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    Thiazole benzenesulfonamides as .beta.3 agonists for treatment of diabetes and obesity
    41.
    发明授权
    Thiazole benzenesulfonamides as .beta.3 agonists for treatment of diabetes and obesity 失效
    噻唑苯磺酰胺作为治疗糖尿病和肥胖症的β3激动剂

    公开(公告)号：US6011048A

    公开(公告)日：2000-01-04

    申请号：US7363

    申请日：1998-01-15

    Applicant: Robert J. Mathvink ,  Emma R. Parmee ,  Samuel Tolman ,  Ann E. Weber

    Inventor： Robert J. Mathvink ,  Emma R. Parmee ,  Samuel Tolman ,  Ann E. Weber

    IPC: C07D20060101 ,  C07D417/12 ,  C07D417/14 ,  C07D417/10 ,  A61K31/44

    CPC classification number: B05D1/305 ,  C07D417/12 ,  C07D417/14 ,  B05D3/044

    Abstract: Thiazole substituted benzenesulfonamides are .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.

    Abstract translation: 噻唑取代的苯磺酰胺是具有非常少的β1和β2肾上腺素能受体活性的β3肾上腺素能受体激动剂，因此化合物能够增加细胞中的脂肪分解和能量消耗。 因此，这些化合物在治疗II型糖尿病和肥胖中具有有效的活性。 该化合物也可用于降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠道运动性。 此外，该化合物可用于减少神经源性炎症或作为抗抑郁剂。 通过将氨基烷基苯基磺酰胺与适当取代的环氧化物偶合来制备化合物。 还公开了使用该化合物治疗糖尿病和肥胖以及降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠蠕动的组合物和方法。

    Polymer coating of metal surfaces
    42.
    发明授权
    Polymer coating of metal surfaces 失效
    金属表面聚合物涂层

    公开(公告)号：US3567521A

    公开(公告)日：1971-03-02

    申请号：US3567521D

    申请日：1968-08-05

    Applicant: MC DONNELL DOUGLAS CORP

    Inventor： TOY MADELINE S ,  TINER NATHAN A

    IPC: B05D3/04 ,  B05D7/24 ,  C23F7/00

    CPC classification number: B05D1/60 ,  B05D3/044 ,  B05D2202/00 ,  B05D2506/10 ,  Y10T428/31544 ,  Y10T428/31692

    Abstract: POLYMER COATED METAL SURFACE AND PROCESS THEREFOR. THE METAL SURFACE IS FIRST TREATED WITH ELEMENTAL FLUORINE TO FORM AN INTEGRAL, CHEMICALLY BONDD SURFACE COATING OF METAL FLUROIDE. THE METAL FLUORIDE SURFACE COATING IS THEN EXPOSED TO A FILM FORMING MONOMER, E.G., TETRAFLUOROETHYLENE, TO CAUSE IN SITU POLYMERIZATION THEREON AND PRODUCE A UNIFORM, CONTINUOUS, ADHERENT POLYMER COATING. SUCH TETRAFLUOROETHYLENE POLYMER COATED METAL SURFACES PROVIDE EXCELLENT CORROSION RESISTANCE USEFUL FOR PROTECTIVE COATINGS PARTICULARLY ON METAL STRUCTURAL COMPONENTS.

    SUBSTRATE PROCESSING APPARATUS AND SUBSTRATE PROCESSING METHOD
    47.
    发明申请
    SUBSTRATE PROCESSING APPARATUS AND SUBSTRATE PROCESSING METHOD 审中-公开
    基板处理装置和基板处理方法

    公开(公告)号：US20160293387A1

    公开(公告)日：2016-10-06

    申请号：US15180935

    申请日：2016-06-13

    Applicant: Song Whe HUH ,  Jeung Hoon HAN

    Inventor： Song Whe HUH ,  Jeung Hoon HAN

    IPC: H01J37/32 ,  C23C16/455 ,  H01L21/02 ,  H01L21/687 ,  H01L21/3065 ,  C23C16/50 ,  H01L21/67

    CPC classification number: H01L21/68764 ,  B05D3/044 ,  C23C16/509 ,  H01J37/32366 ,  H01J37/3244 ,  H01J37/32449 ,  H01J37/3255 ,  H01J37/32568 ,  H01J37/32715 ,  H01J37/32733 ,  H01J37/32752 ,  H01L21/02 ,  H01L21/02057 ,  H01L21/68771

    Abstract: Disclosed is a substrate processing apparatus and method which facilitate to improve uniformity of thin film material and also facilitate to control quality of thin film by the use of plasma forming space and source gas distributing space separately provided from each other, wherein the substrate processing apparatus includes a process chamber; a substrate support for supporting a plurality of substrates, the substrate support rotatably provided inside the process chamber; and an electrode unit arranged above the substrate support and provided with the plasma forming space and the source gas distributing space, wherein the plasma forming space is spatially separated from the source gas distributing space.

    Abstract translation: 公开了一种有利于提高薄膜材料的均匀性的基板处理装置和方法，并且还通过使用彼此分开设置的等离子体形成空间和源气体分配空间来有助于控制薄膜的质量，其中基板处理装置包括 处理室; 用于支撑多个基板的基板支撑件，可旋转地设置在处理室内的基板支撑件; 以及电极单元，其布置在所述基板支撑件上方并设置有所述等离子体形成空间和所述源气体分配空间，其中所述等离子体形成空间与所述源气体分配空间在空间上分离。

    METHOD FOR PREPARING SAMPLES FOR IMAGING
    49.
    发明申请
    METHOD FOR PREPARING SAMPLES FOR IMAGING 有权
    制备图像样本的方法

    公开(公告)号：US20150179402A1

    公开(公告)日：2015-06-25

    申请号：US14572626

    申请日：2014-12-16

    Applicant: FEI Company

    Inventor： Ronald Kelley ,  Michael Moriarty ,  Stacey Stone ,  Jeffrey Blackwood

    IPC: H01J37/305 ,  C23C14/30

    CPC classification number: H01J37/3053 ,  B05D3/044 ,  C23C14/30 ,  G01N1/286 ,  G01N1/32 ,  G01N2001/2886 ,  H01J37/265 ,  H01J37/3056 ,  H01J2237/31745 ,  H01J2237/3348 ,  H01L21/02318

    Abstract: A method and apparatus is provided for preparing samples for observation in a charged particle beam system in a manner that reduces or prevents artifacts. Material is deposited onto the sample using charged particle beam deposition just before or during the final milling, which results in an artifact-free surface. Embodiments are useful for preparing cross sections for SEM observation of samples having layers of materials of different hardnesses. Embodiments are useful for preparation of thin TEM samples.

    Abstract translation: 提供了一种方法和装置，用于以减少或防止伪影的方式制备用于在带电粒子束系统中观察的样品。 在最终研磨之前或期间，使用带电粒子束沉积将材料沉积到样品上，这导致无伪影的表面。 实施例对于制备具有不同硬度的材料层的样品的SEM观察的截面是有用的。 实施例可用于制备薄TEM样品。

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