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    MICROSECOND TIME-RESOLVED MASS SPECTROMETRY
    21.
    发明申请
    MICROSECOND TIME-RESOLVED MASS SPECTROMETRY 审中-公开
    MICROSECOND时间分辨质谱仪

    公开(公告)号：US20140147921A1

    公开(公告)日：2014-05-29

    申请号：US13697621

    申请日：2011-05-17

    Applicant: Hao Chen ,  Zhixin Miao

    Inventor： Hao Chen ,  Zhixin Miao

    IPC: G01N27/68 ,  G01N33/487

    CPC classification number: G01N27/68 ,  G01N1/00 ,  G01N33/48707 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/145 ,  H01J49/165

    Abstract: A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length. An ambient ionization source (10) is directed toward a selected variable location along the continuous liquid jet (50) to desorb at least a portion of the continuous liquid jet (50). A mass analyzer (30) analyzes a mass-to-charge ratio of an ionized sample that is within the desorbed portion of the continuous liquid jet (50). The acquired mass spectra reflect the reaction progress in different reaction times and, therefore, may be used to derive the reaction rate.

    Abstract translation: 描述了用于快速反应的动力学研究的微秒时间分辨质谱装置和使用解吸电喷雾电离的方法（10）。 该装置包括液体喷射发生器（64），其构造成发射具有长度的连续液体射流（50）。 环境电离源（10）沿着连续液体射流（50）指向选定的可变位置以解吸至少一部分连续液体射流（50）。 质量分析器（30）分析在连续液体射流（50）的解吸附部分内的电离样品的质荷比。 所获得的质谱反映了不同反应时间的反应进程，因此可用于得到反应速率。

    Method and system for formation and withdrawal of a sample from a surface to be analyzed
    22.
    发明申请
    Method and system for formation and withdrawal of a sample from a surface to be analyzed 审中-公开
    从待分析的表面形成和取出样品的方法和系统

    公开(公告)号：US20100224013A1

    公开(公告)日：2010-09-09

    申请号：US12380980

    申请日：2009-03-05

    Applicant: Gary J. Van Berkel ,  Vilmos Kertesz

    Inventor： Gary J. Van Berkel ,  Vilmos Kertesz

    IPC: G01N1/20

    CPC classification number: H01J49/0431 ,  G01N35/1095 ,  G01N2001/1031 ,  H01J49/045 ,  H01J49/0463 ,  H01J49/167

    Abstract: A method and system for formation and withdrawal of a sample from a surface to be analyzed utilizes a collection instrument having a port through which a liquid solution is conducted onto the surface to be analyzed. The port is positioned adjacent the surface to be analyzed, and the liquid solution is conducted onto the surface through the port so that the liquid solution conducted onto the surface interacts with material comprising the surface. An amount of material is thereafter withdrawn from the surface. Pressure control can be utilized to manipulate the solution balance at the surface to thereby control the withdrawal of the amount of material from the surface. Furthermore, such pressure control can be coordinated with the movement of the surface relative to the port of the collection instrument within the X-Y plane.

    Abstract translation: 用于从待分析的表面形成和取出样品的方法和系统利用采集仪器，其具有将液体溶液通过该端口传导到要分析的表面上。 端口定位在待分析表面附近，并且液体溶液通过端口传导到表面上，使得被引导到表面上的液体溶液与包含表面的材料相互作用。 此后从表面取出一定量的材料。 可以使用压力控制来操纵表面处的溶液平衡，从而控制从表面撤出的材料量。 此外，这种压力控制可以与表面相对于收集仪器在X-Y平面内的端口的运动相配合。

    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
    23.
    发明授权
    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry 有权

    公开(公告)号：US06610978B2

    公开(公告)日：2003-08-26

    申请号：US09820321

    申请日：2001-03-27

    Applicant: Hongfeng Yin ,  Thomas P. Doherty ,  Sally A Swedberg

    Inventor： Hongfeng Yin ,  Thomas P. Doherty ,  Sally A Swedberg

    IPC: H01J4900

    CPC classification number: H01J49/045 ,  H01J49/0018 ,  H01J49/105

    Abstract: The present invention relates to microdevices for introducing a small volume of a fluid sample into an ionization chamber. The microdevices are constructed from a substrate having a first and second opposing surfaces, the substrate having a microchannel formed in the first surface, and a cover plate arranged over the first surface, the cover plate in combination with the microchannel defining a conduit for conveying the sample. A sample inlet port is provided in fluid communication with the microchannel, wherein the sample inlet port allows the fluid sample from an external source to be conveyed in a defined sample flow path that travels, in order, through the sample inlet port, the conduit and a sample outlet port and into the ionization chamber. Optionally, the fluid sample undergoes a chemical or biochemical reaction within an integrated portion of the microdevice before reaching the ionization chamber. A nebulizing means nebulizes the fluid sample in a nebulizing region adjacent to the sample outlet port. The invention also relates to a method for introducing a fluid sample using the microdevice.

    Pneumatic nebulizing interface to convert an analyte-containing fluid stream into an aerosol, method for using same and instruments including same
    24.
    发明授权
    Pneumatic nebulizing interface to convert an analyte-containing fluid stream into an aerosol, method for using same and instruments including same 有权
    用于将含分析物的流体流转化为气溶胶的气动雾化界面，使用方法及包括其的仪器

    公开(公告)号：US06511850B1

    公开(公告)日：2003-01-28

    申请号：US09614368

    申请日：2000-07-12

    Applicant: Gyula Vigh ,  Alex D. Sokolowski

    Inventor： Gyula Vigh ,  Alex D. Sokolowski

    IPC: H01J4904

    CPC classification number: G01N27/44717 ,  B05B7/0408 ,  B05B7/064 ,  B05B7/066 ,  G01N1/22 ,  G01N31/12 ,  G01N35/085 ,  G01N2030/8464 ,  G01N2030/847 ,  H01J49/045 ,  Y10T436/117497 ,  Y10T436/119163 ,  Y10T436/20 ,  Y10T436/24 ,  Y10T436/25

    Abstract: A self-adjusting, free-flowing pneumatic nebulizer interface is described for coupling fluid phase separation apparatus such as capillary electrophoresis apparatus or fluid-phase analyte delivery apparatus such as flow-injection analysis apparatus to gas phase, post-separation detection apparatus such as mass spectrometers, chemiluminescence detectors, or other similar gas phase detection apparatus. The interface combines the analytes with only the needed amount of sheath fluid to produce a combined flow whose magnitude automatically matches the self-aspiration rate of the pneumatic nebulizer interface, and which is combined with a gas flow to produce an aerosol. The resulting aerosol can then be either deposited directly on a surface, forwarded directly to a detection system or forwarded first to a conversion apparatus such as an oxidizer and the oxidized sample components are then forwarded to a detector.

    Abstract translation: 描述了一种自调节自由流动的气动雾化器界面，用于将流动相分离装置如毛细管电泳装置或流体相分析物输送装置如流动注射分析装置耦合到气相，后分离检测装置如质量 光谱仪，化学发光检测器或其他类似的气相检测装置。 界面将分析物与所需量的鞘液相结合，产生一个组合流量，其大小自动匹配气动雾化器界面的自吸气速率，并与气流组合以产生气溶胶。 所得到的气溶胶然后可以直接沉积在表面上，直接转发到检测系统或首先转发到诸如氧化剂的转化装置，然后将氧化的样品组分转发到检测器。

    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
    25.
    发明申请
    Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry 有权
    综合样品制备，分离和引入电感耦合等离子体质谱法微型装置

    公开(公告)号：US20020139931A1

    公开(公告)日：2002-10-03

    申请号：US09820321

    申请日：2001-03-27

    Inventor： Hongfeng Yin ,  Thomas P. Doherty ,  Sally A. Swedberg

    IPC: H01J049/04

    CPC classification number: H01J49/045 ,  H01J49/0018 ,  H01J49/105

    Abstract: The present invention relates to microdevices for introducing a small volume of a fluid sample into an ionization chamber. The microdevices are constructed from a substrate having a first and second opposing surfaces, the substrate having a microchannel formed in the first surface, and a cover plate arranged over the first surface, the cover plate in combination with the microchannel defining a conduit for conveying the sample. A sample inlet port is provided in fluid communication with the microchannel, wherein the sample inlet port allows the fluid sample from an external source to be conveyed in a defined sample flow path that travels, in order, through the sample inlet port, the conduit and a sample outlet port and into the ionization chamber. Optionally, the fluid sample undergoes a chemical or biochemical reaction within an integrated portion of the microdevice before reaching the ionization chamber. A nebulizing means nebulizes the fluid sample in a nebulizing region adjacent to the sample outlet port. The invention also relates to a method for introducing a fluid sample using the microdevice.

    Abstract translation: 本发明涉及将小体积的流体样品引入电离室的微型装置。 微型器件由具有第一和第二相对表面的衬底构成，衬底具有形成在第一表面中的微通道，以及布置在第一表面上的盖板，盖板与微通道组合，限定用于输送 样品。 提供与微通道流体连通的样品入口端口，其中样品入口端口允许来自外部源的流体样品在限定的样品流动路径中被输送，该样品流动路径依次通过样品入口端口，导管和 样品出口并进入电离室。 任选地，流体样品在到达电离室之前在微型装置的集成部分内经历化学或生物化学反应。 雾化装置使流体样品在邻近样品出口的雾化区域中雾化。 本发明还涉及使用微型装置引入流体样品的方法。

    Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors
    26.
    发明授权
    Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors 失效
    将液体流出物引入质谱仪和其他气相或颗粒检测器的方法和设备

    公开(公告)号：US5285064A

    公开(公告)日：1994-02-08

    申请号：US40073

    申请日：1993-03-30

    Applicant: Ross C. Willoughby

    Inventor： Ross C. Willoughby

    IPC: G01N1/00 ,  G01N30/02 ,  G01N30/30 ,  G01N30/72 ,  H01J49/04

    CPC classification number: H01J49/049 ,  H01J49/045 ,  G01N1/22 ,  G01N2030/027 ,  G01N2030/3038 ,  G01N2030/3061 ,  G01N30/7253

    Abstract: Methods and apparatus for liquid sample introduction into chemical detectors that require the sample to be transformed from a flowing stream into either gaseous or particulate states. The effluent from either a process stream or a liquid chromatograph is nebulized by combined thermal and pneumatic processes within an inner fused silicon capillary tube heated by conduction from a surrounding electrical resistance heated outer capillary tube composed of a pure metal having a comparatively high linear relationship between temperature and electrical resistance to provide a uniform conduction of heat energy to the inner tube to form a well-collimated, partially or completely desolvated aerosol, with the less volatile solute components of the sample stream remaining in the particulate state. The gaseous components of the aerosol are separated from the solvent-depleted solute particles using either cryotrapping or momentum separation. The enriched solute particles are vaporized, ionized, and/or detected by suitable gas-phase or particle detectors. The device is primarily an interface between the liquid chromatograph or process streams and the mass spectrometer.

    Abstract translation: 将液体样品引入化学检测器的方法和设备，其需要将样品从流动物流转变为气态或微粒状态。 来自工艺流或液相色谱仪的流出物通过内部熔融硅毛细管内的组合热和气动工艺进行喷雾，所述内部熔融硅毛细管由来自周围的电阻加热的外部毛细管的传导加热，所述外部毛细管由纯金属组成，所述纯金属具有相对较高的线性关系 温度和电阻，以向内管提供均匀的热能传导，以形成准直的，部分或完全脱溶的气溶胶，其中样品流的挥发性较低的溶质组分保持颗粒状态。 气溶胶的气态组分使用低温震荡或动量分离与溶剂不足的溶质颗粒分离。 富集的溶质颗粒被合适的气相或颗粒检测器蒸发，离子化和/或检测。 该装置主要是液相色谱仪或过程流与质谱仪之间的界面。

    ION ANALYZER
    30.
    发明公开
    ION ANALYZER 审中-公开

    公开(公告)号：US20230260774A1

    公开(公告)日：2023-08-17

    申请号：US18167226

    申请日：2023-02-10

    Applicant: SHIMADZU CORPORATION

    Inventor： Yoshimi HASHIGUCHI

    IPC: H01J49/14 ,  H01J49/04

    CPC classification number: H01J49/14 ,  H01J49/045 ,  H01J49/0468

    Abstract: A mass spectrometer (ion analyzer) includes: an ionization chamber; a sample probe fixed to a wall of the ionization chamber and configured to nebulize a liquid sample into the ionization chamber; a gas heater including a tubular member having both end walls and a peripheral wall, a heater configured to heat the inside of the tubular member, a gas flow inlet and a gas flow outlet provided in the peripheral wall or the end wall of the tubular member, and a gas flow outlet pipe having one end connected to the gas flow outlet and the other end inserted into the ionization chamber; a fixture configured to fix the gas heater to the wall of the ionization chamber; and a cooling unit configured to cool the fixture.

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