公开(公告)号：US20100018602A1

公开(公告)日：2010-01-28

申请号：US12507865

申请日：2009-07-23

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: B65B3/12

CPC classification number: B65B3/003 ,  A61F9/0017 ,  A61F2250/0068

Abstract: The invention relates to systems and methods for filling a medical device with an active agent composition. In an embodiment, the invention includes a method for filling a medical device with an active agent composition. The method can include applying the active agent composition to the outside surface of the medical device, the medical device comprising a housing defining a lumen and a plurality of apertures. The method can also include contacting a surface of a press member against the outside surface of the medical device thereby pushing the active agent composition through the apertures and into the lumen of the medical device. Other embodiments are also included herein.

Abstract translation: 本发明涉及用活性剂组合物填充医疗装置的系统和方法。 在一个实施方案中，本发明包括用活性剂组合物填充医疗装置的方法。 该方法可以包括将活性剂组合物施加到医疗装置的外表面，医疗装置包括限定内腔和多个孔的壳体。 该方法还可以包括将压力构件的表面接触医疗装置的外表面，从而将活性剂组合物通过孔推入并进入医疗装置的内腔。 本文还包括其它实施例。

公开(公告)号：US07575781B2

公开(公告)日：2009-08-18

申请号：US10911228

申请日：2004-08-03

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: C23C16/00 ,  A61L33/04

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B05D1/60 ,  B05D3/0218 ,  B05D2202/15 ,  C08L65/04

Abstract: The present application relates to a method for vapor depositing a polymeric coating onto a substrate. In an embodiment, the invention is a method for applying a polymer coating to a substrate comprising performing a bake-out cycle with a chemical vapor deposition system and performing a deposition cycle with the chemical vapor deposition system.

Abstract translation: 本申请涉及将聚合物涂层气相沉积到基底上的方法。 在一个实施方案中，本发明是一种将聚合物涂层施加到基底上的方法，包括用化学气相沉积系统执行烘烤循环并且与化学气相沉积系统一起进行沉积循环。

公开(公告)号：US06669994B2

公开(公告)日：2003-12-30

申请号：US09840406

申请日：2001-04-23

Applicant: Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

Inventor： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC: C08F248

CPC classification number: C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

公开(公告)号：US06465178B2

公开(公告)日：2002-10-15

申请号：US09227913

申请日：1999-01-08

Applicant: Ralph A. Chappa ,  Sheau-Ping Hu ,  Dale G. Swan ,  Melvin J. Swanson ,  Patrick E. Guire

Inventor： Ralph A. Chappa ,  Sheau-Ping Hu ,  Dale G. Swan ,  Melvin J. Swanson ,  Patrick E. Guire

IPC: C12Q168

CPC classification number: B82Y30/00 ,  B01J2219/00317 ,  B01J2219/00531 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00722 ,  C07B2200/11 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C07H21/00 ,  C12Q1/6834 ,  C40B40/06 ,  C40B60/14 ,  C07C49/813

Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.

Abstract translation: 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够共价结合靶分子的基团。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。

公开(公告)号：US06406754B2

公开(公告)日：2002-06-18

申请号：US09847030

申请日：2001-05-01

Applicant: Ralph A. Chappa ,  Steven J. Porter

Inventor： Ralph A. Chappa ,  Steven J. Porter

IPC: A61L2700

CPC classification number: B05C3/09 ,  B05D1/18 ,  B05D1/32 ,  B05D7/20

Abstract: A process and apparatus for dip-coating intermediate and/or discrete discontinuous portions of longitudinal devices, including medical devices such as catheters and guidewires. The apparatus provides a chamber in which both the desired portion(s) of the device and the coating solution can be controllably contacted. A controlled coating can be achieved within the chamber by providing and controlling one or more of the following relationships: a) the manner in which a chamber (containing solution) is itself moved with respect to a static device, b) the manner in which the device is moved with respect to a fixed chamber position containing a fixed volume of solution, and/or c) the manner in which both the chamber and device are fixed in position, and the coating is achieved by adding and removing a volume of solution from the chamber. The resultant movement of solution and device is intended to mimic or replicate the relative movements involved in a conventional dip-coating procedure, at least along the length of device to be coated.

Abstract translation: 用于浸涂纵向装置的中间和/或离散不连续部分的方法和装置，包括诸如导管和导丝的医疗装置。 该设备提供了一个室，其中装置的期望部分和涂覆溶液都可以可控制地接触。 通过提供和控制一个或多个以下关系，可以在室内实现受控涂层：a）室（含有溶液）本身相对于静态装置自身移动的方式，b） 装置相对于包含固定体积溶液的固定室位移动，和/或c）室和装置两者都固定就位的方式，涂层通过将一定体积的溶液从 房间。 所得到的溶液和装置的运动旨在模拟或复制常规浸涂过程中涉及的相对运动，至少沿待涂覆的装置的长度。

公开(公告)号：US20120172839A1

公开(公告)日：2012-07-05

申请号：US13339926

申请日：2011-12-29

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: A61M25/10

CPC classification number: A61M25/1011 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/00 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1086

Abstract: The present invention relates to a catheter assembly that can deliver a therapeutic composition. The catheter assembly can include an outer balloon with openings for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.

Abstract translation: 本发明涉及可递送治疗组合物的导管组件。 导管组件可以包括具有释放治疗组合物的开口的外球囊。 当导管组件处于其收缩状态时，开口关闭，并且组件保持治疗组合物。 当导管组件处于其扩张状态时，开口是开放的，并且治疗组合物被释放。 本发明还包括制造和使用这种导管组件的方法。

公开(公告)号：US20120172796A1

公开(公告)日：2012-07-05

申请号：US13339908

申请日：2011-12-29

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: A61M25/10 ,  A61K31/436 ,  A61K47/20 ,  A61M25/00 ,  A61K47/10 ,  A61K47/16 ,  A61K47/14 ,  A61K31/337 ,  A61K47/22

CPC classification number: A61K47/22 ,  A61K9/0019 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61L2300/416 ,  A61M25/0009 ,  A61M25/0026 ,  A61M25/0045 ,  A61M25/1011 ,  A61M25/1029 ,  A61M2025/1004 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1088

Abstract: The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.

Abstract translation: 本发明涉及治疗剂如紫杉醇，雷帕霉素或其类似物的血管内递送的药物组合物。 组合物包括治疗剂和生物相容性溶剂，例如糖醇。 该组合物可以帮助组织穿透治疗剂。 将药物组合物与周围环境保护的导管组件可用于其血管内递送。

公开(公告)号：US20120083733A1

公开(公告)日：2012-04-05

申请号：US13248462

申请日：2011-09-29

Applicant: Ralph A. Chappa

Inventor： Ralph A. Chappa

IPC: A61L29/16 ,  B05D3/00 ,  B05D7/00 ,  A61M25/10 ,  B05D5/00

CPC classification number: A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1081

Abstract: A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A guard is bonded to the outer surface of the expandable and collapsible structure. The guard and the expandable and collapsible structure cooperatively define a plurality of reservoirs. A coating disposed in the reservoirs. The coating includes a bioactive agent. The coating protrudes from the reservoirs when the expandable and collapsible structure is expanded to the dilated state.

Abstract translation: 导管组件包括具有外表面的可膨胀和可折叠结构。 可膨胀和可折叠结构适于在收缩状态和膨胀状态之间膨胀。 防护件结合到可膨胀和可折叠结构的外表面。 护罩和可膨胀和可折叠结构协同地限定了多个储存器。 设置在储存器中的涂层。 涂层包括生物活性剂。 当可膨胀和可折叠结构膨胀到膨胀状态时，涂层从储存器突出。

公开(公告)号：US20120021038A1

公开(公告)日：2012-01-26

申请号：US13242837

申请日：2011-09-23

Applicant: Tim M. Kloke ,  Steven J. Keough ,  Nathan Lockwood ,  Margaret R. Gardner ,  Robert W. Hergenrother ,  Ralph A. Chappa

Inventor： Tim M. Kloke ,  Steven J. Keough ,  Nathan Lockwood ,  Margaret R. Gardner ,  Robert W. Hergenrother ,  Ralph A. Chappa

IPC: A61K9/00 ,  A61K38/14 ,  A61P31/04 ,  A61K31/7036

CPC classification number: A61L31/16 ,  A61L17/005 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/406 ,  A61L2300/62

Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.

Abstract translation: 公开了一种包含由不可吸收缝合材料连接的多个珠粒的伤口间隔器。 该装置可以例如由受伤个体的第一响应者应用，或者可以由诸如2级医疗单位的创伤治疗设施应用。 在典型的实施方案中，该装置允许抗微生物剂如妥布霉素的位点特异性受控洗脱，包括在一段时间内如48或72小时的定义的洗脱。

公开(公告)号：US08039524B2

公开(公告)日：2011-10-18

申请号：US12783907

申请日：2010-05-20

Applicant: Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Pam Read, legal representative ,  Dale G. Swan ,  Peter H. Duquette

Inventor： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

IPC: C08F2/50

CPC classification number: B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

Abstract translation: 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。