公开(公告)号：US20210079001A1

公开(公告)日：2021-03-18

申请号：US16967100

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Hilary Plake BECK ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D487/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R1, X1, Ar1 and Ar2 have the meanings provided in the specification.

公开(公告)号：US20240207257A1

公开(公告)日：2024-06-27

申请号：US18555058

申请日：2022-04-14

Applicant: IDEAYA BIOSCIENCES, INC. ,  PFIZER, INC.

Inventor： Matthew Anthony MAURER ,  Michael Gabriel O'QUIGLEY ,  Jaymes HOLLAND ,  Sarah Shwu-Kuan Jaw-Tsai ,  Julie Hambleton ,  MAI HOPE LE

IPC: A61K31/497 ,  A61K31/4184 ,  A61P35/00

CPC classification number: A61K31/497 ,  A61K31/4184 ,  A61P35/00

Abstract: Provided herein is a combination therapy and methods of using such combination therapy to treat diseases or disorders associated with PKC and MEK.

公开(公告)号：US20240173326A1

公开(公告)日：2024-05-30

申请号：US18405638

申请日：2024-01-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Michael Patrick DILLON ,  Claire L. NEILAN ,  Marcus Michael FISCHER ,  Kimberline Yang GERRICK

IPC: A61K31/519 ,  A61K31/502 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/502 ,  A61P35/00

Abstract: Provided herein is a combination product comprising a methionine adenosyltransferase II alpha (MAT2A) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The combination product is useful for the treatment of a variety of cancers, including solid tumors. The combination product is useful for the treatment of any number of MAT2A-associated and/or PRMT-associated diseases.

公开(公告)号：US20240108626A1

公开(公告)日：2024-04-04

申请号：US18501729

申请日：2023-11-03

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Michael Patrick DILLON ,  Claire L. NEILAN ,  Marcus Michael FISCHER ,  Kimberline Yang GERRICK

IPC: A61K31/519 ,  A61K31/502 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/502 ,  A61P35/00

Abstract: Provided herein is a combination product comprising a methionine adenosyltransferase II alpha (MAT2A) inhibitor and a Type II protein arginine methyltransferase (Type II PRMT) inhibitor. The combination product is useful for the treatment of a variety of cancers, including solid tumors. The combination product is useful for the treatment of any number of MAT2A-associated and/or PRMT-associated diseases.

公开(公告)号：US20230257359A1

公开(公告)日：2023-08-17

申请号：US18009194

申请日：2021-06-09

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Leah CLEARY ,  Melissa FLEURY ,  Zhonghua PEI ,  Richard STEEL

IPC: C07D401/04 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61P35/00

Abstract: Disclosed herein are certain 4-arylquinazoline derivatives of Formula (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

公开(公告)号：US11584755B2

公开(公告)日：2023-02-21

申请号：US16648865

申请日：2018-09-25

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Hilary Plake Beck ,  Leah Brigit Cleary ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Luis Ruben P. Martinez ,  James Clifford Sutton, Jr.

IPC: C07D495/04 ,  A61P35/00 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/519 ,  C07D519/00

Abstract: Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.

公开(公告)号：US11548867B2

公开(公告)日：2023-01-10

申请号：US16631738

申请日：2018-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar Alam ,  Hilary Plake Beck ,  Michael Patrick Dillon ,  Marcos Gonzalez-Lopez ,  Alice Chen Rico ,  James Clifford Sutton, Jr.

IPC: C07D401/12 ,  C07D215/12 ,  C07D217/18 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

公开(公告)号：US20220389003A1

公开(公告)日：2022-12-08

申请号：US17761935

申请日：2020-09-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： James Clifford SUTTON, Jr. ,  Michael Patrick Dillon

IPC: C07D417/14 ,  C07D417/04

Abstract: Provided herein are compounds having the formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Ar, X1, X2, and ring B have the meanings as provided herein. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors.

公开(公告)号：US20220340875A1

公开(公告)日：2022-10-27

申请号：US17260936

申请日：2019-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  Alice Chen RICO ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae: wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

公开(公告)号：US20220305008A1

公开(公告)日：2022-09-29

申请号：US17420833

申请日：2020-01-07

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： John Knox ,  Mark Lackner ,  Zineb Mounir ,  Carol O'Brien

IPC: A61K31/497 ,  A61K31/506 ,  C12Q1/6886 ,  A61P35/00

Abstract: The present disclosure relates in part to methods for treating non-uveal melanoma cancers having GNAQ or GNA11 genetic mutations that include administering a PKC small molecule inhibitor.