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    Measuring chip for quantitative analysis of substances
    34.
    发明授权
    Measuring chip for quantitative analysis of substances 有权
    测量芯片进行物质定量分析

    公开(公告)号：US06597456B2

    公开(公告)日：2003-07-22

    申请号：US09851957

    申请日：2001-05-10

    Applicant: Takashi Kubo ,  Masayuki Naya

    Inventor： Takashi Kubo ,  Masayuki Naya

    IPC: G01N2155

    CPC classification number: G01N21/553 ,  G01N2201/0415

    Abstract: A measuring apparatus includes a dielectric block, a film layer which is formed on a first face of the dielectric block and is brought into contact with a sample, an optical system which causes a light beam to enter the dielectric block through a second face so that the light beam is reflected in total internal reflection at the interface of the dielectric block and the film layer and various angles of incidence of the light beam to the interface can be obtained, and a photodetector which detects the intensity of the light beam which is reflected in total internal reflection at the interface and goes outside the dielectric block through a third face thereof. A measuring chip includes a single dielectric block having all the first to third faces and the film layer integrally formed on the first face of the dielectric block.

    Abstract translation: 测量装置包括介质块，形成在介质块的第一面上并与样品接触的膜层，使得光束通过第二面进入介质块的光学系统，使得 光束在介质块和膜层的界面处的全反射中被反射，并且可以获得光束到界面的各种入射角，以及检测被反射的光束的强度的光电检测器 在界面处的全内反射，并通过其第三面向外介质块。 测量芯片包括具有所有第一至第三表面的单个介质块和整体形成在介质块的第一面上的膜层。

    Methods for photometric analysis
    35.
    发明授权
    Methods for photometric analysis 失效
    光度分析方法

    公开(公告)号：US5478750A

    公开(公告)日：1995-12-26

    申请号：US292558

    申请日：1994-08-18

    Applicant: Daniel M. Bernstein ,  Paul J. Lingane ,  Robert Nagle ,  Vladimir E. Ostoich

    Inventor： Daniel M. Bernstein ,  Paul J. Lingane ,  Robert Nagle ,  Vladimir E. Ostoich

    IPC: G01N21/07 ,  G01N21/25 ,  G01N21/17

    CPC classification number: G01N21/07 ,  G01N21/255 ,  G01N2201/0415 ,  Y10T436/10

    Abstract: The present invention provides a compact, highly automated photometric analyzer for measuring the concentration of substances found in a fluid, typically a blood sample or other body fluid sample taken from a patient. The operator places a small quantity of the sample into a special rotor and then loads the rotor into the analyzer. The analyzer accepts the rotor, centrifuges and dilutes the sample, and distributes the sample into a plurality of cuvettes near the outer edge of the rotor. Some of these cuvettes hold reagents which react with the sample. The analyzer then measures light absorption within the sample at a number of preselected frequencies. According to the present invention, a pair of specially designed apertures direct light from the sample through a plurality of beam splitters, interference filters, and associated photodetectors. The system also includes means for performing automatic calibration and error checking functions. These means include a through hole through the rotor, and an opaque body carried by the rotor. Additionally, measurements may be repeated through a given cuvette and the results averaged to minimize the effect of random variations between measurements.

    Abstract translation: 本发明提供了一种紧凑的，高度自动化的光度分析仪，用于测量从流体（通常是从患者获取的血液样本或其他体液样品）中发现的物质的浓度。 操作者将少量样品放入专用转子中，然后将转子装入分析仪。 分析仪接受转子，离心并稀释样品，并将样品分配到转子外边缘附近的多个比色皿中。 其中一些比色皿含有与样品反应的试剂。 然后分析仪以多个预选频率测量样品内的光吸收。 根据本发明，一对特别设计的孔径通过多个分束器，干涉滤光器和相关联的光电检测器引导来自样品的光。 该系统还包括用于执行自动校准和错误检查功能的装置。 这些装置包括通过转子的通孔和由转子承载的不透明体。 此外，可以通过给定的比色杯重复测量，并且平均结果以最小化测量之间的随机变化的影响。

    Erythrocyte sedimentation rate measuring apparatus
    36.
    发明授权
    Erythrocyte sedimentation rate measuring apparatus 失效
    红细胞沉降速率测定仪

    公开(公告)号：US5316729A

    公开(公告)日：1994-05-31

    申请号：US982313

    申请日：1992-11-27

    Applicant: Helmut Orth ,  Joachim Horrer ,  Dietmar Holst

    Inventor： Helmut Orth ,  Joachim Horrer ,  Dietmar Holst

    IPC: G01N15/05 ,  G01N21/59 ,  G01N33/00

    CPC classification number: G01N15/05 ,  G01N2021/5969 ,  G01N2201/0415

    Abstract: An apparatus for measuring the erythrocyte sedimentation rate comprising a measuring head having at least light barrier, which can be moved along a test cell containing a blood sample. The output signals of light detectors (52, 54, 60) of the light barriers are fed to an evaluating processor (74), which continuously compares the profiles of the optical density obtained at different measuring times with various reference curves having a known final value of the position of the interphase between the serum and the blood cake.

    Abstract translation: 一种用于测量红细胞沉降速率的装置，包括具有至少光屏障的测量头，其可以沿着包含血液样本的测试细胞移动。 光栅的光检测器（52,54,60）的输出信号被馈送到评估处理器（74），评估处理器（74）将在不同测量时间获得的光密度的曲线与具有已知最终值的各种参考曲线连续地进行比较 的血清和血饼之间的相位的位置。

    Test array for performing assays
    37.
    发明授权
    Test array for performing assays 失效
    用于进行测定的测试阵列

    公开(公告)号：US5281540A

    公开(公告)日：1994-01-25

    申请号：US796942

    申请日：1991-11-22

    Applicant: Carl W. Merkh ,  James D. Defreese ,  Benton A. Durley, III, deceased

    Inventor： Carl W. Merkh ,  James D. Defreese ,  Benton A. Durley, III, deceased

    IPC: G01N33/50 ,  B01L3/00 ,  G01N33/543 ,  G01N33/68 ,  G01N35/00 ,  G01N35/10 ,  G01N33/545 ,  G01N33/544

    CPC classification number: B01L3/545 ,  G01N33/54366 ,  G01N33/6854 ,  G01N35/00029 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/0621 ,  G01N2201/1211

    Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immunoassays for human IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

    Abstract translation: 提供半自动生物样品分析仪和子系统以同时对多个生物样品中的每一个中预先选择的过敏原组特异的人IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

    Multiple sample characterization of coals and other substances by controlled-atmosphere programmed temperature oxidation
    38.
    发明授权
    Multiple sample characterization of coals and other substances by controlled-atmosphere programmed temperature oxidation 失效
    通过受控气氛程序化温度氧化对煤和其他物质进行多次样品表征

    公开(公告)号：US5204270A

    公开(公告)日：1993-04-20

    申请号：US692981

    申请日：1991-04-29

    Applicant: Robert B. LaCount

    Inventor： Robert B. LaCount

    IPC: G01N21/35 ,  G01N31/12 ,  G01N33/22

    CPC classification number: G01N33/222 ,  G01N21/3504 ,  G01N2021/0382 ,  G01N2201/0415

    Abstract: A furnace with two hot zones holds multiple analysis tubes. Each tube has a separable sample-packing section positioned in the first hot zone and a catalyst-packing section positioned in the second hot zone. A mass flow controller is connected to an inlet of each sample tube, and gas is supplied to the mass flow controller. Oxygen is supplied through a mass flow controller to each tube to either or both of an inlet of the first tube and an intermediate portion between the tube sections to intermingle with and oxidize the entrained gases evolved from the sample. Oxidation of those gases is completed in the catalyst in each second tube section. A thermocouple within a sample reduces furnace temperature when an exothermic condition is sensed within the sample. Oxidized gases flow from outlets of the tubes to individual gas cells. The cells are sequentially aligned with an infrared detector, which senses the composition and quantities of the gas components. Each elongated cell is tapered inward toward the center from cell windows at the ends. Volume is reduced from a conventional cell, while permitting maximum interaction of gas with the light beam. Reduced volume and angulation of the cell inlets provide rapid purgings of the cell, providing shorter cycles between detections. For coal and other high molecular weight samples, from 50% to 100% oxygen is introduced to the tubes.

    Abstract translation: 具有两个热区的炉子容纳多个分析管。 每个管具有位于第一热区中的可分离的样品填充段和位于第二热区中的催化剂填充段。 质量流量控制器连接到每个样品管的入口，并且气体被供应到质量流量控制器。 将氧气通过质量流量控制器供应到每个管道到第一管的入口和管部分之间的中间部分中的任一个或两者，以与样品相互混合并氧化从样品放出的夹带的气体。 这些气体的氧化在每个第二管段中的催化剂中完成。 当在样品内感测到放热条件时，样品内的热电偶会降低炉温。 氧化气体从管的出口流向单独的气室。 细胞与红外检测器顺序对准，红外检测器检测气体组分的组成和数量。 每个细长的细胞在端部处从细胞窗口向内朝向中心渐缩。 体积从常规电池减少，同时允许气体与光束的最大相互作用。 细胞入口的减小体积和角度提供细胞的快速清洗，在检测之间提供较短的循环。 对于煤和其他高分子量样品，将50％至100％的氧气引入管中。

    Constant-temperature air type automatic analysis apparatus
    39.
    发明授权
    Constant-temperature air type automatic analysis apparatus 失效
    恒温空气式自动分析仪

    公开(公告)号：US5133936A

    公开(公告)日：1992-07-28

    申请号：US635429

    申请日：1991-01-04

    Applicant: Hiroshi Umetsu ,  Hiroshi Hashimoto ,  Hajime Betsui

    Inventor： Hiroshi Umetsu ,  Hiroshi Hashimoto ,  Hajime Betsui

    IPC: B01L7/02 ,  C12M1/34 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC classification number: B01L7/02 ,  G01N35/025 ,  G01N2035/00386 ,  G01N2035/00435 ,  G01N2035/00564 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/1086 ,  G01N2201/0415 ,  Y10T436/115831 ,  Y10T436/12

    Abstract: A constant-temperature air type automatic analysis apparatus includes: a reaction table for rotating a row of reaction containers; a batch injecting device for supplying a sample and a reagent into the reaction containers; a photometric device for measuring a reaction within the reaction containers; a constant-temperature air device for keeping the reaction containers warm, the constant-temperature air device having an annular constant-temperature air chamber which is formed in such a manner as to surround the row of reaction containers; a heat block disposed within the annular constant-temperature air chamber; and a preliminary temperature raising device for heating the reaction containers. The preliminary temperature raising device has an air circulation passage, a blowing device for blowing a constant-temperature air against the reaction containers in a region between a injection position of the batch injecting device and a measuring position of the photometric device. Alternatively, the preliminary temperature raising device has a ventilating device for temporarily ventilating the air circulation passage.

    Abstract translation: 恒温空气型自动分析装置包括：用于使一排反应容器旋转的反应台; 用于将样品和试剂供应到反应容器中的批量注入装置; 用于测量反应容器内的反应的测光装置; 用于保持反应容器温暖的恒温空气装置，所述恒温空气装置具有以围绕所述一排反应容器的方式形成的环状恒温空气室; 设置在所述环形恒温空气室内的热块; 以及用于加热反应容器的初步升温装置。 初级升温装置具有空气循环通道，在分批喷射装置的喷射位置和测光装置的测量位置之间的区域中，将恒温空气吹向反应容器的吹风装置。 或者，预备升温装置具有用于使空气循环通道暂时通风的通风装置。

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