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    SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION
    51.
    发明申请
    SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION 审中-公开

    公开(公告)号：US20190301986A1

    公开(公告)日：2019-10-03

    申请号：US16292177

    申请日：2019-03-04

    Applicant: Labcyte Inc.

    Inventor： Joseph D. Olechno ,  Richard N. Ellson

    IPC: G01N1/40 ,  C12N15/10 ,  B01L3/02 ,  B01L3/00 ,  G01N29/02 ,  H01J49/00 ,  H01J49/04 ,  B01D21/28

    Abstract: A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.

    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE
    52.
    发明申请
    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE 审中-公开

    公开(公告)号：US20180231442A1

    公开(公告)日：2018-08-16

    申请号：US15948944

    申请日：2018-04-09

    Applicant: Labcyte Inc.

    Inventor： Richard N. Ellson ,  Richard G. Stearns ,  Joseph D. Olechno ,  Ian Sinclair ,  Jonathan Wingfield

    IPC: G01N1/28 ,  H01J49/04 ,  G01N33/68 ,  C12Q1/68

    CPC classification number: G01N1/28 ,  C12Q1/68 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/04 ,  H01J49/0422 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25875

    Abstract: A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.

    ACOUSTICALLY EJECTING A DROPLET OF FLUID FROM A RESERVOIR BY AN ACOUSTIC FLUID EJECTION APPARATUS
    56.
    发明申请
    ACOUSTICALLY EJECTING A DROPLET OF FLUID FROM A RESERVOIR BY AN ACOUSTIC FLUID EJECTION APPARATUS 有权
    通过声音流体喷射装置从储存器呼出流出液体的液滴

    公开(公告)号：US20140340441A1

    公开(公告)日：2014-11-20

    申请号：US14282996

    申请日：2014-05-20

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns ,  Shehrzad Ahmed Qureshi

    IPC: B41J2/045

    CPC classification number: B05B12/004 ,  B01J2219/00362 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00677 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/0819 ,  B01L2400/0436 ,  B01L2400/0439 ,  B41J2/04541 ,  B41J2/04563 ,  B41J2/04575 ,  B41J2/0458 ,  B41J2/14008

    Abstract: The invention provides apparatuses and methods for acoustically ejecting the fluid from a reservoir contained in or disposed on a substrate. The reservoir has a portion adapted to contain a fluid, and an acoustic radiation generator is positioned in acoustic coupling relationship to the reservoir. Acoustic radiation generated by the acoustic radiation generator is transmitted through at least the portion of the reservoir to an analyzer. The analyzer is capable of determining the energy level of the transmitted acoustic radiation and raising the energy level of subsequent poises to a level sufficient to eject fluid droplets from the reservoir. The invention is particularly suited for delivering fluid from a plurality of reservoirs in an accurate and efficient manner.

    Abstract translation: 本发明提供了用于从包含在或设置在基板上的储存器中喷射流体的装置和方法。 储存器具有适于容纳流体的部分，并且声辐射发生器被定位成与储存器的声耦合关系。 由声辐射发生器产生的声辐射通过至少一部分储存器传输到分析器。 分析仪能够确定所发射的声辐射的能量水平，并且将随后泊位的能量水平提高到足以从储层喷射流体液滴的水平。 本发明特别适用于以准确和有效的方式从多个储层输送流体。

    FOCUS-ACTIVATED ACOUSTIC EJECTION
    57.
    发明申请
    FOCUS-ACTIVATED ACOUSTIC EJECTION 有权
    焦点激发声音喷射

    公开(公告)号：US20140092156A1

    公开(公告)日：2014-04-03

    申请号：US14016909

    申请日：2013-09-03

    Applicant: Labcyte Inc.

    Inventor： Richard N. Ellson

    IPC: B41J29/38

    CPC classification number: B01L3/56 ,  B41J2/04536 ,  B41J2/04575 ,  B41J2/04596

    Abstract: To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.

    Abstract translation: 为了从储存器喷射液滴，保持流体的储存器相对于声学喷射器移动。 当储存器和喷射器靠近在一起时，声学喷射器向贮存器发送一个或多个询问脉冲。 基于询问脉冲，系统确定储存器的运动何时将流体的自由表面放置在可以喷射液滴的位置。

    FOCUSED ACOUSTIC RADIATION FOR THE EJECTION OF SUBWAVELENGTH DROPLETS
    58.
    发明申请
    FOCUSED ACOUSTIC RADIATION FOR THE EJECTION OF SUBWAVELENGTH DROPLETS 有权

    公开(公告)号：US20250018387A1

    公开(公告)日：2025-01-16

    申请号：US18898353

    申请日：2024-09-26

    Applicant: Labcyte Inc.

    Inventor： Richard G. Stearns

    IPC: B01L3/02 ,  H01J49/04

    Abstract: Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    System and method for the acoustic loading of an analytical instrument using a continuous flow sampling probe
    59.
    发明授权
    System and method for the acoustic loading of an analytical instrument using a continuous flow sampling probe 有权

    公开(公告)号：US12154776B2

    公开(公告)日：2024-11-26

    申请号：US18121550

    申请日：2023-03-14

    Applicant: LABCYTE INC. ,  DH Technologies Development Pte. Ltd.

    Inventor： Sammy Datwani ,  Don W. Arnold ,  Lucien P. Ghislain ,  Chang Liu ,  Thomas Covey

    IPC: H01J49/04 ,  B01L3/02 ,  G01N29/02 ,  G01N29/22 ,  H01J49/00 ,  H01J49/16

    Abstract: A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

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