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公开(公告)号：US10068755B2
公开(公告)日：2018-09-04
申请号：US15361968
申请日：2016-11-28
Applicant: Micromass UK Limited
Inventor： Jeffery Mark Brown , Kevin Giles , Daniel James Kenny , Paul Murray , Keith Richardson
CPC classification number: H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
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公开(公告)号：US09852894B2
公开(公告)日：2017-12-26
申请号：US15388368
申请日：2016-12-22
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
CPC classification number: H01J49/0013 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/145 , H01J49/24 , H01J49/40
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyzer, a 3D ion trap mass analyzer, a 2D or linear ion trap mass analyzer, a Time of Flight mass analyzer, a quadrupole-Time of Flight mass analyzer or an electrostatic mass analyzer arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.
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公开(公告)号：US09805920B2
公开(公告)日：2017-10-31
申请号：US15137569
申请日：2016-04-25
Applicant: Micromass UK Limited
Inventor： Daniel James Kenny
CPC classification number: H01J49/0009 , H01J49/0031 , H01J49/40 , H01J49/4215
Abstract: A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.
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公开(公告)号：US09786481B2
公开(公告)日：2017-10-10
申请号：US15023022
申请日：2014-09-17
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny , Richard Barrington Moulds
CPC classification number: H01J49/24 , F04B2205/112 , F04C28/00 , F04C28/02 , G01L19/08 , G01N27/622 , H01J49/0013 , H01J49/067
Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising means for detecting a blockage in an inlet orifice arranged between an ion source and a vacuum chamber. The blockage is detected as a result of a reduction in pressure within the vacuum chamber. This change in pressure is detected indirectly by monitoring the amount of power that a vacuum pump is using, the amount of current that a vacuum pump is drawing, the temperature of a vacuum pump or a region in proximity to the vacuum pump, or the flow rate of gas out of a vacuum pump.
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公开(公告)号：US09530631B2
公开(公告)日：2016-12-27
申请号：US14892360
申请日：2014-05-29
Applicant: Micromass UK Limited
Inventor： David Gordon , Daniel James Kenny
CPC classification number: H01J49/0013 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/145 , H01J49/24 , H01J49/40
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.
Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源和具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 离子检测器位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器位于第二真空室内。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度≤400mm。 质谱仪还包括串联四极杆质谱仪，3D离子阱质谱仪，2D或线性离子阱质谱仪，飞行时间质量分析仪，四极杆飞行时间质量分析仪或静电质量分析仪 第三真空室。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件，第二RF离子导向件的长度L2在0.05-0.3毫巴-cm的范围内。
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Patent Agency Ranking
公开(公告)号：US20160240359A1
公开(公告)日：2016-08-18
申请号：US15137569
申请日：2016-04-25
Applicant: Micromass UK Limited
Inventor： Daniel James Kenny
CPC classification number: H01J49/0009 , H01J49/0031 , H01J49/40 , H01J49/4215
Abstract: A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition.
Abstract translation: 公开了一种质谱法，其包括在实验运行或获取过程中自动校正四极质量过滤器或质量分析器的质量或质量与电荷比分辨率一次或多次，基于质量或质量的测量，确定或估计， 在相同的实验运行或获取期间或在之前的实验运行或采集期间获得的质谱或质谱数据中观察到的一个或多个参考离子的电荷比分辨率。
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公开(公告)号：US20160233073A1
公开(公告)日：2016-08-11
申请号：US15023022
申请日：2014-09-17
Applicant: MICROMASS UK LIMITED
Inventor： David Gordon , Daniel James Kenny , Richard Barrington Moulds
CPC classification number: H01J49/24 , F04B2205/112 , F04C28/00 , F04C28/02 , G01L19/08 , G01N27/622 , H01J49/0013 , H01J49/067
Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising means for detecting a blockage in an inlet orifice arranged between an ion source and a vacuum chamber. The blockage is detected as a result of a reduction in pressure within the vacuum chamber. This change in pressure is detected indirectly by monitoring the amount of power that a vacuum pump is using, the amount of current that a vacuum pump is drawing, the temperature of a vacuum pump or a region in proximity to the vacuum pump, or the flow rate of gas out of a vacuum pump.
Abstract translation: 公开了一种质谱仪或离子迁移谱仪，其包括用于检测布置在离子源和真空室之间的入口孔中的堵塞的装置。 由于真空室内的压力降低，检测到堵塞。 通过监测真空泵正在使用的功率量，真空泵的抽吸量，真空泵的温度或真空泵附近的区域或流量来间接地检测压力变化 真空泵出气量。
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公开(公告)号：US20160233067A1
公开(公告)日：2016-08-11
申请号：US15022634
申请日：2014-09-17
Applicant: MICROMASS UK LIMITED
Inventor： David Gordon , Daniel James Kenny , Richard Barrington Moulds
CPC classification number: H01J49/025 , G01F1/68 , H01J49/0027 , H01J49/0422 , H01J49/10
Abstract: Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater for heating a gas flow to the ion source, a temperature sensor for monitoring the temperature of the heater, and a control system. The control system is arranged and adapted to determine a flow rate of the gas flow by monitoring the power supplied to the heater and the temperature of the heater.
Abstract translation: 公开了一种用于质谱仪的装置，包括离子源，用于加热到离子源的气流的加热器，用于监测加热器的温度的温度传感器和控制系统。 控制系统被布置和适于通过监测供应给加热器的功率和加热器的温度来确定气流的流量。
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公开(公告)号：US20160225601A1
公开(公告)日：2016-08-04
申请号：US15022396
申请日：2014-09-17
Applicant: MICROMASS UK LIMITED
Inventor： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
CPC classification number: H01J49/167 , H01J49/0027 , H01J49/044 , H01J49/165
Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≧100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
Abstract translation: 公开了一种质谱仪，其包括大气压力界面，其包括具有入口孔的气体锥体，其中所述气体锥体具有沿x轴布置的第一纵向轴线和电喷雾离子源，所述电喷雾离子源包括具有出口的第一毛细管， 第二纵向轴线和围绕第一毛细管的第二毛细管。 质谱仪还包括去溶剂化气体供应管和第一装置，其布置并适于经由第一毛细管供应分析物液体，使得液体以>200μL/ min的流速离开第一毛细管的出口。 所述质谱仪还包括第二装置，其布置并适于经由所述第二毛细管以80-150L / hr的流速提供喷雾器气体，其中所述第一毛细管的出口以距离x mm 沿着从气体入口孔的中心测量的沿x轴的距离，沿着y轴的距离ymm，从气体锥入口孔的中心测量，并且沿z轴的距离z mm，从 气锥入口孔的中心。 x轴，y轴和z轴相互正交。 去溶剂化气体供应管围绕第二毛细管并且质谱仪还包括第三装置，其布置并适于经由去溶剂化气体供应管以400-1200L / hr的流量供应去溶剂化气体， 并且适于将去溶剂化气体加热至≥100℃的温度;以及第四装置，其布置并适于以40-80L / hr的流速向锥形锥体供应锥形气体，并且其中x在 范围2.0-5.0mm，并且其中z / x的比率在1-5:1的范围内。
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公开(公告)号：US20160118238A1
公开(公告)日：2016-04-28
申请号：US14892344
申请日：2014-05-29
Applicant: MICROMASS UK LIMITED
Inventor： David Gordon , Daniel James Kenny
CPC classification number: H01J49/24 , H01J49/0013 , H01J49/062
Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure
Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源，具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 第一真空泵布置并适于泵送第一真空室，其中第一真空泵被布置并适于将第一真空室保持在10mbar的压力。 第一RF离子导向器位于第一真空室内，离子检测器位于第三真空室中。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 质谱仪还包括串联四极杆质谱仪，3D离子阱质谱仪，2D或线性离子阱质谱仪，飞行时间质量分析仪，四极杆飞行时间质量分析仪或静电质量分析仪 第三真空室。 包括中间或级间端口的分流式涡轮分子真空泵连接到第二真空室，并且高真空（“HV”）端口连接到第三真空室。 第一真空泵还布置成适用于作为分流式涡轮分子真空泵的背衬真空泵，第一真空泵具有最大泵送速度和最大泵送速度（10m 3 / hr（2.78L / s））。
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