公开(公告)号：US20150103354A1

公开(公告)日：2015-04-16

申请号：US14518974

申请日：2014-10-20

Applicant: Precisive, LLC

Inventor： Vidi A. Saptari

IPC: G01J3/02 ,  G01J3/28 ,  G01N21/27

CPC classification number: G01J3/06 ,  G01J3/32 ,  G01J2003/1247 ,  G01N21/255 ,  G01N21/314 ,  G01N21/33 ,  G01N21/3504 ,  G01N2021/3174 ,  G01N2201/129

Abstract: The invention provides spectroscopic systems and spectrometers employing an optical interference filter module having a plurality of bandpass regions. In certain embodiments, the systems include a mechanism for wavelength tuning/scanning and wavelength band decoding based on an angular motion of one or more filters. A spectral processing algorithm separates the multiplexed wavelength-scanned bandpass regions and quantifies the concentrations of the analyzed chemical and/or biological species. The spectroscopic system allows for compact, multi-compound analysis, employing a single-element detector for maximum performance-to-cost ratio. The spectroscopic system also allows for high-sensitivity measurement and robust interference compensation.

Abstract translation: 本发明提供了使用具有多个带通区域的光学干涉滤光器模块的光谱系统和光谱仪。 在某些实施例中，系统包括用于波长调谐/扫描和基于一个或多个滤波器的角运动的波段解码的机构。 光谱处理算法分离复用的波长扫描带通区域并量化分析的化学和/或生物物种的浓度。 光谱系统允许使用单元素检测器进行紧凑，多重复合分析，以获得最大的性能与成本比。 光谱系统还允许高灵敏度测量和鲁棒干扰补偿。

公开(公告)号：US20150036138A1

公开(公告)日：2015-02-05

申请号：US13958909

申请日：2013-08-05

Applicant: TellSpec Inc.

Inventor： William Stephen Watson ,  Isabel De Oliveira Correa

IPC: G01N21/25

CPC classification number: G01N21/31 ,  A61B10/0045 ,  A61B2010/0083 ,  G01N21/64 ,  G01N21/65 ,  G01N33/02 ,  G01N2021/6493 ,  G01N2201/0221 ,  G01N2201/12 ,  G01N2201/129 ,  G01N2201/1293

Abstract: Obtaining two spectra from the same sample under two different conditions at about the same time for comparison, where at least one of the spectra measures magnitudes of electromagnetic radiation on at least four different ranges or weightings of wavelengths or frequencies. Classifying a sample using these spectra obtained by a user, and using spectra obtained from different samples by different users to identify the sample. Computing correlations between data related to food and ingredient consumption by one or more users over time, and data related to passive personal log data, user entered feedback, user interaction data or personal information related to those users, and detecting: foods or ingredients to which a user may be allergic or intolerant; a possible medical condition of a user; a possible link between food and ingredient consumption and a medical or health condition; or a similarity between at least two such users.

Abstract translation: 在两个不同的条件下，在两个不同的条件下从相同的样品获得两个光谱，大约在同一时间进行比较，其中至少一个光谱测量了至少四个不同的波长或频率范围或重量的电磁辐射的幅度。 使用用户获得的这些光谱对样品进行分类，并使用不同用户从不同样品获得的光谱来鉴定样品。 随着时间的推移，计算一个或多个用户与食物和成分消耗相关的数据之间的相关性，以及与被动个人日志数据，用户输入的反馈，用户交互数据或与这些用户相关的个人信息相关的数据，以及检测： 用户可能会过敏或不耐受; 用户可能的医疗状况; 食物和成分消耗与医疗或健康状况之间的可能联系; 或至少两个此类用户之间的相似性。

公开(公告)号：US08936754B2

公开(公告)日：2015-01-20

申请号：US13129812

申请日：2009-11-12

Applicant: Isao Yamazaki ,  Hiroaki Ishizawa ,  Sakuichiro Adachi

Inventor： Isao Yamazaki ,  Hiroaki Ishizawa ,  Sakuichiro Adachi

IPC: G01N21/31 ,  G01N21/27 ,  G01N21/17 ,  G01N21/62 ,  G01N21/82 ,  G01N35/02

CPC classification number: G01N21/274 ,  G01N21/17 ,  G01N21/27 ,  G01N21/62 ,  G01N21/82 ,  G01N35/025 ,  G01N2201/129 ,  G01N2201/1293 ,  Y10T436/111666

Abstract: There is provided a high-accuracy automatic analysis device achieving both of measurement in a wide concentration range and high sensitivity at a low concentration. The signals of a plurality of wavelengths λ1 to λ12 where the sensitivity of light absorption caused by fine particles is high from a light source 40 are converted to absorbances by a spectroscopic optical system (detector) 41. The absorbances are converted to a secondary parameter from in which a noise component is cancelled by using a previously-defined conversion table 54, so that a concentration of a measured material (predetermined component) is calculated by an operation unit (calculating means) 53 based on the secondary parameter. Thus, analysis being resistant to the noise even at the low concentration can be achieved in a range up to a high concentration.

Abstract translation: 提供了一种高精度自动分析装置，其在宽浓度范围内测量和低浓度下的高灵敏度。 由光源40将由微粒引起的光吸收的敏感度高的多个波长λ1〜λ12的信号通过分光光学系统（检测器）41转换为吸光度。吸光度被转换为二次参数 其中通过使用预定义的转换表54来消除噪声分量，使得基于次要参数由操作单元（计算装置）53计算测量材料（预定分量）的浓度。 因此，即使在低浓度下也能够抵抗噪声的分析，可以在高浓度的范围内实现。

公开(公告)号：US20140377795A1

公开(公告)日：2014-12-25

申请号：US14367060

申请日：2012-12-19

Applicant: OPTICUL DIAGNOSTICS LTD. ,  OPTICUL DIAGNOSTICS Inc.

Inventor： Gallya Gannot ,  Dror Lederman ,  Moinuddin Hassan ,  Israel Gannot

IPC: C12Q1/04 ,  G01N21/65 ,  G01N21/25

CPC classification number: C12Q1/04 ,  C12M41/36 ,  G01N21/255 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/64 ,  G01N21/65 ,  G01N2021/1742 ,  G01N2021/1744 ,  G01N2021/3595 ,  G01N2021/6417 ,  G01N2201/06113 ,  G01N2201/129 ,  G01N2201/1296 ,  G06F19/10

Abstract: A spectroscopic method for spectroscopic detection and identification of bacteria in culture is disclosed. The method incorporates construction of at least one data set, which may be a spectrum, interference pattern, or scattering pattern, from a cultured sample suspected of containing said bacteria. The data set is corrected for the presence of water in the sample, spectral features are extracted using a principal components analysis, and the features are classified using a learning algorithm. In some embodiments of the invention, for example, to differentiate MRSA from MSSA, a multimodal analysis is performed in which identification of the bacteria is made based on a spectrum of the sample, an interference pattern used to determine cell wall thickness, and a scattering pattern used to determine cell wall roughness. An apparatus for performing the method is also disclosed, one embodiment of which incorporates a multiple sample analyzer.

Abstract translation: 公开了用于光谱检测和鉴定培养细菌的光谱方法。 该方法包括来自怀疑含有所述细菌的培养样品的至少一个数据集的构建，其可以是光谱，干涉图案或散射图案。 对样品中水的存在进行数据集的校正，使用主成分分析提取光谱特征，并使用学习算法对特征进行分类。 在本发明的一些实施方案中，例如为了区分MRSA和MSSA，进行多模态分析，其中基于样品的光谱，用于确定细胞壁厚度的干涉图案和散射来确定细菌的鉴定 用于确定细胞壁粗糙度的图案。 还公开了一种用于执行该方法的装置，其一个实施例包括多个样本分析器。

公开(公告)号：US08843324B2

公开(公告)日：2014-09-23

申请号：US12931520

申请日：2011-02-03

Applicant: Yves Lacombe

Inventor： Yves Lacombe

IPC: G01N21/27 ,  G01N21/35 ,  G01N21/85

CPC classification number: G01N21/359 ,  G01N21/274 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/85 ,  G01N2201/129

Abstract: The present invention provides a method to calibrate a NIR analyzer to measure monomer concentrations at one or more locations in a reactor system. The regression coefficients for the NIR analyzer are transferable between reactors using the same process (solution polymerization to solution polymerization) and may be used to control the reaction, or calibrate flow meters on line.

Abstract translation: 本发明提供了一种校准NIR分析仪以测量反应器系统中一个或多个位置处的单体浓度的方法。 NIR分析仪的回归系数可以在反应器之间使用相同的方法（溶液聚合至溶液聚合）转移，并可用于控制反应或校准流量计在线。

公开(公告)号：US08699022B2

公开(公告)日：2014-04-15

申请号：US13760349

申请日：2013-02-06

Applicant: Materialytics, LLC

Inventor： Catherine E. McManus ,  James W. Dowe, III ,  Tristan M. Likes ,  James W. Dowe, IV

IPC: G01J3/30 ,  G01J3/36

CPC classification number: G01N21/62 ,  G01N21/63 ,  G01N21/718 ,  G01N21/87 ,  G01N2201/129 ,  G06F17/00 ,  G06F19/703

Abstract: This disclosure relates to a method for analyzing a sample of material. The method includes (a) converting a portion of the sample into a plasma multiple times; (b) recording a spectrum of electromagnetic radiation emitted in response to each of the sample conversions to define a sequence of spectra for the sample, in which each member of the sequence corresponds to the spectrum recorded in response to a different one of the sample conversions; (c) using an electronic processor to compare the sequence of spectra for the sample to a sequence of spectra for each of at least one reference sample in a reference library; and (d) using the electronic processor to determine information about the sample based on the comparison to the reference samples in the library.

Abstract translation: 本公开涉及一种用于分析材料样品的方法。 该方法包括（a）将样品的一部分转换成等离子体多次; （b）响应于每个样品转换记录发射的电磁辐射谱，以定义样品的光谱序列，其中序列的每个成员对应于响应不同的样品转化而记录的光谱 ; （c）使用电子处理器将样品的光谱序列与参考文库中的至少一个参考样品中的每一个的光谱序列进行比较; 以及（d）使用电子处理器基于与图书馆中的参考样本的比较来确定关于样本的信息。

公开(公告)号：US20140016116A1

公开(公告)日：2014-01-16

申请号：US13987046

申请日：2013-06-28

Applicant: Chemlmage Corporation

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01N21/84

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

公开(公告)号：US20130314695A1

公开(公告)日：2013-11-28

申请号：US13479982

申请日：2012-05-24

Applicant: Melissa Weston ,  Kurt Hoeman ,  Robert P. Freese ,  Johanna Haggstrom

Inventor： Melissa Weston ,  Kurt Hoeman ,  Robert P. Freese ,  Johanna Haggstrom

IPC: G01J3/28

CPC classification number: G01N21/3577 ,  G01N2201/129

Abstract: Spectroscopic analyses of complex mixtures within the matrix of a sample can oftentimes be complicated by spectral overlap of the constituents and/or the matrix, making it difficult to quantitatively assay each constituent therein. Methods for analyzing a sample can comprise: providing a sample comprising a matrix and one or more constituents therein; exposing the sample to electromagnetic radiation in a spectral region where the matrix optically interacts with the electromagnetic radiation, so as to acquire a spectrum of the matrix; and analyzing the spectrum of the matrix within a wavelength range where the matrix has a molar extinction coefficient of at least about 0.01 M−1mm−1 to determine at least one property of the sample, the at least one property of the sample being selected from the group consisting of a concentration of at least one constituent in the sample, at least one characteristic of the sample, and any combination thereof.

Abstract translation: 在样品基质内的复杂混合物的光谱分析通常可能由于组分和/或基质的光谱重叠而复杂化，使得难以定量地测定其中的每种组分。 用于分析样品的方法可以包括：提供包含基质和一种或多种组分的样品; 将样品暴露于光谱区域中的电磁辐射，其中矩阵与电磁辐射光学相互作用，以便获得矩阵的光谱; 以及在所述基质具有至少约0.01M-1mm-1的摩尔消光系数的波长范围内分析所述基质的光谱以确定所述样品的至少一种性质，所述样品的所述至少一种性质选自 由样品中至少一种成分的浓度，样品的至少一种特征以及它们的任何组合组成的组。

公开(公告)号：US08553221B2

公开(公告)日：2013-10-08

申请号：US13547469

申请日：2012-07-12

Applicant: Boris Leonidovich Volodin ,  Vladimir Sinisa Ban

Inventor： Boris Leonidovich Volodin ,  Vladimir Sinisa Ban

IPC: G01J3/44

CPC classification number: G01J3/0256 ,  G01J3/00 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/104 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/1793 ,  G01N2201/0221 ,  G01N2201/129 ,  G01N2201/1296 ,  G02B6/29319 ,  H01S5/005 ,  H01S5/32 ,  H01S5/4012 ,  H01S5/4087

Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. An optical switch may provide switching between the first and second laser sources. An ensemble of individually addressable laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.

Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 光学开关可以提供第一和第二激光源之间的切换。 可以提供可单独寻址的激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。

公开(公告)号：US20130261224A1

公开(公告)日：2013-10-03

申请号：US13991832

申请日：2011-12-21

Applicant: Kishori Deshpande ,  Serena K. Stephenson ,  Ravindra S. Dixit

Inventor： Kishori Deshpande ,  Serena K. Stephenson ,  Ravindra S. Dixit

IPC: C08F210/14

CPC classification number: C08F210/14 ,  C08F10/02 ,  C08F210/16 ,  C08F2400/02 ,  G01N21/65 ,  G01N2021/8416 ,  G01N2201/129 ,  C08F2/00 ,  C08F2/14 ,  C08F2500/08

Abstract: The invention provides a process for monitoring and/or adjusting a dispersion polymerization of an olefin-based polymer, the process comprising monitoring the concentration of the carbon-carbon unsaturations in the dispersion using Raman Spectroscopy. The invention also provides a process for polymerizing an olefin-based polymer, the process comprising polymerizing one or more monomer types, in the presence of at least one catalyst and at least one solvent, to form the polymer as a dispersed phase in the solvent; and monitoring the concentration of the carbon-carbon unsaturations in the dispersion using Raman Spectroscopy.

Abstract translation: 本发明提供了一种用于监测和/或调节烯烃基聚合物的分散聚合的方法，该方法包括使用拉曼光谱法监测分散体中的碳 - 碳不饱和度的浓度。 本发明还提供了一种聚合基于烯烃的聚合物的方法，该方法包括在至少一种催化剂和至少一种溶剂的存在下使一种或多种单体类型聚合，以形成分散相在聚合物中的溶剂; 并使用拉曼光谱法监测分散体中碳 - 碳不饱和度的浓度。