公开(公告)号：US20100085570A1

公开(公告)日：2010-04-08

申请号：US12598061

申请日：2008-06-17

Applicant: Hanee Park ,  Il Kyu Choi ,  Han Oh Park

Inventor： Hanee Park ,  Il Kyu Choi ,  Han Oh Park

IPC: G01N21/64 ,  G01J1/58

CPC classification number: G01N21/6445 ,  G01J3/0224 ,  G01J3/4406 ,  G01N21/6452 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/0631 ,  G01N2201/0636

Abstract: The present invention relates to a real-time PCR monitoring apparatus for real-time monitoring production of reaction product produced during the reaction while performing nucleic acid amplification such as PCR for various kinds of trace samples. Specifically, the present invention relates to an apparatus for real-time monitoring biochemical reaction for efficiently dividing interference between an excitation light and a fluorescence, which includes a polarizer, a polarizing beam splitter, a polarization converter and so on.

Abstract translation: 本发明涉及一种用于实时监测在反应过程中产生的反应产物的实时PCR监测装置，同时对各种痕量样品进行核酸扩增如PCR。 具体地说，本发明涉及一种用于实时监测生化反应的装置，用于有效地分离激发光和荧光之间的干扰，其包括偏振器，偏振分束器，偏振转换器等。

公开(公告)号：US20080259328A1

公开(公告)日：2008-10-23

申请号：US12047844

申请日：2008-03-13

Applicant: Ryoichi HIRANO ,  Riki Ogawa

Inventor： Ryoichi HIRANO ,  Riki Ogawa

IPC: G01N21/00

CPC classification number: G01N21/95607 ,  G01N2021/95676 ,  G01N2201/0631

Abstract: A reticle defect inspection apparatus that suppresses deterioration of optical components resulting from luminescent spots generated by an integrator and can sustain a defect inspection with high precision for a long time is provided. The reticle defect inspection apparatus is a reticle defect inspection apparatus for inspecting for defects on a reticle using a pattern image obtained by irradiating the reticle on which a pattern is formed with light. And the apparatus includes an illuminating optical system for irradiating the reticle with an inspection light and a detecting optical system for detecting a pattern image of the reticle irradiated with the inspection light, wherein the illuminating optical system comprises an integrator for equalizing illumination distribution of the inspection light and a moving mechanism for enabling the integrator to slightly move in a direction perpendicular to an optical axis of the integrator.

Abstract translation: 提供了一种掩模版缺陷检查装置，其抑制由积分器产生的发光点导致的光学部件的劣化，并且能够长期高精度地进行缺陷检查。 掩模版缺陷检查装置是使用通过用光照射其上形成图案的掩模版获得的图案图像来检查掩模版上的缺陷的掩模版缺陷检查装置。 该装置包括用于用检查光照射标线的照明光学系统和用于检测用检查光照射的掩模版的图案图像的检测光学系统，其中照明光学系统包括用于均衡检查的照明分布的积分器 光和移动机构，用于使积分器能够在垂直于积分器的光轴的方向上稍微移动。

公开(公告)号：US20070263914A1

公开(公告)日：2007-11-15

申请号：US11684484

申请日：2007-03-09

Applicant: Clark Tibbetts

Inventor： Clark Tibbetts

IPC: G06K9/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/2846 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/0626 ,  G01N2201/0631

Abstract: An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire micro array.

Abstract translation: 提供了一种用于创建微阵列图像的装置和方法。 该装置包括被配置为将光引向微阵列的至少一个光源。 该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。 二色镜将光反射到微阵列上，导致微阵列发射电磁能。 该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。 该装置还包括具有电荷耦合器件（CCD）的成像单元，该CCD具有被针孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像 。

公开(公告)号：US07242472B2

公开(公告)日：2007-07-10

申请号：US10866747

申请日：2004-06-15

Applicant: Yan Rung Lin ,  Teh Ho Tao ,  Zu Sho Chow ,  Ding Kun Liu

Inventor： Yan Rung Lin ,  Teh Ho Tao ,  Zu Sho Chow ,  Ding Kun Liu

IPC: G01J3/30

CPC classification number: G01N21/6428 ,  G01N21/6456 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2201/0631

Abstract: The present invention discloses a biochip detection system for detecting a biochip labeled with multiple fluorophores. The biochip detection system comprises a broadband light source for generating a light beam, a stand for supporting the biochip, a light integrator positioned between the broadband light source and the biochip, a lens set for adjusting the cross-sectional area of the light beam, a first filter module positioned on the optical path of the light beam, a detector, e.g., CCD camera, photodiode array, for detecting a fluorescence beam emitted from the biochip, and a second filter module positioned on the optical path of the fluorescence beam. The light integrator can be a light tunnel, a lens array or a holographic diffuser for uniforming the intensity distribution of the light beam and changing the cross-sectional shape of the light beam into a rectangle.

Abstract translation: 本发明公开了一种用于检测用多种荧光团标记的生物芯片的生物芯片检测系统。 生物芯片检测系统包括用于产生光束的宽带光源，用于支撑生物芯片的支架，位于宽带光源和生物芯片之间的光积分器，用于调节光束横截面积的透镜组， 定位在光束的光路上的第一滤光器模块，用于检测从生物芯片发射的荧光束的CCD相机，光电二极管阵列的检测器和位于荧光束的光路上的第二滤光器模块。 光积分器可以是光通道，透镜阵列或全息漫射器，用于使光束的强度分布均匀并将光束的横截面形状改变成矩形。

公开(公告)号：US4600302A

公开(公告)日：1986-07-15

申请号：US593470

申请日：1984-03-26

Applicant: Burton H. Sage, Jr.

Inventor： Burton H. Sage, Jr.

IPC: G01N33/49 ,  G01N15/14 ,  G01N33/48 ,  G01N21/64

CPC classification number: G01N15/1434 ,  G01N15/147 ,  G01N2015/1497 ,  G01N2201/0631

Abstract: A flow cytometry apparatus for determining one or more characteristics of particles or the like flowing in a liquid stream includes a nozzle for generating a liquid flow stream for moving particles therethrough substantially one at a time. An arc lamp provides a beam of incoherent light to illuminate the particles moving in the flow stream. A prism in the light beam modifies non-uniform incoherent light, as provided by said arc lamp, to a more uniform beam of illumination which is directed to the flowing particles. A detector is included for detecting light with respect to each moving particle and for associating the detected light with one or more characteristics of the particles.

Abstract translation: 用于确定在液体流中流动的颗粒等的一个或多个特性的流式细胞仪装置包括用于产生用于每次一个地移动颗粒的液体流的喷嘴。 弧光灯提供非相干光束以照射在流动流中移动的颗粒。 光束中的棱镜将由所述弧光灯提供的非均匀非相干光改变为更均匀的照射光束，其被引导到流动的颗粒。 包括检测器，用于检测相对于每个移动颗粒的光，并将检测到的光与颗粒的一个或多个特性相关联。

公开(公告)号：US20240125594A1

公开(公告)日：2024-04-18

申请号：US17769543

申请日：2020-10-16

Applicant: VIRELUX Inspection Systems Sàrl

Inventor： Tom Reichert ,  Gérard Baseotto

IPC: G01B11/25 ,  G01B5/00 ,  G01B11/16 ,  G01B11/24

CPC classification number: G01B11/2545 ,  G01B5/0025 ,  G01B11/167 ,  G01B11/2441 ,  G01N2021/8864 ,  G01N2201/0631

Abstract: A method and system for scanning an outer surface of a three-dimensional object, the outer surface being reflective, the method comprising the following steps: (a) projecting a light pattern on the object with a relative movement between the light pattern and the object; (b) recording with cameras images of the light pattern reflected by the outer surface during the relative movement; (c) processing the recorded reflection images by identifying the outline of the light pattern and determining from the outline characteristics of the outer surface; wherein the light pattern comprises at least one homogenously illuminated strip extending transversally to a direction of the relative movement with at least one border with a non-straight profile so as to form a non-constant width of the strip; and in step (c) the speed of the relative movement is taken into account for determining a three-dimensional definition of the outer surface.

公开(公告)号：US20240035983A1

公开(公告)日：2024-02-01

申请号：US18221043

申请日：2023-07-12

Applicant: WiTrins s.r.o.

Inventor： Pavel Linhart

IPC: G01N21/88 ,  G01N21/95

CPC classification number: G01N21/8806 ,  G01N21/9501 ,  G01N21/8851 ,  G01N2021/8845 ,  G01N2201/06153 ,  G01N2201/0631 ,  G01N2021/8874

Abstract: An inspection system and a method for analyzing defects in a product, in particular a printed circuit board product, a semiconductor wafer or the like, the inspection system includes a projection device , an optical detection device , and a processing device, the projection device having an illuminating unit and a spectrometer member configured to split white light into its spectral components and project a multichromatic light beam thus formed from monochromatic light beams onto a product at an angle of incidence β, the optical detection device having a detection unit comprising a camera and an objective , the camera being configured to detect the multichromatic light beam reflected on the product in a detection plane of the detection unit, the detection plane being perpendicular, preferably orthogonal, to a product surface of the product, the illuminating unit having at least two light-emitting diodes disposed in a row and an exit aperture extending along the row.

公开(公告)号：US11796459B1

公开(公告)日：2023-10-24

申请号：US18329585

申请日：2023-06-06

Applicant: Xinjiang Technical Institute of Physics and Chemistry, CAS

Inventor： Linjun Li ,  Shilie Pan ,  Yu Zhou ,  Xiaoming Duan ,  Qianqian Hao ,  Yingjie Shen ,  Xin He ,  Hongsheng Shi ,  Zheng Cui

IPC: G01N21/3504 ,  G01N21/45

CPC classification number: G01N21/3504 ,  G01N21/45 ,  G01N2021/451 ,  G01N2201/0631 ,  G01N2201/0636 ,  G01N2201/06113

Abstract: A method for measuring multiple parameters of mixed gases based on broadband infrared light source is provided, including: filtering a broadband infrared laser, and forming a laser beam including three narrow-linewidth wavelengths; dividing the laser beam into a first sub-laser beam and a second sub-laser beam; focusing and transmitting the first sub-laser beam to a gas sample cell; focusing and transmitting the first sub-laser beam to a first reflector; reflecting and transmitting the first sub-laser beam; reflecting and transmitting the second sub-laser beam to the second beam splitter; combing the first sub-laser beam transmitted by the second beam splitter and the second sub-laser beam reflected by the second beam splitter, measuring the multiple parameters; combining and transmitting the second sub-laser beam transmitted by the second beam splitter and the first sub-laser beam reflected by the second beam splitter to a spectrometer for measuring concentrations the mixed gases.

公开(公告)号：US11694659B2

公开(公告)日：2023-07-04

申请号：US17120085

申请日：2020-12-11

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Tatsushi Ohyama ,  Mariko Miyashita

IPC: G09G5/377 ,  G09G5/02 ,  G06T17/00 ,  G01N21/64 ,  G01N33/00 ,  G01S17/89 ,  G01N15/00 ,  G01S7/51 ,  G01N21/47 ,  G06T19/20 ,  G01N21/53 ,  G01N21/17 ,  G01S17/86 ,  G01N15/06 ,  G06T19/00 ,  G01S7/48 ,  G06F3/147

CPC classification number: G09G5/377 ,  G01N21/6456 ,  G01N33/0027 ,  G01S17/89 ,  G06T17/00 ,  G09G5/02 ,  G01N15/06 ,  G01N21/53 ,  G01N2015/0046 ,  G01N2015/0693 ,  G01N2021/1793 ,  G01N2021/4792 ,  G01N2201/0631 ,  G01S7/4802 ,  G01S7/51 ,  G01S17/86 ,  G06F3/147 ,  G06T19/006 ,  G06T19/20 ,  G06T2219/004 ,  G06T2219/2012 ,  G09G2340/125

Abstract: A display apparatus includes a display screen, and a controller that causes the display screen to display a composite image in which a first image acquired by imaging a space by a camera and a second image representing at least one type of aerosol existing in the space are combined. The position of the at least one type of aerosol as seen in a depth direction in the first image is reflected in the second image.

公开(公告)号：US20190154652A1

公开(公告)日：2019-05-23

申请号：US16259072

申请日：2019-01-28

Applicant: CELLOMICS, INC.

Inventor： Richik Niloy Ghosh ,  Dirk John VandenBerg, III ,  Keith Rao Heffley ,  Monica Jo Tomaszewski ,  Jeffrey Robert Haskins

IPC: G01N33/487 ,  G02B5/02 ,  G01N21/64 ,  G01N21/31 ,  G01N21/25 ,  G02B21/36 ,  G02B21/16 ,  G01N35/00

CPC classification number: G01N33/487 ,  F21Y2105/10 ,  F21Y2105/14 ,  G01N21/253 ,  G01N21/255 ,  G01N21/31 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G01N35/00029 ,  G01N2021/6439 ,  G01N2021/6491 ,  G01N2035/00158 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/064 ,  G02B5/0278 ,  G02B5/0294 ,  G02B21/16 ,  G02B21/367

Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.