公开(公告)号：US20150008312A1

公开(公告)日：2015-01-08

申请号：US14367236

申请日：2012-12-07

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John Lawrence Campbell ,  Yves LeBlanc

IPC: H01J49/00 ,  H01J49/10

CPC classification number: H01J49/0072 ,  H01J49/0077 ,  H01J49/10 ,  H01J49/107

Abstract: An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as PTRs and ETD using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., PTRs and/or ETD.

Abstract translation: 一种提供允许在质谱仪的内部区域内产生试剂离子以用于离子离子反应如PTR和ETD的试剂离子发生器的装置，系统和方法。 产生这些试剂离子的位置可以尽可能接近作用点，或反应区，其中试剂离子和分析物离子将通过离子 - 离子反应相互作用以引起例如PTR和/或ETD。

公开(公告)号：US20140374591A1

公开(公告)日：2014-12-25

申请号：US14369259

申请日：2012-11-28

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John Lawrence Campbell

IPC: H01J49/00 ,  H01J49/10

CPC classification number: H01J49/005 ,  H01J49/10

Abstract: In some embodiments, a mass spectrometer capable of performing OzID is disclosed that can provide ozone in situ within an evacuated chamber of the spectrometer, e.g., within a collision cell or within the vacuum chamber of the mass spectrometer. In some embodiments, a corona discharge generated within the evacuated chamber can be employed to convert an ozone precursor delivered to the chamber into ozone.

Abstract translation: 在一些实施方案中，公开了能够进行OzID的质谱仪，其能够在光谱仪的抽真空室内原位提供臭氧，例如在碰撞池内或质谱仪的真空室内。 在一些实施例中，在真空室内产生的电晕放电可用于将输送到室的臭氧前体转化为臭氧。

公开(公告)号：US20140353491A1

公开(公告)日：2014-12-04

申请号：US14369954

申请日：2012-12-06

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Hager ,  John Lawrence Campbell

IPC: H01J49/10 ,  H01J49/36 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/107 ,  H01J49/0031 ,  H01J49/0072 ,  H01J49/063 ,  H01J49/36 ,  H01J49/4215 ,  H01J49/4255

Abstract: Methods and systems for creating a region for ion-ion reactions within a mass spectrometer are described. In various aspects, the methods and systems can confine a first group of ions in a sub-volume of a multipole ion trap, and introduce a second group of oppositely-charged ions into the multipole ion trap while maintaining the first group of ions within the sub-volume. In various embodiments, the methods and systems can operated at reduced pressures.

Abstract translation: 描述了在质谱仪内形成离子离子反应区域的方法和系统。 在各个方面，所述方法和系统可以将第一组离子限制在多极离子阱的子体积中，并将第二组相反电荷的离子引入多极离子阱中，同时将第一组离子保持在 子卷。 在各种实施方案中，所述方法和系统可在减压下操作。

公开(公告)号：US08890062B2

公开(公告)日：2014-11-18

申请号：US14361378

申请日：2012-11-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John Lawrence Campbell ,  Yves LeBlanc

IPC: H01J49/26 ,  H01J49/10 ,  H01J49/06 ,  B01D59/44 ,  G01N27/62

CPC classification number: G01N27/624 ,  G01N27/622 ,  G01N33/6848 ,  H01J49/0072

Abstract: An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, a first and a second ion inlet that receive sample ions, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.

Abstract translation: 提供了用于分析分子样品的装置和方法。 该装置包括质量分析系统，其包括差动迁移谱仪，其包括限定两个离子流动路径的至少三个过滤器电极，其中过滤电极基于样品离子的迁移率特性产生用于穿过样本离子的选定部分的电场 。 差动迁移谱仪还包括电压源，其向至少一个滤波电极提供DC和RF电压以产生电场;接收样品离子的第一和第二离子入口;以及输出所选部分的离子出口 的样品离子。 质谱仪接收样品离子的部分或全部选定部分。