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31.发明授权公开(公告)号：US12158505B2
公开(公告)日：2024-12-03
申请号：US18539619
申请日：2023-12-14
Applicant: California Institute of Technology
Inventor： Farshid Roumi , Jamshid Roumi
IPC: G01R31/385 , G01R31/382 , G01R31/64 , H01M10/42 , H01M10/48 , G01R19/165 , G01R29/08 , G01R31/392 , G01R31/50 , G01R31/52 , H01G11/14
Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
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公开(公告)号：US12157705B2
公开(公告)日：2024-12-03
申请号：US18228369
申请日：2023-07-31
Applicant: California Institute of Technology
Inventor： Katherine T. Faber , Julia A. Kornfield , Noriaki Arai , Orland Bateman , Rustem F. Ismagilov
IPC: C04B38/06 , B01D67/00 , B01D69/02 , B01D71/02 , B01J35/56 , B01J35/64 , C04B38/00 , H01B1/14 , H01B1/16
Abstract: Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material.
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公开(公告)号：US20240395397A1
公开(公告)日：2024-11-28
申请号：US18667828
申请日：2024-05-17
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F ISMAGILOV , Minkyo LEE , Si Hyung JIN , Matthew M COOPER , Roey LAZAROVITS
IPC: G16H40/20
Abstract: An interactive modular device for instructing and assisting users on sample handling processes using features to guide a user through the processes in real time. The modules of the device include a processing module (e.g., pooling module), a sample-container module (e.g., tube module), a container-closure module (e.g., cap module), a sample-transfer module (e.g., pipette module), a scanning module (e.g., single barcode module), a multi-scanning module (e.g., multi-barcode module), a waste container module, and a display module. The features include mechanisms to determine presence and absence of items used for sample handling and visual, audible, and tactile indicators in real time.
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34.发明授权公开(公告)号：US12152260B2
公开(公告)日：2024-11-26
申请号：US18333344
申请日：2023-06-12
Applicant: California Institute of Technology
Inventor： Yuki Oka , Allan-Hermann Pool
IPC: C12N9/22 , A61K9/00 , A61K35/12 , A61K38/00 , A61K48/00 , A61P25/04 , A61P25/28 , C12N15/11 , C12N15/86 , C12N15/90
Abstract: Disclosed herein include methods and compositions for incorporating an effector gene into the genome of a cell. The method can comprise introducing into a cell a donor nucleic acid comprising a recognition site, a splice acceptor site, a self-cleaving peptide sequence, an effector gene, and an optional transcript stabilization element. The donor nucleic acid can be incorporated into the intron of a target gene differentially expressed in a unique cell type and/or in a cell during a unique cell state via non-homologous end joining (NHEJ)-dependent DNA repair. There are also provided, in some embodiments, methods and compositions for treating a disease or disorder in a subject.
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公开(公告)号：US20240386629A1
公开(公告)日：2024-11-21
申请号：US18658435
申请日：2024-05-08
Applicant: California Institute of Technology
Inventor： Peng Hu , Lihong Wang
Abstract: Certain aspects pertain to intra-image motion correction methods and systems configured to divide an image domain into subdomains and estimate motion of each subdomain along one or more axes and determine a motion corrected image based on the motions.
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Patent Agency Ranking
公开(公告)号：US20240384331A1
公开(公告)日：2024-11-21
申请号：US18555204
申请日：2022-04-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Long CAI , Yodai TAKEI
IPC: C12Q1/6841 , C12Q1/6876
Abstract: The present disclosure provides methods for analyzing genomic structures by diffraction limited locus imaging and nucleic acid block coding. The methods allow efficient and scalable imaging, which can be applied to multiplexed RNA/DNA fluorescence in situ hybridization (FISH).
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公开(公告)号：US20240376490A1
公开(公告)日：2024-11-14
申请号：US18731302
申请日：2024-06-02
Applicant: California Institute of Technology
Inventor： Yitong Ma , Mark W. Budde , Michaelle N. Mayalu , Michael B. Elowitz
IPC: C12N15/85 , C07K14/415 , C12N9/02 , C12N9/86 , C12N15/11
Abstract: Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.
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公开(公告)号：US12136735B2
公开(公告)日：2024-11-05
申请号：US16444854
申请日：2019-06-18
Applicant: HONDA MOTOR CO., LTD. , California Institute of Technology
Inventor： Qingmin Xu , Christopher Brooks , Ryan McKenney , Thomas Miller, III , Simon C. Jones , Steve Munoz , Victoria Davis
Abstract: An electrochemically active structure having a core and a shell at least partially surrounding the core. Also a method of making the electrochemically active structure as described herein as well as electrochemical cells comprising the electrochemically active structure as described herein.
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公开(公告)号：US20240358328A1
公开(公告)日：2024-10-31
申请号：US18662992
申请日：2024-05-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
IPC: A61B5/00 , A61B5/145 , A61B5/1486 , A61B10/00 , H01M8/16
CPC classification number: A61B5/6832 , A61B5/0004 , A61B5/002 , A61B5/14517 , A61B5/1486 , H01M8/16 , A61B10/0051 , A61B10/0064 , A61B2010/0067 , A61B10/007 , A61B2560/0214
Abstract: An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.
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公开(公告)号：US12129272B2
公开(公告)日：2024-10-29
申请号：US18104297
申请日：2023-02-01
Inventor： William M. Clemons , Michio Kurosu
IPC: C07H19/06 , A61K31/337 , A61K31/7072 , C07H1/00
CPC classification number: C07H19/06 , C07H1/00 , A61K31/337 , A61K31/7072
Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein.
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