公开(公告)号：US20080182310A1

公开(公告)日：2008-07-31

申请号：US12059250

申请日：2008-03-31

Applicant: Su-hyeon KIM ,  Jeong-gun LEE

Inventor： Su-hyeon KIM ,  Jeong-gun LEE

IPC: C12N13/00

CPC classification number: C12M47/06 ,  B01L3/5027 ,  C12N1/066 ,  C12N13/00 ,  G01N1/44 ,  Y10T137/2496 ,  Y10T436/25

Abstract: A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser source for generating a laser is provide. Further, a method of lysing cells or viruses using the cell lysis device is provide. The method comprises introducing a sample containing cells or viruses and optionally magnetic beads to the cell lysis tube through the sample inlet; transferring the sample to a specific region in the cell lysis tube by means of the pump; temporarily sealing the region of the cell lysis tube where the sample is placed with the sealing unit; irradiating the sample with the laser; removing the sealing unit from the cell lysis tube; and discharging the sample from the cell lysis tube by means of the pump.

公开(公告)号：US20060292595A1

公开(公告)日：2006-12-28

申请号：US11376296

申请日：2006-03-16

Applicant: Kyu-Sik Yun ,  Jeong-Gun Lee ,  Je-Kyun Park ,  Su-Hyeon Kim ,  Sang-Eun Lee

Inventor： Kyu-Sik Yun ,  Jeong-Gun Lee ,  Je-Kyun Park ,  Su-Hyeon Kim ,  Sang-Eun Lee

IPC: C12Q1/68

CPC classification number: C12Q1/6816 ,  Y10T436/143333 ,  C12Q2563/173

Abstract: Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling.

公开(公告)号：US20060202133A1

公开(公告)日：2006-09-14

申请号：US11345262

申请日：2006-02-01

Applicant: Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

Inventor： Gyeong-sik Ok ,  Su-hyeon Kim ,  Jin-tae Kim ,  Kwang-wook Oh

IPC: G01J1/58 ,  F21V9/16

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。

公开(公告)号：US06623696B1

公开(公告)日：2003-09-23

申请号：US09697171

申请日：2000-10-27

Applicant: Su-Hyeon Kim ,  Jo-Kyun Park ,  Tae-Han Kim

Inventor： Su-Hyeon Kim ,  Jo-Kyun Park ,  Tae-Han Kim

IPC: G01N2100

CPC classification number: G01N21/6452 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00536 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  B01J2219/00743 ,  B82Y30/00 ,  G01N21/6456 ,  G01N35/00069

Abstract: The present invention provides a biochip which includes: a substrate having a center hole at a central portion, an biomaterial region aranged at a circumferential portion of the top surface of the substrate; and an information region formed on the substrate between the biomaterial region and the center hole and having the information on the biomaterials. In the method for detecting biomaterials using the biochip, a disk-type upper substrate is placed on the top surface of the biochip, a sample is put between the disk-type upper substrate and the biochip, the reaction between the sample solution and the biomaterial of the biochip is accelerated by rotating the biochip, and the detection unit analyzes the biomaterial by receiving the light emitted from the biomaterials, thereby making it possible to analyze the biomaterial of the sample solution. Since the biochip of the present invention is constructed as a disk type, high-priced scanning equipment is not necessary for thereby reducing the cost for detecting biomaterials. Since the sample solution is stirred by rotating the biochip, the speed of binding reaction is increased for thereby decreasing the time for analysis. Since the information on the biomaterial and the analytical information of the biomaterial can be recorded in the biochip, the management of the information of the biomaterials is made easier.

Abstract translation: 本发明提供一种生物芯片，其包括：在中心部分具有中心孔的基板，在所述基板顶面的圆周部分上排列的生物材料区域; 以及形成在生物材料区域和中心孔之间的基板上的信息区域，并且具有关于生物材料的信息。 在使用生物芯片检测生物材料的方法中，将盘状上基板放置在生物芯片的上表面上，将样品放置在盘型上基板和生物芯片之间，样品溶液与生物材料之间的反应 通过旋转生物芯片来加速生物芯片，并且检测单元通过接收从生物材料发射的光来分析生物材料，从而可以分析样品溶液的生物材料。 由于本发明的生物芯片被构造为盘式，因此不需要高价格的扫描设备，从而降低检测生物材料的成本。 由于通过旋转生物芯片搅拌样品溶液，所以结合反应的速度增加，从而减少分析时间。 由于生物材料的信息和生物材料的分析信息可以记录在生物芯片中，因此生物材料信息的管理变得更加容易。

公开(公告)号：US09670568B2

公开(公告)日：2017-06-06

申请号：US14004824

申请日：2012-03-16

Applicant: Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

Inventor： Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

IPC: B22D21/04 ,  C22C32/00 ,  B22D19/14 ,  C22C1/03 ,  C22C29/00 ,  C22C29/12 ,  C22C21/00 ,  C22C21/02 ,  C22C21/06

CPC classification number: C22C32/00 ,  B22D19/14 ,  B22D21/04 ,  C22C1/03 ,  C22C21/00 ,  C22C21/02 ,  C22C21/06 ,  C22C29/005 ,  C22C29/12

Abstract: A method of stably preparing an aluminum composite with excellent mechanical properties while the temperature of molten aluminum is maintained at 950° C. or less, includes mixing aluminum powder, a source material for titanium, a source material for a nonmetallic element that is able to be combined with titanium to form a compound, and an active material to prepare a precursor; adding the precursor to molten aluminum; and casting the molten aluminum.

公开(公告)号：US20160180002A1

公开(公告)日：2016-06-23

申请号：US14966264

申请日：2015-12-11

Applicant: Chul-Hong Park ,  SU-HYEON KIM ,  SHARMA DEEPAK

Inventor： Chul-Hong Park ,  SU-HYEON KIM ,  SHARMA DEEPAK

IPC: G06F17/50

CPC classification number: G06F17/5072 ,  G06F17/5081

Abstract: A method of generating electronic circuit layout data can include electronically providing data representing a first standard cell layout including a first scaling enhanced circuit layout in an electronic storage medium. The first scaling enhanced circuit layout included in the first standard cell layout can be electronically defined using a marker layer. The first scaling enhanced circuit layout can be electronically swapped for a second scaling enhanced circuit layout to electronically generate data representing a second standard cell layout in the electronic storage medium. The data representing the second standard cell layout can be electronically verified.

Abstract translation: 一种产生电子电路布局数据的方法可以包括以电子形式提供表示在电子存储介质中包括第一缩放增强电路布局的第一标准单元布局的数据。 包括在第一标准单元布局中的第一缩放增强电路布局可以使用标记层电子定义。 可以电子交换第一缩放增强电路布局用于第二缩放增强电路布局以电子地生成表示电子存储介质中的第二标准单元布局的数据。 表示第二标准单元布局的数据可以被电子验证。

公开(公告)号：US20140037494A1

公开(公告)日：2014-02-06

申请号：US14004824

申请日：2012-03-16

Applicant: Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

Inventor： Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

IPC: C22C32/00 ,  B22D19/14

CPC classification number: C22C32/00 ,  B22D19/14 ,  B22D21/04 ,  C22C1/03 ,  C22C21/00 ,  C22C21/02 ,  C22C21/06 ,  C22C29/005 ,  C22C29/12

Abstract: A method of stably preparing an aluminum composite with excellent mechanical properties while the temperature of molten aluminum is maintained at 950° C. or less, includes mixing aluminum powder, a source material for titanium, a source material for a nonmetallic element that is able to be combined with titanium to form a compound, and an active material to prepare a precursor; adding the precursor to molten aluminum; and casting the molten aluminum.

Abstract translation: 在熔融铝的温度保持在950℃以下的状态下稳定地制备具有优异的机械性能的铝复合体的方法包括：将铝粉末，钛原料混合，将非金属元素的原料 与钛组合以形成化合物，以及制备前体的活性材料; 将前体添加到熔融铝中; 并铸造熔融铝。

公开(公告)号：US08597572B2

公开(公告)日：2013-12-03

申请号：US12128680

申请日：2008-05-29

Applicant: Su-hyeon Kim ,  Yoon-kyoung Cho ,  Jeong-gun Lee

Inventor： Su-hyeon Kim ,  Yoon-kyoung Cho ,  Jeong-gun Lee

IPC: G01N33/50

CPC classification number: G01N35/00732 ,  G01N35/00069 ,  G01N35/08 ,  G01N2035/00752 ,  Y10T436/11

Abstract: Provided are an automatic analyzing method and apparatus for a microfludic system. The apparatus includes means for recognizing a disc or chip in the microfludic system, performs an operation and detection by automatically loading a DB according to a recognized type, and perform quantization of a test.

Abstract translation: 本发明提供一种微流体系统的自动分析方法和装置。 该装置包括用于识别微流体系统中的盘或芯片的装置，通过根据识别的类型自动加载DB执行操作和检测，并执行测试的量化。

公开(公告)号：US20120019315A1

公开(公告)日：2012-01-26

申请号：US13096173

申请日：2011-04-28

Applicant: June-young LEE ,  Su-hyeon KIM

Inventor： June-young LEE ,  Su-hyeon KIM

IPC: H01L51/30 ,  H01L51/40 ,  H01L51/10

CPC classification number: H01L51/0093 ,  B82Y10/00 ,  H01L27/28 ,  H01L27/281 ,  H01L51/0508

Abstract: A bio material receiving device includes a thin film transistor (“TFT”) including a drain electrode, and a nano well accommodating a bio material. The drain electrode includes the nano well. The TFT may be a bottom gate TFT or a top gate TFT. A nano well array may include a plurality of bio material receiving devices. In a method of operating the bio material receiving device, each of the bio material receiving devices may be individually selected in the nano well array. When the bio material is accommodated in the selected bio material receiving device, a voltage is applied so that another bio material is not accommodated.

Abstract translation: 生物材料接收装置包括包括漏电极的薄膜晶体管（“TFT”）和容纳生物材料的纳米孔。 漏电极包括纳米孔。 TFT可以是底栅极TFT或顶栅极TFT。 纳米孔阵列可以包括多个生物材料接收装置。 在生物材料接收装置的操作方法中，每个生物材料接收装置可以在纳米孔阵列中单独选择。 当生物材料容纳在所选择的生物材料接收装置中时，施加电压，使得不容纳另一生物材料。

公开(公告)号：US07892491B2

公开(公告)日：2011-02-22

申请号：US11533961

申请日：2006-09-21

Applicant: Su Hyeon Kim ,  Jeong Gun Lee ,  Seung Yeon Yang

Inventor： Su Hyeon Kim ,  Jeong Gun Lee ,  Seung Yeon Yang

IPC: G01N15/06

CPC classification number: C12N13/00 ,  C12M47/06 ,  C12N1/066

Abstract: An apparatus for disruption of cells or viruses using a laser and magnetic beads includes a cell lysis chip including a sample inlet hole into which a sample and the magnetic beads are introduced, a vibrator fixing the cell lysis chip and transferring vibrations in a prescribed direction, a laser generator supplying the laser to the cell lysis chip and a controller controlling operations of the vibrator and the laser generator.

Abstract translation: 使用激光和磁珠对细胞或病毒进行破坏的装置包括细胞裂解芯片，其包括样品入口孔和样品入口孔，样品和磁珠被引入其中，振动器固定细胞裂解芯片并沿规定方向传递振动， 将激光器提供给细胞裂解芯片的激光发生器和控制振动器和激光发生器的操作的控制器。