公开(公告)号：US20020145735A1

公开(公告)日：2002-10-10

申请号：US10095938

申请日：2002-03-13

Applicant:

Inventor： Junji Tominaga ,  Masashi Kuwahara ,  Christophe Mihalcea ,  Dorothea Buechel ,  Takashi Kikukawa ,  Hiroshi Fuji

IPC: G01J003/44

CPC classification number: G01N21/658

Abstract: A molecular sensor comprising a sensor film containing a metal compound wherein Raman spectroscopic analysis is carried out utilizing the amplification of Raman light by the localized plasmons that fine particles resulting from reduction of the metal compound generate has a small size and a very high sensitivity. A high sensitivity Raman spectroscopic process is provided.

Abstract translation: 一种分子传感器，包括含有金属化合物的传感器膜，其中通过局部等离子体激元利用拉曼光的扩增进行拉曼光谱分析，产生的金属化合物的还原产生的细小颗粒具有小尺寸和非常高的灵敏度。 提供了高灵敏度拉曼光谱法。

公开(公告)号：US20020113961A1

公开(公告)日：2002-08-22

申请号：US10051305

申请日：2002-01-22

Applicant: Unisearch Associates Inc.

Inventor： Heather A. Gamble ,  John C. Robbins ,  Gervase I. MacKay ,  Harold I. Schiff

IPC: G01J003/44

CPC classification number: G01J3/44 ,  G01N21/05 ,  G01N21/65 ,  G01N21/85

Abstract: The present invention relates to a method and apparatus for detecting transitions between different gas or liquid products in a flow path and, more particularly, it relates to an apparatus and method utilizing Raman spectroscopy for detecting transitions between petroleum products. A Raman spectrometer is preferably to produce a monochromatic excitation beam at a wavelength of approximately 670 nm. The spectrometer consists of an entrance slit, a combined diffraction grating/focussing element, and an exit slit. The Raman signal, which exits the spectrometer exit slit is detected by a highly sensitive photomultiplier tube, and sent to a computer device for data acquisition and analysis. The proposed invention detects liquid or gas products in a flow path by detecting the changes in the composition of various petroleum products flowing through a gasoline pipeline, by means of exposing samples of various petroleum products to the Raman spectrometer system.

Abstract translation: 本发明涉及一种用于检测流路中不同气体或液体产物之间的转变的方法和装置，更具体地说，涉及利用拉曼光谱法检测石油产品之间的转变的装置和方法。 拉曼光谱仪优选地产生波长约670nm的单色激发光束。 光谱仪由入射狭缝，组合衍射光栅/聚焦元件和出口狭缝组成。 通过高灵敏度的光电倍增管检测离开光谱仪出口狭缝的拉曼信号，并发送到计算机设备进行数据采集和分析。 本发明通过将各种石油产品的样品暴露于拉曼光谱仪系统，通过检测流经汽油管道的各种石油产品的组成变化来检测流路中的液体或气体产物。

公开(公告)号：US20020015150A1

公开(公告)日：2002-02-07

申请号：US09797609

申请日：2001-03-01

Inventor： Robert L. Armstrong ,  Vladimir M. Shalaev ,  Harold V. Smith

IPC: G01J003/44

CPC classification number: G01N21/658 ,  B82Y10/00 ,  B82Y20/00 ,  G02F1/353 ,  G02F1/3534 ,  G02F1/3536 ,  G02F1/3538 ,  G02F1/355 ,  G02F1/37 ,  G02F1/39 ,  G02F2202/36 ,  G02F2203/15 ,  G11B7/00453 ,  H01S3/0602 ,  H01S3/30

Abstract: An optical sensing enhancing material (and corresponding method of making) comprising: a medium, the medium comprising a plurality of aggregated nanoparticles comprising fractals; and a microcavity, wherein the medium is located in a vicinity of the microcavity. Also an optical sensor and sensing method comprising: providing a doped medium, the medium comprising a plurality of aggregated nanoparticles comprising fractals, with the material; locating the doped medium in the vicinity of a microcavity; exciting the doped medium with a light source; and detecting light reflected from the doped medium.

Abstract translation: 一种光学感测增强材料（和相应的制备方法），包括：介质，所述介质包含多个包含分形的聚集的纳米颗粒; 和微腔，其中介质位于微腔附近。 还有一种光学传感器和感测方法，包括：提供掺杂介质，所述介质包含多个包含分形的聚集的纳米颗粒与所述材料; 将掺杂介质定位在微腔附近; 用光源激发掺杂介质; 以及检测从掺杂介质反射的光。

公开(公告)号：US20010055113A1

公开(公告)日：2001-12-27

申请号：US09877773

申请日：2001-06-08

Inventor： Huiqi Yin

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0227

Abstract: For identifying black plastics effectively and rapidly, it is desirable to maintain full laser power while reducing the power density. This is achieved by the incorporation of a moving lens that disperses the 0.5mm laser spot over a larger area typically of about 5mm in diameter. The entire signal from the larger (5mm) diameter is collected at the same spot in the fiber bundle leading to a Raman or other spectral analyzer. There are no other modifications required for the rest of the system as the moving lens does not affect the collection efficiency of the characteristic signal from the sample.

Abstract translation: 为了有效和快速地识别黑色塑料，期望在降低功率密度的同时保持完整的激光功率。 这通过结合将0.5mm激光光斑分散在通常为大约5mm直径的较大面积上的移动透镜来实现。 来自较大（5mm）直径的整个信号被收集在纤维束中的相同点处，导致拉曼或其它光谱分析仪。 由于移动镜头不影响来自样品的特征信号的收集效率，因此系统的其余部分不需要其他修改。

公开(公告)号：US20040252299A9

公开(公告)日：2004-12-16

申请号：US10235922

申请日：2002-09-06

Inventor： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Orn Almarsson ,  Christopher McNulty

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

Abstract: Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

Abstract translation: 描述了允许高通量制备，处理和研究样品阵列的系统和方法，每个样品包含至少一种化合物。 本发明的具体实施方案允许在由毫克或微克数量的化合物上的一种或多种化合物组成的样品上并行进行大量实验。 本发明的其它实施例包括用于快速筛选这些实验的结果的方法和装置，以及用于快速确定阵列中的样本组之间是否存在相似性的方法和装置。 本发明的具体实施方案包括用于高通量制备不同形式的化合物（例如不同结晶形式）的方法和装置，用于发现新形式的旧化合物，以及发现生产此类形式的新方法。 本发明的实施方案还允许高通量测定当化合物或形式的化合物在暴露于其它化学物质或环境条件时的表现。

公开(公告)号：US20040207842A1

公开(公告)日：2004-10-21

申请号：US10845035

申请日：2004-05-13

Inventor： David M. Rzasa ,  Robert J. Faus ,  Brian Curtiss ,  Alexander F. H. Goetz ,  John Enterline

IPC: G01J003/28 ,  G01J003/44

CPC classification number: G07F17/0092 ,  G01J3/02 ,  G01J3/0264 ,  G01J3/0291 ,  G01N21/31 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/65 ,  G01N21/9508 ,  G06F19/00 ,  G06F19/326 ,  G16H40/63

Abstract: An apparatus for verifying the identity of a dispensed pharmaceutical comprises an analysis unit adapted to determine a property of the dispensed pharmaceutical, an input device adapted to receive predetermined identifying information corresponding to the dispensed pharmaceutical, and a comparison unit adapted to compare the determined property of the dispensed pharmaceutical with the predetermined identifying information. In addition, a method of verifying a prescription, wherein the prescription comprises a pharmaceutical compound, comprises associating the prescription with a unique identifier, storing the unique identifier, determining the identity of the pharmaceutical compound, and comparing the identity of the pharmaceutical compound with the unique identifier.

Abstract translation: 用于验证分配的药物的身份的装置包括适于确定分配药物的性质的分析单元，适于接收与分配的药物相对应的预定识别信息的输入装置，以及比较单元， 所述分配的药物具有预定的识别信息。 另外，验证处方的方法，其中处方包括药物化合物，包括将处方与唯一标识符相关联，存储唯一标识符，确定药物化合物的身份，并将药物化合物的身份与 唯一标识符。

公开(公告)号：US20040160601A1

公开(公告)日：2004-08-19

申请号：US10367238

申请日：2003-02-14

Inventor： M. Edward Womble ,  Richard H. Clarke

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N21/276 ,  G01N2201/06113 ,  G01N2201/08

Abstract: Raman spectroscopy probe assemblies are disclosed for use with portable and/or handheld analyzers. The probes are also adaptable to sample liquids, and/or powders, tablets and/or other solids and are capable of withstanding harsh environmental conditions. The probes include an optical head assembly, associated optical fibers and replaceable sampling tubes. Safety shut-off mechanisms are provided to reduce the risk of inadvertent exposure to radiation. In one embodiment, the shut-off switch is a spring-biased shutter that is opened by a solenoid only under predefined proper operating conditions. In another aspect of the invention, a simple orthogonal optical head assembly is disclosed that does not require collinear optical paths. The orthogonal arrangement of input and captured light paths also reduces the need for precise alignment of the optical components. The orthogonal optical head assemblies of the present invention are well suited to accommodate the shutoff mechanisms of the present invention. The open architecture of the orthogonal assembly also facilitates the placement of lenses and/or filters within the head assembly, and also accommodates other elements, such as energy absorbing chambers, within the head assembly. In another aspect of the invention, sampling tubes, and replaceable end caps for such tubes, are disclosed that facilitate hand measurements of substances.

Abstract translation: 公开了用于便携式和/或手持式分析仪的拉曼光谱探测器组件。 探针还适用于液体和/或粉末，片剂和/或其他固体的样品，并能够承受恶劣的环境条件。 探头包括光头组件，相关联的光纤和可更换的采样管。 提供安全关闭机制，以减少无意中暴露于辐射的风险。 在一个实施例中，切断开关是仅在预定义的适当操作条件下由螺线管打开的弹簧偏压快门。 在本发明的另一方面，公开了一种不需要共线光路的简单正交光学头组件。 输入和捕获的光路的正交布置也减少了对光学部件的精确对准的需要。 本发明的正交光学头组件非常适合于适应本发明的切断机构。 正交组件的开放结构也有助于将头部组件内的透镜和/或过滤器放置，并且还容纳头部组件内的其它元件，例如能量吸收室。 在本发明的另一方面，公开了用于这种管的取样管和可替换的端盖，其便于手测量物质。

公开(公告)号：US20040150818A1

公开(公告)日：2004-08-05

申请号：US10661319

申请日：2003-09-12

Inventor： Robert L. Armstrong ,  Vladimir M. Shalaev ,  Harold V. Smith ,  Andrey K. Sarychev ,  Z. Charles Ying

IPC: G01J003/44

CPC classification number: B82Y20/00 ,  B82Y10/00 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/655 ,  G02F1/353 ,  G02F1/3534 ,  G02F1/3536 ,  G02F1/3538 ,  G02F1/355 ,  G02F1/37 ,  G02F1/39 ,  G02F2202/36 ,  G02F2203/15 ,  G11B7/00453 ,  H01S3/0602 ,  H01S3/30

Abstract: An optical sensing enhancing material (and corresponding method of making) comprising: a medium, the medium comprising a plurality of aggregated nanoparticles comprising fractals; and a microcavity, wherein the medium is located in a vicinity of the microcavity. Also an optical sensor and sensing method comprising: providing a doped medium, the medium comprising a plurality of aggregated nanoparticles comprising fractals, with the material; locating the doped medium in the vicinity of a microcavity; exciting the doped medium with a light source; and detecting light reflected from the doped medium. Also an optical sensing enhancing material comprising a medium, the medium comprising a semicontinuous metal film of randomly distributed metal particles and their clusters at approximately their percolation threshold. The medium preferably additionally comprises a microcavity/microresonator. Also devices and methods employing such material.

Abstract translation: 一种光学感测增强材料（和相应的制备方法），包括：介质，所述介质包含多个包含分形的聚集的纳米颗粒; 和微腔，其中介质位于微腔附近。 还有一种光学传感器和感测方法，包括：提供掺杂介质，所述介质包含多个包含分形的聚集的纳米颗粒与所述材料; 将掺杂介质定位在微腔附近; 用光源激发掺杂介质; 以及检测从掺杂介质反射的光。 还有一种包括介质的光学感测增强材料，该介质包括大致其渗透阈值下随机分布的金属颗粒及其簇的半连续金属膜。 该介质优选地另外包括微腔/微谐振器。 也是采用这种材料的装置和方法。

公开(公告)号：US20040135997A1

公开(公告)日：2004-07-15

申请号：US10680583

申请日：2003-10-07

Inventor： Selena Chan ,  Andrew A. Berlin ,  Sunghoon Kwon ,  Narayanan Sundararajan ,  Mineo Yamakawa

IPC: G01J003/44 ,  G01N021/65

CPC classification number: C12Q1/6825 ,  B82Y15/00 ,  B82Y30/00 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/6439 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/632 ,  C12Q2563/155

Abstract: The disclosed methods and apparatus concern Raman spectroscopy using metal coated nanocrystalline porous silicon substrates. Porous silicon substrates may be formed by anodic etching in dilute hydrofluoric acid. A thin coating of a Raman active metal, such as gold or silver, may be coated onto the porous silicon by cathodic electromigration or any known technique. In certain alternatives, the metal coated porous silicon substrate comprises a plasma-oxidized, dip and decomposed porous silicon substrate. The metal-coated substrate provides an extensive, metal rich environment for SERS, SERRS, hyper-Raman and/or CARS Raman spectroscopy. In certain alternatives, metal nanoparticles may be added to the metal-coated substrate to further enhance the Raman signals. Raman spectroscopy may be used to detect, identify and/or quantify a wide variety of analytes, using the disclosed methods and apparatus. In some disclosed methods, Raman spectroscopy may be used to detect nucleotides, purines or pyrimidines at the single molecule level.

Abstract translation: 所公开的方法和装置涉及使用金属涂覆的纳米晶体多孔硅衬底的拉曼光谱。 多孔硅衬底可以通过在稀氢氟酸中的阳极蚀刻形成。 拉曼活性金属如金或银的薄涂层可以通过阴极电迁移或任何已知技术涂覆在多孔硅上。 在某些替代方案中，金属涂覆的多孔硅衬底包括等离子体氧化的，浸渍和分解的多孔硅衬底。 金属涂层的基底为SERS，SERRS，超拉曼和/或CARS拉曼光谱提供了广泛的金属丰富的环境。 在某些替代方案中，可以将金属纳米颗粒加入到金属涂覆的基底中以进一步增强拉曼信号。 使用所公开的方法和装置，可以使用拉曼光谱来检测，鉴定和/或定量各种分析物。 在一些公开的方法中，可以使用拉曼光谱法在单一分子水平检测核苷酸，嘌呤或嘧啶。

公开(公告)号：US20030160955A1

公开(公告)日：2003-08-28

申请号：US10345677

申请日：2003-01-16

Inventor： Xiaoliang Sunney Xie ,  Ji-Xin Cheng ,  Andreas Volkmer

IPC: G01J003/44 ,  G01N021/65

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N15/1434 ,  G01N15/1475 ,  G01N2015/1006 ,  G01N2021/653

Abstract: Systems and methods are disclosed for detecting a coherent anti-Stokes Raman scattering (CARS) signal from a microscopic sample in an epi-direction. In an embodiment, the system includes at least two sources having a pump source for generating a pump field at the pump frequency, a Stoke source for generating a Stoke field at the Stoke frequency that is different from the pump frequency, optics (64) for directing the pump and Stoke beams (60) in a collinear fashion through a focusing lens (66) toward a common focal spot in a sample (70), and detector optics that images the CARS in epi-direction, which is generated by the interaction of the pump and Stoke fields (60) with the sample (70) and is collected by the same focusing lens (66), towards an epi-detector (78).

Abstract translation: 公开了用于从表面方向检测来自微观样品的相干反斯托克斯拉曼散射（CARS）信号的系统和方法。 在一个实施例中，该系统包括至少两个源，其具有用于产生泵频率的泵浦场的泵浦源，用于产生Stoke频率不同于泵浦频率的Stoke场的Stoke源，用于 将泵和Stoke梁（60）以共线的方式通过聚焦透镜（66）朝向样品（70）中的公共焦斑引导，以及检测器光学器件，其通过相互作用产生的外延方向成像CARS 的泵和Stoke磁场（60）与样品（70）并且被相同的聚焦透镜（66）收集到外部探测器（78）。