公开(公告)号：US20180144917A1

公开(公告)日：2018-05-24

申请号：US15852412

申请日：2017-12-22

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kelly

IPC: H01J49/00 ,  H01J49/24 ,  H01J49/14

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24 ,  H01J49/40

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

公开(公告)号：US20180102241A1

公开(公告)日：2018-04-12

申请号：US15837016

申请日：2017-12-11

Applicant: MICROMASS UK LIMITED

Inventor： David Gordon ,  Daniel James Kenny ,  Howard Read ,  Kate Whyatt

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/10

Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.

公开(公告)号：US09779924B2

公开(公告)日：2017-10-03

申请号：US15022634

申请日：2014-09-17

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny ,  Richard Barrington Moulds

IPC: H01J49/02 ,  H01J49/04 ,  H01J49/00 ,  H01J49/10 ,  G01F1/68

CPC classification number: H01J49/025 ,  G01F1/68 ,  H01J49/0027 ,  H01J49/0422 ,  H01J49/10

Abstract: Apparatus for a mass spectrometer is disclosed comprising an ion source, a heater for heating a gas flow to the ion source, a temperature sensor for monitoring the temperature of the heater, and a control system. The control system is arranged and adapted to determine a flow rate of the gas flow by monitoring the power supplied to the heater and the temperature of the heater.

公开(公告)号：US20160111266A1

公开(公告)日：2016-04-21

申请号：US14892406

申请日：2014-05-29

Applicant: MICROMASS UK LIMITED

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/24 ,  H01J49/10 ,  H01J49/06

CPC classification number: H01J49/0013 ,  H01J49/062 ,  H01J49/10 ,  H01J49/24

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源，具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 离子检测器位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器位于第二真空室内。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件，第二RF离子导向件的长度L2在0.05-0.3毫巴-cm的范围内。

公开(公告)号：US20160093479A1

公开(公告)日：2016-03-31

申请号：US14892360

申请日：2014-05-29

Applicant: MICROMASS UK LIMITED

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/40

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/145 ,  H01J49/24 ,  H01J49/40

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≦400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyser, a 3D ion trap mass analyser, a 2D or linear ion trap mass analyser, a Time of Flight mass analyser, a quadrupole-Time of Flight mass analyser or an electrostatic mass analyser arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源和具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 离子检测器位于第三真空室中。 第一RF离子引导件位于第一真空室内，第二RF离子导向器位于第二真空室内。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 质谱仪还包括串联四极杆质谱仪，3D离子阱质谱仪，2D或线性离子阱质谱仪，飞行时间质量分析仪，四极杆飞行时间质量分析仪或静电质量分析仪 第三真空室。 第一RF离子导向器附近的压力P1与第一RF离子导向件的长度L1的乘积在10-100mbar-cm的范围内，第二RF离子附近的压力P2的乘积 引导件，第二RF离子导向件的长度L2在0.05-0.3毫巴-cm的范围内。

公开(公告)号：US12230491B2

公开(公告)日：2025-02-18

申请号：US18489510

申请日：2023-10-18

Applicant: Micromass UK Limited

Inventor： Ian David Trivett ,  Anthony Hesse ,  Mark Walford ,  Daniel J. Kenny ,  David Gordon ,  Stanislaw Koziol ,  Steve D. Trudeau ,  Alastair M. Booth ,  Stephen Ayrton

IPC: H01J49/04 ,  B33Y80/00 ,  H01J49/16

Abstract: A nebuliser outlet comprises an inlet end and an outlet end, a first channel and one or more second channels arranged between the inlet end and the outlet end. The first channel is configured to receive a capillary, and the one or more second channels are configured to pass gas to the outlet end. The nebuliser outlet is a single integrated component.

公开(公告)号：US12061166B2

公开(公告)日：2024-08-13

申请号：US17286180

申请日：2019-10-22

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny ,  Richard Barrington Moulds ,  David J. Langridge

IPC: G01N27/622 ,  H01J49/00 ,  H01J49/02

CPC classification number: G01N27/622 ,  H01J49/0095 ,  H01J49/025

Abstract: A dual-mode ion detector for a mass and/or ion mobility spectrometer comprising a first conversion electrode (20) that is maintained, in use, at a negative potential and arranged for converting incident positive ions (32) into secondary electrons (34), and a second conversion electrode (22) that is maintained, in use, at a positive potential and arranged for converting incident negative ions (42) into secondary positive ions (44) and/or secondary electrons (74). The detector also comprises an electron detecting surface (26) and an entrance electrode (24) for drawing ions into the ion detector. The ion detector is switchable between a first mode for detecting positive ions and a second mode for detecting negative ions.

公开(公告)号：US20220384168A1

公开(公告)日：2022-12-01

申请号：US17767227

申请日：2020-10-06

Applicant: Micromass UK Limited

Inventor： Jason Lee Wildgoose ,  Martin Raymond Green ,  Keith Richardson ,  Daniel James Kenny ,  David Gordon ,  Kate Whyatt

IPC: H01J49/00 ,  G01N27/622

Abstract: A method of mass spectrometry is disclosed comprising: a step (10) of analysing a reference compound in a first mass spectrometer and outputting mass spectral data in response thereto; a step (20) of analysing the reference compound in a second, different mass spectrometer and outputting mass spectral data in response thereto; and a step (30) of automatically adjusting an operational parameter, duty cycle (e.g. duty cycle of data acquisition), or acquired spectral data of at least one mass spectrometer such that, for the same (given) consumption of reference compound by the spectrometer, the statistical precision of quantification (the number of detected ions) and/or of mass measurement (the mass resolution) by the mass spectrometer is substantially the same as that of the other mass spectrometer. A similar method of ion mobility spectrometry is disclosed.

公开(公告)号：US20210398789A1

公开(公告)日：2021-12-23

申请号：US17355779

申请日：2021-06-23

Applicant: Micromass UK Limited

Inventor： Ian David Trivett ,  Anthony Hesse ,  Mark Walford ,  Daniel J. Kenny ,  David Gordon ,  Stanislaw Koziol ,  Steve D. Trudeau ,  Alastair Booth ,  Stephen Aryton

IPC: H01J49/04 ,  H01J49/16

Abstract: A nebuliser outlet comprises an inlet end and an outlet end, a first channel and one or more second channels arranged between the inlet end and the outlet end. The first channel is configured to receive a capillary, and the one or more second channels are configured to pass gas to the outlet end. The nebuliser outlet is a single integrated component.

公开(公告)号：US11017990B2

公开(公告)日：2021-05-25

申请号：US16929840

申请日：2020-07-15

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/24 ,  H01J49/00 ,  H01J49/10 ,  H01J49/40 ,  H01J49/14 ,  H01J49/06

Abstract: A miniature mass spectrometer includes an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber downstream of the first vacuum chamber, and a third vacuum chamber downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer also includes a tandem quadrupole mass analyser, 3D ion trap mass analyser, 2D or linear ion trap mass analyser, Time of Flight mass analyser, quadrupole-Time of Flight mass analyser, or electrostatic mass analyser arranged in the third vacuum chamber.