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公开(公告)号：US08957368B2
公开(公告)日：2015-02-17
申请号：US14187613
申请日：2014-02-24
Applicant: Micromass UK Limited
Inventor： Daniel James Kenny
CPC classification number: H01J49/062 , H01J49/02 , H01J49/065 , H01J49/422
Abstract: An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments.
Abstract translation: 公开了一种离子导向器，其包括多个轴向分组的电极，其中电极的每个轴向分组包括已经被径向分割成多个电极段的环形或环形电极。
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公开(公告)号：US08803081B2
公开(公告)日：2014-08-12
申请号：US13891718
申请日：2013-05-10
Applicant: Micromass UK Limited
Inventor： Daniel James Kenny
CPC classification number: H01J49/0045 , H01J49/0031 , H01J49/06 , H01J49/10
Abstract: A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyzer for subsequent mass analysis.
Abstract translation: 公开了一种质谱仪，其包括离子阱和碎裂装置。 离子阱中的离子被分散以形成第一代碎片离子。 离子阱具有较高的质量截止。 然后将第一代碎片离子转移到碎片装置，碎裂装置被布置成具有基本上较低的低质量截止值。 第一代碎片离子在碎裂装置内碎裂，任何可以任选地存储在离子聚集区域中，然后被传递到质量分析器进行后续的质量分析。
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公开(公告)号：US20140117219A1
公开(公告)日：2014-05-01
申请号：US14003176
申请日：2012-03-07
Applicant: MICROMASS UK LIMITED
Inventor： Daniel James Kenny
CPC classification number: H01J49/0009 , H01J49/0031 , H01J49/40 , H01J49/4215
Abstract: A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.
Abstract translation: 公开了一种质谱法，其包括在实验运行或获取过程中自动校正四极质量过滤器或质量分析器的质量或质量与电荷比分辨率一次或多次，基于质量或质量的测量，确定或估计， 在相同的实验运行或采集期间或在之前的实验运行或采集期间获得的质谱或质谱数据中观察到的一个或多个参考离子的电荷比分辨率。
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公开(公告)号：US08642950B2
公开(公告)日：2014-02-04
申请号：US13848504
申请日：2013-03-21
Applicant: Micromass UK Limited
Inventor： Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap.
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公开(公告)号：US10679840B2
公开(公告)日：2020-06-09
申请号：US16256687
申请日：2019-01-24
Applicant: Micromass UK Limited
Inventor： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
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Patent Agency Ranking
公开(公告)号：US20200006044A1
公开(公告)日：2020-01-02
申请号：US16559150
申请日：2019-09-03
Applicant: Micromass UK Limited
Inventor： David Gordon , Joseph Jarrell , Daniel James Kenny , Stephen O'Brien , Ian Trivett
Abstract: An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body (325) having a sampling orifice (329). The sampling limiting body (325) comprises a nickel disk wherein the disk and sampling orifice (329) are made or formed by an electroforming process.
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公开(公告)号：US10446378B2
公开(公告)日：2019-10-15
申请号：US15022677
申请日：2014-09-17
Applicant: Micromass UK Limited
Inventor： David Gordon , Joseph Jarrell , Daniel James Kenny , Stephen O'Brien , Ian Trivett
Abstract: An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body having a sampling orifice. The sampling limiting body comprises a nickel disk wherein the disk and sampling orifice are made or formed by an electroforming process.
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公开(公告)号：US10424473B2
公开(公告)日：2019-09-24
申请号：US16106774
申请日：2018-08-21
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
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公开(公告)号：US10304674B2
公开(公告)日：2019-05-28
申请号：US15504434
申请日：2015-08-19
Applicant: Micromass UK Limited
Inventor： Daniel James Kenny , Jason Lee Wildgoose
Abstract: There is provided a mass spectrometer comprising a time of flight mass analyzer comprising an acceleration electrode, a time of flight region and an ion detector, and a control system arranged and adapted (i) to apply a plurality of extraction pulses to said acceleration electrode in order to accelerate consecutive groups of ions into said time of flight region, wherein ions having a relatively high mass to charge ratio in a preceding group of ions arrive at said detector after ions having a relatively low mass to charge ratio in a subsequent group of ions, wherein ions within each consecutive group of ions have a mass to charge ratio within one or more predetermined, selected or otherwise known mass to charge ratio ranges, and (ii) to determine a frequency or period of said plurality of extraction pulses that will avoid coincidence of ions from said consecutive groups of ions at said ion detector, wherein said plurality of extraction pulses are applied at said determined frequency or period.
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公开(公告)号：US20180358218A1
公开(公告)日：2018-12-13
申请号：US16106774
申请日：2018-08-21
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
CPC classification number: H01J49/24 , H01J49/0013 , H01J49/062
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
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