公开(公告)号：US20200323890A1

公开(公告)日：2020-10-15

申请号：US16915513

申请日：2020-06-29

Applicant: ABBOTT LABORATORIES

Inventor： JOMAY CHOW ,  PEDRO PRIETO ,  NED MCCOY

IPC: A61K31/702 ,  A61K9/00 ,  A23L33/16 ,  A23L33/21 ,  A23L2/52 ,  A23L2/39 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K31/194 ,  A61K31/7004 ,  A61K31/717 ,  A61K33/00 ,  A61K33/14 ,  A61K33/30 ,  A61K35/741

Abstract: The general inventive concepts are directed to compositions and methods for the prevention and treatment of dehydration. Provided herein are nutritional compositions including oral rehydration compositions. Certain embodiments of the nutritional compositions have an acidic pH, and comprise a digestible carbohydrate, sodium, citrate, and an oligosaccharide selected from a fucosylated oligosaccharide and an N-acetylated oligosaccharide.

公开(公告)号：US10792294B2

公开(公告)日：2020-10-06

申请号：US15302793

申请日：2015-04-03

Applicant: ABBOTT LABORATORIES

Inventor： Rachael Buck ,  Geralyn Duska-McEwen ,  Steven Davis

IPC: A61K31/7016 ,  A61K31/702 ,  A23L33/00 ,  A23L2/52

Abstract: A method for enhancing an individual's mucosal innate immune response to pathogens is disclosed. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes about 0.05 to about 0.5 mg/mL 2′-fucosyllactose (2′-FL), about 0.05 to about 0.5 mg/mL lacto-N-neotetraose (LNnT), or a combination of both. Also disclosed is a method for enhancing an individual's mucosal innate immune detection of pathogens. The method includes a step of administering a nutritional composition to the individual. The nutritional composition includes a neutral human milk oligosaccharide.

公开(公告)号：US10775388B2

公开(公告)日：2020-09-15

申请号：US15106223

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC ,  ABBOTT LABORATORIES

Inventor： Partha S. Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker ,  Gerard Davis ,  Nicolette Jeanblanc ,  Susan Brophy ,  Bruce Dille

IPC: G01N33/68 ,  C07K16/18 ,  A61P11/06 ,  A61P17/00 ,  A61P11/00 ,  A61K9/00 ,  A61K31/137 ,  A61K31/56 ,  A61K31/58 ,  A61K39/395 ,  C07K16/24 ,  C07K16/28 ,  A61K39/00

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US20200256783A1

公开(公告)日：2020-08-13

申请号：US16657691

申请日：2019-10-18

Applicant: Abbott Laboratories

Inventor： Richard G. Kendall ,  John W. Roche

IPC: G01N15/14 ,  G01N1/28 ,  G01N33/72 ,  G01N21/59 ,  G01N21/27 ,  G01N21/49

Abstract: A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.

公开(公告)号：US10702496B2

公开(公告)日：2020-07-07

申请号：US15962545

申请日：2018-04-25

Applicant: ABBOTT LABORATORIES

Inventor： Chron-si Lai ,  Matthew Kuchan

IPC: A61K31/202 ,  A61K31/355 ,  A61K47/22 ,  A61K9/00 ,  A61P3/02 ,  A23L33/00 ,  A23L33/12 ,  A23L33/15

Abstract: Disclosed are methods of using nutritional compositions generally, and infant formulas specifically, to improve cognitive, brain and/or central nervous system development in an individual. The nutritional compositions include a combination of RRR-alpha tocopherol acetate, non-RRR-alpha-tocopherol stereoisomers, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited.

公开(公告)号：US10695358B2

公开(公告)日：2020-06-30

申请号：US15106568

申请日：2014-12-19

Applicant: ABBOTT LABORATORIES

Inventor： Jomay Chow ,  Pedro Prieto ,  Ned McCoy

IPC: A61K31/00 ,  A61K9/00 ,  A61K31/702 ,  A23L33/16 ,  A23L33/21 ,  A23L2/52 ,  A23L2/39 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K31/194 ,  A61K31/7004 ,  A61K31/717 ,  A61K33/00 ,  A61K33/14 ,  A61K33/30 ,  A61K35/741 ,  A61K35/00

Abstract: The general inventive concepts are directed to compositions and methods for the prevention and treatment of dehydration. Provided herein are nutritional compositions including oral rehydration compositions. Certain embodiments of the nutritional compositions have an acidic pH, and comprise a digestible carbohydrate, sodium, citrate, and an oligosaccharide selected from a fucosylated oligosaccharide and an N-acetylated oligosaccharide.

公开(公告)号：USD886609S1

公开(公告)日：2020-06-09

申请号：US29638686

申请日：2018-02-28

Applicant: Abbott Laboratories

Designer： Roger W. Accurso

公开(公告)号：US10656071B1

公开(公告)日：2020-05-19

申请号：US16664650

申请日：2019-10-25

Applicant: Abbott Laboratories

Inventor： Amish P. Shah ,  Frederic M. Hulett, III

IPC: G01N15/14 ,  G01N21/64 ,  G01N15/10 ,  G01N15/00 ,  G01N21/15 ,  G01N21/05

Abstract: Aspects of the present disclosure include methods for detecting events in a flow cytometer. Also provided are methods of detecting cells in a flow cytometer. Other aspects of the present disclosure include methods for determining a level of contamination in a flow cell. Computer-readable media and systems, e.g., for practicing the methods summarized above, are also provided.

公开(公告)号：USD879993S1

公开(公告)日：2020-03-31

申请号：US29684515

申请日：2019-03-21

Applicant: Abbott Laboratories

Designer： Christina A. Barton ,  Rachel Elizabeth Wallace ,  Ami Marie Verhalen ,  Daniel Roger Nett

公开(公告)号：US20200098105A1

公开(公告)日：2020-03-26

申请号：US16562828

申请日：2019-09-06

Applicant: Abbott Laboratories

Inventor： Rene Nieves Alicea ,  Wenjing Li

IPC: G06T7/00 ,  G06K9/00 ,  G06K9/46 ,  G06K9/52 ,  G06K9/62

Abstract: The instant disclosure provides methods of extracting stain-independent features from digital images of histologically stained cells. Stain-independent features provide consistent assessment of cell morphology in the presence of staining variation and across different stains or stain formulations. Improved consistency in cell morphology assessments finds use in automated cell classification and other image processing applications. Also included are systems for practicing the described methods. The instant disclosure also provides computer readable media storing instructions that, when executed by a computing device, cause the computing device and/or components of a described system to perform steps of a method involving of extraction of stain-independent features from digital images.