公开(公告)号：US20020109842A1

公开(公告)日：2002-08-15

申请号：US09782089

申请日：2001-02-12

Applicant: Engelhard Corp.

Inventor： James B. Carroll JR. ,  Charles Willard

IPC: G01J003/42

CPC classification number: G01J3/50 ,  G01J3/463 ,  G01J3/504 ,  G01N21/05 ,  G01N21/251 ,  G01N21/45 ,  G01N21/85 ,  G01N2021/0346

Abstract: An apparatus and a method for objectively ascertaining a color match between a selected standard color and the color exhibited by an interference effect pigment during processing thereof and terminating the process upon achieving a match. The invention provides a spectrophotometer attached to a flow cell to monitor the color of a platy effect pigment to monitor pigment color and ascertain completion of the coating reaction process involved in interference pigment production.

Abstract translation: 一种用于客观地确定所选标准颜色与干涉效应颜料在其处理期间展现的颜色之间的颜色匹配的装置和方法，并且在实现匹配时终止处理。 本发明提供一种附着在流动池上的分光光度计，以监测片状效应颜料的颜色，以监测颜料颜色，并确定涉及干涉颜料生产的涂层反应过程的完成。

公开(公告)号：US20020102595A1

公开(公告)日：2002-08-01

申请号：US10059754

申请日：2002-01-29

Inventor： Lloyd Mervyn Davis

IPC: C12Q001/68 ,  C12M001/34 ,  G01J003/42 ,  G01J003/427

CPC classification number: G01N15/14 ,  C12Q1/6869 ,  G01N2015/1415 ,  G01N2015/1438 ,  C12Q2533/101

Abstract: Methods and devices for detecting the incorporation of NTPs into immobilized enzyme-nucleic acid complexes are disclosed. The methods and devices can be used to genotype or sequence nucleic acids, including DNA and RNA, and are capable, in preferred embodiments, of detecting single incorporation events.

Abstract translation: 公开了用于检测NTPs结合到固定化酶 - 核酸复合物中的方法和装置。 方法和装置可用于对核酸（包括DNA和RNA）进行基因型或序列测定，并且在优选实施方案中能够检测单一掺入事件。

公开(公告)号：US20020067481A1

公开(公告)日：2002-06-06

申请号：US09899706

申请日：2001-07-05

Inventor： Udo Wolf ,  Friedrich-Karl Bruder ,  Jurgen Diefendahl ,  Andreas Elschner ,  Uwe Hucks ,  Detlef Riesebeck ,  Bodo Schnittka ,  Manfred Schraut ,  Lutz Spauschus

IPC: G01J003/42

CPC classification number: G01N21/85 ,  G01N21/31

Abstract: An apparatus for the spectroscopic analysis of the composition of the contents of vessels, especially of conduits, by recording transmission spectra is described. The apparatus comprises at least a radiation source for generating the measuring radiation, and a spectral analyzer for measuring the transmitted radiation, two windows which are disposed opposite one another on the vessel and are transparent to the measuring radiation, and two collimators which are designed to spread the measuring radiation within the range of the measuring section and are disposed opposite one another in front of the windows, characterized in that the collimators are positioned relative to one another in a mounting joined to the vessel and the collimators can, while their relative alignment is maintained, be swung out in parallel from the range of the measuring section in the vessel or be displaced and/or be fixed to the mounting, so that the measuring section bypasses the vessel.

Abstract translation: 描述了通过记录透射光谱对容器的内容物，特别是导管的成分进行光谱分析的装置。 该装置至少包括用于产生测量辐射的辐射源，以及用于测量透射辐射的光谱分析仪，在容器上彼此相对设置并对测量辐射透明的两个窗口，以及两个准直器，其被设计为 将测量辐射扩展到测量部分的范围内，并且在窗口前方彼此相对设置，其特征在于，准直器在连接到容器的安装件中相对于彼此定位，并且准直器可以在其相对对准 被保持，从容器中的测量部分的范围平行摆动或移位和/或固定到安装件，使得测量部分绕过容器。

公开(公告)号：US20020024664A1

公开(公告)日：2002-02-28

申请号：US09922845

申请日：2001-08-07

Applicant: Shimadzu Corporation

Inventor： Kazumi Yokota ,  Kaori Kinoshita

IPC: G01J003/42

CPC classification number: G01J3/36 ,  G01J1/04 ,  G01J3/0254 ,  G01N2201/065

Abstract: In a detector for spectrometry attached to an integrating sphere, a plurality of detection elements having different spectral sensitivity characteristics is arranged side by side in the same plane on a base, and a side cover is provided such that the detection elements receive light. Thus, the measurement light is directly irradiated to the respective detection elements. Accordingly, the detector for spectrometry has a fast response speed and is excellent in the sensitivity characteristics in a wide wavelength region in the near-infrared area.

Abstract translation: 在附着于积分球的光谱测定装置中，具有不同光谱灵敏度特性的多个检测元件并排设置在基座的同一平面上，并且设置侧盖，使得检测元件接收光。 因此，测量光直接照射到各个检测元件。 因此，用于光谱测定的检测器具有快速的响应速度，并且在近红外区域的宽波长区域中的灵敏度特性优异。

公开(公告)号：US20010052979A1

公开(公告)日：2001-12-20

申请号：US09800953

申请日：2001-03-07

Inventor： Patrick J. Treado ,  Arjun Bangalore ,  Matthew P. Nelson ,  Christopher T. Zugates

IPC: G01J003/42 ,  G01B009/02

CPC classification number: G02B21/365 ,  G01B11/2545 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/447

Abstract: An apparatus incorporated within a spectroscopic imaging system, typically a microscope, but also applicable to other image gathering platforms, namely fiberscopes, macrolens imaging systems and telescopes employing a polarizing beam splitting element is disclosed. The apparatus allows simultaneous spectroscopic (i.e. chemical) imaging and rapid acquisition spectroscopy to be performed without the need for moving mechanical parts or time sequenced sampling and without introducing significant optical signal loss or degradation to the spectroscopic imaging capability. In addition, the apparatus affords a more compact design, an improved angular field of view and an improved overall ruggedness of optical design at a lower manufacturing and maintenance cost compared to previous devices.

Abstract translation: 公开了一种结合在分光成像系统（通常为显微镜）内的装置，但也适用于采用偏振分束元件的其它图像采集平台，即纤维内窥镜，宏观成像系统和望远镜。 该装置允许执行同时分光（即化学）成像和快速采集光谱，而不需要移动机械部件或时间顺序采样，并且不会对光谱成像能力引入显着的光信号损失或劣化。 此外，与先前的设备相比，该设备以更低的制造和维护成本提供更紧凑的设计，改进的角视场和改进的光学设计的整体耐用性。

公开(公告)号：US20010013931A1

公开(公告)日：2001-08-16

申请号：US09752732

申请日：2001-01-03

Applicant: SHIMADZU CORPORATION

Inventor： Tatsumi Sato

IPC: G01J003/42

CPC classification number: G01J3/08

Abstract: In a double beam spectrophotometer, a sample beam is irradiated to a large-sized sample in a substantially vertical direction, and the beam upwardly transmitted through the large-sized sample is reflected by a reflecting mirror and sent to an integrating sphere including a detector. A reference beam irradiated parallel to the sample beam is deflected by reflecting mirrors such that the reference beam goes around the large-sized sample, and guided to the integrating sphere. Thus, a holder is not required to correspond to a size or shape of the sample, and measurement position can be freely changed by moving the sample. Also, in case of utilizing a conventional standard sample chamber, movable reflecting mirrors are inserted in the optical paths to transfer the beams to the standard sample chamber.

Abstract translation: 在双光束分光光度计中，将样品光束在大致垂直方向上照射到大尺寸样品上，并且向上透射通过大尺寸样品的光束被反射镜反射并发送到包括检测器的积分球。 平行于样品光束照射的参考光束通过反射镜偏转，使得参考光束绕大尺寸样品并被引导到积分球。 因此，保持器不需要对应于样品的尺寸或形状，并且通过移动样品可以自由地改变测量位置。 此外，在利用传统的标准样品室的情况下，将可动反射镜插入到光路中以将光束传送到标准样品室。

公开(公告)号：US20010003044A1

公开(公告)日：2001-06-07

申请号：US09765874

申请日：2001-01-19

Applicant: LJL BioSystems, Inc.

Inventor： Douglas N. Modlin ,  Todd E. French ,  John C. Owicki

IPC: G06F019/00 ,  G01N033/48 ,  G01N033/50 ,  G01J003/42

CPC classification number: G01N21/6452 ,  B82Y15/00 ,  G01N21/51 ,  G01N21/6408 ,  G01N21/6445 ,  G01N21/645 ,  G01N2021/6471

Abstract: Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take frequency-domain time-resolved measurements of one or more of luminescence lifetimes and reorientational correlation times of a luminescent analyte in the sample.

Abstract translation: 用于测量从样品透射的光的装置和方法。 该装置可以包括舞台，光源和检测器。 该台可以被配置成容纳具有多个样品孔的微孔板。 该装置可以被配置为进行样品中发光分析物的发光寿命和重新定向相关时间中的一个或多个的频域时间分辨测量。

公开(公告)号：US20040239928A1

公开(公告)日：2004-12-02

申请号：US10882398

申请日：2004-07-02

Inventor： Yutaka Masuda

IPC: G01J003/28 ,  G01J003/42 ,  G01J003/46

CPC classification number: G01J3/46 ,  G01J3/463 ,  G01J3/504 ,  Y02T10/82

Abstract: To provide a modified-color generation and display method using computer graphic, including measuring the spectral reflectance of an original color by using a spectrophotometer, obtaining the modified spectral reflectance of a modified color by changing the measured spectral reflectance, and displaying the computer graphic of the modified color on a monitor.

Abstract translation: 为了提供使用计算机图形的修改颜色生成和显示方法，包括通过使用分光光度计测量原始颜色的光谱反射率，通过改变测量的光谱反射率来获得修改的颜色的修改的光谱反射率，并且显示计算机图形 监视器上的修改颜色。

公开(公告)号：US20040115796A1

公开(公告)日：2004-06-17

申请号：US10721216

申请日：2003-11-26

Inventor： Ralph E. Burns

IPC: C12M001/34 ,  G01J003/42 ,  G01J003/427

CPC classification number: C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

Abstract translation: 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，预处理分析物分离程序以及确定目标分析物的存在的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

公开(公告)号：US20040085534A1

公开(公告)日：2004-05-06

申请号：US10390817

申请日：2003-03-17

Inventor： Robert E. Parks ,  William P. Kuhn ,  Bryan Loucks ,  Michael R. Jacobson

IPC: G01J003/42

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01J3/0254 ,  G01J3/08

Abstract: A modular dual-beam source, sample compartment and beam-combining system are provided when used with a monochromator and detector to form a spectrophotometer consisting of: (a) a source module where two ellipsoidal mirrors each produce an image of the light source, and (b) a reflecting sample-compartment module, wherein each side has two plane-mirrors, of the four plane mirrors, three are reference and one is the sample, or (c) a transmission sample-compartment module, wherein each side has two plane-mirrors, and a sample is placed between one pair of plane-mirrors, and (d) a beam-combining module wherein the source images are imaged by a second pair of ellipsoidal mirrors on a reflective chopper that combines the images at a single location that is imaged, external to the module, by another mirror, each module being kinematically located with respect to each other so the system remains optically aligned as modules are interchanged.

Abstract translation: 当与单色仪和检测器一起使用时，提供模块化双光束源，样品室和光束组合系统，以形成分光光度计，其由以下组成：（a）源模块，其中两个椭圆面镜各自产生光源的图像，以及 （b）反射样品室模块，其中每个侧面具有两个平面镜，四个平面镜中的三个是参考的，一个是样品，或者（c）透射样品室模块，其中每个侧面具有两个 平面镜，并且将样品放置在一对平面镜之间，和（d）光束组合模块，其中源图像由反射斩波器上的第二对椭球镜成像，其将单个图像组合在一起 通过另一个镜子在模块外部成像的位置，每个模块相对于彼此被运动地定位，使得当模块互换时，系统保持光学对准。