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21.发明申请公开(公告)号：US20150138504A1
公开(公告)日：2015-05-21
申请号：US14543583
申请日：2014-11-17
Applicant: TearScience, Inc.
Inventor： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
CPC classification number: A61B3/101 , A61B3/0025 , G01B11/06 , G06T7/0012 , G06T2207/30041
Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for peak detection and/or determining stabilization of an ocular tear film. Embodiments disclosed herein also include various image capturing and processing methods and related systems for providing various information about a patient's ocular tear film (e.g., the lipid and aqueous layers) and a patient's meibomian glands that can be used to analyze tear film layer thickness(es) (TFLT), and related characteristics as it relates to dry eye.
Abstract translation: 公开眼表干涉测量（OSI）装置，系统和方法用于峰值检测和/或确定眼泪膜的稳定性。 本文公开的实施例还包括用于提供关于患者眼泪膜（例如，脂质和水层）以及可用于分析泪膜层厚度的患者睑板腺的各种图像捕获和处理方法和相关系统（es ）（TFLT），以及与干眼相关的相关特征。
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22.发明授权公开(公告)号：US11844586B2
公开(公告)日：2023-12-19
申请号：US17498102
申请日：2021-10-11
Applicant: TearScience, Inc.
Inventor： Stephen M. Grenon , Donald R. Korb , Joshua Grenon , Scott Liddle , Steve Bacich , John M. Jans
CPC classification number: A61B5/0082 , A61B3/0008 , A61B3/101 , A61B5/0077 , A61B5/6821
Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured, showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray-like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.
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公开(公告)号：US10980413B2
公开(公告)日：2021-04-20
申请号：US16557276
申请日：2019-08-30
Applicant: TearScience, Inc.
Inventor： Donald R. Korb , Stephen M. Grenon , Caroline Blackie , Timothy R. Willis , Steve Bacich
IPC: A61B3/10 , G06T7/00 , A61B3/00 , G06T7/11 , A61B3/14 , G06T7/90 , G06K9/00 , G06K9/62 , G06K9/78
Abstract: Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.
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24.发明授权公开(公告)号：US10278587B2
公开(公告)日：2019-05-07
申请号：US14269646
申请日：2014-05-05
Applicant: TEARSCIENCE, INC.
Inventor： Stephen M. Grenon , Donald R. Korb , Joshua Grenon , Scott Liddle , Steve Bacich , John M. Jans
IPC: A61B5/00
Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.
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公开(公告)号：US20190060158A1
公开(公告)日：2019-02-28
申请号：US16172159
申请日：2018-10-26
Applicant: TearScience, Inc.
Inventor： Stephen M. Grenon , Omer Jack Barrier , David Foshee , Donald R. Korb , Timothy R. Willis
Abstract: An apparatus providing heat for treatment of an eyelid includes a heater unit configured to apply heat directly to an outer surface of the eyelid when an electrical signal is applied to the heater unit. The heater unit is affixed directly to the outer surface of the eyelid using an adhesive. A temperature regulator applies the electrical signal to the heater unit in order to achieve heating of the outer surface of the eyelid to a specified temperature range. A method is also disclosed that comprises affixing a heater unit directly into contact with the outer surface of the eyelid using an the adhesive. A control signal is applied to the heater unit to generate heat to the outer surface of the eyelid and is maintained for a period of time until the outer surface of the eyelid is heated to a specified temperature range.
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Patent Agency Ranking
公开(公告)号：US20180177391A1
公开(公告)日：2018-06-28
申请号：US15892549
申请日：2018-02-09
Applicant: TearScience, Inc.
Inventor： Donald R. Korb , Stephen M. Grenon , Steve Bacich
CPC classification number: A61B3/0025 , A61B3/101 , G06T7/0012 , G06T2207/30041
Abstract: Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on tear film characteristics analysis and dry eye symptoms are disclosed. In embodiments herein, imaging of the ocular tear film is performed during contact lens wear. An analysis of the image of the ocular tear film is performed to determine one or more tear film characteristics of the ocular tear film. The tear film characteristics can be used to determine the effect or possible effect of contact lens wear on the ocular tear film, and thus be used to determine contact lens intolerance of the patient. The tear film characteristics used to analyze contact lens intolerance based on images of the ocular tear film involving contact lens wear may include dry eye symptoms, including but not limited to tear film (e.g., lipid and/or aqueous) thickness, tear film viscosity, and tear film movement rate in the eye.
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27.发明申请公开(公告)号：US20180042472A1
公开(公告)日：2018-02-15
申请号：US15791615
申请日：2017-10-24
Applicant: TearScience, Inc.
Inventor： Stephen M. Grenon , Scott Liddle , Donald R. Korb
Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for peak detection and/or determining stabilization of an ocular tear film. Embodiments disclosed herein also include various image capturing and processing methods and related systems for providing various information about a patient's ocular tear film (e.g., the lipid and aqueous layers) and a patient's meibomian glands that can be used to analyze tear film layer thickness(es) (TFLT), and related characteristics as it relates to dry eye.
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公开(公告)号：US09408534B2
公开(公告)日：2016-08-09
申请号：US14299504
申请日：2014-06-09
Applicant: TearScience Inc.
Inventor： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
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29.发明授权Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography 有权用于确定泪膜厚度和/或提供眼部形貌的眼泪膜的全眼照明眼表面成像公开(公告)号：US09339177B2
公开(公告)日：2016-05-17
申请号：US14543931
申请日：2014-11-18
Applicant: TearScience, Inc.
Inventor： Stephen M. Grenon , Donald R. Korb
CPC classification number: A61B3/101 , A61B3/0008 , A61B3/0025 , A61B3/0058 , A61B3/1005 , A61B3/107 , A61B3/14 , G02B26/023
Abstract: Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including the lipid layer thickness (LLT) and/or the aqueous layer thickness (ALT). The TFLT can be used to diagnose dry eye syndrome (DES). Certain embodiments also include ocular topography devices, systems and methods for deducing corneal shape by capturing an image of a target reflecting from the surface of the cornea. The image of the target contains topography information that is reviewable by a clinician to diagnose the health of the patient's eye by detecting corneal aberrations and/or abnormalities in corneal shape. Certain embodiments also include a combination of the OSI and ocular topography devices, systems and methods to provide imaging that can be used to yield a combined diagnosis of the patient's tear film and corneal shape.
Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。 TFLT可用于诊断干眼综合征（DES）。 某些实施例还包括眼部地形设备，用于通过捕获从角膜表面反射的目标的图像来推导角膜形状的系统和方法。 目标的图像包含地形信息，临床医生可以通过检测角膜畸形和/或角膜形状的异常来诊断患者眼睛的健康状况。 某些实施方案还包括OSI和眼部形貌设备的组合，用于提供可用于产生患者的泪膜和角膜形状的组合诊断的成像的系统和方法。
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30.发明申请METHODS AND APPARATUSES FOR TREATING GLAND DYSFUNCTION EMPLOYING HEATED MEDIUM 审中-公开用于处理加热介质的腺体功能障碍的方法和装置公开(公告)号：US20150283402A1
公开(公告)日：2015-10-08
申请号：US14746328
申请日：2015-06-22
Applicant: TearScience, Inc.
Inventor： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
CPC classification number: A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
Abstract: A method of treating dry eye includes delivering light energy from outside an eyelid toward the eyelid, and maintaining the delivery of the light energy toward the eyelid for a period of time sufficient to soften an obstruction of at least one meibomian gland. The light energy may be delivered specifically to the obstruction within the at least one meibomian gland without physically contacting the at least one meibomian gland, or the light energy delivered toward the eyelid may conductively apply heat to the meibomain gland sufficient to melt the obstruction. A corresponding apparatus includes a light energy source positionable outside an eyelid and configured to deliver the light energy from outside an eyelid toward the eyelid, and a controller configured to control the light energy source to maintain the delivery of the light energy toward the eyelid for a period of time sufficient to soften the obstruction.
Abstract translation: 治疗干眼症的方法包括从眼睑外侧向眼睑递送光能，并且保持光能朝着眼睑传送足够的时间以软化至少一个睑板腺的阻塞。 光能可以专门地递送到至少一个睑板腺内的阻塞物，而不物理接触至少一个睑板腺，或者朝向眼睑传递的光能可以传导性地将热量施加到足以熔化阻塞物的睑板腺。 相应的装置包括可定位在眼睑外部并被配置为将眼睛外侧的光能传递到眼睑的光能源，以及控制器，被配置为控制光能源以维持光能向眼睑的传送， 足以软化阻塞的时间段。
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