公开(公告)号：US20180148392A1

公开(公告)日：2018-05-31

申请号：US15571670

申请日：2016-05-16

Applicant: DAICEL CORPORATION

Inventor： Jun SHEN ,  Qiang LI ,  Geng LI ,  Yoshio OKAMOTO

IPC: C07B57/00 ,  B01J20/281 ,  G01N30/88

CPC classification number: C07B57/00 ,  B01J20/281 ,  B01J20/286 ,  B01J20/29 ,  B01J20/328 ,  G01N30/88

Abstract: Provided is a separating agent for optical isomers, which is configured of a novel xylan derivative and a carrier. Specifically provided is a separating agent for optical isomers, which is configured of a carrier and a xylan-phenylcarbamate derivative that is obtained by substituting a hydroxy group of xylan with a group represented by formula (I) or (II). (In formula (I), R1 represents a halogen or an alkyl group having 1-5 carbon atoms; and the position of substitution of the R1 moiety is the meta position or the para position. In formula (II), each of R2 and R3 independently represents a halogen or an alkyl group having 1-5 carbon atoms, and R2 and R3 are groups different from each other.)

公开(公告)号：US20180056271A1

公开(公告)日：2018-03-01

申请号：US15783248

申请日：2017-10-13

Applicant: Kaneka Corporation

Inventor： Yoshikazu Kawai ,  Asuka Hayashi ,  Masaru Hirano ,  Yosuke Kawahata

IPC: B01J20/24 ,  B01D15/38 ,  B01J20/30 ,  B01J20/28 ,  B01J20/285 ,  C08J9/28 ,  B01J20/281

CPC classification number: B01J20/24 ,  B01D15/08 ,  B01D15/3809 ,  B01J20/28016 ,  B01J20/285 ,  B01J20/30 ,  B01J20/3085 ,  B01J2220/52 ,  C08J9/28 ,  G01N30/482 ,  G01N30/88

Abstract: A method for producing porous cellulose beads includes preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose; preparing a mixed liquid by adding a crosslinking agent to the fine cellulose dispersion; preparing an emulsion by dispersing the mixed liquid in a dispersion medium; and contacting the emulsion with a coagulating solvent.

公开(公告)号：US20180050282A1

公开(公告)日：2018-02-22

申请号：US15560933

申请日：2016-03-24

Applicant: DAICEL CORPORATION

Inventor： Kanji NAGAI ,  Satoshi SHINKURA

IPC: B01D15/40 ,  B01J20/281 ,  C08L39/00 ,  G01N30/88

CPC classification number: B01D15/40 ,  B01J20/28 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/281 ,  B01J20/288 ,  B01J20/30 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3278 ,  B01J20/3293 ,  C08F2/44 ,  C08L39/00 ,  G01N30/02 ,  G01N30/88

Abstract: Provided is a stationary phase for supercritical fluid chromatography, the stationary phase having satisfactory molecule-identifying ability, in particular, satisfactory separating properties with respect to not only acidic compounds or basic compounds but also fused aromatic compounds or aromatic isomers. The stationary phase for supercritical fluid chromatography includes a support having, bonded thereto, a polymer in which the main chain has nitrogenous aromatic rings in the repeating units.

公开(公告)号：US20170326103A1

公开(公告)日：2017-11-16

申请号：US15502757

申请日：2015-08-12

Applicant: Monash University

Inventor： Chris Porter ,  Jamie Simpson ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K31/365 ,  A61K31/568 ,  C07J7/00 ,  C07J1/00 ,  A61K31/4025 ,  B01J20/281 ,  C07J5/00 ,  A61K45/06 ,  A61K31/40 ,  C07J9/00 ,  C07J31/00 ,  G01N30/00

CPC classification number: A61K31/365 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/568 ,  A61K45/06 ,  A61P5/24 ,  C07J1/0025 ,  C07J1/0029 ,  C07J5/00 ,  C07J7/002 ,  C07J9/00 ,  C07J31/00 ,  C07J31/006 ,  C09J5/00 ,  G01N30/48 ,  G01N2030/486 ,  A61K2300/00

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

公开(公告)号：US20170320051A1

公开(公告)日：2017-11-09

申请号：US15658587

申请日：2017-07-25

Applicant: AGC SI-TECH CO., LTD.

Inventor： YOUICHI KAYANO ,  RYOU NAKASHIMA ,  HIROYOSHI MIYAHARA

IPC: B01J39/17 ,  B01J39/26 ,  B01J39/18 ,  B01J20/281 ,  B01J39/04

CPC classification number: B01J39/17 ,  B01J20/0259 ,  B01J20/06 ,  B01J20/103 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3274 ,  B01J39/04 ,  B01J39/18 ,  B01J39/26 ,  C01B33/18 ,  G01N30/482

Abstract: To provide a porous silica having high alkali resistance; and a chromatographic carrier using such a porous silica. A porous silica comprising a phosphorus oxide component and a zirconium oxide component, wherein the amount of phosphorus atoms per unit specific surface area of the porous silica is from 1 μmol/m2 to 25 μmol/m2; and the amount of zirconium atoms per unit specific surface area of the porous silica is from 1 μmol/m2 to 15 μmol/m2. And, a chromatographic carrier which contains a ligand immobilized to such a porous silica.

公开(公告)号：US20170320041A1

公开(公告)日：2017-11-09

申请号：US15661754

申请日：2017-07-27

Applicant: Impossible Foods Inc. ,  The Board of Trustees of the Leland Stanford Junior University

Inventor： Patrick O'Reilly Brown ,  R. Edward Watts ,  Pehr Harbury

IPC: B01J20/281 ,  G01N33/543 ,  C07K1/22 ,  C07D251/70 ,  B01J20/32 ,  A61K31/53 ,  B01J20/286 ,  G01N33/68 ,  C07D251/54

CPC classification number: B01J20/281 ,  A61K31/53 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3251 ,  C07D251/54 ,  C07D251/70 ,  C07K1/22 ,  G01N33/543 ,  G01N33/6818

Abstract: Disclosed herein are methods and compositions for purifying proteins from crude solutions.

公开(公告)号：US09809706B2

公开(公告)日：2017-11-07

申请号：US14915326

申请日：2014-09-01

Applicant: Council of Scientific & Industrial Research

Inventor： Sachin Tanaji Mane ,  Siona Virgil Daniels ,  Sarika Babasaheb Deokar ,  Smita Atmaram Mule ,  Surendra Ponrathnam ,  Nayaku Nivrati Chavan

IPC: B01J20/22 ,  B01J20/26 ,  B01J20/281 ,  C08L33/12 ,  C08L33/14 ,  C08L47/00 ,  C08F2/18 ,  C08F220/14 ,  C08F8/14 ,  C08F8/30 ,  C08L33/06 ,  C08F120/32 ,  C08F226/10

CPC classification number: C08L33/14 ,  B01J20/22 ,  B01J20/261 ,  B01J20/267 ,  B01J20/281 ,  C08F2/18 ,  C08F8/14 ,  C08F8/30 ,  C08F120/32 ,  C08F220/14 ,  C08F226/10 ,  C08L33/06 ,  C08L33/12 ,  C08L47/00 ,  C08F2222/1013 ,  C08F212/14

Abstract: The present invention relates to a process for the separation of enantiomers or resolution of racemic mixtures using high surface area core-shell polymer beads. The present invention further relates to a core-shell functionalized polymer comprising a core which comprises copolymer made from monomers selected from non-aromatic acrylate, ethylene dimethacrylate and divinyl-benzene, a shell which comprises monomers selected from glycidyl ethers of methacrylate and a chiral selector selected from tartaric acid derivatives and amino acids.

公开(公告)号：US09675959B2

公开(公告)日：2017-06-13

申请号：US13872081

申请日：2013-04-27

Applicant: Xinmiao Liang ,  Huihui Wan ,  Xingya Xue

Inventor： Xinmiao Liang ,  Huihui Wan ,  Xingya Xue

IPC: B01D15/26 ,  B01J20/28 ,  B01J20/283 ,  B01J20/32 ,  B01J20/288 ,  C01B21/082 ,  B01D15/22 ,  B01J20/282 ,  B01J20/281

CPC classification number: B01J20/288 ,  B01D15/26 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28083 ,  B01J20/281 ,  B01J20/282 ,  B01J20/283 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3248 ,  C01B21/0823 ,  C01P2002/86 ,  C01P2002/87 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  Y10T428/2982

Abstract: Novel material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, the novel materials are porous silicon oxynitride materials, which desirably can be surface modified and have enhanced stability at high pH. The novel porous silicon oxynitride material may offer efficient chromatographic separations, and hold great promise as packing material for chromatographic separations.

公开(公告)号：US09630165B2

公开(公告)日：2017-04-25

申请号：US14629315

申请日：2015-02-23

Applicant: Genzyme Corporation

Inventor： Rahul Godawat ,  Veena Warikoo ,  Rohan Patil ,  Konstantin Konstantinov ,  Venkat Kishore Ryakala

IPC: B01J20/34 ,  B01D15/36 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J41/12 ,  B01J41/20 ,  C07K1/16 ,  C07K1/22 ,  A61L2/08 ,  C07K1/18 ,  B01D15/18 ,  B01D15/20 ,  B01D15/32 ,  B01D15/34 ,  B01J39/26

CPC classification number: B01J20/3441 ,  A61L2/081 ,  B01D15/1864 ,  B01D15/20 ,  B01D15/327 ,  B01D15/34 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01J20/265 ,  B01J20/281 ,  B01J39/26 ,  B01J41/12 ,  B01J41/20 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22 ,  Y10T29/49826

Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

公开(公告)号：US09625426B2

公开(公告)日：2017-04-18

申请号：US14638544

申请日：2015-03-04

Applicant: Janusz Boleslaw Pawliszyn ,  Jonathan James Grandy ,  German Augusto Gomez Rios

Inventor： Janusz Boleslaw Pawliszyn ,  Jonathan James Grandy ,  German Augusto Gomez Rios

IPC: B01J20/281 ,  G01N1/40 ,  G01N30/04 ,  B01D15/10 ,  G01N30/00 ,  G01N30/06 ,  G01N1/28

CPC classification number: G01N30/04 ,  B01L2300/069 ,  G01N1/405 ,  G01N30/08 ,  G01N30/48 ,  G01N2001/2893 ,  G01N2030/009 ,  G01N2030/045 ,  G01N2030/062 ,  G01N2030/488

Abstract: The invention describes the process by which a standard mixture of organic compounds are spiked and retained onto a composite sorbent matrix for the controlled generation of a standard in fluid above the spiked matrix either in a gaseous or aqueous phase. The novelty of the aforementioned composite matrix stems from the combination of an immobilizing liquid phase such as silicone oil or a polyacrylonitrile solution, and solid, porous particles such as polystyrene-co-divinylbenzene (PS-DVB) or hydrophilic/Lipophilic Balance (HLB) particles to strongly retain the spiked standards. These novel composite mixtures exhibit sorptive capabilities greater than the sum of their individual components. In addition swelling of the particles with the liquid phase facilitates immobilization of the composite sorbent matrix in the vial. With thermodynamic equilibrium strongly favoring the sorbent phase for a wide range of chemical compounds, this invention allows for the reproducible generation of an ultra-low concentration standard analyte mixture in fluid.