公开(公告)号：US20170227523A1

公开(公告)日：2017-08-10

申请号：US15015258

申请日：2016-02-04

Applicant: Nova Biomedical Corporation

Inventor： Michael S. Cafferty ,  Scott P. Cionek

IPC: G01N33/49 ,  G01N21/27

CPC classification number: G01J3/0256 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/2866 ,  G01N21/27 ,  G01N21/274 ,  G01N21/31 ,  G01N33/4925 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/0683

Abstract: A compact optical spectrometer for measuring hemoglobin parameters in whole blood includes an enclosed spectrometer housing having a light entrance port, a light input slit disposed on one side of a circuit board substrate and positioned adjacent to and aligned with the light entrance port, a light-array detector disposed on the one side of the circuit board substrate adjacent the light input slit, a light dispersing element disposed downstream from the light input slit and an achromatic lens disposed between the light input slit and the light dispersing element to direct the light from the input slit to the light dispersing element and to direct the dispersed light from the light dispersing element to the light-array detector.

公开(公告)号：US09612198B2

公开(公告)日：2017-04-04

申请号：US14314268

申请日：2014-06-25

Applicant: ORIDION MEDICAL 1987 LTD.

Inventor： Joshua Lewis Colman ,  Konstantin Goulitski ,  Mark Golberg

IPC: G01N21/59 ,  G01N21/3504 ,  A61B5/097 ,  G01N33/497 ,  G01N33/00 ,  A61B5/00 ,  A61B5/08 ,  A61B5/083 ,  A61B5/087

CPC classification number: G01N21/59 ,  A61B5/0059 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/0873 ,  A61B5/097 ,  A61B5/4836 ,  A61B5/6819 ,  G01N21/3504 ,  G01N33/004 ,  G01N2201/022 ,  G01N2201/061

Abstract: There are provided Nano-Opto-Mechanical sensors for measuring concentration of a component in a gas flow, methods for their use and system comprising the same.

公开(公告)号：US09594005B2

公开(公告)日：2017-03-14

申请号：US14754618

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： David Barsic ,  Rachel Dreilinger ,  Martin Krauss ,  Jon Boro ,  James Ingle

IPC: G01N21/64 ,  G01N21/63 ,  G01N33/52 ,  G01N33/50 ,  G01N1/22 ,  G01N33/497 ,  G01D11/24

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: A fluorescence detection assembly that includes an emitter, a detector, a housing that defines an light chamber, a fluorescence chamber and a well, a light path that extends from the emitter, through the light chamber and through the well, and a fluorescence path that extends from the well, through the fluorescence chamber and to the detector.

Abstract translation: 一种荧光检测组件，其包括发射器，检测器，限定光室的壳体，荧光腔和阱，从发射器延伸穿过光室并通过阱的光路，以及荧光路径， 从孔延伸通过荧光室和检测器。

公开(公告)号：US20150377859A1

公开(公告)日：2015-12-31

申请号：US14754594

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： Martin Krauss ,  Maura Mahon ,  Adrew E. King ,  Steve Cooper ,  James Ingle ,  Gerald Thomas ,  David Barsic ,  Neal Andrews ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC: G01N33/497 ,  G01N21/64

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.

Abstract translation: 分析盒包括主体部分和过滤器组件。 主体部分包括限定上室的上部和限定流体室的下部。 过滤器组件可沿着过滤器组件路径在第一位置和第二位置之间移动。 过滤器组件具有通过其限定的开口。 在第一位置，开口部分地限定上室，并且在第二位置，开口部分地限定流体室。

公开(公告)号：US20150377858A1

公开(公告)日：2015-12-31

申请号：US14754567

申请日：2015-06-29

Applicant: Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

Inventor： Gerald Thomas ,  Brian Young ,  Juven Lara ,  Charles Noll ,  James Ingle

IPC: G01N33/497

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: Fluorescence chromophores such as phenylene diamine derivatives can undergo oxidative coupling and polymerization to form optical, colorimetric and fluorogenic, multimers and polymers. The presence of carbonyl containing moieties such as aldehydes and ketones under favorable environmental conditions can initiate, catalyze, accelerate and modulate this reaction which in turn provides a mechanism for the detection and quantitation of such moieties. Selected phenylene diamine derivatives can be used for the detection and quantitation of aldehyde and ketones via measurement of the reaction and the associated spectroscopic transformation. In particular, the use of meta-phenylene diamine (mPDA) and related compounds for aldehyde detection and quantitation is described. The method provides a convenient means for monitoring aldehyde and ketone levels without use of separation steps. The method is applicable to kinetic and quasi-endpoint detection assay formats.

Abstract translation: 荧光发色团如苯二胺衍生物可进行氧化偶联和聚合以形成光学，比色和荧光，多聚体和聚合物。 在有利的环境条件下，含有羰基的部分如醛和酮的存在可引发，催化，加速和调节该反应，而反应又提供了检测和定量这些部分的机理。 选择的苯二胺衍生物可用于通过测量反应和相关的光谱转化来检测和定量醛和酮。 特别地，描述了使用间苯二胺（mPDA）和相关化合物进行醛检测和定量。 该方法提供了在不使用分离步骤的情况下监测醛和酮水平的方便手段。 该方法适用于动力学和准终点检测测定方法。

公开(公告)号：US20150377748A1

公开(公告)日：2015-12-31

申请号：US14754534

申请日：2015-06-29

Applicant: Pulse Health LLC

Inventor： Steve Cooper ,  Neal Andrews ,  Martin Krauss ,  Andrew E. King ,  Maura Mahon ,  Weston Myler ,  James Ingle ,  Gerald Thomas ,  Rachel Dreilinger ,  David Barsic ,  Rick Myers ,  Craig Carlsen ,  Scot Herbst ,  Brian Young ,  Juven Lara ,  Charles Noll

IPC: G01N1/22 ,  G01N21/64 ,  G01D11/24 ,  G01N33/497

CPC classification number: G01N1/22 ,  A61B5/0071 ,  A61B5/082 ,  A61B5/087 ,  G01D11/24 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/497 ,  G01N33/4972 ,  G01N33/52 ,  G01N33/64 ,  G01N2001/2244 ,  G01N2021/6482 ,  G01N2033/4975 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/068 ,  Y10T436/200833 ,  Y10T436/202499

Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.

Abstract translation: 一种呼吸分析系统，其包括在其上端具有分析盒的手柄组件。 手柄包括具有压力开口的主体部分和其中的压力换能器。 分析盒包括主体部分，其具有限定呼吸室的上部，限定流体室的下部和可在呼吸捕获位置和分析位置之间移动的过滤器组件。 过滤器组件具有通过其限定的开口。 在呼吸捕获位置，开口部分地限定呼吸室，并且在分析位置中，开口部分地限定流体室。 该系统还包括具有壳体的分析装置，门，控制电动机的控制器和位于壳体内部的荧光检测组件和旋转组件。 旋转组件包括具有用于接收分析盒的漏斗部分的护罩。

公开(公告)号：US09212990B1

公开(公告)日：2015-12-15

申请号：US13707300

申请日：2012-12-06

Applicant: Zybertec LLC

Inventor： Andrey Muraviev

IPC: G01N21/39 ,  G01N21/3504 ,  G01J3/02

CPC classification number: G01N21/39 ,  G01J3/0205 ,  G01N21/3504 ,  G01N2021/391 ,  G01N2201/022 ,  G01N2201/06113 ,  G01N2201/0636

Abstract: In a gas phase analyte testing method a laser beam is generated using a laser beam from a laser gain medium located within an external laser cavity. A gain parameter of the laser gain medium is changed so that the laser gain medium emits across a range of wavelengths in response to the change. The beam is passed through a test sample as the gain parameter is changed, the test sample being positioned inside the external laser cavity. A change in the spatial or spectral mode distribution or dynamics of the laser emission spectrum is detected. It is then determined whether the change in the spatial or spectral mode distribution or dynamics of the laser emission spectrum is caused by the test sample.

Abstract translation: 在气相分析物测试方法中，使用来自位于外部激光腔内的激光增益介质的激光束产生激光束。 改变激光增益介质的增益参数，使得激光增益介质响应于变化而在一定波长范围内发射。 当增益参数改变时，光束通过测试样品，测试样品位于外部激光腔内。 检测激光发射光谱的空间或光谱分布或动态变化。 然后确定激光发射光谱的空间或光谱分布或动力学的变化是否由测试样品引起。

公开(公告)号：US20150323443A1

公开(公告)日：2015-11-12

申请号：US14270768

申请日：2014-05-06

Applicant: SMOBIO TECHNOLOGY, INC.

Inventor： CHEN-SHENG WU ,  CHUN-HSIEN KUO ,  KUAN-LIN LEE

IPC: G01N21/01 ,  G01N21/64

CPC classification number: G01N21/645 ,  G01N21/01 ,  G01N21/6447 ,  G01N2201/022 ,  G01N2201/062

Abstract: An adjustable cabinet includes a machine and a transparent top board. The machine has a case and a light module, wherein the case is provided with a sample table and a slot; the light module emits light to the sample table of the case. The top board has a first side and a second side at opposite sides thereof, wherein the top board has a main portion and a first insert portion connected to an end of the main portion, and the first insert portion is detachably inserted into the slot of the case. With either the first or the second side facing the sample table, the angle formed between the main portion and the sample table is different. Whereby, the cabinet is more compatible for researchers of different body types, and the top board can be avoided from being scraped.

Abstract translation: 可调式机柜包括机器和透明顶板。 机器具有外壳和灯模块，其中，所述壳体设置有样品台和槽; 灯模块向壳体的样品台发光。 顶板在其相对侧具有第一侧和第二侧，其中顶板具有连接到主体部分的端部的主要部分和第一插入部分，并且第一插入部分可拆卸地插入到 案子。 当第一或第二面朝向样品台时，主要部分和样品台之间形成的角度是不同的。 因此，橱柜与不同身体类型的研究人员更加兼容，可以避免顶板被刮伤。

公开(公告)号：US20150211990A1

公开(公告)日：2015-07-30

申请号：US14630492

申请日：2015-02-24

Applicant: Pranalytica, Inc.

Inventor： C. Kumar Patel ,  L. Ravi Narasimhan

IPC: G01N21/39 ,  G01N21/17 ,  G01N21/59

CPC classification number: G01N21/39 ,  G01N21/1702 ,  G01N21/59 ,  G01N2021/1704 ,  G01N2201/022 ,  G01N2201/06113

Abstract: A system for collecting gas samples emitted from skin and detecting concentrations of specified components therein. The system includes a collection chamber housing defining an interior space, the collection chamber housing having a gas inlet, a gas outlet, and an opening. The opening is configured for enclosing a skin portion from which to receive an emitted gas sample and sealing the interior space against the skin portion. An inert gas source is connected to the gas inlet, which is capable of allowing inert gas from the inert gas source to flow into the interior space. A gas cell is connected to the gas outlet, which is capable of allowing the inert gas and the gas sample to flow from the interior space into the gas cell. As a laser travels through the gas cell, power and optoacoustic signals are measured and used to determine a concentration of the specified component.

Abstract translation: 用于收集从皮肤发出的气体样品并检测其中特定组分的浓度的系统。 该系统包括限定内部空间的收集室壳体，收集室壳体具有气体入口，气体出口和开口。 开口构造成用于封闭皮肤部分，从该部分接收发射的气体样品并将内部空间密封抵靠皮肤部分。 惰性气体源连接到气体入口，其能够允许来自惰性气体源的惰性气体流入内部空间。 气体单元连接到气体出口，其能够允许惰性气体和气体样品从内部空间流入气体单元。 当激光穿过气室时，测量功率和光声信号，并用于确定特定部件的浓度。

公开(公告)号：US09060684B2

公开(公告)日：2015-06-23

申请号：US13808520

申请日：2011-08-30

Applicant: Mikio Houjou ,  Atsushi Oda

Inventor： Mikio Houjou ,  Atsushi Oda

IPC: G06K9/00 ,  A61B5/00 ,  G01N21/13 ,  G02B21/00 ,  G02B21/36 ,  C12M1/34

CPC classification number: H04N5/2254 ,  A61B5/0033 ,  C12M41/36 ,  G01N21/01 ,  G01N21/13 ,  G01N2201/022 ,  G01N2201/062 ,  G01N2201/0638 ,  G02B21/0088 ,  G02B21/361 ,  G02B21/365 ,  H04N5/2256

Abstract: An observation device (1) is provided with: a general observation unit (10) for observing sample cells by observing an entire container (C) containing the cells and a culture solution; and a magnification observation unit (20) for magnifying a region within the container (C) and observing the cells, the general observation unit (10) and the magnification observation unit (20) each individually having lighting for illuminating the cells with light, and an optical system for observing the cells. The general observation unit (10) and the magnification observation unit (20) are thereby each provided with an individual optical system and lighting, making it possible to configure an appropriate observation unit for use both when the cells are observed by observing the entire container (C) and when a part within the container (C) is magnified and the cells are observed.

Abstract translation: 观察装置（1）具备：通过观察包含细胞的整个容器（C）和培养液观察样品池的一般观察单元（10） 以及用于放大容器（C）内的区域并观察细胞的放大观察单元（20），一般观察单元（10）和放大观察单元（20）各自具有用光照亮细胞的照明，以及 用于观察细胞的光学系统。 一般观察单元（10）和放大率观察单元（20）各自设置有单独的光学系统和照明，使得可以配置在通过观察整个容器观察细胞时使用的适当的观察单元（ C），并且当容器（C）中的一部分被放大并观察细胞时。