公开(公告)号：US20180050282A1

公开(公告)日：2018-02-22

申请号：US15560933

申请日：2016-03-24

Applicant: DAICEL CORPORATION

Inventor： Kanji NAGAI ,  Satoshi SHINKURA

IPC: B01D15/40 ,  B01J20/281 ,  C08L39/00 ,  G01N30/88

CPC classification number: B01D15/40 ,  B01J20/28 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/281 ,  B01J20/288 ,  B01J20/30 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3278 ,  B01J20/3293 ,  C08F2/44 ,  C08L39/00 ,  G01N30/02 ,  G01N30/88

Abstract: Provided is a stationary phase for supercritical fluid chromatography, the stationary phase having satisfactory molecule-identifying ability, in particular, satisfactory separating properties with respect to not only acidic compounds or basic compounds but also fused aromatic compounds or aromatic isomers. The stationary phase for supercritical fluid chromatography includes a support having, bonded thereto, a polymer in which the main chain has nitrogenous aromatic rings in the repeating units.

公开(公告)号：US20180001229A1

公开(公告)日：2018-01-04

申请号：US15536506

申请日：2015-12-16

Applicant: Waters Technologies Corporation

Inventor： Pamela C. Iraneta ,  Xin Zhang ,  Frank John Marszalkowski, Jr.

IPC: B01D15/38 ,  B01J20/287 ,  B01J20/288 ,  B01J20/32 ,  B01J20/28 ,  G01N30/00 ,  G01N1/40

CPC classification number: B01D15/3847 ,  B01J20/28052 ,  B01J20/287 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  G01N30/50 ,  G01N30/72 ,  G01N2001/4061 ,  G01N2030/009

Abstract: Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis. In particular, the sorbents includes at least one sorbent which is water-wettable and contains at least one hydrophobic component and at least one hydrophilic component and at least one of sorbent having a specific affinity for a matrix interference like phospholipids. Further disclosed is a method using the device of the present invention.

公开(公告)号：US09675959B2

公开(公告)日：2017-06-13

申请号：US13872081

申请日：2013-04-27

Applicant: Xinmiao Liang ,  Huihui Wan ,  Xingya Xue

Inventor： Xinmiao Liang ,  Huihui Wan ,  Xingya Xue

IPC: B01D15/26 ,  B01J20/28 ,  B01J20/283 ,  B01J20/32 ,  B01J20/288 ,  C01B21/082 ,  B01D15/22 ,  B01J20/282 ,  B01J20/281

CPC classification number: B01J20/288 ,  B01D15/26 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28083 ,  B01J20/281 ,  B01J20/282 ,  B01J20/283 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3248 ,  C01B21/0823 ,  C01P2002/86 ,  C01P2002/87 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  Y10T428/2982

Abstract: Novel material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, the novel materials are porous silicon oxynitride materials, which desirably can be surface modified and have enhanced stability at high pH. The novel porous silicon oxynitride material may offer efficient chromatographic separations, and hold great promise as packing material for chromatographic separations.

公开(公告)号：US20170065962A1

公开(公告)日：2017-03-09

申请号：US15357124

申请日：2016-11-21

Applicant: ASAHI KASEI CHEMICALS CORPORATION

Inventor： Naoyuki SHINOHARA ,  Yuta SATO

IPC: B01J20/26 ,  B01J20/288 ,  B01J20/32 ,  B01J41/20 ,  B01J41/04 ,  C07K1/22 ,  B01J47/12 ,  B01J39/04 ,  B01J39/20 ,  B01J39/26 ,  C08J5/22 ,  B01J20/28 ,  B01J41/14

CPC classification number: B01J20/265 ,  B01J20/28023 ,  B01J20/288 ,  B01J20/3078 ,  B01J20/321 ,  B01J20/3217 ,  B01J20/327 ,  B01J20/3278 ,  B01J20/3293 ,  B01J39/07 ,  B01J39/20 ,  B01J39/26 ,  B01J41/07 ,  B01J41/13 ,  B01J41/14 ,  B01J41/20 ,  B01J47/12 ,  B01J47/127 ,  B01J47/133 ,  B01J2220/52 ,  C07K1/22 ,  C08J5/2243 ,  C08J2351/06 ,  C08J2351/08

Abstract: A method for producing a protein adsorbent comprising a substrate and a molecular chain fixed on the surface of the substrate is disclosed. The method comprises, in this order: a dry-heat treatment step of heating a pretreatment adsorbent comprising the substrate and the molecular chain fixed on the surface of the substrate, in which the molecular chain contains a weak electrolytic ion-exchange group; and a wet-heat treatment step of heating the pretreatment adsorbent in a moistened state with a liquid or steam to obtain the protein adsorbent.

Abstract translation: 公开了一种生产蛋白质吸附剂的方法，该方法包括固定在基底表面上的基底和分子链。 该方法按照以下顺序进行：将包含基板的预处理吸附剂和固定在基板表面上的分子链进行加热的干热处理工序，其中分子链含有弱电解离子交换基团; 以及湿润处理步骤，用液体或蒸汽将预处理吸附剂加湿，得到蛋白质吸附剂。

公开(公告)号：US09486799B2

公开(公告)日：2016-11-08

申请号：US13610495

申请日：2012-09-11

Applicant: Christopher A. Pohl

Inventor： Christopher A. Pohl

IPC: B01J41/08 ,  B01J20/32 ,  B01J41/20 ,  B01D15/36 ,  B01J20/288

CPC classification number: B01J41/20 ,  B01D15/363 ,  B01J20/288 ,  B01J20/3251 ,  B01J20/3289 ,  B01J41/09

Abstract: Treatment of anion exchange materials containing hydroxyl containing moieties in the beta position relative to the quaternary center in the hydroxide form with glycidol substantially alters the selectivity of the anion exchange material. Furthermore, sequential treatments of first a hydroxide containing solution to put the anion exchange material in the hydroxide form followed by treatment with glycidol in an alternating sequence progressively changes selectivity in a predictable manner allowing facile manipulation of selectivity. Unique to the selectivities achievable with this chemistry is the ability to reverse the elution order of sulfate and carbonate. With all other known systems, carbonate elutes ahead of sulfate and sometimes compromises the ability to quantitate sulfate. With glycidol treatment, carbonate can be moved after sulfate which eliminates interference issues for samples containing significantly more carbonate than sulfate. This modification is useful for columns operated with a hydroxide or carbonate eluent system.

Abstract translation: 含有羟基的阴离子交换材料相对于具有缩水甘油的氢氧化物形式的季中心的β位置的处理基本上改变了阴离子交换材料的选择性。 此外，首先连续处理含氢氧化物溶液以将阴离子交换材料置于氢氧化物形式，然后以交替的顺序用缩水甘油处理，以可预测的方式逐渐改变选择性，从而容易地操纵选择性。 通过该化学可以实现的选择性独特的是反转硫酸盐和碳酸盐的洗脱顺序的能力。 使用所有其他已知的系统，碳酸盐在硫酸盐之前洗脱，有时会损害硫酸盐的定量能力。 通过缩水甘油处理，碳酸盐可以在硫酸盐之后移动，消除了含有比硫酸盐显着更多的碳酸盐的样品的干扰问题。 该修饰对于用氢氧化物或碳酸盐洗脱液系统操作的柱是有用的。

公开(公告)号：US20160272676A1

公开(公告)日：2016-09-22

申请号：US15033940

申请日：2014-11-06

Applicant: EMD MILLIPORE CORPORATION

Inventor： Mikhail Kozlov ,  William Cataldo ,  Jeffrey Caron

IPC: C07K1/34 ,  C07K16/00 ,  C08F220/56 ,  C08F220/54 ,  C08F220/18 ,  B01J20/289 ,  C08J5/22 ,  C08F259/08 ,  B01D15/10 ,  B01D37/00 ,  B01J20/26 ,  B01J20/288 ,  C07K1/18 ,  C08F220/58

CPC classification number: C07K1/34 ,  B01D15/10 ,  B01D37/00 ,  B01J20/267 ,  B01J20/288 ,  B01J20/289 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/327 ,  B01J20/3276 ,  B01J20/3291 ,  B01J39/26 ,  B01J2220/80 ,  C07K1/18 ,  C07K16/00 ,  C08F220/18 ,  C08F220/54 ,  C08F220/56 ,  C08F220/58 ,  C08F259/08 ,  C08F2220/1825 ,  C08F2220/1858 ,  C08J5/2243 ,  C08J2351/00

Abstract: Novel compositions for re-moving impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can be used prior to the virus filtration step during protein purification, to remove aggregates and protect the virus filter from fouling, therefore improving virus filter capacity. A porous solid support including a co-polymer having at least two monomers, wherein at least one of the monomers comprises acrylamide and at least a second monomer comprises a hydrophobic binding group, where the solid support selectively binds protein aggregates, thereby to separate the monomeric protein of interest from the protein aggregates. The method can be performed under neutral to high pH and high conductivity conditions.

Abstract translation: 用于从含有目的蛋白质的样品例如抗体重新杂交诸如蛋白质聚集体的新型组合物。 这样的组合物可以在蛋白质纯化期间的病毒过滤步骤之前使用，以除去聚集体并保护病毒过滤器免于结垢，从而提高病毒过滤能力。 一种多孔固体支持物，包括具有至少两种单体的共聚物，其中所述单体中的至少一种包含丙烯酰胺，并且至少第二单体包含疏水性结合基团，其中所述固体支持物选择性地结合蛋白质聚集体，由此分离单体 来自蛋白质聚集体的目标蛋白质。 该方法可在中性至高pH和高电导条件下进行。

公开(公告)号：US09353317B2

公开(公告)日：2016-05-31

申请号：US13237568

申请日：2011-09-20

Applicant: John F. Schabron ,  Ryan B. Boysen ,  Eric W. Kalberer ,  Joseph F. Rovani, Jr.

Inventor： John F. Schabron ,  Ryan B. Boysen ,  Eric W. Kalberer ,  Joseph F. Rovani, Jr.

IPC: C10G53/08 ,  C10G25/00 ,  B01D15/26 ,  C10G25/12 ,  G01N30/46 ,  G01N33/28 ,  B01J20/281 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01J20/287 ,  B01D15/00 ,  G01N30/08 ,  G01N30/88

CPC classification number: C10G53/08 ,  B01D15/00 ,  B01D15/08 ,  B01D15/265 ,  B01J20/103 ,  B01J20/281 ,  B01J20/283 ,  B01J20/284 ,  B01J20/286 ,  B01J20/287 ,  B01J20/288 ,  B01J2220/603 ,  C10G25/00 ,  C10G25/003 ,  C10G25/12 ,  C10G2300/206 ,  C10G2400/30 ,  G01N30/14 ,  G01N30/461 ,  G01N30/468 ,  G01N33/2823 ,  G01N33/2835 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/143 ,  G01N2030/8854

Abstract: The inventive technology may involve, in particular embodiments, novel use of a non-porous, high surface energy stationary phase to adsorb, in reversible fashion, the most polar component of a resins fraction of an input hydrocarbon when a mobile phase is passed over the stationary phase. Such reversible adsorption prevents irreversibly adsorption of such components on active stationary phase(s) downflow of the non-porous, high surface energy stationary phase, thereby conserving stationary phase costs and increasing resolution of resins elutions, and accuracy of hydrocarbon component results. Aspects of the inventive technology may also involve a novel combination of a solubility based asphaltene component fractionating and analysis method and an adsorption chromatography method for separating and/or analyzing saturate, aromatics and resins components of an input hydrocarbon.

Abstract translation: 在具体实施方案中，本发明的技术可以涉及无孔高表面能固定相的新用途，以可逆的方式吸附输入烃的树脂级分的最极性组分，当流动相通过 固定相。 这种可逆吸附防止这些组分在无孔，高表面能固定相的活性固定相向下流动中的不可逆吸附，从而保持固定相成本和提高树脂洗脱液的分离度以及烃组分结果的准确性。 本发明技术的方面还可以涉及一种基于溶解度的沥青质组分分馏和分析方法的新型组合以及用于分离和/或分析输入烃的饱和物，芳族化合物和树脂组分的吸附层析方法。

公开(公告)号：US20150141241A1

公开(公告)日：2015-05-21

申请号：US14400227

申请日：2013-05-10

Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Eiji Yashima ,  Hiroki Iida ,  Zhenglin Tang ,  Yuki Naito

IPC: B01J20/288 ,  B01J20/10 ,  B01J20/26

CPC classification number: B01J20/288 ,  B01D15/3833 ,  B01J20/103 ,  B01J20/262 ,  B01J20/264 ,  B01J20/28016 ,  B01J20/283 ,  B01J20/29 ,  B01J2220/80 ,  G01N2030/8877

Abstract: Provided is a novel separating agent for optical isomers based on a helical polymer having optically active sites. The separating agent for optical isomers has a helical polymer having a structure represented by Formula (I), and a carrier that supports the helical polymer, wherein the helical polymer is supported by the carrier. (In Formula (I), X represents a divalent aromatic group, a single bond or a methylene group; R represents hydrogen or a C1-C5 alkoxy; and n represents an integer equal to or higher than 5. When X is a divalent aromatic group, Y represents —CONH—, —COO—, —NHCONH—, —NHCSNH—, —SO2NH— or —NHCOO—, and when X is a single bond or a methylene group, Y represents —COO—, —NHCONH—, —NHCSNH— or —NHCOO—.)

Abstract translation: 提供了一种基于具有光学活性位点的螺旋聚合物的光学异构体的新型分离剂。 用于光学异构体的分离剂具有由式（I）表示的结构的螺旋聚合物和支持螺旋聚合物的载体，其中螺旋聚合物由载体负载。 （式（I）中，X表示二价芳基，单键或亚甲基，R表示氢或C1-C5烷氧基，n表示5以上的整数。X表示二价芳香族 基团，Y表示-CONH-，-COO - ， - NHCONH - ， - NHCSNH-， - SO 2 NH-或-NHCOO-，当X是单键或亚甲基时，Y表示-COO - ， - NHCONH-， -NHCSNH-或-NHCOO-））

公开(公告)号：US20150045545A1

公开(公告)日：2015-02-12

申请号：US14344171

申请日：2012-09-17

Applicant: INSTRACTION GMBH

Inventor： Markus Arendt ,  Björn Degel ,  Thomas Schwarz ,  Gerhard Stumm ,  Martin Welter

IPC: B01J20/289 ,  C07H15/248 ,  C07H1/06 ,  C07H17/08

CPC classification number: B01J20/289 ,  A61K31/7032 ,  A61K31/7036 ,  B01J20/288 ,  B01J20/3219 ,  B01J20/3253 ,  B01J20/328 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/80 ,  C07H1/06 ,  C07H15/248 ,  C07H17/08

Abstract: The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications.

Abstract translation: 本发明涉及包含固体支持材料的吸附剂，其表面包含通式（I）的残基，其中所述残基通过共价单键连接到本体固体的表面上的官能团 支撑材料本身或固体支撑材料表面上的聚合物膜。 此外，本发明涉及根据本发明的吸附剂用于纯化有机分子，特别是药学活性化合物，优选在色谱应用中的用途。

公开(公告)号：US20140243498A1

公开(公告)日：2014-08-28

申请号：US14348634

申请日：2012-09-28

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： Eggert Brekkan ,  Kjell Eriksson ,  Bo-Lennart Johansson ,  Jamil Shanagar

IPC: C07K14/62

CPC classification number: C07K14/62 ,  B01D15/361 ,  B01D15/362 ,  B01J20/286 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3293 ,  B01J39/26

Abstract: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.

Abstract translation: 本发明在生物分子纯化领域内。 更具体地，本发明涉及使用具有内核和外功能化层的特定种类的壳珠的色谱纯化胰岛素。 该方法能够在高流速和高纯度下纯化，超过90％。