告)日：2014-05-06
申请号：US13761024
申请日：2013-02-06
Inventor： Charles DeBoer , Yu-Chong Tai , Mark Humayun
IPC: A61F2/16
CPC classification number: A61F2/1613 , A61F2/1635 , A61F9/0017 , A61F2250/0003 , A61L27/48 , A61L2430/16 , C08L65/04
Abstract: Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.
Abstract translation: 系统，装置和方法用于假体可注射的眼内透镜。 透镜可以由硅酮，氟硅酮和苯基取代的硅氧烷制成，并且对透气半透膜。 可以通过外科手术针来访问位于前侧但远离赤道的光路外侧的一个或多个有机硅弹性体贴片，以便填充或调整透镜内的光学透明流体。 可以调节流体以便设置透镜的基础屈光度，并在其初始插入之后调整透镜。 弹性体贴片的尺寸使得它们在针被取出后自我密封。 贴片中的直的或阶梯的狭缝可以使钝针更容易地进入透镜的内部。
-
24.发明申请公开(公告)号：US20140048481A1
公开(公告)日：2014-02-20
申请号：US14065210
申请日：2013-10-28
Applicant: California Institute of Technology
Inventor： Chi-Yuan Shih , Yu-Chong Tai , Jun Xie , Darron K. Young , Po-Jui Chen
IPC: B01D15/22
CPC classification number: B01D15/22 , G01N30/02 , G01N30/461 , G01N30/466 , G01N30/6095 , G01N30/78 , G01N30/96 , G01N2030/524 , Y10T29/49826 , B01D15/363 , B01D15/3804 , B01D15/362 , B01D15/34 , B01D15/325 , B01D15/361
Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.
Abstract translation: 使用集成色谱系统和设备实时监测分析物的系统和方法。 集成的微流体液相色谱装置和系统包括集成到单个底物中的多个分离柱。 使用这样的器件，可以同时执行多个样本的并行分析和/或可以在单个芯片或衬底上同时执行单个样本的顺序分析。 该装置和系统非常适用于高压液相色谱（HPLC）应用。 包括嵌入式聚对二甲苯通道的HPLC芯片和器件可以使用单一掩模工艺制造。
-
公开(公告)号：US20130297019A1
公开(公告)日：2013-11-07
申请号：US13830272
申请日：2013-03-14
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Han-Chieh Chang
IPC: A61F2/14
CPC classification number: A61N1/0546 , H01L21/4846 , H01L23/4985 , H01L23/49894 , H01L2924/0002 , H01M2/026 , H01L2924/00
Abstract: The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to attach a chip to the targeted thin-film (e.g., parylene) substrate so that the chip is used as an attachment to prevent delamination.
Abstract translation: 本发明提供了用于组装视网膜假体装置的芯片封装和工艺。 有利地，光可图案化粘合剂或环氧树脂如光致抗蚀剂用作胶粘剂以将芯片附着到目标薄膜（例如聚对二甲苯）基材上，使得芯片用作附着物以防止分层。
-
Patent Agency Ranking
公开(公告)号：US20130150960A1
公开(公告)日：2013-06-13
申请号：US13761024
申请日：2013-02-06
Inventor： Charles DeBoer , Yu-Chong Tai , Mark Humayun
IPC: A61F2/16
CPC classification number: A61F2/1613 , A61F2/1635 , A61F9/0017 , A61F2250/0003 , A61L27/48 , A61L2430/16 , C08L65/04
Abstract: Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.
Abstract translation: 系统，装置和方法用于假体可注射的眼内透镜。 透镜可以由硅酮，氟硅酮和苯基取代的硅氧烷制成，并且对透气半透膜。 可以通过外科手术针来访问位于前侧但远离赤道的光路外侧的一个或多个有机硅弹性体贴片，以便填充或调整透镜内的光学透明流体。 可以调节流体以便设置透镜的基础屈光度，并在其初始插入之后调整透镜。 弹性体贴片的尺寸使得它们在针被取出后自我密封。 贴片中的直的或阶梯的狭缝可以使钝针更容易地进入透镜的内部。
-
27.发明申请IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT 有权IC处理聚合物纳米液相色谱系统及其制备方法公开(公告)号：US20130140270A1
公开(公告)日：2013-06-06
申请号：US13680030
申请日：2012-11-17
Inventor： Yu-Chong Tai , Qing He , Jun Xie , Changlin Pang , Terry D. Lee , Damien Rodger , Matthieu Liger
IPC: H05K3/28
CPC classification number: H05K3/284 , G01N30/6047 , G01N30/6095 , G01N2030/645 , G03F1/80 , G01N2030/625
Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.
Abstract translation: 根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。 微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。 该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。 交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。 集成在色谱柱出口处的电化学/电导率传感器测量分离信号。 自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。 使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。
-
公开(公告)号：US20240315628A1
公开(公告)日：2024-09-26
申请号：US18679283
申请日：2024-05-30
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Shane S. Shahrestani
CPC classification number: A61B5/245 , A61B5/067 , A61B5/4839 , A61B5/6803 , A61B5/684 , A61B5/7246 , A61B2562/0223
Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.
-
公开(公告)号：US12029566B2
公开(公告)日：2024-07-09
申请号：US18446327
申请日：2023-08-08
Applicant: California Institute of Technology
Inventor： Yu-Chong Tai , Shane S. Shahrestani
CPC classification number: A61B5/245 , A61B5/067 , A61B5/4839 , A61B5/6803 , A61B5/684 , A61B5/7246 , A61B2562/0223
Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.
-
公开(公告)号：US12025858B2
公开(公告)日：2024-07-02
申请号：US17013759
申请日：2020-09-07
Inventor： Yu-Chong Tai , Nicholas E. Scianmarello , Charles M. T. DeBoer , Mark S. Humayun
CPC classification number: G02C7/049 , G02C7/04 , G02C7/041 , G02C7/085 , A61K9/0051
Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
-
-
-
-
-
-
-
-
-
Search Results
132
records
(took 0.032 seconds)
