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公开(公告)号：US11325321B2
公开(公告)日：2022-05-10
申请号：US17147660
申请日：2021-01-13
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: Method and apparatus are disclosed for mechanically opening a heat-bonded connection site between two hollow, flexible, thermoplastic segments of a medical fluid flow path, the heat-bonded connection site having an axis. The connection site is compressed between two facing surfaces, and the facing surfaces are relatively moved to rotate the connection site about the connection site axis and to apply force to the connection site substantially perpendicular to the connection site axis.
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公开(公告)号：US11311823B2
公开(公告)日：2022-04-26
申请号：US16807233
申请日：2020-03-03
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: Blood in a separation chamber is separated into a red blood cell layer, a plasma constituent, and a mononuclear cell-containing layer. A portion of the plasma constituent exits the chamber via a plasma outlet, while a first portion of the red blood cell layer exits via a red blood cell outlet. A second portion of the red blood cell layer exits the chamber via the red blood cell outlet and is collected. At least a portion of the collected red blood cell layer may then be conveyed to the chamber via the red blood cell outlet to convey at least a portion of the mononuclear cell-containing layer out of the chamber via the plasma outlet for collection. A second portion of the plasma constituent may be conveyed out of the chamber via the plasma outlet to more fully collect the mononuclear cell-containing layer without the use of collected plasma.
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23.发明授权公开(公告)号：US11291953B2
公开(公告)日：2022-04-05
申请号：US16869968
申请日：2020-05-08
Applicant: Fenwal, Inc.
Inventor： Richard I. Brown , Benjamin E. Kusters , Kyungyoon Min
Abstract: A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.
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公开(公告)号：US20210353841A1
公开(公告)日：2021-11-18
申请号：US17386992
申请日：2021-07-28
Applicant: Fenwal, Inc.
Inventor： Amit J. Patel , Samantha M. Planas , Walter T. Watts , Kyungyoon Min , Daniel R. Boggs
Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.
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公开(公告)号：US20210291200A1
公开(公告)日：2021-09-23
申请号：US17336394
申请日：2021-06-02
Applicant: Fenwal, Inc.
Inventor： Gregory G. Pieper , Salvatore Manzella, JR. , Brian C. Case , Steven R. Katz , Kyungyoon Min
Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
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Patent Agency Ranking
公开(公告)号：US20210100943A1
公开(公告)日：2021-04-08
申请号：US17044635
申请日：2019-04-03
Applicant: Fenwal, Inc.
Inventor： Kyungyoon Min
Abstract: Methods and systems for the automated collection of plasma from a donor are disclosed. The methods and systems deliver anticoagulant to whole blood and/or to selected and separated components at selected times to provide a sufficient amount of anticoagulant to the selected components to prevent coagulation and/or flocculation. The methods and systems limit the amount of anticoagulant returned to the donor and maximize the amount of collected plasma. Methods and systems for maximize the collection of IgG based on a measured level of total plasma protein are also disclosed.
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公开(公告)号：US20190336659A1
公开(公告)日：2019-11-07
申请号：US16515114
申请日：2019-07-18
Applicant: Fenwal, Inc.
Inventor： Katherine N. Radwanski , Kyungyoon Min , Zahra R. Ali
Abstract: Systems and methods are provided for depleting platelets from blood. The system includes a multi-stage blood separation chamber in which blood is separated into red blood cells and platelet-rich plasma. The platelet-rich plasma is conveyed from a first stage of the chamber to a second stage, where it is separated into platelets and platelet-poor plasma. The platelet-poor plasma is conveyed out of the chamber while the platelets are allowed to accumulate in the second stage of the chamber. When a controller of the system has determined that the maximum chamber capacity of platelets has been accumulated in the second stage of the chamber, the platelets are conveyed out of the chamber to a waste container. The cycle of separating blood into its components, accumulating platelets in the chamber, and then flushing the platelets from the chamber is repeated until a target platelet concentration of the blood is achieved.
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公开(公告)号：US10307582B2
公开(公告)日：2019-06-04
申请号：US14088781
申请日：2013-11-25
Applicant: Fenwal, Inc.
Inventor： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
IPC: A61M39/14 , B29C65/30 , B29C65/32 , B29C65/00 , B29C65/02 , B29C65/20 , B29C65/36 , B29C65/78 , B29C65/58 , B29C65/72 , B29C65/34 , B29C65/48 , B29C65/50
Abstract: Fluid flow conduits and apparatus and methods for joining the conduits, preferably in a sterile manner, are disclosed. Each conduit has a polymeric open end that is sealed by a sealing member that may include a heating element. The polymeric end material is melted, the sealing members are moved to expose the melted open ends of the conduits and the ends are brought together to form a fused or welded connection between the conduits.
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公开(公告)号：US10274495B2
公开(公告)日：2019-04-30
申请号：US15498965
申请日：2017-04-27
Applicant: Fenwal, Inc.
Inventor： Christopher J. Wegener , Kyungyoon Min
IPC: G01N33/543 , G01N33/569 , C12M1/00 , C12M1/36 , A61M1/02 , A61M1/34 , A61M1/26 , A61M1/36
Abstract: A cell processing system includes a first processor connectable to a source container filled with a biological fluid, a second processor, and a controller coupled to the processors. The first processor includes a separator configured to separate the biological fluid into at least two streams of material, and a first container configured to receive one of the streams. The second processor includes a magnetic separator configured to select target cells, the target cells being associated with magnetic particles, a second, pass-through container associated with the magnetic separator, the second container connected at a first end to the first container, and a third container connected to a second end of the pass-through container. One of the processors includes at least one pump configured to transfer material between the separator and the first container, and between the first container and the second container.
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公开(公告)号：US10235567B2
公开(公告)日：2019-03-19
申请号：US15305260
申请日：2015-05-13
Applicant: Fenwal, Inc.
Inventor： William Cork , Brian Case , Kevin Krause , Kyungyoon Min , Witold Moskal
Abstract: A head-mounted display device for interface with a medical device configured to perform an invasive procedure on a patient, such as a blood component collection, an infusion, a feeding operation, etc.
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