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    FREQUENCY DECOUPLING IN DYNAMIC FLUIDIC ANALYSIS AND ACOUSTIC DROPLET EJECTION
    1.
    发明申请
    FREQUENCY DECOUPLING IN DYNAMIC FLUIDIC ANALYSIS AND ACOUSTIC DROPLET EJECTION 有权

    公开(公告)号：US20250166984A1

    公开(公告)日：2025-05-22

    申请号：US18934048

    申请日：2024-10-31

    Applicant: Labcyte Inc.

    Inventor： Chang Liu ,  Jing Ma ,  Heguang Ji ,  Stephen Hinkson ,  Christian Miller ,  Xu Du

    IPC: H01J49/04 ,  H01J49/16

    Abstract: Systems and methods are disclosed herein that prevent over-production of acoustically ejected droplets into a mass spectrometer, without increase to the time required to conduct pre-ejection sample analysis. This is accomplished by decoupling the repetition rate of energy pulses delivered to the sample during an analysis mode from the repetition rate of energy pulses delivered to the sample during ejection mode. The repetition rate during analysis is higher than the repetition rate used during droplet ejection, which is reduced to a level that can be ingested by the acoustically emitted mass spectrometry system.

    FOCUSED ACOUSTIC RADIATION FOR RAPID SEQUENTIAL EJECTION OF SUBWAVELENGTH DROPLETS
    3.
    发明公开
    FOCUSED ACOUSTIC RADIATION FOR RAPID SEQUENTIAL EJECTION OF SUBWAVELENGTH DROPLETS 审中-公开

    公开(公告)号：US20240290598A1

    公开(公告)日：2024-08-29

    申请号：US18657016

    申请日：2024-05-07

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: H01J49/04 ,  B01L3/00

    CPC classification number: H01J49/0445 ,  B01L3/502 ,  B01L2200/06 ,  B01L2200/14 ,  B01L2400/0436

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. In one embodiment, a first toneburst is applied to temporarily raise a mound or protuberance on a free surface of the fluid. After the mound has reached a certain state, at least two additional toneburst can be applied to the protuberance to sequentially eject multiple bursts of multiple droplets. In one embodiment, the state of the mound can be maintained by a sustained acoustic signal, during which time multiple additional tonebursts can be applied to sequentially eject multiple bursts of multiple droplets from the mound.

    Focused acoustic radiation for the ejection of sub wavelength droplets
    4.
    发明授权
    Focused acoustic radiation for the ejection of sub wavelength droplets 有权

    公开(公告)号：US11717818B2

    公开(公告)日：2023-08-08

    申请号：US17321201

    申请日：2021-05-14

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: H01J49/04 ,  B01L3/02

    CPC classification number: B01L3/0268 ,  H01J49/0454 ,  B01L2200/0642 ,  B01L2200/141 ,  B01L2400/0436

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    ACOUSTIC DROPLET EJECTION OF NON-NEWTONIAN FLUIDS
    6.
    发明申请
    ACOUSTIC DROPLET EJECTION OF NON-NEWTONIAN FLUIDS 有权

    公开(公告)号：US20210394171A1

    公开(公告)日：2021-12-23

    申请号：US17289552

    申请日：2019-10-29

    Applicant: Labcyte Inc.

    Inventor： Sammy S. Datwani ,  Carson Riche ,  Marsha N. Blauwkamp ,  Justin Blonigan

    IPC: B01L3/02 ,  B05B17/06 ,  B01J19/26 ,  B01J19/00

    Abstract: Methods of ejecting droplets containing a non-Newtonian fluid by an acoustic droplet ejector can include applying a tone burst of focused acoustic energy to a fluid reservoir containing a non-Newtonian fluid at sufficient amplitude to effect droplet ejection according to a tone burst pattern. The tone burst pattern may include three discrete tone burst segments, the first tone burst segment having greater duration than the second and third segments, and third segment having greater duration than the second segment. The exact durations and amplitudes of the tone burst segments can be tuned to influence the ejection properties.

    ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS
    9.
    发明申请
    ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS 审中-公开

    公开(公告)号：US20180282781A1

    公开(公告)日：2018-10-04

    申请号：US15870541

    申请日：2018-01-12

    Applicant: Labcyte Inc.

    Inventor： Mitchell W. Mutz ,  Richard N. Ellson

    IPC: C12Q1/22

    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.

    ACOUSTICALLY EJECTING A DROPLET OF FLUID FROM A RESERVOIR BY AN ACOUSTIC FLUID EJECTION APPARATUS
    10.
    发明申请
    ACOUSTICALLY EJECTING A DROPLET OF FLUID FROM A RESERVOIR BY AN ACOUSTIC FLUID EJECTION APPARATUS 有权
    通过声音流体喷射装置从储存器呼出流出液体的液滴

    公开(公告)号：US20160243569A1

    公开(公告)日：2016-08-25

    申请号：US14944874

    申请日：2015-11-18

    Applicant: LABCYTE INC.

    Inventor： Richard G. STEARNS ,  Shehrzad Ahmed QURESHI

    IPC: B05B12/00 ,  B41J2/045

    CPC classification number: B05B12/004 ,  B01J2219/00362 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00677 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/0819 ,  B01L2400/0436 ,  B01L2400/0439 ,  B41J2/04541 ,  B41J2/04563 ,  B41J2/04575 ,  B41J2/0458 ,  B41J2/14008

    Abstract: The invention provides apparatuses and methods for acoustically ejecting the fluid from a reservoir contained in or disposed on a substrate. The reservoir has a portion adapted to contain a fluid, and an acoustic radiation generator is positioned in acoustic coupling relationship to the reservoir. Acoustic radiation generated by the acoustic radiation generator is transmitted through at least the portion of the reservoir to an analyzer. The analyzer is capable of determining the energy level of the transmitted acoustic radiation and raising the energy level of subsequent pulses to a level sufficient to eject fluid droplets from the reservoir. The invention is particularly suited for delivering fluid from a plurality of reservoirs in an accurate and efficient manner.

    Abstract translation: 本发明提供了用于从包含在或设置在基板上的储存器中喷射流体的装置和方法。 储存器具有适于容纳流体的部分，并且声辐射发生器被定位成与储存器的声耦合关系。 由声辐射发生器产生的声辐射通过至少一部分储存器传输到分析器。 分析仪能够确定所发射的声辐射的能量水平，并且将后续脉冲的能量水平提高到足以从储存器喷射流体液滴的水平。 本发明特别适用于以准确和有效的方式从多个储层输送流体。

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