公开(公告)号：US20070287708A1

公开(公告)日：2007-12-13

申请号：US11818119

申请日：2007-06-13

Applicant: Derek Cole ,  Diane Boschelli ,  Yanong Wang ,  Magda Asselin ,  Diane Joseph-McCarthy ,  Amarnauth Prashad ,  Allan Wissner ,  Russell Dushin ,  Biqi Wu ,  Lawrence Tumey ,  Chuan Niu ,  Joan Chen

Inventor： Derek Cole ,  Diane Boschelli ,  Yanong Wang ,  Magda Asselin ,  Diane Joseph-McCarthy ,  Amarnauth Prashad ,  Allan Wissner ,  Russell Dushin ,  Biqi Wu ,  Lawrence Tumey ,  Chuan Niu ,  Joan Chen

IPC: A61K31/5377 ,  A61K31/4439 ,  C07D413/14 ,  C07D405/14 ,  C07D409/14 ,  C07D403/14

CPC classification number: C07D213/85 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.

Abstract translation: 本发明提供式I化合物及其药学上可接受的盐，水合物和酯，其中R 1，R 2和X如本文所定义。 本教导还提供制备式I化合物的方法，以及通过向包括人的哺乳动物施用治疗有效量的式I化合物或化合物来治疗自身免疫性和炎性疾病的方法。

公开(公告)号：US20070022923A1

公开(公告)日：2007-02-01

申请号：US11543382

申请日：2006-10-05

Applicant: E. Beaumont ,  Edward Champagne ,  Joseph Giardina ,  Chester Halek ,  Joseph McCarthy ,  Kevin O'Rourke ,  E. Porter ,  Mark Rice ,  Kevin Rousseau

Inventor： E. Beaumont ,  Edward Champagne ,  Joseph Giardina ,  Chester Halek ,  Joseph McCarthy ,  Kevin O'Rourke ,  E. Porter ,  Mark Rice ,  Kevin Rousseau

IPC: F23J1/00 ,  F23H3/00

CPC classification number: F23G5/002 ,  F23G5/16 ,  F23G5/165 ,  F23G2203/101 ,  F23G2203/803 ,  F23G2900/00001 ,  F23H7/08 ,  F23J1/00 ,  F23J15/027 ,  F23L1/02 ,  F23M5/00

Abstract: An inclined hearth combustor which generally includes a primary combustion chamber having a plurality of stepped hearths, a secondary combustion chamber in communication with the primary combustion chamber and a boiler having an inlet in communication with the secondary combustion chamber. The secondary combustion chamber includes a refractory-lined cyclone separator for removing fly ash from combustion gases exiting the primary combustion chamber and the boiler inlet is surrounded by the cyclone separator. The primary combustion chamber may further include an ash transfer ram movably disposed between two stepped hearths, wherein the ash transfer ram includes a top layer of refractory material extending rearwardly from a leading edge thereof. The ash transfer ram may further include a plurality of V-shaped wheels attached to a bottom surface thereof, a replaceable wear plate disposed on a side surface thereof and/or a wiper blade fixed on a forward face thereof. At least one hearth may include two spaced rows of air feed-tubes longitudinally embedded therein for delivering a combustion gas into the combustion chamber. The air-feed tubes may intersect with an air distribution plenum for simultaneously delivering the combustion gas to the air feed-tubes. The primary combustion chamber may further include a reciprocating loader ram movably disposed on the top surface of the top-most hearth for pushing combustible material on the top-most hearth, wherein the loader ram has a bottom surface and at least one longitudinally extending replaceable wear strip disposed thereon.

公开(公告)号：US06726503B2

公开(公告)日：2004-04-27

申请号：US10177509

申请日：2002-06-21

Applicant: Kent D. Waddell ,  Peter Curtin ,  Eugene Folan ,  John M. Horgan ,  Enda Kelly ,  Joseph McCarthy ,  John Meaney ,  Brian Murphy ,  John Wallace ,  Michael J. Miskin

Inventor： Kent D. Waddell ,  Peter Curtin ,  Eugene Folan ,  John M. Horgan ,  Enda Kelly ,  Joseph McCarthy ,  John Meaney ,  Brian Murphy ,  John Wallace ,  Michael J. Miskin

IPC: H01R1358

CPC classification number: H01R24/60 ,  H01R13/6585 ,  H01R2107/00 ,  Y10S439/941

Abstract: An electrical connector assembly is provided for terminating a plurality of electrical wires. A non-conductive connector housing mounts a plurality of signal terminals. A wire management module includes a non-conductive body mounting a plurality of ground terminals. The body positions a plurality of signal conductors and a plurality of ground conductors of the electrical wires, the ground conductors being terminated to the ground terminals. The ground terminals interengage with the connector housing to mount the wire management module to the housing with the signal wire conductors in position for termination to the signal terminals.

Abstract translation: 提供电连接器组件用于端接多个电线。 非导电连接器壳体安装多个信号端子。 线管理模块包括安装多个接地端子的非导电体。 主体定位电线的多个信号导体和多个接地导体，接地导体终止于接地端子。 接地端子与连接器壳体相互接合，以将导线管理模块安装到壳体，信号线导体就位于信号端子端。

公开(公告)号：US06667808B2

公开(公告)日：2003-12-23

申请号：US09788855

申请日：2001-02-20

Applicant: Todd R. Clermont ,  Francis Jerome Deck ,  Louie Delaware ,  James Ronald Hyatt ,  George Douglas Jones ,  Gabor John Kemeny ,  Steven Ralph Lowry ,  William Joseph McCarthy ,  John R. O'Keefe

Inventor： Todd R. Clermont ,  Francis Jerome Deck ,  Louie Delaware ,  James Ronald Hyatt ,  George Douglas Jones ,  Gabor John Kemeny ,  Steven Ralph Lowry ,  William Joseph McCarthy ,  John R. O'Keefe

IPC: G01J345

CPC classification number: G01J3/02 ,  G01J3/0254 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/10 ,  G01J3/4535 ,  G01J2001/0481 ,  G01J2003/2866 ,  G01N21/3563 ,  G01N2021/3595

Abstract: A multifunctional infrared spectrometer system has an interferometer which receives the infrared beam from a source and provides a modulated output beam on beam paths to multiple spatially separated infrared detectors. A multi-position mirror element mounted at a junction position receives the beam on a main beam path and directs it on branch beam paths to sample positions, with the beam then being directed on the branch beam path to one of the detectors. One of the branch beam paths may include a sample holder at the sample position which can index between a position at which a sample is analyzed, to a reference material position, to a pass-through position for calibration purposes. The multi-position mirror element may also be indexed to direct the beam on a branch path to a fiber optic cable which has a probe at the end of it which may be inserted in a sample fluid or powder to be analyzed, with the reflected light from the probe being directed back on an optical fiber cable to a detector at the spectrometer. The multi-position mirror element may be moved to a position at which the beam is directed on a beam path to and through an integrating sphere to a solid sample, with the reflected light from the sample being directed by the surfaces of the integrating sphere to a detector. A detector may be mounted to detect the light transmitted through the sample to obtain measurements of both reflected and transmitted infrared light at the sample.

Abstract translation: 多功能红外光谱仪系统具有干涉仪，其接收来自源的红外光束，并将光束路径上的调制输出光束提供给多个空间分离的红外探测器。 安装在连接位置处的多位镜子元件在主光束路径上接收光束并将其引导到分支光束路径到采样位置，然后光束被引导到分支光束路径到其中一个检测器。 分支光束路径中的一个可以包括在采样位置处的样品保持器，其可以将样品被分析的位置与参考材料位置之间的位置转换成用于校准目的的通过位置。 多位置反射镜元件还可被索引以将光束引导到光纤电缆的分支路径上，该光纤电缆在其末端具有探针，该探针可以插入待分析的样品流体或粉末中，其中反射光 从探头引导回光纤光缆到光谱仪上的检测器。 多位置反射镜元件可以被移动到光束被引导到通过积分球并通过积分球的光束到固体样品的位置，其中来自样品的反射光被积分球的表面引导到 检测器 可以安装检测器以检测通过样品透射的光，以获得样品上的反射和透射的红外光的测量。

公开(公告)号：US06638111B1

公开(公告)日：2003-10-28

申请号：US10193037

申请日：2002-07-11

Applicant: Padrig McDaid ,  Kent D. Waddell ,  Denise Brennan ,  Eugene Folan ,  John M. Horgan ,  Enda Kelly ,  Joseph McCarthy ,  Brian Murphy ,  John Wallace

Inventor： Padrig McDaid ,  Kent D. Waddell ,  Denise Brennan ,  Eugene Folan ,  John M. Horgan ,  Enda Kelly ,  Joseph McCarthy ,  Brian Murphy ,  John Wallace

IPC: H01R13648

CPC classification number: H01R12/724 ,  H01R13/6471 ,  H01R13/6589 ,  H01R13/6594

Abstract: An electrical connector is provided for mounting on a printed circuit board and includes an elongated dielectric housing having a front mating end and a rear terminating end. A plurality of signal terminals are mounted on the housing and are spaced longitudinally thereof. Each signal terminal includes a contact portion at the mating end of the housing and a tail portion at the terminating end of the housing. A plurality of ground plates are mounted on the housing between at least some of the signal terminals. Each ground plate includes a body portion, a front portion and a tail portion. The signal terminals are disposed substantially within the longitudinal profiles of the body portions and front portions of the ground plates in a direction longitudinally of the housing, with the tail portions of the ground plates projecting rearwardly of the profiles.

Abstract translation: 提供电连接器用于安装在印刷电路板上，并且包括具有前配合端和后终端的细长绝缘壳体。 多个信号端子安装在壳体上并且其纵向间隔开。 每个信号端子包括在壳体的配合端处的接触部分和在壳体的终端处的尾部。 多个接地板在至少一些信号端子之间安装在壳体上。 每个接地板包括主体部分，前部部分和尾部部分。 信号端子基本上设置在主体部分的纵向轮廓和接地板的前部沿着壳体纵向的方向上，其中接地板的尾部向轮廓向后突出。

公开(公告)号：US5637708A

公开(公告)日：1997-06-10

申请号：US460113

申请日：1995-06-02

Applicant: James M. Hogle ,  Martin Karplus ,  Diane Joseph-McCarthy

Inventor： James M. Hogle ,  Martin Karplus ,  Diane Joseph-McCarthy

IPC: C07D209/08 ,  C07D215/14 ,  C07D235/12 ,  C07D401/10 ,  C07D401/02

CPC classification number: C07D209/08 ,  C07D215/14 ,  C07D235/12 ,  C07D401/10

Abstract: Agents having the structure,U--CH.sub.2 --V--CH.sub.2 --W,and agents having the structure,U--CH.sub.2 --V--CH.sub.2 --W--X--Y--Z,where U, W, and Z are double fused aromatic rings, V is a single six-membered aromatic ring with a hydroxyl group constituent, X is a polar group, and Y is a positively charged group, are disclosed. The double fused aromatic rings can be a five-membered aromatic ring, or a six-membered aromatic ring, fused to a six-membered aromatic ring; the double fused aromatic rings can comprise heteroatoms. The agents can be used as capsid stabilizing or antiviral agents.

Abstract translation: 具有结构的试剂U-CH2-V-CH2-W和具有以下结构的试剂：U-CH2-V-CH2-WXYZ，其中U，W和Z是双稠合芳环，V是单六 - 公开了具有羟基成分的X元环，X为极性基，Y为带正电荷的基。 双稠合芳环可以是与六元芳环稠合的五元芳环或六元芳环; 双稠合芳环可以包含杂原子。 所述试剂可用作衣壳稳定剂或抗病毒剂。

公开(公告)号：US2414053A

公开(公告)日：1947-01-07

申请号：US42352141

申请日：1941-12-18

Applicant: JOSEPH MCCARTHY PATRICK

Inventor： JOSEPH MCCARTHY PATRICK

IPC: A47J19/02

CPC classification number: A47J19/02

公开(公告)号：US901279A

公开(公告)日：1908-10-13

申请号：US1907357907

申请日：1907-02-18

Applicant: JOSEPH MCCARTHY ,  CRENSHAW JOHN T

Inventor： CRENSHAW JOHN T

CPC classification number: A01G23/046

公开(公告)号：US08951187B2

公开(公告)日：2015-02-10

申请号：US13547740

申请日：2012-07-12

Applicant: David Ryan Anderson ,  Daniel Joseph McCarthy ,  Caitlin Elizabeth McCarthy ,  Alexander Munro ,  Raime Phillips

Inventor： David Ryan Anderson ,  Daniel Joseph McCarthy ,  Caitlin Elizabeth McCarthy ,  Alexander Munro ,  Raime Phillips

IPC: A61B1/05 ,  A61B1/00 ,  A61B1/247

CPC classification number: A61B1/00066 ,  A61B1/00016 ,  A61B1/00018 ,  A61B1/00183 ,  A61B1/00188 ,  A61B1/247

Abstract: An intraoral imaging system includes a receiving module that communicates with an imaging display device. The imaging device includes handle having a transmitter module and a power source as well as neck and head portions that extend from the handle. The device includes a camera module that rotates in the distal and proximal direction to view and process still images and video. The camera module includes a movable image sensor to provide focus capability. The imaging device further includes a control assembly having a plurality of control members. The control assembly includes image capture controls that an operator engages in a lateral motion to capture images or video. A focus control member controls the spatial relationship between the image sensor and the stationary lens and an articulation control member to articulate the camera module to provide a greater range of imaging.

Abstract translation: 口内成像系统包括与成像显示装置通信的接收模块。 成像装置包括具有发射器模块和电源以及从手柄延伸的颈部和头部的手柄。 该装置包括相机模块，该相机模块在远端和近端方向上旋转以观看和处理静止图像和视频。 相机模块包括可移动图像传感器以提供聚焦能力。 成像装置还包括具有多个控制构件的控制组件。 控制组件包括图像捕获控制，操作者参与横向运动以捕获图像或视频。 焦点控制构件控制图像传感器和固定透镜之间的空间关系以及关节运动控制构件，以便关联相机模块以提供更大范围的成像。

公开(公告)号：US08812818B2

公开(公告)日：2014-08-19

申请号：US13372609

申请日：2012-02-14

Applicant: Eric Lawrence Barsness ,  David L. Darrington ,  Patrick Joseph McCarthy ,  Amanda Peters ,  John Matthew Santosuosso

Inventor： Eric Lawrence Barsness ,  David L. Darrington ,  Patrick Joseph McCarthy ,  Amanda Peters ,  John Matthew Santosuosso

IPC: G06F13/00 ,  G06F9/26

CPC classification number: G06F12/1027 ,  G06F12/1072

Abstract: A method and apparatus creates and manages persistent memory (PM) in a multi-node computing system. A PM Manager in the service node creates and manages pools of nodes with various sizes of PM. A node manager uses the pools of nodes to load applications to the nodes according to the size of the available PM. The PM Manager can dynamically adjust the size of the PM according to the needs of the applications based on historical use or as determined by a system administrator. The PM Manager works with an operating system kernel on the nodes to provide persistent memory for application data and system metadata. The PM Manager uses the persistent memory to load applications to preserve data from one application to the next. Also, the data preserved in persistent memory may be system metadata such as file system data that will be available to subsequent applications.

Abstract translation: 方法和装置在多节点计算系统中创建和管理持久存储器（PM）。 服务节点中的PM管理器创建和管理具有各种大小的PM的节点池。 节点管理器使用节点池根据可用PM的大小将应用程序加载到节点。 PM管理员可以根据历史使用或系统管理员确定的应用程序的需要动态调整PM的大小。 PM管理器与节点上的操作系统内核一起工作，为应用程序数据和系统元数据提供持久性内存。 PM管理器使用持久性内存来加载应用程序以将数据从一个应用程序保留到下一个应用程序。 此外，保留在持久存储器中的数据可以是诸如文件系统数据的系统元数据，这些数据将可用于后续应用。