公开(公告)号：US20020169379A1

公开(公告)日：2002-11-14

申请号：US10142003

申请日：2002-05-09

Applicant: HOSPITAL FOR SPECIAL SURGERY

Inventor： Nancy P. Camacho ,  Mathias P.G. Bostrom ,  Steve L. Bertha

IPC: A61B005/00 ,  A61B017/22

CPC classification number: G01N21/552 ,  A61B5/0059 ,  A61B5/4504 ,  G01N21/35 ,  G01N21/359 ,  G01N2021/559 ,  G01N2201/0846

Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

Abstract translation: 一种评估具有可区别的红外光谱的材料的表面的方法，包括（a）将红外光纤探针定位成与感兴趣区域的样品或材料的表面接触以检测衰减的全反射率，或者在 距离用于检测反射的区域的表面足够的距离，（b）检测中间或近红外辐射减弱了样品或材料表面的全反射或反射，（c）分析来自步骤（b）的红外辐射 ），用于峰高，峰面积，频率和化学计量参数中的至少一个，以及（d）当来自红外光纤探针的信号处于峰值高度，峰值面积之中的至少一个的预选值之间时，启动去除装置 ，样品的频率和化学计量参数。

公开(公告)号：US20010029049A1

公开(公告)日：2001-10-11

申请号：US09287573

申请日：1999-04-06

Inventor： DAVID R. WALT ,  TODD A. DICKINSON

IPC: G01N033/543

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：US5835649A

公开(公告)日：1998-11-10

申请号：US867621

申请日：1997-06-02

Applicant: Robin Fredrick Bruce Turner ,  Michael Walter Blades ,  Lloyd Shane Greek ,  Hans Georg Schulze

Inventor： Robin Fredrick Bruce Turner ,  Michael Walter Blades ,  Lloyd Shane Greek ,  Hans Georg Schulze

IPC: G01N21/64 ,  G01N21/65 ,  G02B6/24 ,  G02B6/26

CPC classification number: G01N21/8507 ,  G01N21/645 ,  G02B6/241 ,  G01N2021/6484 ,  G01N21/65 ,  G01N2201/0846

Abstract: A fiber-optic probe is formed by a pair of optical fibers one of which delivers light to a target zone and the other collects light from a field of view in the target zone. One of these fibers is provided with a window that opens substantially perpendicular to the longitudinal axis of the fiber and with a transverse surface oriented at an angle to the longitudinal axis of the fiber to reflect light through the window or from the window longitudinally of the axis of this fiber. Two fibers are physically interconnected to position the window on one side of and immediately adjacent to the target zone and the axial end of other fiber to deliver or receive light from another side of the target zone preferably substantially perpendicular to the one side.

Abstract translation: 光纤探针由一对光纤形成，其中一个光纤将光传送到目标区域，另一个光纤从目标区域的视场中收集光。 这些光纤中的一个设置有基本上垂直于光纤的纵向轴线的窗口，并且横向表面定向成与光纤的纵向轴线成一定角度，以反射光线穿过窗口或从窗口纵向轴线反射 的纤维。 两个纤维物理互连，以将窗口定位在目标区域的一侧并且紧邻其它光纤的轴向端，以将目标区域另一侧的光优选地基本垂直于该一侧。

公开(公告)号：US12078581B2

公开(公告)日：2024-09-03

申请号：US18087787

申请日：2022-12-22

Applicant: TASCOM CO., LTD.

Inventor： Sung Dong Lee

IPC: B01L3/00 ,  B04B9/14 ,  G01N1/40 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N33/49 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  B04B5/04 ,  G01N21/03

CPC classification number: G01N1/4077 ,  B01L3/502753 ,  B04B9/14 ,  B04B9/146 ,  G01N21/07 ,  G01N21/31 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/76 ,  G01N33/491 ,  G01N35/00594 ,  G01N35/025 ,  G01N35/04 ,  B04B5/0407 ,  G01N2001/4083 ,  G01N2021/0325 ,  G01N2021/0378 ,  G01N2035/00504 ,  G01N2201/0423 ,  G01N2201/08 ,  G01N2201/0846

Abstract: A biological material measuring instrument is described. The biological material measuring instrument includes a rotating body and a main body. The rotating body includes one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react. The main body includes a pair of light-emitting parts and light-receiving parts to optically measure the analyte in the sample. The rotating body further includes a light-emitting optical waveguide for guiding the light of the light-emitting parts to the cuvette, and a light-receiving optical waveguide for guiding.

公开(公告)号：US12025562B2

公开(公告)日：2024-07-02

申请号：US17809620

申请日：2022-06-29

Applicant: Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung E.V.

Inventor： Peter Hartmann ,  Tobias Baselt ,  Wulf Grählert ,  Oliver Throl ,  Philipp Wollmann

IPC: G01N21/27 ,  G01J3/50 ,  G01N21/47 ,  G01N21/84

CPC classification number: G01N21/8422 ,  G01J3/50 ,  G01N21/27 ,  G01N21/47 ,  G01N2021/8427 ,  G01N2201/0846

Abstract: In the method for optical monitoring and/or determination of properties on samples, monochromatic electromagnetic radiation with a predetermined wavelength is sequentially directed from several radiation sources onto a sample influenced by an electronic evaluation unit. The respective intensity specific to the wavelength of the electromagnetic radiation scattered and/or reflected by the sample is detected by at least one detector and fed to the electronic evaluation unit for spectrally resolved evaluation in order to use it to monitor and/or determine properties of the respective sample.

公开(公告)号：US20190250392A1

公开(公告)日：2019-08-15

申请号：US16343229

申请日：2016-10-25

Applicant: LYNCEE TEC SA

Inventor： Etienne CUCHE ,  Yves EMERY

IPC: G02B21/14 ,  G03H1/04 ,  G03H1/00 ,  G02B27/14 ,  G01N21/45

CPC classification number: G02B21/14 ,  G01B9/02007 ,  G01B9/02028 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/453 ,  G01N2021/4186 ,  G01N2021/458 ,  G01N2201/082 ,  G01N2201/0846 ,  G02B21/06 ,  G02B27/10 ,  G02B27/14 ,  G03H1/0005 ,  G03H1/041 ,  G03H1/0443 ,  G03H1/0465 ,  G03H2001/005 ,  G03H2001/0452 ,  G03H2001/0456 ,  G03H2001/0469 ,  G03H2001/0471 ,  G03H2223/16 ,  G03H2223/24 ,  G03H2223/26

Abstract: An optical fiber splitter device comprising at least two optical fibers of different lengths is disclosed for partial or complete compensation of the optical path difference between waves interfering to generate a hologram or an interferogram. Various implementations of this fiber splitter device are described in apparatuses for holographic and interferometric imaging of microscopic and larger samples.

公开(公告)号：US09824440B2

公开(公告)日：2017-11-21

申请号：US14085732

申请日：2013-11-20

Applicant: VANDERBILT UNIVERSITY

Inventor： Anita Mahadevan-Jansen ,  The-Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Ginger Holt ,  Isaac Pence

IPC: G06T7/00 ,  G01N21/64 ,  G01N21/65 ,  A61B5/00

CPC classification number: G06T7/0012 ,  A61B5/0071 ,  A61B5/0075 ,  A61B2505/05 ,  G01N21/6486 ,  G01N21/65 ,  G01N2201/0846 ,  G06T2207/30096

Abstract: In one aspect, the present invention relates to a system evaluating a surgical margin of tumor tissues of a living subject. In one embodiment, the system includes a light source configured to emit a source light; at least one optical probe; a scanner; a spectrometer; and a controller coupled with the scanner and the spectrometer for operably controlling the scanner and the spectrometer. In operation, a working end of the optical probe is positioned proximate to a surface of a specimen of the tumor tissues. A source channel of the optical probe deliver the source light emitted by the light source from the working end to the surface of the specimen, and a plurality of collection channels collect from the working end diffused/reflected light generated from interaction of the source light with the specimen. The spectrometer receives the collected diffused/reflected light to evaluate a margin status of the specimen.

公开(公告)号：US09702816B2

公开(公告)日：2017-07-11

申请号：US15105397

申请日：2013-12-17

Applicant: AKTIEBOLAGET SKF

Inventor： Florin Tatar ,  Defeng Lang

IPC: G01N21/3577 ,  G01J3/42 ,  G01N33/28 ,  G01N21/3554 ,  G01N21/359 ,  G01N21/45 ,  G01N21/85 ,  G01J3/02

CPC classification number: G01N21/3577 ,  G01J3/0218 ,  G01J3/42 ,  G01J3/45 ,  G01J3/4531 ,  G01N21/3554 ,  G01N21/359 ,  G01N21/45 ,  G01N21/8507 ,  G01N33/2847 ,  G01N33/2888 ,  G01N2201/0846

Abstract: A detector for oil condition monitoring includes an optical fiber having a first end and a second end having an end face. A sensor body has a gap in which a sample of the oil may be received and a reflecting surface, the second end of the optical fiber being embedded in the sensor body and having an end face spaced from the reflecting surface across the gap. Light emitted from the optical fiber can pass through the sample of oil and be reflected by the reflecting surface back into the optical fiber. By interferometry of the respective signals, the condition of the oil can be determined.

公开(公告)号：US20170113225A1

公开(公告)日：2017-04-27

申请号：US15301765

申请日：2015-04-07

Applicant: James Richard HOWELL ,  Benjamin Masterman WEBSTER

Inventor： James Richard HOWELL ,  Benjamin Masterman WEBSTER

IPC: B01L7/00 ,  G01N21/27

CPC classification number: B01L7/52 ,  B01L9/06 ,  B01L2300/02 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N21/272 ,  G01N2201/0231 ,  G01N2201/0846

Abstract: A chemical and/or biochemical apparatus (10) for receiving a plurality of reaction vessels in which chemical and/or biochemical reactions may take place includes a thermal mount (14) having a plurality of wells (26) for receiving the reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and a plurality of thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) is provided for delivering excitation light to a reaction vessel, and a second set of light waveguides (38) is provided for receiving light from a reaction vessel and for delivering the light to the light sensor (52). The first heat sink (18) comprises an interior space (5) and the printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within the interior space (5).

公开(公告)号：US09146189B2

公开(公告)日：2015-09-29

申请号：US14631914

申请日：2015-02-26

Applicant: ASL Analytical, Inc.

Inventor： Edwin John Koerperick ,  Jonathon Todd Olesberg ,  Christine Esther Evans ,  Mark Allen Arnold ,  Gregory Allan Brower

IPC: G01J5/02 ,  G01N21/03 ,  G01N21/359 ,  G01N21/05 ,  A61M1/36 ,  G01N15/14

CPC classification number: G01N21/05 ,  A61M1/3693 ,  A61M1/3696 ,  G01N15/1404 ,  G01N21/0332 ,  G01N21/359 ,  G01N2021/0321 ,  G01N2021/0364 ,  G01N2021/054 ,  G01N2201/0846

Abstract: An optical apparatus with a single-use, disposable fluid flow cartridge and cell and associated optical interface is employed in determining characteristics of a fluid and/or suspended materials or cells contained therein which are introduced into the apparatus. The optical interface communicates electromagnetic radiation from an optical instrument through the fluid within the cell and to an appropriate sensor within the optical instrument. The interaction of the electromagnetic radiation with the fluid is measured by the signal generated by the sensor. Fluid present within the cell may be static or flowing, allowing both discrete sample measurements and monitoring of continuous processes.

Abstract translation: 使用具有一次性一次性流体流动筒和细胞和相关联的光学界面的光学装置来确定被引入到装置中的流体和/或其中包含的悬浮材料或细胞的特性。 光学接口将来自光学仪器的电磁辐射通过细胞内的流体传递到光学仪器内的适当的传感器。 通过传感器产生的信号来测量电磁辐射与流体的相互作用。 存在于电池内的流体可以是静态的或流动的，允许离散的样品测量和连续过程的监测。