公开(公告)号：US20160153944A1

公开(公告)日：2016-06-02

申请号：US14956781

申请日：2015-12-02

Applicant: Micromass UK Limited

Inventor： David S. Douce ,  John Chipperfield ,  Stevan Bajic ,  James Murphy ,  David Gordon

IPC: G01N30/72

CPC classification number: G01N30/7266 ,  H01J49/165

Abstract: An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2. A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer.

Abstract translation: 公开了一种用于质谱仪的界面，其包括微流体衬底，包括液相色谱分离柱和电喷射发射器2的瓷砖或筒1.反电极4布置在电喷雾发射器2的末端的下游， 将离子直接导向质谱仪的大气压界面或离子入口孔5。

公开(公告)号：US20250157806A1

公开(公告)日：2025-05-15

申请号：US19024872

申请日：2025-01-16

Applicant: Micromass UK Limited

Inventor： Ian David Trivett ,  Anthony Hesse ,  Mark Walford ,  Daniel J. Kenny ,  David Gordon ,  Stanislaw Koziol ,  Steve D. Trudeau ,  Alastair M. Booth ,  Stephen Ayrton

IPC: H01J49/04 ,  B33Y80/00 ,  H01J49/16

Abstract: A nebuliser outlet comprises an inlet end and an outlet end, a first channel and one or more second channels arranged between the inlet end and the outlet end. The first channel is configured to receive a capillary, and the one or more second channels are configured to pass gas to the outlet end. The nebuliser outlet is a single integrated component.

公开(公告)号：US20190287779A1

公开(公告)日：2019-09-19

申请号：US16301428

申请日：2017-05-15

Applicant: MICROMASS UK LIMITED

Inventor： Stephen Patrick Slater ,  John Iveson ,  Oliver John Malpas ,  Bharat Chande ,  David Gordon

IPC: H01J49/06 ,  H01J49/02

Abstract: Disclosed herein is an ion guide comprising a plurality of axially stacked plates, wherein at least some or all of said plates comprise: a first electrically conductive portion; and a second electrically conductive portion, wherein the second electrically conductive portion is electrically isolated from the first electrically conductive portion, the first and second electrically conductive portions being shaped and arranged relative to each other so as to define an opening through which ions are axially transmitted in use; wherein, in use, a first AC or RF voltage is applied to the first electrically conductive portion and a second AC or RF voltage is applied to the second electrically conductive portion in order to confine ions radially within said opening. The first and second electrically conductive portions (1, 2) may be separately formed and interleaved within the ion guide to define the plates. Alternatively the first (41, 43) and second (42, 44) electrically conductive portions may be printed onto a common substrate (4).

公开(公告)号：US20190244800A1

公开(公告)日：2019-08-08

申请号：US16256687

申请日：2019-01-24

Applicant: Micromass UK Limited

Inventor： Stevan Bajic ,  David Gordon ,  Daniel James Kenny ,  Richard Barrington Moulds ,  Stephen O'Brien ,  Ian Trivett ,  Kate Whyatt

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/00

Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

公开(公告)号：US20190237317A1

公开(公告)日：2019-08-01

申请号：US16382714

申请日：2019-04-12

Applicant: Micromass UK Limited

Inventor： Kevin Giles ,  David Gordon

IPC: H01J49/06 ,  H01J49/00

CPC classification number: H01J49/062 ,  H01J49/0027 ,  H01J49/065

Abstract: An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion in order to generate an electric field that directs ions from the first ion guiding path of the first ion guide portion into the second ion guiding path of the second ion guide portion. The use of plural different first voltages can provide a controlled transfer of ions from the first ion guiding path into the second ion guiding path.

公开(公告)号：US10354847B2

公开(公告)日：2019-07-16

申请号：US16020482

申请日：2018-06-27

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24 ,  H01J49/16

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump 707 is arranged and adapted to maintain the first vacuum chamber at a pressure

公开(公告)号：US10217623B2

公开(公告)日：2019-02-26

申请号：US15317731

申请日：2015-06-12

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  David Gordon ,  Daniel James Kenny ,  Paul Murray

IPC: H01J49/16 ,  H01J49/14 ,  G01N27/62 ,  H01J49/00 ,  H01J49/24

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte in a vacuum housing; electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions; conveying the charged droplets and/or reagent ions into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analyzing the analyte ions with a mass analyzer and/or ion mobility analyzer. Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.

公开(公告)号：US10199205B2

公开(公告)日：2019-02-05

申请号：US15852412

申请日：2017-12-22

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/24 ,  H01J49/10 ,  H01J49/40 ,  H01J49/14 ,  H01J49/06

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyzer, a 3D ion trap mass analyzer, a 2D or linear ion trap mass analyzer, a Time of Flight mass analyzer, a quadrupole-Time of Flight mass analyzer or an electrostatic mass analyzer arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

公开(公告)号：US10128092B2

公开(公告)日：2018-11-13

申请号：US14892374

申请日：2014-05-29

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24 ,  H01J49/16

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure

公开(公告)号：US10090138B2

公开(公告)日：2018-10-02

申请号：US14892406

申请日：2014-05-29

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24 ,  H01J49/10

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.