公开(公告)号：US07697976B2

公开(公告)日：2010-04-13

申请号：US10586272

申请日：2005-01-18

Applicant: Jinguang Wu ,  Yuanfu Zhang ,  Yizhuang Xu ,  Qingbo Li ,  Shifu Weng ,  Limin Yang ,  Li Zhang ,  Weijin Zhou ,  Zhanlan Yang ,  Weihong Li ,  Huizhong Wu ,  Rongye Gong ,  Xuejun Gao ,  Duanfu Xu ,  Ying Zhao ,  Zhi Xu ,  Nengwei Zhang ,  Lixin Wang ,  Kaihua Sun ,  Xin Peng ,  Yufeng Liu ,  Xuejun Sun ,  Xiaofeng Ling ,  Su Zhou ,  Zhi Liu ,  Guoqiao Lai ,  Jianxiong Jiang ,  Qinghua Pan ,  Qiguang Wu ,  Guangyan Yu ,  Bingbing Wang

Inventor： Jinguang Wu ,  Yuanfu Zhang ,  Yizhuang Xu ,  Qingbo Li ,  Shifu Weng ,  Limin Yang ,  Li Zhang ,  Weijin Zhou ,  Zhanlan Yang ,  Weihong Li ,  Huizhong Wu ,  Rongye Gong ,  Xuejun Gao ,  Duanfu Xu ,  Ying Zhao ,  Zhi Xu ,  Nengwei Zhang ,  Lixin Wang ,  Kaihua Sun ,  Xin Peng ,  Yufeng Liu ,  Xuejun Sun ,  Xiaofeng Ling ,  Su Zhou ,  Zhi Liu ,  Guoqiao Lai ,  Jianxiong Jiang ,  Qinghua Pan ,  Qiguang Wu ,  Guangyan Yu ,  Bingbing Wang

IPC: A61B5/02

CPC classification number: A61B5/0059 ,  A61B5/6848 ,  A61B5/7257

Abstract: The invention relates to a non-invasive method to diagnose the changes of molecular structures of organism tissues from body surface and a dedicated apparatus. The apparatus is comprised of a Fourier Transform infrared spectrometer and a set of additional accessories. Said additional accessories include a mid-IR fiber optics sampling attachment, a fiber coupling part, and an infrared detector part. The detection method is comprised of placing the ATR probe of the dedicated apparatus on the skin surface of a region to be tested, and scanning more than one time in which the resolution of the apparatus is 1-32 cm−1 and the range of the spectrum is 800-4000 cm−1. It is possible to detect changes in molecular structures of living biological tissues in the early stages of cancer, and testees will not feel uncomfortable during testing. The method is easy to operate, quick, accurate, and it doesn't harm the body.

Abstract translation: 本发明涉及用于诊断来自身体表面的生物体组织的分子结构的变化的非侵入性方法和专用设备。 该装置由傅里叶变换红外光谱仪和一组附加附件组成。 所述附加附件包括中红外光纤采样附件，光纤耦合部件和红外探测器部件。 检测方法包括将专用装置的ATR探针放置在要测试的区域的皮肤表面上，扫描多于一次，其中装置的分辨率为1-32cm-1，并且扫描范围 光谱为800-4000cm-1。 在癌症早期阶段可以检测生物体组织的分子结构变化，受试者在测试过程中不会感到不适。 该方法易于操作，快速，准确，不伤身体。

公开(公告)号：US20090116017A1

公开(公告)日：2009-05-07

申请号：US12256028

申请日：2008-10-22

Applicant: Zhi Xu ,  Robert D. Rosenthal

Inventor： Zhi Xu ,  Robert D. Rosenthal

IPC: G01N21/00 ,  F21V7/04

CPC classification number: G01N21/474 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  G01N2201/0633

Abstract: Embodiments of the invention relate to an internal reflection light funnel, including an internal reflection cone having a first diameter at an entrance end and a second diameter at an exit end, the first diameter being greater than the second diameter; and a light source embedded within the cone. The funnel has a half angle of less than about 25 degrees.

Abstract translation: 本发明的实施例涉及一种内反射光漏斗，其包括在入射端具有第一直径且在出射端具有第二直径的内反射锥体，第一直径大于第二直径; 以及嵌入锥体内的光源。 漏斗的半角小于约25度。

公开(公告)号：US20070023037A1

公开(公告)日：2007-02-01

申请号：US11191272

申请日：2005-07-27

Applicant: David Larsen ,  Zhi Xu

Inventor： David Larsen ,  Zhi Xu

IPC: A61M11/00

CPC classification number: A61M11/005 ,  A61M11/001 ,  A61M16/1095 ,  G01N30/74 ,  G01N30/84 ,  G01N2030/847 ,  G01N21/47

Abstract: A focused droplet nebulizer of the invention produces substantially uniform droplets of a predetermined size. Droplets are pushed out through a small outlet orifice by the contraction of a chamber. The droplets can be carried on a substantially non-divergent path in a drift tube. A piezo membrane micro pump acts in response to an electrical control signal to force a droplet out of the outlet orifice. The nebulizer can operate at frequencies permitting a stream of individual droplets of the predetermined size to be sent along the substantially non-divergent path in the drift tube in a preferred embodiment ELSD device.

Abstract translation: 本发明的聚焦液滴雾化器产生预定尺寸的基本均匀的液滴。 通过室的收缩将液滴从小出口孔推出。 液滴可以在漂移管中的基本上不发散的路径上承载。 压电膜微泵响应于电控制信号而起作用以迫使液滴离开出口孔。 在优选实施例的ELSD装置中，雾化器可以以允许预定尺寸的各个液滴流沿漂移管中的基本非发散路径发送的频率工作。

公开(公告)号：US06741348B2

公开(公告)日：2004-05-25

申请号：US10135854

申请日：2002-04-29

Applicant: David W. Larsen ,  Zhi Xu ,  Wayne Garver

Inventor： David W. Larsen ,  Zhi Xu ,  Wayne Garver

IPC: G01J340

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42

Abstract: The invention concerns improvements in spectrophotometry. Aspects of the invention may be used independently or together to increase the sensitivity of spectrophotometry. One aspect of the invention is a spectrophotometer detection circuit. In this aspect of the invention, currents attributable to reference and sample beams are cancelled in the current mode. The detection circuit produces a first voltage proportional to the difference in currents and a second voltage proportional to one of the reference or sample beams. Both voltages are available to allow simultaneous measurement and analysis. Another aspect of the invention concerns thermal stability. According to the invention, thermal conductivity is established among the housing and optical system components to promote equilibrium. Another preferred embodiment has a unitary solid metal housing with a hollowed portion defined to mount and place optical system components. Recognition and identification of important noise sources in spectrophotometers forms an aspect of the invention contributing to the features and combinations of features in preferred embodiments. Many noise sources would not normally be considered in conventional spectrophotometry because the magnitude of particular noise sources dominates device performance.

Abstract translation: 本发明涉及分光光度法的改进。 本发明的各方面可以独立地或一起使用来提高分光光度法的灵敏度。 本发明的一个方面是分光光度计检测电路。 在本发明的这个方面，在当前模式下，归因于参考和采样光束的电流被消除。 检测电路产生与电流差成比例的第一电压和与参考或采样光束之一成比例的第二电压。 两种电压均可用于同时测量和分析。 本发明的另一方面涉及热稳定性。 根据本发明，在壳体和光学系统部件之间建立导热性以促进平衡。 另一个优选实施例具有整体的实心金属外壳，其具有限定为安装和放置光学系统部件的中空部分。 识别和识别分光光度计中的重要噪声源形成本发明的一个方面，其有利于优选实施例中的特征和特征的组合。 常规分光光度法通常不会考虑许多噪声源，因为特定噪声源的大小主导器件性能。

公开(公告)号：US10542919B2

公开(公告)日：2020-01-28

申请号：US12407999

申请日：2009-03-20

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/1455

Abstract: A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

公开(公告)号：US09814415B2

公开(公告)日：2017-11-14

申请号：US13610387

申请日：2012-09-11

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample.

公开(公告)号：US20130006073A1

公开(公告)日：2013-01-03

申请号：US13610387

申请日：2012-09-11

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample.

Abstract translation: 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括配置成撞击样品的目标区域的至少一个光源，至少一个光检测器，其包括具有反馈电阻器的前置放大器，其被定位成接收来自至少一个光源的光并产生输出信号， 具有指示所检测的光的功率的时间相关电流，以及被配置为从所述至少一个光检测器接收输出信号并且基于所接收的输出信号的处理器计算归因于存在的样本中的血液的衰减 在目标区域中消除由所述至少一个光检测器的温度依赖性检测器响应引起的不确定性的影响，并且基于所计算的衰减，确定与样品相关联的血糖水平。

公开(公告)号：US20130006072A1

公开(公告)日：2013-01-03

申请号：US13610342

申请日：2012-09-11

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area.

Abstract translation: 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括配置成撞击样品的目标区域的至少一个光源，至少一个光检测器，定位成接收来自至少一个光源的光并产生具有时间相关电流的输出信号，其指示 检测到的光的功率，以及被配置为从所述至少一个光检测器接收输出信号并且基于所接收的输出信号的处理器计算归因于存在于目标区域中的样本中的血液的衰减并消除不确定性的影响 通过所述至少一个光检测器的温度依赖性检测器响应，并且基于所计算的衰减，确定与存在于所述目标区域中的样品相关联的血糖水平。

公开(公告)号：US08040509B2

公开(公告)日：2011-10-18

申请号：US12325890

申请日：2008-12-01

Applicant: David W. Larsen ,  Zhi Xu

Inventor： David W. Larsen ,  Zhi Xu

IPC: G01N21/00 ,  G01N21/53

CPC classification number: G01N30/74 ,  G01N21/0303 ,  G01N21/53 ,  G01N2030/847 ,  G01N2030/8494 ,  G01N2201/0642 ,  G01N21/47

Abstract: The invention concerns high sensitivity light scattering detection and its application to evaporative light scattering detection in liquid chromatography. The exemplary embodiment includes a detection cell to accept particles suspended in a gas stream and permit a polarized light beam to pass through a trajectory of the particles and gas stream. A sample light detector is disposed to detect light scattered in the detection cell. A light trap accepts the polarized beam after it passes through the detection cell. The light trap includes an elongated housing through which the polarized beam passes, and light absorptive material within the elongated housing. An absorptive filter is aligned such that the angle of incidence of the light beam upon the filter approximates Brewster's angle and the electric field vector of the beam is aligned with the plane of incidence between the beam and the filter. Other embodiments of the invention provide increased light collection. Embodiments of the invention include temperature-controlled entrance and exit ports that control particle trajectory. Embodiments of the invention include a reference cell disposed between a detection cell and a light trap, and the reference cell includes lensing and a spherical mirror to direct light toward a reference light detector. The reference light detector provides a reference signal that may be used with noise cancellation circuitry, operating in either voltage or current mode, to reduce light source noise in the sample signal.

Abstract translation: 本发明涉及高灵敏度光散射检测及其在液相色谱中的蒸发光散射检测中的应用。 该示例性实施例包括接收悬浮在气流中的颗粒并允许偏振光束通过颗粒和气流的轨迹的检测单元。 设置采样光检测器以检测在检测单元中散射的光。 光阱在其通过检测单元之后接受偏振光束。 光阱包括通过偏振光束通过的细长壳体和细长壳体内的光吸收材料。 对准吸收滤光器，使得光束在滤光片上的入射角近似于布鲁斯特角，并且光束的电场矢量与光束与滤光片之间的入射平面对准。 本发明的其它实施例提供增加的光收集。 本发明的实施例包括控制粒子轨迹的温度控制的入口和出口。 本发明的实施例包括设置在检测单元和光阱之间的参考单元，并且参考单元包括透镜和球面镜，以将光引向参考光检测器。 参考光检测器提供可用于噪声消除电路的参考信号，其以电压或电流模式工作，以减少采样信号中的光源噪声。

公开(公告)号：US07968441B2

公开(公告)日：2011-06-28

申请号：US12247448

申请日：2008-10-08

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: H01L21/425

CPC classification number: H01L21/2236 ,  H01J37/321 ,  H01J37/32357 ,  H01L21/324 ,  Y10T29/41

Abstract: A method and apparatus for forming a semiconductor device. A semiconductor substrate is implanted with dopants. The substrate is subjected to a cleaning process employing electrically neutral nitrogen and fluorine radicals to produce an oxygen-free surface having dangling bonds. Before any further exposure to oxidizing gases, the substrate is annealed by thermal treatment to activate and distribute the dopants. A gate oxide layer is formed over the annealed surface. The apparatus performs all such treatments without breaking vacuum.

Abstract translation: 一种形成半导体器件的方法和装置。 用掺杂剂注入半导体衬底。 对衬底进行采用电中性氮和氟自由基的清洗工艺，以产生具有悬挂键的无氧表面。 在任何进一步暴露于氧化气体之前，通过热处理对衬底进行退火以激活和分布掺杂剂。 在退火表面上形成栅氧化层。 该设备执行所有这样的处理而不破坏真空。