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    Method for dispensing drops of different volumes
    31.
    发明授权
    Method for dispensing drops of different volumes 有权

    公开(公告)号：US11040341B2

    公开(公告)日：2021-06-22

    申请号：US15886744

    申请日：2018-02-01

    Applicant: Labcyte Inc.

    Inventor： Michael James Forbush

    IPC: B01L3/02 ,  G01N35/10

    Abstract: A method that allows a user to dispense a desired volume of solution from an acoustic dispensing apparatus by allowing the user to select the drop volume to be dispensed. A typical drop volume is in the range of one to twenty-five nanoliters. The method comprises the steps of creating two or more burst curves that give the relationship between liquid level and burst value, using data from the burst curves to create two or more calibration functions, and using data from the calibration functions to create a dispensing data set that is used to set the burst parameter required to dispense the selected drop volume.

    Focused acoustic radiation for the ejection of sub wavelength droplets
    32.
    发明授权
    Focused acoustic radiation for the ejection of sub wavelength droplets 有权

    公开(公告)号：US11033895B1

    公开(公告)日：2021-06-15

    申请号：US16222737

    申请日：2018-12-17

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: H01J49/04 ,  B01L3/02

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    Sample containers having identification marks embedded therein and being adapted for acoustic ejections
    35.
    发明授权
    Sample containers having identification marks embedded therein and being adapted for acoustic ejections 有权

    公开(公告)号：US10592793B2

    公开(公告)日：2020-03-17

    申请号：US14595073

    申请日：2015-01-12

    Applicant: LABCYTE INC.

    Inventor： Lars Majlof ,  Richard N. Ellson

    IPC: G06K19/06 ,  B01L3/00 ,  G06K1/12

    Abstract: A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. The container further may include an identification mark embedded within the tubular sidewall at a plurality of sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. An exemplary method for preparing such a container is also provided.

    AVOIDANCE OF BOUNCING AND SPLASHING IN DROPLET-BASED FLUID TRANSPORT
    36.
    发明申请
    AVOIDANCE OF BOUNCING AND SPLASHING IN DROPLET-BASED FLUID TRANSPORT 审中-公开

    公开(公告)号：US20190160478A1

    公开(公告)日：2019-05-30

    申请号：US16135337

    申请日：2018-09-19

    Applicant: LABCYTE INC.

    Inventor： Richard G. Stearns ,  Stephen J. Hinkson

    IPC: B05B5/00 ,  B05B17/06 ,  G01N35/10 ,  B01L3/02

    Abstract: A system for fluid transport is provided where a quantity of fluid is held in a reservoir. A droplet generator is employed to generate droplets from the fluid, for example a nozzle-based system or a nozzleless system such as an acoustic ejection system. A generated droplet has a trajectory whereby it arrives at a target. A circuit is used to modify one or more characteristics of the generated droplet in a way which increases the likelihood that the droplet will not splash or bounce when it arrives at the target. The circuit may in different embodiments control the speed of the droplet or the Weber number of the droplet. The circuit may create an electric field in an area of space where the droplet passes. The circuit may charge the droplet by causing it to contact ions.

    Method and system for determining the concentration of an analyte in a fluid sample
    37.
    发明授权
    Method and system for determining the concentration of an analyte in a fluid sample 有权

    公开(公告)号：US09939352B2

    公开(公告)日：2018-04-10

    申请号：US14887320

    申请日：2015-10-19

    Applicant: Labcyte Inc.

    Inventor： Richard N. Ellson ,  Richard G. Stearns ,  Joseph D. Olechno ,  Ian Sinclair ,  Jonathan Wingfield

    IPC: G01N1/28 ,  H01J49/04 ,  C12Q1/68 ,  G01N33/68

    CPC classification number: G01N1/28 ,  C12Q1/68 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/04 ,  H01J49/0422 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25875

    Abstract: A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.

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