公开(公告)号：US11953507B2

公开(公告)日：2024-04-09

申请号：US17949863

申请日：2022-09-21

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Cory Bystrom ,  Shijun Sheng ,  Nigel Clarke ,  Richard Reitz

IPC: G01N33/74 ,  G01N33/68

CPC classification number: G01N33/74 ,  G01N33/6848

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

公开(公告)号：US20230417760A1

公开(公告)日：2023-12-28

申请号：US18465292

申请日：2023-09-12

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N33/74 ,  H01J49/04

CPC classification number: G01N33/6848 ,  G01N33/487 ,  G01N30/7266 ,  G01N33/74 ,  G01N33/6851 ,  H01J49/0431 ,  G01N2030/027

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US11835505B2

公开(公告)日：2023-12-05

申请号：US17893950

申请日：2022-08-23

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel Clarke

IPC: G01N33/94 ,  G01N33/15 ,  G01N33/49 ,  G01N33/48 ,  G01N30/72 ,  H01J49/00 ,  H01J49/10

CPC classification number: G01N33/15 ,  G01N30/7233 ,  G01N33/49 ,  G01N33/94 ,  H01J49/004 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/10 ,  G01N33/48 ,  H01J49/00 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.

公开(公告)号：US11789026B2

公开(公告)日：2023-10-17

申请号：US17827333

申请日：2022-05-27

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N33/74 ,  H01J49/04 ,  G01N30/02 ,  H01J49/00 ,  H01J49/16 ,  H01J49/40

CPC classification number: G01N33/6848 ,  G01N30/7266 ,  G01N33/487 ,  G01N33/6851 ,  G01N33/74 ,  H01J49/0431 ,  G01N2030/027 ,  G01N2333/62 ,  G01N2560/00 ,  H01J49/005 ,  H01J49/165 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US20230324414A1

公开(公告)日：2023-10-12

申请号：US18132009

申请日：2023-04-07

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Cory Bystrom ,  Shijun Sheng ,  Nigel Clarke ,  Richard Reitz

IPC: G01N33/68 ,  G01N33/74

CPC classification number: G01N33/74 ,  G01N33/6848

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution / high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution / high accuracy mass spectrometry.

公开(公告)号：US11761968B2

公开(公告)日：2023-09-19

申请号：US17208564

申请日：2021-03-22

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N33/68 ,  H01J49/00

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/0027 ,  G01N2560/00 ,  H01J49/00 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US11428682B2

公开(公告)日：2022-08-30

申请号：US17093472

申请日：2020-11-09

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel Clarke

IPC: G01N33/94 ,  G01N33/15 ,  G01N33/49 ,  G01N30/72 ,  H01J49/00 ,  H01J49/10 ,  G01N33/48

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.

公开(公告)号：US10648989B2

公开(公告)日：2020-05-12

申请号：US15602764

申请日：2017-05-23

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Cory Bystrom ,  Shijun Sheng ,  Nigel Clarke ,  Richard E. Reitz

IPC: G01N33/74 ,  G01N33/68

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

公开(公告)号：US10317377B2

公开(公告)日：2019-06-11

申请号：US15016105

申请日：2016-02-04

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Mildred M. Goldman

IPC: B01D15/18 ,  B01D15/34 ,  B01J20/28 ,  B01J20/281 ,  G01N30/40 ,  G01N30/46 ,  G01N30/88 ,  G01N30/52 ,  G01N30/60 ,  G01N30/72

Abstract: Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of other substances by applying the mixture to the column, reversing the flow through the column to elute the analyte, which is applied to an analytical column provided in-line with the preparative column. In other aspects, a single monolithic column is used to perform both the preparative chromatography and analytical chromatography steps in succession. In another aspect, a chromatography system is provided to perform preparative and analytical chromatography using a single monolithic column.

公开(公告)号：US10309972B1

公开(公告)日：2019-06-04

申请号：US16259606

申请日：2019-01-28

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/68 ,  G01N30/72 ,  G01N33/487 ,  G01N33/74 ,  G01N30/02 ,  H01J49/00 ,  H01J49/16 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.