公开(公告)号：US07063784B2

公开(公告)日：2006-06-20

申请号：US10736338

申请日：2003-12-15

Applicant: Shahnaz Ghassemi Jamalabadi ,  Peter C. Rahn ,  Kelvin J. Hammond ,  Omar Mneimne ,  Jeffrey A. Horsman ,  Peter C. Van Davelaar

Inventor： Shahnaz Ghassemi Jamalabadi ,  Peter C. Rahn ,  Kelvin J. Hammond ,  Omar Mneimne ,  Jeffrey A. Horsman ,  Peter C. Van Davelaar

IPC: B01D15/08

CPC classification number: B01D15/3857 ,  B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  B01J19/126 ,  B01J20/281 ,  B01J20/286 ,  B01J20/3242 ,  B01J2219/1227 ,  B01J2220/54 ,  G01N30/06 ,  G01N30/12 ,  G01N30/48 ,  G01N30/6091 ,  G01N2030/121 ,  G01N2030/3046 ,  H05B6/806

Abstract: A method of processing a sample comprising introducing a sample into a flow-through device containing a porous solid media therein, and thereafter subjecting the device to microwave energy.

公开(公告)号：US20050250857A1

公开(公告)日：2005-11-10

申请号：US10515209

申请日：2003-05-22

Applicant: Kjeld Jacobus Cornelis van Bommel ,  Johannes van Esch ,  Maaike de Loos ,  Andre Heeres ,  Bernard Feringa

Inventor： Kjeld Jacobus Cornelis van Bommel ,  Johannes van Esch ,  Maaike de Loos ,  Andre Heeres ,  Bernard Feringa

IPC: C09K3/00 ,  B01J20/291 ,  C07C229/08 ,  C07C229/36 ,  C07C233/63 ,  C07C233/83 ,  C07C233/87 ,  C07C237/20 ,  C07C237/22 ,  C07C271/22 ,  C07C275/26 ,  C07C275/40 ,  C07D213/40 ,  C07D233/54 ,  C07F5/02 ,  C07K5/06 ,  B01F17/00 ,  B01F3/08

CPC classification number: B01J20/291 ,  B01J20/22 ,  B01J20/281 ,  B01J2220/54 ,  C07C229/08 ,  C07C229/36 ,  C07C237/20 ,  C07C237/22 ,  C07C271/22

Abstract: The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a core which is functionalized with three amino acid derived groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.

Abstract translation: 本发明涉及一类新颖的胶凝剂，制备所述试剂的方法，所述试剂用于制备凝胶以及所得凝胶。 根据本发明的胶凝剂或增稠剂包括通过酰胺或脲键与三个氨基酸衍生基团官能化的核心。 它可用于使许多溶剂凝胶化或增稠。

公开(公告)号：US20050045561A1

公开(公告)日：2005-03-03

申请号：US10936846

申请日：2004-09-09

Applicant: Yoshio Okamoto ,  Chiyo Yamamoto ,  Takateru Kubota

Inventor： Yoshio Okamoto ,  Chiyo Yamamoto ,  Takateru Kubota

IPC: B01D15/08 ,  B01D15/38 ,  B01J20/22 ,  B01J20/24 ,  B01J20/281 ,  C07B57/00 ,  C08B3/00

CPC classification number: B01J20/285 ,  B01D15/3833 ,  B01J20/22 ,  B01J20/24 ,  B01J20/262 ,  B01J20/265 ,  B01J20/281 ,  B01J20/29 ,  B01J2220/54 ,  C07B57/00 ,  C07H13/02 ,  G01N30/48

Abstract: The present invention provides a separating agent for enantiomeric isomers having no large UV absorption, as represented by an aromatic group, and having high asymmetric recognizability, particularly, high asymmetric recognizability in an aqueous mobile phase, or a separating agent for enantiomeric isomers containing a polysaccharide alicyclic ester derivative free from an aromatic group as an effective component.

Abstract translation: 本发明提供了由芳族基团表示的不具有大的紫外线吸收的对映体异构体的分离剂，并且具有高不对称可识别性，特别是水性流动相中的高不对称可识别性，或含有多糖的对映体异构体的分离剂 不含芳族基团的脂环族酯衍生物作为有效成分。

公开(公告)号：US20050003373A1

公开(公告)日：2005-01-06

申请号：US10710991

申请日：2004-08-16

Applicant: Kemmons Tubbs ,  Karl Gruber ,  Randall Nelson

Inventor： Kemmons Tubbs ,  Karl Gruber ,  Randall Nelson

IPC: B01D15/08 ,  B01J20/281 ,  B01J20/32 ,  C12M1/34 ,  C12Q1/68 ,  G01N30/02 ,  G01N33/68 ,  G01N33/558

CPC classification number: G01N33/6845 ,  B01J20/28097 ,  B01J20/281 ,  B01J20/286 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3265 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/54 ,  B01J2220/64 ,  B82Y30/00 ,  G01N30/02 ,  G01N30/48 ,  G01N30/6095 ,  G01N33/54366 ,  G01N33/545 ,  G01N33/6803 ,  G01N2570/00 ,  H01J49/164 ,  H01J49/40 ,  Y10T436/255 ,  B01D15/3804

Abstract: Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.

Abstract translation: 描述了一种亲和力微柱，其包含高表面积材料，其具有包含在壳体内的高流动性和低死体积，并且具有结合到高表面积材料的表面的亲和试剂，其被激活或可激活。 结合亲和微柱表面的亲和试剂还包含用于整合生物分子的高通量分析的亲和受体。

公开(公告)号：US20050003372A1

公开(公告)日：2005-01-06

申请号：US10710990

申请日：2004-08-16

Applicant: Kemmons Tubbs ,  Karl Gruber ,  Randall Nelson

Inventor： Kemmons Tubbs ,  Karl Gruber ,  Randall Nelson

IPC: B01D15/08 ,  B01J20/281 ,  B01J20/32 ,  C12M1/34 ,  C12Q1/68 ,  G01N30/02 ,  G01N33/68 ,  G01N33/558

CPC classification number: G01N33/6845 ,  B01J20/28097 ,  B01J20/281 ,  B01J20/286 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3265 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/54 ,  B01J2220/64 ,  B82Y30/00 ,  G01N30/02 ,  G01N30/48 ,  G01N30/6095 ,  G01N33/54366 ,  G01N33/545 ,  G01N33/6803 ,  G01N2570/00 ,  H01J49/164 ,  H01J49/40 ,  Y10T436/255 ,  B01D15/3804

Abstract: Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.

公开(公告)号：US06783672B2

公开(公告)日：2004-08-31

申请号：US10053098

申请日：2002-01-15

Applicant: Kemmons A. Tubbs ,  Karl F. Gruber ,  Randall W. Nelson

Inventor： Kemmons A. Tubbs ,  Karl F. Gruber ,  Randall W. Nelson

IPC: B01D1508

CPC classification number: G01N33/6845 ,  B01J20/28097 ,  B01J20/281 ,  B01J20/286 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3265 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/54 ,  B01J2220/64 ,  B82Y30/00 ,  G01N30/02 ,  G01N30/48 ,  G01N30/6095 ,  G01N33/54366 ,  G01N33/545 ,  G01N33/6803 ,  G01N2570/00 ,  H01J49/164 ,  H01J49/40 ,  Y10T436/255 ,  B01D15/3804

Abstract: Described is an affinity microcolumn comprising a high surface area material, which has high flow properties and a low dead volume, contained within a housing and having affinity reagents bound to the surface of the high surface area material that are either activated or activatable. The affinity reagents bound to the surface of the affinity microcolumn further comprise affinity receptors for the integration into high throughput analysis of biomolecules.

Abstract translation: 描述了一种亲和力微柱，其包含高表面积材料，其具有包含在壳体内的高流动性和低死体积，并且具有结合到高表面积材料的表面的亲和试剂，其被激活或可激活。 结合亲和微柱表面的亲和试剂还包含用于整合生物分子的高通量分析的亲和受体。

公开(公告)号：US20030230524A1

公开(公告)日：2003-12-18

申请号：US10173538

申请日：2002-06-18

Inventor： Naohiro Soga ,  Kazuki Nakanishi ,  Hiroyoshi Minakuchi

IPC: B01D015/08

CPC classification number: G01N30/6095 ,  B01J20/103 ,  B01J20/28042 ,  B01J20/28092 ,  B01J20/281 ,  B01J20/283 ,  B01J2220/54 ,  B01J2220/82 ,  G01N2030/525 ,  G01N2030/528

Abstract: A chromatographic chip is formed of a plate member, a plurality of grooves formed on the plate member, and silica gel having monolithic bimodal pore structure formed in at least one of the grooves. The monolithic bimodal pore structure includes through pores and mesopores smaller than those of the through pores.

Abstract translation: 色谱芯片由板件，形成在板件上的多个槽和形成在至少一个槽中的整体双峰孔结构的硅胶形成。 整体双峰孔结构包括通孔和中孔比通孔更小。

公开(公告)号：US20020155509A1

公开(公告)日：2002-10-24

申请号：US10150587

申请日：2002-05-17

Applicant: CIPHERGEN BIOSYSTEMS, INC.

Inventor： T. William Hutchens ,  Tai-Tung Yip

IPC: G01N033/53 ,  G01N033/542 ,  G01N033/537 ,  G01N033/543

CPC classification number: C40B30/04 ,  B01D15/1878 ,  B01D15/305 ,  B01D15/3809 ,  B01J20/281 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3265 ,  B01J20/3274 ,  B01J20/3289 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2220/54 ,  C12Q1/00 ,  C40B40/10 ,  G01N30/00 ,  G01N30/02 ,  G01N30/461 ,  G01N30/463 ,  G01N30/466 ,  G01N30/48 ,  G01N30/482 ,  G01N30/90 ,  G01N30/95 ,  G01N33/531 ,  G01N33/538 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/566 ,  G01N33/6803 ,  G01N33/6845 ,  G01N33/6851 ,  G01N2030/008 ,  G01N2030/009 ,  Y02A90/26 ,  Y10S422/906 ,  Y10S435/803 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S435/815 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/809 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  Y10T436/255 ,  B01D15/363 ,  B01D15/322 ,  B01D15/327 ,  B01D15/3804 ,  B01D15/362 ,  B01D15/38 ,  B01D15/26

Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.

公开(公告)号：US20020100727A1

公开(公告)日：2002-08-01

申请号：US09975258

申请日：2001-10-12

Inventor： Robert C. Corcoran

IPC: B01D015/08

CPC classification number: B01D15/3857 ,  B01D15/3804 ,  B01J20/281 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54

Abstract: The invention relates to the separation of at least one target from a sample composition using a naturally reversible reaction comprising the formation of at least one covalent bond. One embodiment of the invention is a chromatographic method in which the affinity of a stationary phase for at least one target is based on the equilibrium constant of such a naturally reversible reaction between the stationary phase and the target.

Abstract translation: 本发明涉及使用包含形成至少一个共价键的天然可逆反应从样品组合物中分离至少一种靶。 本发明的一个实施方案是其中固定相对至少一种靶的亲和性基于固定相和靶之间的这种天然可逆反应的平衡常数的色谱法。

公开(公告)号：US06225047B1

公开(公告)日：2001-05-01

申请号：US09100302

申请日：1998-06-19

Applicant: T. William Hutchens ,  Tai-Tung Yip

Inventor： T. William Hutchens ,  Tai-Tung Yip

IPC: G01N33543

CPC classification number: C40B30/04 ,  B01D15/1878 ,  B01D15/305 ,  B01D15/3809 ,  B01J20/281 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3253 ,  B01J20/3265 ,  B01J20/3274 ,  B01J20/3289 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2220/54 ,  C12Q1/00 ,  C40B40/10 ,  G01N30/00 ,  G01N30/02 ,  G01N30/461 ,  G01N30/463 ,  G01N30/466 ,  G01N30/48 ,  G01N30/482 ,  G01N30/90 ,  G01N30/95 ,  G01N33/531 ,  G01N33/538 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/566 ,  G01N33/6803 ,  G01N33/6845 ,  G01N33/6851 ,  G01N2030/008 ,  G01N2030/009 ,  Y02A90/26 ,  Y10S422/906 ,  Y10S435/803 ,  Y10S435/81 ,  Y10S435/814 ,  Y10S435/815 ,  Y10S435/97 ,  Y10S435/973 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/809 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375 ,  Y10T436/255 ,  B01D15/363 ,  B01D15/322 ,  B01D15/327 ,  B01D15/3804 ,  B01D15/362 ,  B01D15/38 ,  B01D15/26

Abstract: This is invention is directed to methods of identifying analytes that are differentially present between two samples. The methods involve determining retention data by desorption spectrometry for analytes in different samples using the same selectivity conditions, comparing the data, and identifying analytes that are differentially retained.

Abstract translation: 本发明涉及鉴定两个样品之间差异存在的分析物的方法。 这些方法涉及通过解吸光谱法确定不同样品中分析物的保留数据，使用相同的选择性条件，比较数据和鉴定差异保留的分析物。